7TR4: MA2-MART1-HLAA0201

MA2-MART1-HLAA0201. Determined by X-ray diffraction at 2.3 Å resolution. Released 23 Nov 2022.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 5
Atoms: 6,361
Mol. weight: 90.85 kDa
Released: 23 Nov 2022

Explore 7TR4 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7TR4 contains 25 α-helices and 76 β-strands across 4 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	51-54	4
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-164	6
α-helix	165-174	10
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-192	7	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chain B: 4 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
α-helix	14-15	2
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain H: 6 helices, 24 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	8
β-strand	5	1	9
β-strand	9-12	4	10
β-strand	18-23	6	9
β-strand	36-40	5	10
β-strand	47-51	5	10
β-strand	55-56	2	10
α-helix	57	1
β-strand	64-69	6	9
β-strand	72-77	6	9
α-helix	82-84	3
β-strand	87-94	8	10
β-strand	97-100	4	10
β-strand	101	1	8
β-strand	104-108	5	10
β-strand	114	1	11
β-strand	117-121	5	12
α-helix	122-124	3
α-helix	125-129	5
β-strand	134-142	9	12
β-strand	143	1	11
β-strand	148-153	6	13
β-strand	157	1	13
β-strand	162-164	3	12
α-helix	165-167	3
β-strand	168-169	2	12
β-strand	175-182	8	12
α-helix	185-190	6
β-strand	194-200	7	13
β-strand	203-209	7	13

Chain L: 5 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	3-7	5	14
β-strand	11-12	2	15
β-strand	18-25	8	14
α-helix	29-31	3
β-strand	33-39	7	16
β-strand	45-51	7	16
β-strand	58-60	3	16
β-strand	68-73	6	14
β-strand	78-83	6	14
α-helix	88-90	3
β-strand	92-99	8	16
β-strand	108-109	2	16
β-strand	113-115	3	16
β-strand	116-117	2	15
β-strand	123	1	17
β-strand	126-130	5	18
β-strand	142-151	10	18
β-strand	152	1	17
β-strand	157-160	4	19
α-helix	161-163	3
β-strand	169-171	3	18
α-helix	172-174	3
β-strand	175-176	2	18
β-strand	182-190	9	18
α-helix	192-194	3
β-strand	201-206	6	19
β-strand	211-216	6	19

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA-A*02:01	A	protein	278	Homo sapiens	A0A140T9X5
Beta-2-microglobulin	B	protein	98	Homo sapiens	P61769 (AlphaFold model)
Light chain	H	protein	214	Homo sapiens
Heavy chain	L	protein	220	Homo sapiens
Melanoma antigen recognized by T-cells 1	P	protein	10	Homo sapiens	Q16655 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7TR4_1 HLA-A*02:01 (chains A)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSS

Sequence of entity 2 (B), FASTA

>7TR4_2 Beta-2-microglobulin (chains B)
QRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWS
FYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (H), FASTA

>7TR4_3 Light chain (chains H)
QSELTQPRSVSGSPGQSVTISCTGTDRDVGGQNYVSWYQQHPGKAPKLIIHDVIERSSGV
PDRFSGSKSGNTASLTISGLQAEDEADYYCWSPAWPYAVFGTGTDVTVLGQPKAAPSVTL
FPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSY
LSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEC

Sequence of entity 4 (L), FASTA

>7TR4_4 Heavy chain (chains L)
EVQLLESGGGLVQPGGSLRLSCAASGFTFSTYQMSWVRQAPGKGLEWVSGIVSSGGSTAY
ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAGELLPGYGMDVWGQGTTVTVSSA
STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG
LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK

Sequence of entity 5 (P), FASTA

>7TR4_5 Melanoma antigen recognized by T-cells 1 (chains P)
ELAGIGILTV

Primary citation

Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Yang, X., Nishimiya, D., Lochte, S. et al. Nat Biotechnol (2023) 41:932-943. DOI 10.1038/s41587-022-01567-w · PubMed

Other PDB entries of the same protein (UniProt A0A140T9X5), best resolution first:

8EB2 2.9 Å, Structure of HLA-A*02:01 in complex with NY-ESO-1 peptide and PA2.1 Fab

Browse structure collections

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