7TZ6: Mitochondrial bc1
Structure of mitochondrial bc1 in complex with ck-2-68. Determined by electron microscopy at 2.88 Å resolution. Released 22 Feb 2023.
- Method
- Electron microscopy
- Resolution
- 2.88 Å
- Organism
- Bos taurus
- Chains
- 22
- Atoms
- 32,742
- Mol. weight
- 487.48 kDa
- Ligands
- FES, HEC, JHB, HEM
- Released
- 22 Feb 2023
Explore 7TZ6 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7TZ6 contains 232 α-helices and 119 β-strands across 22 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 25 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-9 | 6 | |
| α-helix | 12-14 | 3 | |
| β-strand | 15-18 | 4 | 1 |
| β-strand | 24-29 | 6 | 1 |
| β-strand | 34-41 | 8 | 1 |
| α-helix | 45-47 | 3 | |
| α-helix | 55-61 | 7 | |
| β-strand | 67 | 1 | 2 |
| α-helix | 74-81 | 8 | |
| β-strand | 85-90 | 6 | 1 |
| β-strand | 95-102 | 8 | 1 |
| α-helix | 106-116 | 11 | |
| β-strand | 120 | 1 | 2 |
| α-helix | 124-140 | 17 | |
| α-helix | 141-143 | 3 | |
| α-helix | 145-157 | 13 | |
| α-helix | 162-164 | 3 | |
| α-helix | 171-176 | 6 | |
| α-helix | 179-189 | 11 | |
| α-helix | 192-194 | 3 | |
| β-strand | 195-201 | 7 | 1 |
| α-helix | 205-215 | 11 | |
| β-strand | 239-245 | 7 | 3 |
| β-strand | 251-258 | 8 | 3 |
| α-helix | 266-277 | 12 | |
| β-strand | 280-281 | 2 | 3 |
| α-helix | 287-289 | 3 | |
| α-helix | 293-301 | 9 | |
| β-strand | 306-314 | 9 | 3 |
| β-strand | 317-326 | 10 | 3 |
| α-helix | 331-347 | 17 | |
| α-helix | 351-368 | 18 | |
| α-helix | 373-385 | 13 | |
| α-helix | 389-391 | 3 | |
| α-helix | 392-400 | 9 | |
| α-helix | 404-414 | 11 | |
| β-strand | 421-426 | 6 | 3 |
| α-helix | 432-433 | 2 | |
| α-helix | 434-439 | 6 | |
Chain B: 21 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 18-23 | 6 | |
| β-strand | 25-28 | 4 | 4 |
| β-strand | 34-38 | 5 | 4 |
| β-strand | 44-51 | 8 | 4 |
| α-helix | 55-57 | 3 | |
| α-helix | 65-71 | 7 | |
| β-strand | 77 | 1 | 5 |
| α-helix | 82-91 | 10 | |
| β-strand | 95-100 | 6 | 4 |
| β-strand | 105-112 | 8 | 4 |
| α-helix | 113-115 | 3 | |
| α-helix | 116-128 | 13 | |
| β-strand | 130 | 1 | 5 |
| α-helix | 134-139 | 6 | |
| α-helix | 141-151 | 11 | |
| α-helix | 155-167 | 13 | |
| β-strand | 168 | 1 | 6 |
| α-helix | 180-182 | 3 | |
| α-helix | 188-198 | 11 | |
| α-helix | 201-203 | 3 | |
| β-strand | 204-209 | 6 | 4 |
| α-helix | 213-219 | 7 | |
| α-helix | 220-224 | 5 | |
| β-strand | 239 | 1 | 6 |
| β-strand | 243-247 | 5 | 7 |
| β-strand | 252-260 | 9 | 7 |
| α-helix | 267-279 | 13 | |
| β-strand | 285 | 1 | 1 |
| α-helix | 294-302 | 9 | |
| β-strand | 307-315 | 9 | 7 |
| β-strand | 320-329 | 10 | 7 |
| α-helix | 333-349 | 17 | |
| α-helix | 354-371 | 18 | |
| α-helix | 375-388 | 14 | |
| α-helix | 395-403 | 9 | |
| α-helix | 407-418 | 12 | |
| β-strand | 423-428 | 6 | 7 |
Chain C: 26 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 4-6 | 3 | |
| α-helix | 11-14 | 4 | |
| α-helix | 15-19 | 5 | |
| β-strand | 22-24 | 3 | 8 |
| α-helix | 29-32 | 4 | |
| α-helix | 33-51 | 19 | |
| α-helix | 59-61 | 3 | |
| α-helix | 63-71 | 9 | |
| α-helix | 76-103 | 28 | |
| α-helix | 106-108 | 3 | |
| α-helix | 110-130 | 21 | |
| β-strand | 136 | 1 | 9 |
| α-helix | 137-149 | 13 | |
| α-helix | 150-152 | 3 | |
| α-helix | 157-165 | 9 | |
| α-helix | 172-203 | 32 | |
| β-strand | 217-219 | 3 | 8 |
| α-helix | 223-245 | 23 | |
| α-helix | 253-256 | 4 | |
| β-strand | 258 | 1 | 9 |
| α-helix | 259 | 1 | |
| α-helix | 275-283 | 9 | |
| α-helix | 287-299 | 13 | |
| α-helix | 300-303 | 4 | |
| α-helix | 305-307 | 3 | |
| α-helix | 315-317 | 3 | |
| α-helix | 319-339 | 21 | |
| α-helix | 347-360 | 14 | |
| α-helix | 361-365 | 5 | |
| α-helix | 366-376 | 11 | |
Chain D: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-8 | 3 | |
| α-helix | 23-35 | 13 | |
| α-helix | 37-39 | 3 | |
| β-strand | 42 | 1 | 10 |
| β-strand | 47 | 1 | 11 |
| α-helix | 48-51 | 4 | |
| β-strand | 52 | 1 | 12 |
| β-strand | 56 | 1 | 12 |
| α-helix | 58-65 | 8 | |
| β-strand | 69-72 | 4 | 13 |
| β-strand | 81-84 | 4 | 13 |
| α-helix | 89 | 1 | |
| β-strand | 90 | 1 | 11 |
| α-helix | 91-93 | 3 | |
| α-helix | 98-103 | 6 | |
| α-helix | 108-111 | 4 | |
| β-strand | 112 | 1 | 10 |
| α-helix | 124-131 | 8 | |
| α-helix | 136-138 | 3 | |
| β-strand | 148 | 1 | 14 |
| β-strand | 158 | 1 | 14 |
| α-helix | 179-194 | 16 | |
| α-helix | 198-231 | 34 | |
| β-strand | 234-237 | 4 | 3 |
Chain E: 7 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-9 | 3 | |
| β-strand | 14 | 1 | 15 |
| α-helix | 16-18 | 3 | |
| α-helix | 26-61 | 36 | |
| β-strand | 74-77 | 4 | 16 |
| β-strand | 86-88 | 3 | 17 |
| β-strand | 91 | 1 | 18 |
| β-strand | 94 | 1 | 18 |
| β-strand | 97-99 | 3 | 17 |
| α-helix | 103-109 | 7 | |
| α-helix | 123-125 | 3 | |
| β-strand | 133-135 | 3 | 17 |
| α-helix | 144-146 | 3 | |
| β-strand | 147-148 | 2 | 19 |
| β-strand | 156-158 | 3 | 19 |
| β-strand | 163-165 | 3 | 19 |
| β-strand | 171-173 | 3 | 19 |
| α-helix | 179-181 | 3 | |
| β-strand | 185-187 | 3 | 16 |
| β-strand | 192-195 | 4 | 16 |
Chain F: 9 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-24 | 17 | |
| α-helix | 26-29 | 4 | |
| α-helix | 34-36 | 3 | |
| α-helix | 38-39 | 2 | |
| α-helix | 41-48 | 8 | |
| α-helix | 52-71 | 20 | |
| α-helix | 77-79 | 3 | |
| α-helix | 81-82 | 2 | |
| α-helix | 91-109 | 19 | |
Chain G: 1 helix, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 11-18 | 8 | 3 |
| β-strand | 23 | 1 | 20 |
| α-helix | 33-70 | 38 | |
Chain H: 3 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 16-24 | 9 | |
| α-helix | 28-46 | 19 | |
| α-helix | 56-76 | 21 | |
13 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Cytochrome b-c1 complex subunit 1, mitochondrial | A, N | protein | 446 | Bos taurus | P31800 (AlphaFold model) |
| Cytochrome b-c1 complex subunit 2, mitochondrial | B, O | protein | 439 | Bos taurus | P23004 (AlphaFold model) |
| Cytochrome b | C, P | protein | 379 | Bos taurus | P00157 (AlphaFold model) |
| Cytochrome c1, heme protein, mitochondrial | D, Q | protein | 241 | Bos taurus | P00125 (AlphaFold model) |
| Cytochrome b-c1 complex subunit Rieske, mitochondrial | E, R | protein | 196 | Bos taurus | P13272 |
| Cytochrome b-c1 complex subunit 7 | F, S | protein | 110 | Bos taurus | P00129 |
| Cytochrome b-c1 complex subunit 8 | G, T | protein | 80 | Bos taurus | P13271 |
| Cytochrome b-c1 complex subunit 6, mitochondrial | H, U | protein | 78 | Bos taurus | P00126 |
| Cytochrome b-c1 complex subunit Rieske, mitochondrial | I, V | protein | 78 | Bos taurus | P13272 |
| Cytochrome b-c1 complex subunit 9 | J, W | protein | 63 | Bos taurus | P00130 |
| Cytochrome b-c1 complex subunit 10 | K, X | protein | 56 | Bos taurus | P07552 |
Sequence of entity 1 (A, N), FASTA
>7TZ6_1 Cytochrome b-c1 complex subunit 1, mitochondrial (chains A, N)
TATYAQALQSVPETQVSQLDNGLRVASEQSSQPTCTVGVWIDAGSRYESEKNNGAGYFVE
HLAFKGTKNRPGNALEKEVESMGAHLNAYSTREHTAYYIKALSKDLPKAVELLADIVQNC
SLEDSQIEKERDVILQELQENDTSMRDVVFNYLHATAFQGTPLAQSVEGPSENVRKLSRA
DLTEYLSRHYKAPRMVLAAAGGLEHRQLLDLAQKHFSGLSGTYDEDAVPTLSPCRFTGSQ
ICHREDGLPLAHVAIAVEGPGWAHPDNVALQVANAIIGHYDCTYGGGAHLSSPLASIAAT
NKLCQSFQTFNICYADTGLLGAHFVCDHMSIDDMMFVLQGQWMRLCTSATESEVLRGKNL
LRNALVSHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAEVDARVVREVCSKYFYDQCP
AVAGFGPIEQLPDYNRIRSGMFWLRF
Sequence of entity 2 (B, O), FASTA
>7TZ6_2 Cytochrome b-c1 complex subunit 2, mitochondrial (chains B, O)
SLKVAPKVKATEAPAGVPPHPQDLEFTRLPNGLVIASLENYAPASRIGLFIKAGSRYENS
NNLGTSHLLRLASSLTTKGASSFKITRGIEAVGGKLSVTSTRENMAYTVECLRDDVDILM
EFLLNVTTAPEFRRWEVAALQPQLRIDKAVALQNPQAHVIENLHAAAYRNALANSLYCPD
YRIGKVTPVELHDYVQNHFTSARMALIGLGVSHPVLKQVAEQFLNIRGGLGLSGAKAKYH
GGEIREQNGDSLVHAALVAESAAIGSAEANAFSVLQHVLGAGPHVKRGSNATSSLYQAVA
KGVHQPFDVSAFNASYSDSGLFGFYTISQAASAGDVIKAAYNQVKTIAQGNLSNPDVQAA
KNKLKAGYLMSVESSEGFLDEVGSQALAAGSYTPPSTVLQQIDAVADADVINAAKKFVSG
RKSMAASGNLGHTPFIDEL
Sequence of entity 3 (C, P), FASTA
>7TZ6_3 Cytochrome b (chains C, P)
MTNIRKSHPLMKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTT
TAFSSVTHICRDVNYGWIIRYMHANGASMFFICLYMHVGRGLYYGSYTFLETWNIGVILL
LTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFA
FHFILPFIIMAIAMVHLLFLHETGSNNPTGISSDVDKIPFHPYYTIKDILGALLLILALM
LLVLFAPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAFSILI
LALIPLLHTSKQRSMMFRPLSQCLFWALVADLLTLTWIGGQPVEHPYITIGQLASVLYFL
LILVLMPTAGTIENKLLKW
Sequence of entity 4 (D, Q), FASTA
>7TZ6_4 Cytochrome c1, heme protein, mitochondrial (chains D, Q)
SDLELHPPSYPWSHRGLLSSLDHTSIRRGFQVYKQVCSSCHSMDYVAYRHLVGVCYTEDE
AKALAEEVEVQDGPNEDGEMFMRPGKLSDYFPKPYPNPEAARAANNGALPPDLSYIVRAR
HGGEDYVFSLLTGYCEPPTGVSLREGLYFNPYFPGQAIGMAPPIYNEVLEFDDGTPATMS
QVAKDVCTFLRWAAEPEHDHRKRMGLKMLLMMGLLLPLVYAMKRHKWSVLKSRKLAYRPP
K
Sequence of entity 5 (E, R), FASTA
>7TZ6_5 Cytochrome b-c1 complex subunit Rieske, mitochondrial (chains E, R)
SHTDIKVPDFSDYRRPEVLDSTKSSKESSEARKGFSYLVTATTTVGVAYAAKNVVSQFVS
SMSASADVLAMSKIEIKLSDIPEGKNMAFKWRGKPLFVRHRTKKEIDQEAAVEVSQLRDP
QHDLERVKKPEWVILIGVCTHLGCVPIANAGDFGGYYCPCHGSHYDASGRIRKGPAPLNL
EVPSYEFTSDDMVIVG
Sequence of entity 6 (F, S), FASTA
>7TZ6_6 Cytochrome b-c1 complex subunit 7 (chains F, S)
AGRPAVSASSRWLEGIRKWYYNAAGFNKLGLMRDDTIHENDDVKEAIRRLPENLYNDRVF
RIKRALDLSMRQQILPKEQWTKYEEDKSYLEPYLKEVIRERKEREEWAKK
Sequence of entity 7 (G, T), FASTA
>7TZ6_7 Cytochrome b-c1 complex subunit 8 (chains G, T)
GRQFGHLTRVRHVITYSLSPFEQRAFPHYFSKGIPNVLRRTRACILRVAPPFVAFYLVYT
WGTQEFEKSKRKNPAAYEND
Sequence of entity 8 (H, U), FASTA
>7TZ6_8 Cytochrome b-c1 complex subunit 6, mitochondrial (chains H, U)
GDPKEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSQTEEDCTEELLD
FLHARDHCVAHKLFNSLK
Sequence of entity 9 (I, V), FASTA
>7TZ6_9 Cytochrome b-c1 complex subunit Rieske, mitochondrial (chains I, V)
MLSVAARSGPFAPVLSATSRGVAGALRPLVQAAVPATSESPVLDLKRSVLCRESLRGQAA
GRPLVASVSLNVPASVRY
Sequence of entity 10 (J, W), FASTA
>7TZ6_10 Cytochrome b-c1 complex subunit 9 (chains J, W)
VAPTLTARLYSLLFRRTSTFALTIVVGALFFERAFDQGADAIYEHINEGKLWKHIKHKYE
NKE
Sequence of entity 11 (K, X), FASTA
>7TZ6_11 Cytochrome b-c1 complex subunit 10 (chains K, X)
MLTRFLGPRYRQLARNWVPTASLWGAVGAVGLVWATDWRLILDWVPYINGKFKKDD
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| FES | FE2/S2 (inorganic) cluster | Fe2 S2 | 2 |
| HEC | Heme C | C34 H36 Fe N4 O4 | 2 |
| JHB | 7-chloranyl-3-methyl-2-[4-[[4-(trifluoromethyloxy)phenyl]methyl]phenyl]-1~{H}-q… | C24 H17 Cl F3 N O2 | 2 |
| HEM | Protoporphyrin IX containing FE | C34 H32 Fe N4 O4 | 4 |
Primary citation
Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc 1 complexes. Esser, L., Zhou, F., Zeher, A. et al. J Biol Chem (2023) 299:104860-104860. DOI 10.1016/j.jbc.2023.104860 · PubMed
Other PDB entries of the same protein (UniProt P31800 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 1PP9 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin bound
- 1PPJ 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin and antimycin
- 2A06 2.1 Å, Bovine cytochrome bc1 complex with stigmatellin bound
- 9W2X 2.2 Å, Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-1
- 2FYU 2.26 Å, Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
- 1L0L 2.35 Å, structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone
- 1NTM 2.4 Å, Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom
- 9W2Y 2.4 Å, Cryo-EM structure of complex III on the bovine heart submitochondrial particles, III-2
- 1L0N 2.6 Å, native structure of bovine mitochondrial cytochrome bc1 complex
- 1NTK 2.6 Å, Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1
- 1NTZ 2.6 Å, Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone
- 1SQX 2.6 Å, Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A
Browse structure collections
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