7VPW: Transportin-1

Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724). Determined by X-ray diffraction at 3.76 Å resolution. Released 20 Apr 2022.

Method
X-ray diffraction
Resolution
3.76 Å
Organism
Homo sapiens
Chains
2
Atoms
6,705
Mol. weight
100.97 kDa
Released
20 Apr 2022

Explore 7VPW in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7VPW contains 70 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 70 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix12-2211
α-helix27-4014
α-helix45-5612
α-helix62-7716
α-helix80-823
α-helix85-9713
α-helix104-11916
α-helix123-1253
α-helix129-1357
α-helix136-1383
α-helix142-15817
α-helix160-1634
α-helix166-1683
α-helix172-18110
α-helix182-1843
α-helix188-19912
α-helix207-2104
α-helix213-22311
α-helix229-24517
α-helix247-2504
α-helix251-2533
α-helix254-26512
α-helix270-28415
α-helix289-2924
α-helix293-2953
α-helix297-30711
α-helix310-3112
α-helix312-3187
α-helix375-39016
α-helix391-3977
α-helix399-4057
α-helix411-42313
α-helix425-4328
α-helix433-4353
α-helix436-44611
α-helix452-46413
α-helix466-4716
α-helix474-4785
α-helix479-48911
α-helix494-51118
α-helix512-5187
α-helix519-53214
α-helix536-55217
α-helix553-5564
α-helix559-57517
α-helix583-59715
α-helix598-6047
α-helix605-62824
α-helix634-6363
α-helix639-65517
α-helix656-6594
α-helix660-6634
α-helix668-6758
α-helix681-69717
α-helix699-7024
α-helix703-7053
α-helix706-71611
α-helix722-73918
α-helix740-7467
α-helix747-75812
α-helix765-78117
α-helix783-7864
α-helix787-7926
α-helix794-8018
α-helix808-82114
α-helix826-8294
α-helix832-8409
α-helix847-86418
α-helix866-8738
α-helix878-88811

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
BRCA1-associated protein 1 (BAP1)Bprotein19Homo sapiensQ92560 (AlphaFold model)
Transportin-1Aprotein870Homo sapiensQ92973 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>7VPW_1 BRCA1-associated protein 1 (BAP1) (chains B)
IGRLHKQRKPDRRKRSRPY
Sequence of entity 2 (A), FASTA
>7VPW_2 Transportin-1 (chains A)
GGSKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTK
LKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITT
IASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMI
PKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVC
RALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRH
LPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRGGSGGSGDTISDWNLRKCSA
AALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELI
PHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAA
CSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPE
YIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTL
AQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKM
PEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMG
IEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTS
LRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGF
KNQVGDENWRRFSDQFPLPLKERLAAFYGV

Primary citation

Tumor suppressor BAP1 nuclear import is governed by transportin-1. Yang, T.J., Li, T.N., Huang, R.S. et al. J Cell Biol (2022) 221. DOI 10.1083/jcb.202201094 · PubMed

Other PDB entries of the same protein (UniProt Q92560 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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