7W1M: Human cohesin-CTCF-DNA complex
Cryo-EM structure of human cohesin-CTCF-DNA complex. Determined by electron microscopy at 6.5 Å resolution. Released 31 May 2023.
- Method
- Electron microscopy
- Resolution
- 6.5 Å
- Organism
- Homo sapiens
- Chains
- 8
- Atoms
- 34,251
- Mol. weight
- 826.7 kDa
- Ligands
- ADP, BEF, ZN
- Released
- 31 May 2023
Explore 7W1M in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7W1M contains 176 α-helices and 60 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 13 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 3-10 | 8 | 1 |
| β-strand | 12 | 1 | 2 |
| β-strand | 18-20 | 3 | 1 |
| α-helix | 21-23 | 3 | |
| β-strand | 29-31 | 3 | 3 |
| α-helix | 39-49 | 11 | |
| α-helix | 53-56 | 4 | |
| β-strand | 65 | 1 | 2 |
| β-strand | 78-86 | 9 | 1 |
| β-strand | 90-99 | 10 | 1 |
| β-strand | 102-107 | 6 | 1 |
| β-strand | 111-112 | 2 | 1 |
| α-helix | 114-124 | 11 | |
| α-helix | 140-144 | 5 | |
| α-helix | 148-158 | 11 | |
| α-helix | 162-164 | 3 | |
| α-helix | 165-200 | 36 | |
| α-helix | 1028-1088 | 61 | |
| β-strand | 1096-1100 | 5 | 4 |
| β-strand | 1111-1115 | 5 | 4 |
| α-helix | 1125-1127 | 3 | |
| α-helix | 1130-1147 | 18 | |
| β-strand | 1152-1156 | 5 | 3 |
| α-helix | 1164-1181 | 18 | |
| β-strand | 1183-1188 | 6 | 3 |
| α-helix | 1191-1195 | 5 | |
| β-strand | 1199-1206 | 8 | 3 |
| β-strand | 1212-1219 | 8 | 3 |
Chain B: 18 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-9 | 8 | 5 |
| β-strand | 27-31 | 5 | 6 |
| α-helix | 39-49 | 11 | |
| α-helix | 52-55 | 4 | |
| α-helix | 58-62 | 5 | |
| α-helix | 72-73 | 2 | |
| β-strand | 76-83 | 8 | 5 |
| β-strand | 95-102 | 8 | 5 |
| β-strand | 107-111 | 5 | 5 |
| β-strand | 115 | 1 | 5 |
| α-helix | 120-128 | 9 | |
| α-helix | 146-149 | 4 | |
| α-helix | 152-162 | 11 | |
| α-helix | 168-255 | 88 | |
| α-helix | 916-935 | 20 | |
| α-helix | 939-946 | 8 | |
| α-helix | 952-954 | 3 | |
| α-helix | 964-978 | 15 | |
| α-helix | 986-1047 | 62 | |
| β-strand | 1051-1057 | 7 | 7 |
| β-strand | 1096-1102 | 7 | 7 |
| α-helix | 1117-1134 | 18 | |
| β-strand | 1139-1143 | 5 | 6 |
| α-helix | 1151-1164 | 14 | |
| β-strand | 1169-1173 | 5 | 6 |
| α-helix | 1178-1181 | 4 | |
| β-strand | 1185-1192 | 8 | 6 |
| β-strand | 1195-1201 | 7 | 6 |
| α-helix | 1203-1207 | 5 | |
| α-helix | 1208-1212 | 5 | |
Chain C: 15 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 15-18 | 4 | |
| α-helix | 19-23 | 5 | |
| α-helix | 29-34 | 6 | |
| α-helix | 38-45 | 8 | |
| α-helix | 53-85 | 33 | |
| β-strand | 331 | 1 | 8 |
| α-helix | 334-342 | 9 | |
| α-helix | 345-347 | 3 | |
| β-strand | 348 | 1 | 9 |
| β-strand | 353 | 1 | 10 |
| α-helix | 354-355 | 2 | |
| α-helix | 358-364 | 7 | |
| α-helix | 369-372 | 4 | |
| α-helix | 383-390 | 8 | |
| α-helix | 559-574 | 16 | |
| β-strand | 579-580 | 2 | 11 |
| α-helix | 581-584 | 4 | |
| α-helix | 590-605 | 16 | |
| β-strand | 609-612 | 4 | 11 |
| α-helix | 619-620 | 2 | |
| β-strand | 621-624 | 4 | 11 |
Chain D: 51 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 87-92 | 6 | |
| α-helix | 98-111 | 14 | |
| α-helix | 113-127 | 15 | |
| α-helix | 136-140 | 5 | |
| α-helix | 144-153 | 10 | |
| α-helix | 169-188 | 20 | |
| α-helix | 193-195 | 3 | |
| α-helix | 199-211 | 13 | |
| α-helix | 216-256 | 41 | |
| α-helix | 261-291 | 31 | |
| α-helix | 292-296 | 5 | |
| α-helix | 297-299 | 3 | |
| β-strand | 302 | 1 | 8 |
| α-helix | 305-321 | 17 | |
| α-helix | 329-338 | 10 | |
| α-helix | 344-358 | 15 | |
| α-helix | 365-373 | 9 | |
| α-helix | 375-382 | 8 | |
| β-strand | 384 | 1 | 9 |
| α-helix | 387-403 | 17 | |
| α-helix | 410-419 | 10 | |
| β-strand | 422 | 1 | 10 |
| α-helix | 425-438 | 14 | |
| α-helix | 462-474 | 13 | |
| α-helix | 482-487 | 6 | |
| α-helix | 493-496 | 4 | |
| α-helix | 499-504 | 6 | |
| α-helix | 519-537 | 19 | |
| α-helix | 554-581 | 28 | |
| α-helix | 586-592 | 7 | |
| α-helix | 595-598 | 4 | |
| α-helix | 602-607 | 6 | |
| α-helix | 610-626 | 17 | |
| α-helix | 630-643 | 14 | |
| α-helix | 651-676 | 26 | |
| α-helix | 685-703 | 19 | |
| α-helix | 713-725 | 13 | |
| α-helix | 731-750 | 20 | |
| α-helix | 760-781 | 22 | |
| α-helix | 785-801 | 17 | |
| α-helix | 804-807 | 4 | |
| α-helix | 820-822 | 3 | |
| α-helix | 823-836 | 14 | |
| α-helix | 858-877 | 20 | |
| α-helix | 884-890 | 7 | |
| α-helix | 897-914 | 18 | |
| α-helix | 916-938 | 23 | |
| α-helix | 947-962 | 16 | |
| α-helix | 970-985 | 16 | |
| α-helix | 998 | 1 | |
| α-helix | 1003-1011 | 9 | |
| α-helix | 1018-1026 | 9 | |
| α-helix | 1032-1036 | 5 | |
| α-helix | 1043-1050 | 8 | |
Chain E: 67 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 1200-1215 | 16 | |
| α-helix | 1235-1245 | 11 | |
| α-helix | 1249-1252 | 4 | |
| α-helix | 1258-1275 | 18 | |
| α-helix | 1295-1318 | 24 | |
| α-helix | 1330-1343 | 14 | |
| α-helix | 1344-1348 | 5 | |
| α-helix | 1349-1352 | 4 | |
| α-helix | 1381-1403 | 23 | |
| α-helix | 1408-1419 | 12 | |
| α-helix | 1420-1423 | 4 | |
| α-helix | 1428-1444 | 17 | |
| α-helix | 1449-1458 | 10 | |
| α-helix | 1460-1462 | 3 | |
| β-strand | 1471-1473 | 3 | 12 |
| β-strand | 1487-1488 | 2 | 12 |
| α-helix | 1489-1500 | 12 | |
| α-helix | 1525-1550 | 26 | |
| α-helix | 1559-1571 | 13 | |
| β-strand | 1575 | 1 | 13 |
| β-strand | 1578 | 1 | 13 |
| α-helix | 1581-1596 | 16 | |
| α-helix | 1603-1627 | 25 | |
| α-helix | 1647-1665 | 19 | |
| α-helix | 1670-1689 | 20 | |
| α-helix | 1709-1728 | 20 | |
| α-helix | 1750-1763 | 14 | |
| α-helix | 1767-1769 | 3 | |
| α-helix | 1770-1779 | 10 | |
| α-helix | 1786-1802 | 17 | |
| α-helix | 1810-1820 | 11 | |
| α-helix | 1825-1841 | 17 | |
| α-helix | 1850-1855 | 6 | |
| α-helix | 1863-1878 | 16 | |
| α-helix | 1885-1891 | 7 | |
| α-helix | 1893-1895 | 3 | |
| α-helix | 1900-1913 | 14 | |
| α-helix | 1923-1939 | 17 | |
| α-helix | 1946-1958 | 13 | |
| α-helix | 1966-1985 | 20 | |
| α-helix | 1999-2015 | 17 | |
| α-helix | 2028-2032 | 5 | |
| α-helix | 2038-2057 | 20 | |
| α-helix | 2063-2078 | 16 | |
| α-helix | 2082-2096 | 15 | |
| α-helix | 2103-2126 | 24 | |
| α-helix | 2132-2135 | 4 | |
| α-helix | 2137-2153 | 17 | |
| α-helix | 2169-2181 | 13 | |
| α-helix | 2187-2202 | 16 | |
| α-helix | 2204-2208 | 5 | |
| α-helix | 2210-2220 | 11 | |
| α-helix | 2228-2253 | 26 | |
| α-helix | 2259-2261 | 3 | |
| α-helix | 2270-2289 | 20 | |
| α-helix | 2295-2311 | 17 | |
| α-helix | 2320-2325 | 6 | |
| α-helix | 2326-2328 | 3 | |
| α-helix | 2332-2346 | 15 | |
| α-helix | 2352-2355 | 4 | |
| α-helix | 2358-2371 | 14 | |
| α-helix | 2393-2399 | 7 | |
| α-helix | 2403-2416 | 14 | |
| α-helix | 2425-2437 | 13 | |
| β-strand | 2442 | 1 | 14 |
| α-helix | 2444-2470 | 27 | |
| α-helix | 2534-2557 | 24 | |
| α-helix | 2561-2566 | 6 | |
| α-helix | 2578 | 1 | |
| β-strand | 2579 | 1 | 14 |
| α-helix | 2580-2581 | 2 | |
| α-helix | 2589-2600 | 12 | |
| α-helix | 2608-2626 | 19 | |
Chain H: 12 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 224-226 | 3 | |
| β-strand | 266-267 | 2 | 15 |
| β-strand | 274-275 | 2 | 15 |
| α-helix | 278-289 | 12 | |
| β-strand | 294-295 | 2 | 16 |
| β-strand | 302-303 | 2 | 16 |
| α-helix | 306-316 | 11 | |
| β-strand | 322-323 | 2 | 17 |
| β-strand | 330-331 | 2 | 17 |
| α-helix | 334-344 | 11 | |
| β-strand | 351-352 | 2 | 18 |
| β-strand | 359-360 | 2 | 18 |
| α-helix | 363-374 | 12 | |
| β-strand | 380 | 1 | 19 |
| β-strand | 387 | 1 | 19 |
| α-helix | 391-402 | 12 | |
| α-helix | 419-429 | 11 | |
| β-strand | 437-438 | 2 | 20 |
| β-strand | 445-446 | 2 | 20 |
| α-helix | 449-459 | 11 | |
| β-strand | 462-468 | 7 | 21 |
| β-strand | 475-478 | 4 | 21 |
| α-helix | 479-489 | 11 | |
| β-strand | 495-496 | 2 | 22 |
| β-strand | 503-504 | 2 | 22 |
| α-helix | 507-517 | 11 | |
| β-strand | 523-524 | 2 | 23 |
| β-strand | 531-532 | 2 | 23 |
| α-helix | 537-546 | 10 | |
| α-helix | 567-575 | 9 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Structural maintenance of chromosomes protein 1A | A | protein | 1233 | Homo sapiens | Q14683 (AlphaFold model) |
| Structural maintenance of chromosomes protein 3 | B | protein | 1217 | Homo sapiens | Q9UQE7 (AlphaFold model) |
| Double-strand-break repair protein rad21 homolog | C | protein | 631 | Homo sapiens | O60216 (AlphaFold model) |
| Cohesin subunit SA-1 | D | protein | 1258 | Homo sapiens | Q8WVM7 (AlphaFold model) |
| Nipped-B-like protein | E | protein | 1467 | Homo sapiens | Q6KC79 |
| DNA (118-mer) | F | DNA | 118 | Homo sapiens | |
| DNA (118-mer) | G | DNA | 118 | Homo sapiens | |
| Transcriptional repressor CTCF | H | protein | 727 | Homo sapiens | P49711 |
Sequence of entity 1 (A), FASTA
>7W1M_1 Structural maintenance of chromosomes protein 1A (chains A)
MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKT
LRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGSSEYKINNKVVQLHEYSEE
LEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEE
DTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNK
ELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIK
AKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMDELEKEMLSVEKARQEFEERMEEESQS
QGRDLTLEENQVKKYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAK
IKQKLREIEENQKRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQV
MEQLGDARIDRQESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGK
NMDAIIVDSEKTGRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRY
EPPHIKKALQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLK
AKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLE
QTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEF
CREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQ
TVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGG
ANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGE
DSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRI
AAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATN
IDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALAL
LFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESL
IGVYPEQGDCVISKVLTFDLTKYPDANPNPNEQ
Sequence of entity 2 (B), FASTA
>7W1M_2 Structural maintenance of chromosomes protein 3 (chains B)
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ
RLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKND
VMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMK
ETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLD
ELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIK
QRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEER
GIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDL
EDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQ
QALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNF
ECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAY
PETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSH
RGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQ
IETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAE
LGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRL
DQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKS
MERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTL
SLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNV
LELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERG
SGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFY
LFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDV
ITAEMAKDFVEDDTTHG
Sequence of entity 3 (C), FASTA
>7W1M_3 Double-strand-break repair protein rad21 homolog (chains C)
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLL
LGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQP
LPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMAEGSAFEDD
DMLVSTTTSNLLLESEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGG
IFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPASVDPVEPMPTMTDQTTLVPNE
EEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKL
MMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEF
ENPEVPREDQQQQHQQRDVIDEPIIEEPSALQESVMEASRTNIDESAMPPPPPQGVKRKA
GQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEE
DEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSF
LVLKKQQAIELTQEEPYSDIIATPGPRFHII
Sequence of entity 4 (D), FASTA
>7W1M_4 Cohesin subunit SA-1 (chains D)
MITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRI
EAGIRGAGRGRANGHPQQNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDL
INFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMPGPQWKKFRSNFCE
FIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNL
SIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRY
RDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVRLKCLKALQSLYTN
RELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLV
YSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEH
AAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIELMVCTIRQAAEAH
PPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFD
LEIYSTGRMEKHLDALLKQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQ
LIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDLTKWDLFGNCYRLL
KTGIEHGAMPEQIVVQALQCSHYSILWQLVKITDGSPSKEDLLVLRKTVKSFLAVCQQCL
SNVNTPVKEQAFMLLCDLLMIFSHQLMTGGREGLQPLVFNPDTGLQSELLSFVMDHVFID
QDEENQSMEGDEEDEANKIEALHKRRNLLAAFSKLIIYDIVDMHAAADIFKHYMKYYNDY
GDIIKETLSKTRQIDKIQCAKTLILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFA
LTFGLDQIKTREAVATLHKDGIEFAFKYQNQKGQEYPPPNLAFLEVLSEFSSKLLRQDKK
TVHSYLEKFLTEQMMERREDVWLPLISYRNSLVTGGEDDRMSVNSGSSSSKTSSVRNKKG
RPPLHKKRVEDESLDNTWLNRTDTMIQTPGPLPAPQLTSTVLRENSRPMGDQIQEPESEH
GSEPDFLHNPQMQISWLGQPKLEDLNRKDRTGMNYMKVRTGVRHAVRGLMEEDAEPIFED
VMMSSRSQLEDMNEEFEDTMVIDLPPSRNRRERAELRPDFFDSAAIIEDDSGFGMPMF
Sequence of entity 5 (E), FASTA
>7W1M_5 Nipped-B-like protein (chains E)
SLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGD
DDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQDGSKLSTLL
NHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERVIQYTKFH
LQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQRVIVMLYNKVCDIVSSLSELLEI
QLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTAVFSRYEKHRQLILEEIFTSLARL
PTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQCVVHLPSSEKDSNAEEDSNKKIDQ
DVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRPLFENFVQDLLSTVNKPEWPAAEL
LLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARLRKDAVTSKMDQGSIERILKQVSG
GEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQWFRDTTLETEKAMKSQKDEESSEG
THHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFSTLKMNSDTVDYDDACLIVRYLASM
RPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVVAVDPSILARLDMQRGVHGRLMDN
STSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDTGISVRKRVIKILRDICIEQPTFP
KITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPHNDKEAMTRKILNITDVVAACRDT
GYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVEHILKYEESLADSDNKGVNSGRLV
ACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQNDFMVICNVAKILELVVPLMEHPSE
TFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVTQNFKFVWACFNRYYGAISKLKSQ
HQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLEDFKGNSKVNIKDKVLELLMYFTKH
SDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNILSDKNSSVNLKIQVLKNLQTYLQE
EDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQLYLKQVLEAFFHTQSSVRHFALN
VIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQQLVEIDKKYAGFIHMKAVAGMKM
SYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKT
DVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSS
PSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGI
LLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMAN
SKITEEVKRSIVKQYLDFKLLMEHLDP
Sequence of entity 6 (F), FASTA
>7W1M_6 DNA (118-MER) (chains F)
GATAAATTCTTGTTTTCATATCCTAAAATTAAAGGGAAAATAAACAATACATAACAAAAC
ATATAAAAACCACCTCACTAGCGCCCCCTGCTGGCCTCTGTGGGCACTGCAATCTTGC
Sequence of entity 7 (G), FASTA
>7W1M_7 DNA (118-MER) (chains G)
GCAAGATTGCAGTGCCCACAGAGGCCAGCAGGGGGCGCTAGTGAGGTGGTTTTTATATGT
TTTGTTATGTATTGTTTATTTTCCCTTTAATTTTAGGATATGAAAACAAGAATTTATC
Sequence of entity 8 (H), FASTA
>7W1M_8 Transcriptional repressor CTCF (chains H)
MEGDAVEAIVEESETFIKGKERKTYQRRREGGQEEDACHLPQNQTDGGEVVQDVNSSVQM
VMMEQLDPTLLQMKTEVMEGTVAPEAEAAVDDTQIITLQVVNMEEQPINIGELQLVQVPV
PVTVPVATTSVEELQGAYENEVSKEGLAESEPMICHTLPLPEGFQVVKVGANGEVETLEQ
GELPPQEDPSWQKDPDYQPPAKKTKKTKKSKLRYTEEGKDVDVSVYDFEEEQQEGLLSEV
NAEKVVGNMKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHLCG
RAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYAS
VEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG
TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERY
ALIQHQKSHKNEKRFKCDQCDYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDM
HFKRYHDPNFVPAAFVCSKCGKTFTRRNTMARHADNCAGPDGVEGENGGETKKSKRGRKR
KMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRTN
QPKQNQPTAIIQVEDQNTGAIENIIVEVKKEPDAEPAEGEEEEAQPAATDAPNGDLTPEM
ILSMMDR
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
| BEF | Beryllium trifluoride ion | Be F3 | 2 |
| ZN | Zinc ion | Zn | 11 |
Primary citation
CTCF and R-loops are boundaries of cohesin-mediated DNA looping. Zhang, H., Shi, Z., Banigan, E.J. et al. Mol Cell (2023) 83:2856-2871.e8. DOI 10.1016/j.molcel.2023.07.006 · PubMed
Other PDB entries of the same protein (UniProt Q14683 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8ROE 1.36 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-bound conformation
- 8ROD 1.5 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Open/closed P-loop conformation
- 8ROF 1.65 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ADP-Mg-bound conformation
- 8RO9 1.77 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Open/closed P-loop conformation
- 8ROC 1.85 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - Apo closed P-loop conformation
- 8RO8 1.9 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - Apo closed P-loop conformation
- 8ROG 1.94 Å, Human cohesin SMC1A-HD(shortCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation
- 8RO7 2.09 Å, Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Open/closed P-loop conformation
- 8RO6 2.2 Å, Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Apo closed P-loop conformation
- 6WG4 2.31 Å, Crystal structure of human SMC1-SMC3 hinge domain heterodimer in south-open conformation
- 8ROA 2.44 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ADP-bound conformation
- 8ROB 2.5 Å, Human cohesin SMC1A-HD(longCC-EQ)/RAD21-C complex - ATPgS-Mg-bound conformation
Browse structure collections
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