7W3I: Ubiquitin carboxyl-terminal hydrolase 14
Structure of USP14-bound human 26S proteasome in substrate-inhibited state SB_USP14. Determined by electron microscopy at 3.5 Å resolution. Released 18 May 2022.
- Method
- Electron microscopy
- Resolution
- 3.5 Å
- Organism
- Homo sapiens
- Chains
- 48
- Atoms
- 110,481
- Mol. weight
- 1732.87 kDa
- Ligands
- ATP, ADP, ZN
- Released
- 18 May 2022
Explore 7W3I in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7W3I contains 595 α-helices and 588 β-strands across 48 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 19 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-10 | 6 | |
| α-helix | 18-28 | 11 | |
| α-helix | 35-37 | 3 | |
| α-helix | 53-66 | 14 | |
| α-helix | 73-87 | 15 | |
| α-helix | 90-103 | 14 | |
| α-helix | 110-121 | 12 | |
| α-helix | 131-139 | 9 | |
| α-helix | 150-162 | 13 | |
| α-helix | 170-182 | 13 | |
| α-helix | 190-205 | 16 | |
| α-helix | 231-242 | 12 | |
| α-helix | 247-256 | 10 | |
| α-helix | 265-273 | 9 | |
| α-helix | 277-283 | 7 | |
| α-helix | 293-300 | 8 | |
| α-helix | 304-317 | 14 | |
| β-strand | 320 | 1 | 103 |
| β-strand | 323-324 | 2 | 85 |
| β-strand | 331-332 | 2 | 85 |
| β-strand | 335 | 1 | 103 |
| α-helix | 343-345 | 3 | |
| α-helix | 346-375 | 30 | |
Chain A: 22 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-33 | 7 | |
| α-helix | 42-49 | 8 | |
| α-helix | 50-52 | 3 | |
| α-helix | 75-79 | 5 | |
| α-helix | 80-82 | 3 | |
| β-strand | 97-101 | 5 | 13 |
| β-strand | 111-112 | 2 | 14 |
| β-strand | 113-114 | 2 | 13 |
| β-strand | 121-123 | 3 | 14 |
| β-strand | 124-125 | 2 | 13 |
| β-strand | 139-142 | 4 | 13 |
| β-strand | 148-152 | 5 | 13 |
| α-helix | 154-156 | 3 | |
| α-helix | 159-162 | 4 | |
| β-strand | 165 | 1 | 15 |
| α-helix | 174-177 | 4 | |
| α-helix | 181-196 | 16 | |
| α-helix | 200-204 | 5 | |
| β-strand | 211-215 | 5 | 15 |
| α-helix | 222-231 | 10 | |
| β-strand | 236-239 | 4 | 15 |
| α-helix | 242-244 | 3 | |
| α-helix | 252-266 | 15 | |
| β-strand | 270-273 | 4 | 15 |
| α-helix | 277-280 | 4 | |
| α-helix | 294-306 | 13 | |
| β-strand | 315-320 | 6 | 15 |
| α-helix | 324-326 | 3 | |
| β-strand | 339-342 | 4 | 15 |
| α-helix | 350-358 | 9 | |
| α-helix | 371-375 | 5 | |
| α-helix | 382-397 | 16 | |
| α-helix | 406-414 | 9 | |
| α-helix | 415-419 | 5 | |
| α-helix | 426-428 | 3 | |
Chain b: 9 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-9 | 6 | 109 |
| β-strand | 13 | 1 | 110 |
| α-helix | 14-17 | 4 | |
| α-helix | 25-43 | 19 | |
| β-strand | 48-52 | 5 | 109 |
| β-strand | 53 | 1 | 111 |
| β-strand | 55 | 1 | 112 |
| β-strand | 59 | 1 | 111 |
| β-strand | 65 | 1 | 109 |
| α-helix | 69-74 | 6 | |
| β-strand | 82 | 1 | 110 |
| β-strand | 83 | 1 | 112 |
| α-helix | 86-98 | 13 | |
| α-helix | 105 | 1 | |
| β-strand | 106-113 | 8 | 109 |
| α-helix | 121-133 | 13 | |
| β-strand | 137-142 | 6 | 109 |
| α-helix | 151-160 | 10 | |
| β-strand | 171 | 1 | 109 |
| α-helix | 172-174 | 3 | |
| α-helix | 185-189 | 5 | |
Chain B: 17 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 35-37 | 3 | |
| α-helix | 59-78 | 20 | |
| α-helix | 79-83 | 5 | |
| α-helix | 95-102 | 8 | |
| β-strand | 108-116 | 9 | 13 |
| β-strand | 120-124 | 5 | 13 |
| β-strand | 130-135 | 6 | 13 |
| β-strand | 149-152 | 4 | 13 |
| β-strand | 159-162 | 4 | 13 |
| α-helix | 171-174 | 4 | |
| β-strand | 175 | 1 | 18 |
| α-helix | 191-197 | 7 | |
| α-helix | 198-202 | 5 | |
| α-helix | 203-206 | 4 | |
| α-helix | 211-214 | 4 | |
| α-helix | 217-219 | 3 | |
| β-strand | 221-223 | 3 | 18 |
| α-helix | 232-241 | 10 | |
| β-strand | 247-251 | 5 | 18 |
| α-helix | 262-276 | 15 | |
| β-strand | 281-285 | 5 | 18 |
| α-helix | 289-292 | 4 | |
| α-helix | 303-317 | 15 | |
| β-strand | 326-330 | 5 | 18 |
| β-strand | 347-349 | 3 | 18 |
| α-helix | 358-370 | 13 | |
| α-helix | 392-408 | 17 | |
| α-helix | 416-427 | 12 | |
Chain c: 12 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 31-33 | 3 | 116 |
| α-helix | 35-47 | 13 | |
| β-strand | 54-60 | 7 | 116 |
| β-strand | 67-74 | 8 | 116 |
| α-helix | 84-86 | 3 | |
| α-helix | 89-98 | 10 | |
| β-strand | 108 | 1 | 116 |
| β-strand | 110-114 | 5 | 116 |
| α-helix | 124-136 | 13 | |
| β-strand | 141-145 | 5 | 116 |
| β-strand | 159-160 | 2 | 116 |
| α-helix | 162-164 | 3 | |
| α-helix | 166-169 | 4 | |
| α-helix | 189-192 | 4 | |
| β-strand | 203 | 1 | 116 |
| β-strand | 205-207 | 3 | 116 |
| α-helix | 214-220 | 7 | |
| α-helix | 227-229 | 3 | |
| α-helix | 237-261 | 25 | |
| α-helix | 268-272 | 5 | |
| α-helix | 286-308 | 23 | |
Chain C: 18 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-64 | 44 | |
| α-helix | 65-67 | 3 | |
| α-helix | 68-70 | 3 | |
| β-strand | 71-75 | 5 | 14 |
| β-strand | 76 | 1 | 13 |
| β-strand | 84-87 | 4 | 13 |
| β-strand | 94-98 | 5 | 13 |
| β-strand | 113-116 | 4 | 14 |
| β-strand | 122 | 1 | 13 |
| β-strand | 123-126 | 4 | 14 |
| α-helix | 130-132 | 3 | |
| α-helix | 155-170 | 16 | |
| α-helix | 173-178 | 6 | |
| α-helix | 181-183 | 3 | |
| β-strand | 185-189 | 5 | 22 |
| α-helix | 196-206 | 11 | |
| β-strand | 210-213 | 4 | 22 |
| α-helix | 230-232 | 3 | |
| α-helix | 233-234 | 2 | |
| α-helix | 235-239 | 5 | |
| β-strand | 244-249 | 6 | 22 |
| α-helix | 267-281 | 15 | |
| β-strand | 289-295 | 7 | 22 |
| α-helix | 298-300 | 3 | |
| β-strand | 313-316 | 4 | 22 |
| α-helix | 318-321 | 4 | |
| α-helix | 322-333 | 12 | |
| α-helix | 345-350 | 6 | |
| α-helix | 359-373 | 15 | |
| α-helix | 380-390 | 11 | |
Chain d: 10 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 17-30 | 14 | |
| α-helix | 44-64 | 21 | |
| α-helix | 68-82 | 15 | |
| α-helix | 95-108 | 14 | |
| α-helix | 112-121 | 10 | |
| α-helix | 131-143 | 13 | |
| α-helix | 149-155 | 7 | |
| α-helix | 164-182 | 19 | |
| α-helix | 205-212 | 8 | |
| β-strand | 217 | 1 | 120 |
| β-strand | 222 | 1 | 120 |
| α-helix | 239-253 | 15 | |
Chain D: 12 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 41-80 | 40 | |
| β-strand | 87-97 | 11 | 14 |
| β-strand | 100-105 | 6 | 14 |
| β-strand | 109-115 | 7 | 14 |
| α-helix | 121-123 | 3 | |
| β-strand | 129-132 | 4 | 14 |
| β-strand | 139-142 | 4 | 14 |
| α-helix | 171-186 | 16 | |
| α-helix | 188-194 | 7 | |
| β-strand | 201-205 | 5 | 27 |
| α-helix | 216-221 | 6 | |
| β-strand | 226-230 | 5 | 27 |
| α-helix | 242-257 | 16 | |
| β-strand | 260-265 | 6 | 27 |
| α-helix | 267-269 | 3 | |
| α-helix | 283-297 | 15 | |
| β-strand | 306-310 | 5 | 27 |
| β-strand | 329-332 | 4 | 27 |
| α-helix | 338-349 | 12 | |
| α-helix | 360-363 | 4 | |
| α-helix | 372-388 | 17 | |
| α-helix | 396-406 | 11 | |
40 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Ubiquitin carboxyl-terminal hydrolase 14 | x | protein | 494 | Homo sapiens | P54578 (AlphaFold model) |
| 26S protease regulatory subunit 7 | A | protein | 433 | Homo sapiens | P35998 (AlphaFold model) |
| 26S protease regulatory subunit 4 | B | protein | 440 | Homo sapiens | P62191 (AlphaFold model) |
| Isoform 2 of 26S proteasome regulatory subunit 8 | C | protein | 398 | Homo sapiens | P62195 (AlphaFold model) |
| 26S protease regulatory subunit 6B | D | protein | 418 | Homo sapiens | P43686 |
| 26S proteasome regulatory subunit 10B | E | protein | 403 | Homo sapiens | A0A087X2I1 |
| 26S protease regulatory subunit 6A | F | protein | 439 | Homo sapiens | P17980 |
| Proteasome subunit alpha type-6 | G, g | protein | 246 | Homo sapiens | P60900 |
| Proteasome subunit alpha type-2 | H, h | protein | 234 | Homo sapiens | P25787 |
| Proteasome subunit alpha type-4 | I, i | protein | 261 | Homo sapiens | P25789 |
| Proteasome subunit alpha type-7 | J, j | protein | 248 | Homo sapiens | O14818 |
| Proteasome subunit alpha type-5 | K, k | protein | 241 | Homo sapiens | P28066 |
22 more molecules are not listed.
Sequence of entity 1 (x), FASTA
>7W3I_1 Ubiquitin carboxyl-terminal hydrolase 14 (chains x)
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
Sequence of entity 2 (A), FASTA
>7W3I_2 26S protease regulatory subunit 7 (chains A)
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
Sequence of entity 3 (B), FASTA
>7W3I_3 26S protease regulatory subunit 4 (chains B)
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL
Sequence of entity 4 (C), FASTA
>7W3I_4 Isoform 2 of 26S proteasome regulatory subunit 8 (chains C)
MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQE
QGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILP
NKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLL
YGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFM
DEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRP
GRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGM
YALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Sequence of entity 5 (D), FASTA
>7W3I_5 26S protease regulatory subunit 6B (chains D)
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Sequence of entity 6 (E), FASTA
>7W3I_6 26S proteasome regulatory subunit 10B (chains E)
MAIPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSEND
LKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLT
IMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIP
PKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQ
PCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLD
PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNV
CTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
Sequence of entity 7 (F), FASTA
>7W3I_7 26S protease regulatory subunit 6A (chains F)
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
MEGILEVQAKKKANLQYYA
Sequence of entity 8 (G, g), FASTA
>7W3I_8 Proteasome subunit alpha type-6 (chains G, g)
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
Sequence of entity 9 (H, h), FASTA
>7W3I_9 Proteasome subunit alpha type-2 (chains H, h)
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
Sequence of entity 10 (I, i), FASTA
>7W3I_10 Proteasome subunit alpha type-4 (chains I, i)
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
Sequence of entity 11 (J, j), FASTA
>7W3I_11 Proteasome subunit alpha type-7 (chains J, j)
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
Sequence of entity 12 (K, k), FASTA
>7W3I_12 Proteasome subunit alpha type-5 (chains K, k)
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 4 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
| ZN | Zinc ion | Zn | 1 |
Primary citation
USP14-regulated allostery of the human proteasome by time-resolved cryo-EM. Zhang, S., Zou, S., Yin, D. et al. Nature (2022) 605:567-574. DOI 10.1038/s41586-022-04671-8 · PubMed
Other PDB entries of the same protein (UniProt P54578 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9F6G 1.5 Å, Human USP30 chimera bound to Ubiquitin-PA
- 6IIK 1.97 Å, USP14 catalytic domain with IU1
- 6IIL 2.2 Å, USP14 catalytic domain bind to IU1-47
- 6IIM 2.21 Å, USP14 catalytic domain with IU1-206
- 6IIN 2.53 Å, USP14 catalytic domain with IU1-248
- 6LVS 2.73 Å, USP14 catalytic domain mutant C114S
- 9F19 2.75 Å, Human USP30 chimera in complex with NK036 inhibitor
- 7W37 3.0 Å, Structure of USP14-bound human 26S proteasome in state EA1_UBL
- 7W38 3.1 Å, Structure of USP14-bound human 26S proteasome in state EA2.0_UBL
- 2AYN 3.2 Å, Structure of USP14, a proteasome-associated deubiquitinating enzyme
- 7W39 3.2 Å, Structure of USP14-bound human 26S proteasome in state EA2.1_UBL
- 7W3G 3.2 Å, Structure of USP14-bound human 26S proteasome in substrate-engaged state ED2.0_USP14
Browse structure collections
About this viewer
MolViewer shows 7W3I directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.