7W6R: Angiotensin-converting enzyme

Structure of Bat coronavirus RaTG13 spike receptor-binding domain complexed with its receptor equine ACE2. Determined by X-ray diffraction at 2.6 Å resolution. Released 8 Jun 2022.

Method
X-ray diffraction
Resolution
2.6 Å
Organisms
Equus caballus, Bat coronavirus RaTG13
Chains
2
Atoms
6,591
Mol. weight
95.21 kDa
Ligands
NAG, ZN
Released
8 Jun 2022

Explore 7W6R in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7W6R contains 51 α-helices and 26 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 40 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix21-5131
α-helix56-8025
α-helix85-873
α-helix91-10111
α-helix104-1074
α-helix110-12920
β-strand132-13431
β-strand137-14261
α-helix144-1485
α-helix149-1546
α-helix158-16710
α-helix168-1725
α-helix173-19321
α-helix199-2046
α-helix205-2073
β-strand20912
β-strand21712
α-helix219-25133
α-helix2611
β-strand262-26323
α-helix264-2663
α-helix276-2783
α-helix279-2824
α-helix294-2996
α-helix304-31714
α-helix320-3245
α-helix325-3306
β-strand33214
β-strand347-35264
β-strand355-35954
α-helix366-38419
α-helix385-3873
α-helix390-3923
α-helix400-41314
α-helix415-4206
α-helix432-44615
α-helix449-46517
α-helix470-4723
α-helix473-4808
α-helix481-4855
β-strand487-48823
α-helix499-5024
α-helix504-5074
α-helix514-53219
α-helix539-5413
α-helix548-55811
α-helix566-5749
α-helix582-5876
α-helix589-59911
Chain B: 11 helices, 17 β-strands
ElementResiduesLengthSheet
β-strand33515
α-helix338-3425
β-strand34916
α-helix350-3523
β-strand354-35856
β-strand361-36225
α-helix366-3694
β-strand376-37946
α-helix385-3895
β-strand391-39225
β-strand394-403106
α-helix404-4074
α-helix417-4215
β-strand431-43776
α-helix439-4424
β-strand44817
β-strand452-45438
α-helix460-4623
α-helix471-4722
β-strand473-47429
β-strand48519
β-strand488-48929
β-strand492-49438
β-strand49717
α-helix503-5053
β-strand507-516106
β-strand524-52525
α-helix526-5283

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Angiotensin-converting enzymeAprotein602Equus caballusA0A9L0TPT7 (AlphaFold model)
Spike glycoproteinBprotein223Bat coronavirus RaTG13A0ABF7PLN6
Sequence of entity 1 (A), FASTA
>7W6R_1 Angiotensin-converting enzyme (chains A)
STTEDLAKTFLEKFNSEAEELSHQSSLASWSYNTNITDENVQKMNEAGARWSAFYEEQCK
LAKTYPLEEIQNLTVKRQLQALQQSGSSVLSADKSKRLNEILNTMSTIYSTGKVCNPSNP
QECLLLEPGLDAIMENSKDYNQRLWAWEGWRSEVGKQLRPLYEEYVVLKNEMARANNYED
YGDYWRGDYEAEGPSGYDYSRDQLIEDVERTFAEIKPLYEHLHAYVRAKLMDTYPSHINP
TGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQSWDAKRIFEEAEKFFVSV
GLPNMTQGFWENSMLTEPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMDDFLTAHHEMGH
IQYDMAYAVQPYLLRNGANEGFHEAVGEIMSLSAATPNHLKAIGLLPPDFYEDSETEINF
LLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKEEWMKKWWEMKREIVGVVEPVPHDETYC
DPAALFHVANDYSFIRYYTRTIYQFQFQEALCQTAKHEGPLHKCDISNSTEAGQKLLQML
SLGKSEPWTLALERIVGVKNMDVRPLLNYFEPLFTWLKDQNKNSFVGWSTNWSPYAHHHH
HH
Sequence of entity 2 (B), FASTA
>7W6R_2 Spike glycoprotein (chains B)
RVQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFK
CYGVSPTKLNDLCFTNVYADSFVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNS
KHIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKPCNGQTGLNCYYPLYRYGFY
PTDGVGHQPYRVVVLSFELLNAPATVCGPKKSTNLVKNKCVNF

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O61
ZNZinc ionZn1

Primary citation

Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses. Xu, Z., Kang, X., Han, P. et al. Nat Commun (2022) 13:3547. DOI 10.1038/s41467-022-31276-6

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