7YG3: HLA-B*13:01

Crystal structure of HLA-B*13:01. Determined by X-ray diffraction at 1.5 Å resolution. Released 26 Jul 2023.

Method: X-ray diffraction
Resolution: 1.5 Å
Organisms: Homo sapiens, Human immunodeficiency virus
Chains: 3
Atoms: 3,807
Mol. weight: 44.89 kDa
Released: 26 Jul 2023

Explore 7YG3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

7YG3 contains 15 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-85	29
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-159	8
α-helix	160-164	5
α-helix	165-174	10
α-helix	182	1
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	225-227	3
β-strand	229-230	2	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chain C: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	276	Homo sapiens	F4NBP7 (AlphaFold model)
Beta-2-microglobulin	C	protein	99	Homo sapiens	P61769 (AlphaFold model)
Arg-gln-asp-ile-leu-asp-leu-trp-ile	B	protein	9	Human immunodeficiency virus	P04601 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>7YG3_1 MHC class I antigen (chains A)
GSHSMRYFYTAMSRPGRGEPRFITVGYVDDTQFVRFDSDATSPRMAPRAPWIEQEGPEYW
DRETQISKTNTQTYRENLRTALRYYNQSEAGSHIIQRMYGCDLGPDGRLLRGHNQLAYDG
KDYIALNEDLSSWTAADTAAQITQLKWEAARVAEQLRAYLEGECVEWLRRYLENGKETLQ
RADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDRT
FQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP

Sequence of entity 2 (C), FASTA

>7YG3_2 Beta-2-microglobulin (chains C)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (B), FASTA

>7YG3_3 ARG-GLN-ASP-ILE-LEU-ASP-LEU-TRP-ILE (chains B)
RQDILDLWI

Primary citation

Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity. Jiang, H., Wang, C.W., Wang, Z. et al. J Biomed Sci (2022) 29:58-58. DOI 10.1186/s12929-022-00845-8 · PubMed

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