Cryo-EM structure of EBV gHgL-gp42 in complex with mAb 6H2 (localized refinement). Determined by electron microscopy at 3.52 Å resolution. Released 31 Jan 2024.
Explore 7YP2 in 3D Show helices and sheets RCSB PDB PDBe
7YP2 contains 20 α-helices and 37 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 370-382 | 13 | |
| α-helix | 390-392 | 3 | |
| α-helix | 393-404 | 12 | |
| α-helix | 408 | 1 | |
| α-helix | 412-413 | 2 | |
| α-helix | 417-423 | 7 | |
| α-helix | 426-429 | 4 | |
| α-helix | 441-452 | 12 | |
| α-helix | 456-468 | 13 | |
| α-helix | 477-479 | 3 | |
| β-strand | 483 | 1 | 1 |
| α-helix | 488-491 | 4 | |
| α-helix | 503-516 | 14 | |
| α-helix | 521-523 | 3 | |
| α-helix | 530-533 | 4 | |
| β-strand | 535 | 1 | 2 |
| α-helix | 538-540 | 3 | |
| β-strand | 541-546 | 6 | 1 |
| β-strand | 550-555 | 6 | 1 |
| β-strand | 560 | 1 | 2 |
| β-strand | 566-567 | 2 | 1 |
| β-strand | 578-583 | 6 | 1 |
| α-helix | 591-593 | 3 | |
| α-helix | 595-596 | 2 | |
| β-strand | 597-598 | 2 | 1 |
| β-strand | 601-602 | 2 | 3 |
| β-strand | 618 | 1 | 3 |
| β-strand | 621-623 | 3 | 3 |
| β-strand | 627-630 | 4 | 3 |
| β-strand | 633 | 1 | 3 |
| α-helix | 637-644 | 8 | |
| β-strand | 656-661 | 6 | 3 |
| β-strand | 667-670 | 4 | 3 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-7 | 3 | 4 |
| β-strand | 10-12 | 3 | 5 |
| β-strand | 17-23 | 7 | 4 |
| β-strand | 33-38 | 6 | 6 |
| β-strand | 46-51 | 6 | 6 |
| β-strand | 58-60 | 3 | 6 |
| β-strand | 68-73 | 6 | 4 |
| β-strand | 78-84 | 7 | 4 |
| β-strand | 92 | 1 | 5 |
| β-strand | 94-99 | 6 | 6 |
| β-strand | 109 | 1 | 6 |
| β-strand | 116-118 | 3 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 7 | 1 | 7 |
| β-strand | 10-13 | 4 | 8 |
| β-strand | 19-24 | 6 | 7 |
| β-strand | 40-44 | 5 | 8 |
| β-strand | 51-55 | 5 | 8 |
| β-strand | 59-60 | 2 | 8 |
| α-helix | 61 | 1 | |
| β-strand | 68-72 | 5 | 7 |
| β-strand | 76-81 | 6 | 7 |
| α-helix | 86-88 | 3 | |
| β-strand | 91-95 | 5 | 8 |
| β-strand | 107-111 | 5 | 8 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Envelope glycoprotein H | A | protein | 314 | Human gammaherpesvirus 4 | P03231 (AlphaFold model) |
| 6H2 heavy chain | H | protein | 120 | Mus musculus | |
| 6H2 light chain | L | protein | 112 | Mus musculus |
>7YP2_1 Envelope glycoprotein H (chains A) MEELGHLTTEKQEYALRLATVGYPKAGVYSGLIGGATSVLLSAYNRHPLFQPLHTVMRET LFIGSHVVLRELRLNVTTQGPNLALYQLLSTALCSALEIGEVLRGLALGTESGLFSPCYL SLRFDLTRDKLLSMAPQEATLDQAAVSNAVDGFLGRLSLEREDRDAWHLPAYKCVDRLDK VLMIIPLINVTFIISSDREVRGSALYEASTTYLSSSLFLSPVIMNKCSQGAVAGEPRQIP KIQNFTRTQKSCIFCGFALLSYDEKEGLETTTYITSQEVQNSILSSNYFDFDNLHVHYLL LTTNGTVMEIAGLY
>7YP2_2 6H2 heavy chain (chains H) EVKLLESGGGLVQPGGSLKLSCAASGFDFSRYWMTWVRQAPGQGLEWIGEINPDSSTINY TPSLKDKFIISRDNAKNTLYLQVSKLRSEDTALYYCARSPYYYGSSYDVWGAGTAVTVSS
>7YP2_3 6H2 light chain (chains L) DIVMSQSPSSLAVSAGEKVTMNCKSSQSLLNSRTRKNYLAWYQQKPGQSPKLLIYWASTR ESGVPDRFTGSGSGTDFTLTISSVQAEDLAFYYCKQSYNLPTFGGGTKLEIK
Non-overlapping epitopes on the gHgL-gp42 complex for the rational design of a triple-antibody cocktail against EBV infection. Hong, J., Zhong, L., Liu, L. et al. Cell Rep Med (2023) 4:101296-101296. DOI 10.1016/j.xcrm.2023.101296 · PubMed
Other PDB entries of the same protein (UniProt P03231 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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