7ZJW: EEFSec
Rabbit 80S ribosome as it decodes the Sec-UGA codon. Determined by electron microscopy at 2.8 Å resolution. Released 19 Oct 2022.
- Method
- Electron microscopy
- Resolution
- 2.8 Å
- Organisms
- Homo sapiens, Cricket paralysis virus, Rattus norvegicus
- Chains
- 86
- Atoms
- 230,266
- Mol. weight
- 4626.61 kDa
- Ligands
- GTP, SER, MG, ZN
- Released
- 19 Oct 2022
Explore 7ZJW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ZJW contains 612 α-helices and 601 β-strands across 79 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain B: 10 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 433-435 | 3 | |
| β-strand | 445 | 1 | 35 |
| α-helix | 450-452 | 3 | |
| α-helix | 459-471 | 13 | |
| α-helix | 639-661 | 23 | |
| α-helix | 664-666 | 3 | |
| β-strand | 674-675 | 2 | 36 |
| α-helix | 678-685 | 8 | |
| β-strand | 691-694 | 4 | 36 |
| α-helix | 707-721 | 15 | |
| β-strand | 725-727 | 3 | 36 |
| α-helix | 731-737 | 7 | |
| β-strand | 746-749 | 4 | 36 |
| α-helix | 756-763 | 8 | |
| α-helix | 766-779 | 14 | |
Chain E: 13 helices, 40 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-14 | 5 | 1 |
| α-helix | 21-28 | 8 | |
| β-strand | 52-58 | 7 | 1 |
| α-helix | 62-65 | 4 | |
| β-strand | 86-92 | 7 | 1 |
| α-helix | 100-107 | 8 | |
| β-strand | 112-116 | 5 | 1 |
| α-helix | 125-136 | 12 | |
| β-strand | 141-145 | 5 | 1 |
| α-helix | 153-157 | 5 | |
| α-helix | 163-166 | 4 | |
| α-helix | 168-171 | 4 | |
| α-helix | 178-181 | 4 | |
| β-strand | 182-183 | 2 | 1 |
| β-strand | 185 | 1 | 2 |
| β-strand | 200 | 1 | 2 |
| α-helix | 202-209 | 8 | |
| β-strand | 225-234 | 10 | 3 |
| β-strand | 238-247 | 10 | 3 |
| β-strand | 255 | 1 | 4 |
| β-strand | 257 | 1 | 5 |
| β-strand | 258 | 1 | 6 |
| β-strand | 263 | 1 | 6 |
| β-strand | 266 | 1 | 4 |
| β-strand | 269-271 | 3 | 3 |
| β-strand | 276 | 1 | 3 |
| β-strand | 285-290 | 6 | 3 |
| β-strand | 301-303 | 3 | 3 |
| β-strand | 304 | 1 | 5 |
| β-strand | 312-321 | 10 | 7 |
| β-strand | 335 | 1 | 7 |
| β-strand | 336 | 1 | 8 |
| β-strand | 338 | 1 | 9 |
| β-strand | 343 | 1 | 9 |
| β-strand | 346-347 | 2 | 7 |
| β-strand | 351-353 | 3 | 10 |
| α-helix | 356-358 | 3 | |
| β-strand | 373-375 | 3 | 10 |
| β-strand | 411 | 1 | 10 |
| β-strand | 414-420 | 7 | 7 |
| α-helix | 422-423 | 2 | |
| β-strand | 427-429 | 3 | 7 |
| β-strand | 431 | 1 | 8 |
| β-strand | 446-453 | 8 | 7 |
| α-helix | 457-461 | 5 | |
| β-strand | 469-482 | 14 | 10 |
| β-strand | 488-491 | 4 | 10 |
| α-helix | 500-503 | 4 | |
| β-strand | 507-510 | 4 | 10 |
| β-strand | 515-520 | 6 | 10 |
| β-strand | 528-531 | 4 | 10 |
| β-strand | 575-583 | 9 | 10 |
| β-strand | 591-592 | 2 | 10 |
Chain La: 8 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 45 | 1 | 118 |
| α-helix | 48-50 | 3 | |
| α-helix | 54-56 | 3 | |
| α-helix | 66-68 | 3 | |
| α-helix | 73-76 | 4 | |
| β-strand | 77-80 | 4 | 37 |
| α-helix | 84-92 | 9 | |
| β-strand | 95-100 | 6 | 37 |
| α-helix | 106-117 | 12 | |
| β-strand | 121-128 | 8 | 37 |
| β-strand | 134-140 | 7 | 37 |
| α-helix | 141 | 1 | |
| α-helix | 146-153 | 8 | |
Chain Lb: 7 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 11-19 | 9 | |
| α-helix | 23-29 | 7 | |
| β-strand | 31-33 | 3 | 42 |
| β-strand | 34 | 1 | 43 |
| α-helix | 35 | 1 | |
| α-helix | 36-42 | 7 | |
| β-strand | 46-48 | 3 | 42 |
| β-strand | 54-57 | 4 | 43 |
| β-strand | 68-69 | 2 | 43 |
| β-strand | 70-74 | 5 | 44 |
| β-strand | 79-82 | 4 | 44 |
| β-strand | 86-88 | 3 | 45 |
| β-strand | 94-96 | 3 | 45 |
| α-helix | 97-98 | 2 | |
| β-strand | 99 | 1 | 44 |
| α-helix | 101-103 | 3 | |
| β-strand | 104-108 | 5 | 43 |
| α-helix | 113-133 | 21 | |
Chain Lc: 6 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-13 | 5 | 54 |
| β-strand | 22-29 | 8 | 54 |
| β-strand | 40-48 | 9 | 54 |
| α-helix | 49-52 | 4 | |
| α-helix | 59-65 | 7 | |
| β-strand | 69-76 | 8 | 54 |
| α-helix | 77-79 | 3 | |
| β-strand | 80-86 | 7 | 54 |
| α-helix | 98-101 | 4 | |
| α-helix | 104-123 | 20 | |
| α-helix | 128-131 | 4 | |
Chain Ld: 6 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-5 | 3 | |
| α-helix | 7-10 | 4 | |
| α-helix | 42-48 | 7 | |
| β-strand | 72-74 | 3 | 58 |
| α-helix | 75-81 | 7 | |
| α-helix | 84-92 | 9 | |
| β-strand | 98 | 1 | 148 |
| β-strand | 100-102 | 3 | 59 |
| β-strand | 110-112 | 3 | 58 |
| β-strand | 123-126 | 4 | 59 |
| β-strand | 128-129 | 2 | 58 |
| α-helix | 131-139 | 9 | |
| β-strand | 143-146 | 4 | 59 |
Chain LD: 12 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-9 | 4 | |
| α-helix | 14-16 | 3 | |
| α-helix | 29-32 | 4 | |
| α-helix | 34-38 | 5 | |
| β-strand | 40-50 | 11 | 62 |
| β-strand | 57-64 | 8 | 62 |
| β-strand | 71-77 | 7 | 62 |
| β-strand | 79 | 1 | 63 |
| β-strand | 83 | 1 | 64 |
| β-strand | 87-91 | 5 | 62 |
| β-strand | 101-103 | 3 | 62 |
| α-helix | 104-106 | 3 | |
| α-helix | 108 | 1 | |
| β-strand | 112-114 | 3 | 62 |
| β-strand | 116 | 1 | 65 |
| β-strand | 126 | 1 | 65 |
| β-strand | 134-140 | 7 | 62 |
| β-strand | 145-149 | 5 | 62 |
| β-strand | 155-159 | 5 | 62 |
| β-strand | 163-166 | 4 | 62 |
| β-strand | 169 | 1 | 63 |
| α-helix | 174-176 | 3 | |
| α-helix | 182-190 | 9 | |
| α-helix | 201-203 | 3 | |
| α-helix | 206-208 | 3 | |
| β-strand | 224-225 | 2 | 66 |
| α-helix | 229-230 | 2 | |
| β-strand | 237-238 | 2 | 66 |
| α-helix | 250-251 | 2 | |
Chain Le: 7 helices, 1 β-strand
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-18 | 7 | |
| α-helix | 22-25 | 4 | |
| α-helix | 37-48 | 12 | |
| α-helix | 51-53 | 3 | |
| α-helix | 54-75 | 22 | |
| α-helix | 91-99 | 9 | |
| α-helix | 106-116 | 11 | |
| β-strand | 118 | 1 | 99 |
71 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| eEFSec | E | protein | 616 | Homo sapiens | P57772 (AlphaFold model) |
| human Ser-tRNA-Sec | F | RNA | 90 | Homo sapiens | |
| Crpv ires | I | RNA | 1072 | Cricket paralysis virus | |
| GPX4 SECIS element | S | RNA | 855 | Rattus norvegicus | |
| SECIS Binding Protein 2 | B | protein | 854 | Homo sapiens | Q96T21 (AlphaFold model) |
| 28S rRNA | L5 | RNA | 4808 | Oryctolagus cuniculus | |
| 5S rRNA | L7 | RNA | 119 | Oryctolagus cuniculus | |
| 5.8S rRNA | L8 | RNA | 158 | Oryctolagus cuniculus | |
| 60S ribosomal protein uL2 | LD | protein | 257 | Oryctolagus cuniculus | A0A8B8VPA8 (AlphaFold model) |
| 60S ribosomal protein L3 | LE | protein | 403 | Oryctolagus cuniculus | G1TL06 (AlphaFold model) |
| 60S ribosomal protein L4 | LF | protein | 413 | Oryctolagus cuniculus | G1SVW5 |
| Ribosomal_L18_c domain-containing protein | LG | protein | 297 | Oryctolagus cuniculus | P19949 |
74 more molecules are not listed.
Sequence of entity 1 (E), FASTA
>7ZJW_1 eEFSec (chains E)
MGSSHHHHHHSSGLVPRGSHMAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQP
QSRERGITLDLGFSCFSVPLPARLRSSLPEFQAAPEAEPEPGEPLLQVTLVDCPGHASLI
RTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAI
DKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGIPELIELLTSQISIPTRDP
SGPFLMSVDHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPITSA
MQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVG
HETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQYLSKDLTPAVTDNDEADKKAGQ
ATEGHCPREQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGILLHGLEDRNYA
DSFLPRLKVYKLKHKHGLVERAMDDYSVIGRSLFKKETNIQLFVGLKVHLSTGELGIIDS
AFGQSGKFKIHIPGGLSPESKKILTPALKKRARAGRGEATRQEESAERSEPSQHVVLSLT
FKRYVFDTHKRMVQSP
Sequence of entity 2 (F), FASTA
>7ZJW_2 human Ser-tRNA-Sec (chains F)
GCCCGGAUGAUCCUCAGUGGUCUGGGGUGCAGGCUUCAAACCUGUAGCUGUCUAGCGACA
GAGUGGUUCAAUUCCACCUUUCGGGCGCCA
Sequence of entity 3 (I), FASTA
>7ZJW_3 CrPV IRES (chains I)
CAAAAAUGUGAUCUUGCUUGUAAAUACAAUUUUGAGAGGUUAAUAAAUUACAAGUAGUGC
UAUUUUUGUAUUUAGGUUAGCUAUUUAGCUUUACGUUCCAGGAUGCCUAGUGGCAGCCCC
ACAAUAUCCAGGAAGCCCUCUCUGCGGUUAUUCAGAUUAGGUAGUCGAAAAACCUAAGAA
AUUUACCUUGAGGCUUCGGAGUCGUCUUAAUGUAUAGAUUUGAAGAAGAGCUGUUUUUAC
GAUCCCUUCAGGAUUACAAAAUUCAAAGUGCGUUGCUAGUACCAACCCUAUUUUCAUUCU
UCGCCAAAAGCACUCUGAUUGACAAAUACGAUUUAUCUAAUUUACACGAAAUUGCUUCUG
GGGGCGCACCUCUUUCGAAAGAAGUCGGGGAAGCGGUUGCAAAACGCUUCCAUCUUCCAG
GGAUACGACAAGGAUAUGGGCUCACUGAGACUACAUCAGCUAUUCUGAUUACACCCGAGG
GGGAUGAUAAACCGGGCGCGGUCGGUAAAGUUGUUCCAUUUUUUGAAGCGAAGGUUGUGG
AUCUGGAUACCGGGAAAACGCUGGGCGUUAAUCAGAGAGGCGAAUUAUGUGUCAGAGGAC
CUAUGAUUAUGUCCGGUUAUGUAAACAAUCCGGAAGCGACCAACGCCUUGAUUGACAAGG
AUGGAUGGCUACAUUCUGGAGACAUAGCUUACUGGGACGAAGACGAACACUUCUUCAUAG
UUGACCGCUUGAAGUCUUUGAUUAAAUACAAAGGAUAUCAGGUGGCCCCCGCUGAAUUGG
AAUCGAUAUUGUUACAACACCCCAACAUCUUCGACGCGGGCGUGGCAGGUCUUCCCGACG
AUGACGCCGGUGAACUUCCCGCCGCCGUUGUUGUUUUGGAGCACGGAAAGACGAUGACGG
AAAAAGAGAUCGUGGAUUACGUCGCCAGUCAAGUAACAACCGCGAAAAAGUUGCGCGGAG
GAGUUGUGUUUGUGGACGAAGUACCGAAAGGUCUUACCGGAAAACUCGACGCAAGAAAAA
UCAGAGAGAUCCUCAUAAAGGCCAAGAAGGGCGGAAAGUCCAAAUUGUAAAA
Sequence of entity 4 (S), FASTA
>7ZJW_4 GPX4 SECIS element (chains S)
AUUGGUCGGCUGGACGAGGGGAGGAGCCGCUGGCUCCCAGCCCCGCCGCGAUGAGCCUCG
GCCGCCUUUGCCGCCUACUGAAGCCGGCGCUGCUCUGUGGGGCUCUGGCCGCGCCUGGCC
UGGCCGGGACCAUGUGCGCGUCCCGGGACGACUGGCGCUGUGCGCGCUCCAUGCACGAGU
UUUCCGCCAAGGACAUCGACGGGCACAUGGUUAACCUGGACAAGUACCGGGGCUUCGUGU
GCAUCGUCACCAACGUGGCCUCCCAGUGAGGCAAGACCGAAGUAAACUACACUCAGCUCG
UCGACCUGCACGCCCGAUACGCUGAGUGUGGUUUGCGGAUCCUGGCCUUCCCGUGUAACC
AGUUCGGGAAGCAGGAGCCAGGGAGUAACGAAGAGAUCAAAGAGUUCGCCGCGGGCUACA
ACGUCAAAUUCGAUAUGUUCAGCAAGAUCUGCGUGAACGGGGACGACGCCCACCCGCUGU
GGAAGUGGAUGAAGAUCCAACCCAAGGGCAAGGGCAUCCUGGGAAAUGCCAUCAAGUGGA
ACUUCACCAAGUUCCUCAUCGACAAGAACGGCUGCGUGGUGAAGCGCUACGGACCCAUGG
AGGAGCCCCUGGUGAUAGAGAAGGACCUGCCCCACUAUUUCUAGCUCCACAAGUGUGUGG
CCCCGCCCGAGCCCCUGCCCACGCCCUUGGAGCCUUCCACCGGCACUCAUGACGGUCUGC
CUGAAAACCAGCCCGCUGGUGGGGCAGUCCCGAAAAUCCAGCGUGCACCCCGCCGGAGGA
AGGUCCCAUGGCCUGCUGGGCUUGGCUCGGCGCCCCCACCCCUGGCUACCUUGUGGGAAU
AAACAGACAAAUUAG
Sequence of entity 5 (B), FASTA
>7ZJW_5 SECIS Binding Protein 2 (chains B)
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVT
EQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYR
GFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHH
LSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQP
KWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPM
GYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHP
TQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRD
RIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSVG
AVPVLSKECASGERGRRMSQMKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKER
QERKQRLQENAVSPAFTSDDTQDGESGGDDQFPEQAELSGPEGMDELISTPSVEDKSEEP
PGTELQRDTEASHLAPNHTTFPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMY
QKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKIQSKGGLDDTLHTIIDYACE
QNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTVAARQAYKTMLENV
QQELVGEPRPQAPPSLPTQGPSCPAEDGPPALKEKEEPHYIEIWKKHLEAYSGCTLELEE
SLEASTSQMMNLNL
Sequence of entity 6 (L5), FASTA
>7ZJW_6 28S rRNA (chains L5)
CGCGACCUCAGAUCAGACGUGGCGACCCGCUGAAUUUAAGCAUAUUAGUCAGCGGAGGAA
AAGAAACUAACCAGGAUUCCCUCAGUAACGGCGAGUGAACAGGGAAGAGCCCAGCGCCGA
AUCCCCGCCCCGCGGUGGGGCGCGGGAAAUGUGGCGUACGGAAGACCCACUCCCCGGCGC
CGCUCGUGGGGGGCCCAAGUCCUUCUGAUCGAGGCCCAGCCCGUGGACGGUGUGAGGCCG
GUAGCGGCCCCCGGCGCGCCGGGCCCGGGUCUUCCCGGAGUCGGGUUGCUUGGGAAUGCA
GCCCAAAGCGGGUGGUAAACUCCAUCUAAGGCUAAAUACCGGCACGAGACCGAUAGUCAA
CAAGUACCGUAAGGGAAAGUUGAAAAGAACUUUGAAGAGAGAGUUCAAGAGGGCGUGAAA
CCGUUAAGAGGUAAACGGGUGGGGUCCGCGCAGUCCGCCCGGAGGAUUCAACCCGGCGGC
GUGGUCCGGCCGUGCCGGCGGUCUCGGCGGAUCUUUCCCGCUCCCCGUUCCUCCCGACCC
CUCCACCCGCUCCCCCUCCCCCGCCGGUCUUCUCCCUUCACGGGGGGUGGGUCGGCGGGU
GCGGGGGUGGGCGGGCGGGGCCGGGGGUGGGGUCGGCGGGGGACCGCCCCCCGGCCGGCG
ACCGGCCGCCGCCGGGCGCAUUUCCACCGCGGCGGUGCGCCGCGACCGGCUCCGGGACGG
CUGGGAAGGCCCCGGCGGGGAAGGUGGCCCGGGGGGACGCCUCGCCGCCGUCGUCCGCGG
CGGCGGCGGGCGCGACCCCUCCCCGGGUGUUACAGCCCCGCCCCGGCAGCAGCAGCUCGC
CGAAUCCCGGGGCCGAGGGAGCGAGACCUGUGUCGCCGCGCUCUCCCCCCUCCCGGCGCU
CCCCCCCGCGGGGGUCCCCCGCGAGGGGGCUCCCCCCGCGGGGGCGCGCCGGUGUCGCCG
CCCUCGCGGGCGCGGCACGGGGGGGCCGGGCCGCCCCUCCCACGGCGCGACCGCUCUCCC
GGCCCCCGCCGCCGCCUCUUCGGGCGUGCGGCGGGGGUGGGGCGGACUGUCCCCAGUGCG
CCCCGGGCGUGUCACGCCGUCGGGCUCGGGGGAGAAGUCGGCCACGGCGCGUCGCGCGCC
UCCGCGUCCCCCCCUCGCCGUCUCCGGGCGGCGGGGGGGGGUUUCGGCGCGGUGUUCUCG
GCGCGCGCGCGCGAGCGAGCGCACGGGGUCGGCGGCGAUGUCGGCUACCCACCCGACCCG
UCUUGAAACACGGACCAAGGAGUCUAACACGUGCGCGAGUCGGGGGCUCGCACGAAAGCC
GCCGUGGCGCAAUGAAGGUGAAGGCCGGCGGCGGCUUCCCGCCGUCGUCGGCCGAGGUGG
GAUCCCGAGGCCCUUCCAGUCCGCCGAGGGCGCACCACCGGCCCGUCUCGCCCGCCGCGC
CGGGGAGGUGGAGCACGAGCGCACGUGUUAGGACCCGAAAGAUGGUGAACUAUGCCUGGG
CAGGGCGAAGCCAGAGGAAACUCUGGUGGAGGUCCGUAGCGGUCCUGACGUGCAAAUCGG
UCGUCCGACCUGGGUAUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCCUC
CGAAGUUUCCCUCAGGAUAGCUGGCGCUCUCGCAACCCCGCAGUUUUAUCCGGUAAAGCG
AAUGAUUAGAGGUCUUGGGGCCGAAACGAUCUCAACCUAUUCUCAAACUUUAAAUGGGUA
AGAAGCCCGGCUCGCUGGCGUGGAGCCGGGCGUGGAAUGCGAGUGCCUAGUGGGCCACUU
UUGGUAAGCAGAACUGGCGCUGCGGGAUGAACCGAACGCCGGGUUAAGGCGCCCGAUGCC
GACGCUCAUCAGACCCCAGAAAAGGUGUUGGUUGAUAUAGACAGCAGGACGGUGGCCAUG
GAAGUCGGAAUCCGCUAAGGAGUGUGUAACAACUCACCUGCCGAAUCAACUAGCCCUGAA
AAUGGAUGGCGCUGGAGCGUCGGGCCCAUACCCGGCCGUCGCUGGCAGUCGGCAGAGCGA
GAAAGAGAGUGGAGCGCGCCGCGGGACUCCCCCCGCGGGGGUCCCCGGCCACCCCCCCCC
CGCGGACGCUACGCCGCGACGAGUAGGAGGGCCGCUGCGGUGAGCCUUGAAGCCUAGGGC
GCGGGCCCGGGUGGAGCCGCCGCAGGUGCAGAUCUUGGUGGUAGUAGCAAAUAUUCAAAC
GAGAACUUUGAAGGCCGAAGUGGAGAAGGGUUCCAUGUGAACAGCAGUUGAACAUGGGUC
AGUCGGUCCUGAGAGAUGGGCGAGCGCCGUUCCGAAGGGACGGGCGAUGGCCUCCGUUGC
CCUCAGCCGAUCGAAAGGGAGUCGGGUUCAGAUCCCCGAAUCCGGAGUGGCGGAGAUGGG
CGCCGCGAGGCGUCCAGUGCGGUAACGCGACCGAUCCCGGAGAAGCCGGCGGGAGCCCCG
GGGAGAGUUCUCUUUUCUUUGUGAAGGGCAGGGCGCCCUGGAAUGGGUUCGCCCCGAGAG
AGGGGCCCGUGCCUUGGAAAGCGUCGCGGUUCCGGCGGCGUCCGGUGAGCUCUCGCUGGC
CCUUGAAAAUCCGGGGGAGAGGGUGUAAAUCUCGCGCCGGGCCGUACCCAUAUCCGCAGC
AGGUCUCCAAGGUGAACAGCCUCUGGCAUGUUGGAACAAUGUAGGUAAGGGAAGUCGGCA
AGCCGGAUCCGUAACUUCGGGAUAAGGAUUGGCUCUAAGGGCUGGGUCGGUCGGGCUGGG
GCGCGAAGCGGGGCUGGGCGCGCGCCGCGGCUGGACGAGGCGCCGCCGCCCCCCCCACGC
CCGGGGCGCCCUCCCCCGGCCGGGUCCGCUCCCUCGCGCGCGCGUGCGCCGUGGCGCGCG
CCGCGCGCGCGGCCGAGCCCCGUCUCCCUCCCCCCCUCUCCCCUCCCGGGGCGGGGUGCG
GGGAGGGGCGGGCGGGGCCGUCGCUCGCCGCGCGUGCGCGUCGCUGCGCGUGCGCCGCGC
GGGGGGUCCGGCGGGCCUCCGGACGGGGGCUCCGGGCACCCGGGCACCCGGGGGGCCGGC
GGCGGCGGCGACUCUGGACGCGAGCCGGGCCCUUCCCGUGGAUCGCCCCAGCUGCGGCGG
GCGUCGCGGCCGCCCUCGGGGAGCCCGGCGGGCGCCGCGUGCGCGCGCGUGCGCGCCCGG
GGUCGGGGGGGUGCGAGGCAGGGGAGGCCCUCUCUCCUCCUCCCCCACCCCGGCGCCGCG
GCGCCGCGCGUGCGCGCGCGGUCUCCCCCCGCCGGGUCCGCCCCCGGGGCCGCGGUUCCG
CGCGGCGCCUCGCCUCGGCCGGCGCCUAGCAGCCGACUUAGAACUGGUGCGGACCAGGGG
AAUCCGACUGUUUAAUUAAAACAAAGCAUCGCGAAGGCCCGCGGCGGGUGUUGACGCGAU
GUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAAAUUCAAUGAAGCGCGGGUAAA
CGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUGCCUCGUCAUCUAAUUAGUGAC
GCGCAUGAAUGGAUGAACGAGAUUCCCACUGUCCCUACCUACUAUCCAGCGAAACCACAG
CCAAGGGAACGGGCUUGGCGGAAUCAGCGGGGAAAGAAGACCCUGUUGAGCUUGACUCUA
GUCUGGCACGGUGAAGAGACAUGAGAGGUGUAGAAUAAGUGGGAGGCCCCCGGCGCCCUC
CCGCCCCCGCGAGGGGGCGGGGCGGGGUCCGCCGGCCUUGCGGGCCGCCGGUGAAAUACC
ACUACUCUUAUCGUUUUUUCACUGACCCGGUGAGGCGGGGGGGCGAGCCCCGAGGGGCUC
UCGCUUCUGGCGCCAAGCGCCGGGCCCCGUCGGUCCGCGCGGGCCGGCGGCGGCCGGGCG
CGACCCGCUCCGGGGACAGUGCCAGGUGGGGAGUUUGACUGGGGCGGUACACCUGUCAAA
CGGUAACGCAGGUGUCCUAAGGCGAGCUCAGGGAGGACAGAAACCUCCCGUGGAGCAGAA
GGGCAAAAGCUCGCUUGAUCUUGAUUUUCAGUACGAAUACAGACCGUGAAAGCGGGGCCU
CACGAUCCUUCUGAGCUUUUGGGUUUUAAGCAGGAGGUGUCAGAAAAGUUACCACAGGGA
UAACUGGCUUGUGGCGGCCAAGCGUUCAUAGCGACGUCGCUUUUUGAUCCUUCGAUGUCG
GCUCUUCCUAUCAUUGUGAAGCAGAAUUCACCAAGCGUUGGAUUGUUCACCCACUAAUAG
GGAACGUGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAUGU
GUUGUUGCCAUGGUAAUCCUGCUCAGUACGAGAGGAACCGCAGGUUCAGACAUUUGGUGU
AUGUGCUUGGCUGAGGAGCCAAUGGGGCGAAGCUACCAUCUGUGGGAUUAUGACUGAACG
CCUCUAAGUCAGAAUCCCGCCCAGGCGGAACGAUACGGCAGCGCCGAAGGAGCCUCGGUU
GGCCUCGGAUAGCCGGUCCCCCGCCGUCCCCGCCGGCGGCCCGCGUCGUGCGUCCGCCUC
GGCGGCGUGCGGCGCGCCCCCCGCCGCGCGUCGGGACCGGGGUCCGGUGCGGAGAGCCCU
UCGUCCCGGGAAAUGGGGCGCGGCCGGAAAGGGGGCCGCCCUCUCGCCCGUCACGCACCG
CACGUUCGUGGGGAACCUGGCGCUAAACCAUUCGUAGACGACCUGCUUCUGGGUCGGGGU
UUCGUACGUAGCAGAGCAGCUCCCUCGCUGCGAUCUAUUGAAAGUCAGCCCUCGACACAA
GGGUUUGU
Sequence of entity 7 (L7), FASTA
>7ZJW_7 5S rRNA (chains L7)
UCUACGGCCAUACCACCCUGAACGCGCCCGAUCUCGUCUGAUCUCGGAAGCUAAGCAGGG
UCGGGCCUGGUUAGUACUUGGAUGGGAGACCGCCUGGGAAUACCGGGUGCUGUAGGCUU
Sequence of entity 8 (L8), FASTA
>7ZJW_8 5.8S rRNA (chains L8)
CGACUCUUAGCGGUGGAUCACUCGGCUCGUGCGUCGAUGAAGAACGCAGCUAGCUGCGAG
AAUUAAUGUGAAUUGCAGGACACAUUGAUCAUCGACACUUCGAACGCACUUGCGGCCCCG
GGUUCCUCCCGGGGCUACGCCUGUCUGAGCGUCGCUUG
Sequence of entity 9 (LD), FASTA
>7ZJW_9 60S ribosomal protein uL2 (chains LD)
MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAK
VVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKP
GDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPIL
KAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAA
RRTGRLRGTKTVQEKEN
Sequence of entity 10 (LE), FASTA
>7ZJW_10 60S ribosomal protein L3 (chains LE)
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDDAGKRQLDKDFSSMKKYCQVIRVLAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVSQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTVEEKKAFMGPLKKDRIAKEEGA
Sequence of entity 11 (LF), FASTA
>7ZJW_11 60S ribosomal protein L4 (chains LF)
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGH
QTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQK
RYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAWNDI
KKVYASQRMRAGKGKMRNRRRIQRRGPCVIYNEDNGIVKAFRNIPGITLLNVTKLNILKL
APGGHVGRFCIWTESAFRKLDDLYGTWRKAASLKSNYNLPMHKMLNTDLSRILKSPEIQR
ALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVERAAAALAA
KSDPKEAPAKKKPVVGKKKKPVVGRKAAAAKKPAADKKAADKRAGPEDKKPAA
Sequence of entity 12 (LG), FASTA
>7ZJW_12 Ribosomal_L18_c domain-containing protein (chains LG)
MXFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDI
ICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYE
GQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRF
PGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMY
KKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| GTP | Guanosine-5'-triphosphate | C10 H16 N5 O14 P3 | 2 |
| SER | Serine | C3 H7 N O3 | 1 |
| MG | Magnesium ion | Mg | 225 |
| ZN | Zinc ion | Zn | 9 |
Water and common crystallization additives (K, NA) are not listed.
Primary citation
Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon. Hilal, T., Killam, B.Y., Grozdanovic, M. et al. Science (2022) 376:1338-1343. DOI 10.1126/science.abg3875 · PubMed
Other PDB entries of the same protein (UniProt P57772 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5IZL 2.72 Å, The crystal structure of human eEFSec in complex with GDPCP
- 5IZK 3.25 Å, The crystal structure of human eEFSec in complex with GDP
- 5IZM 3.4 Å, The crystal structure of human eEFSec in complex with GDPNP
Browse structure collections
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