7ZVW: NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex. Determined by electron microscopy at 3.4 Å resolution. Released 31 May 2023.
- Method
- Electron microscopy
- Resolution
- 3.4 Å
- Organism
- Komagataella phaffii GS115
- Chains
- 7
- Atoms
- 37,905
- Mol. weight
- 922.61 kDa
- Ligands
- MG, ATP
- Released
- 31 May 2023
Explore 7ZVW in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
7ZVW contains 292 α-helices and 84 β-strands across 7 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 199 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-13 | 9 | |
| α-helix | 21-35 | 15 | |
| α-helix | 44-56 | 13 | |
| α-helix | 70-84 | 15 | |
| α-helix | 90-107 | 18 | |
| α-helix | 115-126 | 12 | |
| α-helix | 136-157 | 22 | |
| α-helix | 188-202 | 15 | |
| α-helix | 209-223 | 15 | |
| α-helix | 264-288 | 25 | |
| α-helix | 300-311 | 12 | |
| α-helix | 317-330 | 14 | |
| α-helix | 334-339 | 6 | |
| α-helix | 349-353 | 5 | |
| α-helix | 357-378 | 22 | |
| α-helix | 379-381 | 3 | |
| α-helix | 384-399 | 16 | |
| α-helix | 405-424 | 20 | |
| α-helix | 429-451 | 23 | |
| α-helix | 453-456 | 4 | |
| α-helix | 542-544 | 3 | |
| α-helix | 551-553 | 3 | |
| α-helix | 557-580 | 24 | |
| α-helix | 605-621 | 17 | |
| α-helix | 622-624 | 3 | |
| α-helix | 654-668 | 15 | |
| α-helix | 672-690 | 19 | |
| α-helix | 694-697 | 4 | |
| α-helix | 698-705 | 8 | |
| α-helix | 707-724 | 18 | |
| α-helix | 725-727 | 3 | |
| α-helix | 733-752 | 20 | |
| α-helix | 754-776 | 23 | |
| α-helix | 783-795 | 13 | |
| α-helix | 799-821 | 23 | |
| α-helix | 830-840 | 11 | |
| α-helix | 846-849 | 4 | |
| α-helix | 853-864 | 12 | |
| α-helix | 868-884 | 17 | |
| α-helix | 887-894 | 8 | |
| α-helix | 895-897 | 3 | |
| α-helix | 898-907 | 10 | |
| α-helix | 916-929 | 14 | |
| β-strand | 954-957 | 4 | 1 |
| β-strand | 959 | 1 | 2 |
| β-strand | 966-969 | 4 | 1 |
| α-helix | 974-982 | 9 | |
| α-helix | 988-1006 | 19 | |
| α-helix | 1010-1012 | 3 | |
| α-helix | 1015-1028 | 14 | |
| α-helix | 1031-1034 | 4 | |
| α-helix | 1048-1067 | 20 | |
| α-helix | 1068-1070 | 3 | |
| α-helix | 1075-1098 | 24 | |
| α-helix | 1124-1133 | 10 | |
| α-helix | 1137-1158 | 22 | |
| α-helix | 1161-1166 | 6 | |
| α-helix | 1170-1180 | 11 | |
| α-helix | 1186-1201 | 16 | |
| α-helix | 1207-1212 | 6 | |
| α-helix | 1214-1227 | 14 | |
| α-helix | 1235-1250 | 16 | |
| α-helix | 1258-1261 | 4 | |
| α-helix | 1264-1275 | 12 | |
| α-helix | 1281-1297 | 17 | |
| α-helix | 1302-1306 | 5 | |
| α-helix | 1311-1318 | 8 | |
| α-helix | 1327-1341 | 15 | |
| α-helix | 1352-1363 | 12 | |
| α-helix | 1383-1403 | 21 | |
| α-helix | 1405-1411 | 7 | |
| α-helix | 1416-1428 | 13 | |
| α-helix | 1433-1447 | 15 | |
| α-helix | 1455-1470 | 16 | |
| α-helix | 1477-1487 | 11 | |
| α-helix | 1497-1510 | 14 | |
| α-helix | 1514-1517 | 4 | |
| α-helix | 1527-1537 | 11 | |
| α-helix | 1546-1547 | 2 | |
| α-helix | 1550-1563 | 14 | |
| α-helix | 1573-1582 | 10 | |
| α-helix | 1584-1592 | 9 | |
| α-helix | 1598-1609 | 12 | |
| α-helix | 1614-1622 | 9 | |
| α-helix | 1624-1632 | 9 | |
| α-helix | 1644-1657 | 14 | |
| α-helix | 1659-1664 | 6 | |
| α-helix | 1666-1683 | 18 | |
| α-helix | 1694-1713 | 20 | |
| α-helix | 1718-1726 | 9 | |
| α-helix | 1733-1735 | 3 | |
| α-helix | 1736-1747 | 12 | |
| α-helix | 1754-1765 | 12 | |
| α-helix | 1774-1794 | 21 | |
| α-helix | 1812-1819 | 8 | |
| α-helix | 1825-1828 | 4 | |
| α-helix | 1837-1853 | 17 | |
| α-helix | 1860-1873 | 14 | |
| α-helix | 1878-1894 | 17 | |
| α-helix | 1902-1909 | 8 | |
| α-helix | 1915-1932 | 18 | |
| α-helix | 1944-1951 | 8 | |
| α-helix | 1959-1969 | 11 | |
| α-helix | 1970-1974 | 5 | |
| α-helix | 1981-1993 | 13 | |
| α-helix | 2001-2019 | 19 | |
| α-helix | 2086-2101 | 16 | |
| α-helix | 2111-2123 | 13 | |
| α-helix | 2135-2139 | 5 | |
| α-helix | 2153-2167 | 15 | |
| α-helix | 2174-2187 | 14 | |
| α-helix | 2196-2213 | 18 | |
| α-helix | 2222-2238 | 17 | |
| α-helix | 2249-2261 | 13 | |
| α-helix | 2273-2285 | 13 | |
| α-helix | 2304-2311 | 8 | |
| α-helix | 2313-2321 | 9 | |
| α-helix | 2330-2343 | 14 | |
| α-helix | 2348-2362 | 15 | |
| α-helix | 2371-2385 | 15 | |
| α-helix | 2392-2406 | 15 | |
| α-helix | 2412-2427 | 16 | |
| α-helix | 2431-2444 | 14 | |
| α-helix | 2449-2454 | 6 | |
| α-helix | 2455-2459 | 5 | |
| α-helix | 2471-2479 | 9 | |
| β-strand | 2482 | 1 | 2 |
| α-helix | 2522-2535 | 14 | |
| α-helix | 2541-2550 | 10 | |
| α-helix | 2555-2571 | 17 | |
| α-helix | 2575-2577 | 3 | |
| α-helix | 2578-2590 | 13 | |
| α-helix | 2592-2597 | 6 | |
| α-helix | 2604-2614 | 11 | |
| α-helix | 2622-2631 | 10 | |
| α-helix | 2635-2646 | 12 | |
| α-helix | 2651-2653 | 3 | |
| α-helix | 2654-2670 | 17 | |
| α-helix | 2674-2684 | 11 | |
| α-helix | 2688-2699 | 12 | |
| α-helix | 2703-2717 | 15 | |
| α-helix | 2728-2741 | 14 | |
| α-helix | 2745-2755 | 11 | |
| α-helix | 2759-2760 | 2 | |
| α-helix | 2761-2765 | 5 | |
| α-helix | 2775-2785 | 11 | |
| α-helix | 2791-2806 | 16 | |
| α-helix | 2812-2832 | 21 | |
| α-helix | 2841-2865 | 25 | |
| α-helix | 2872-2887 | 16 | |
| α-helix | 2897-2917 | 21 | |
| α-helix | 2943-2958 | 16 | |
| α-helix | 2963-2973 | 11 | |
| α-helix | 2980-2996 | 17 | |
| α-helix | 2998-3003 | 6 | |
| α-helix | 3005-3008 | 4 | |
| α-helix | 3018-3034 | 17 | |
| α-helix | 3038-3051 | 14 | |
| α-helix | 3056-3072 | 17 | |
| α-helix | 3080-3090 | 11 | |
| α-helix | 3100-3111 | 12 | |
| α-helix | 3118-3125 | 8 | |
| α-helix | 3129-3130 | 2 | |
| α-helix | 3133-3135 | 3 | |
| α-helix | 3139-3146 | 8 | |
| α-helix | 3151-3164 | 14 | |
| α-helix | 3166-3175 | 10 | |
| α-helix | 3282-3295 | 14 | |
| α-helix | 3298-3314 | 17 | |
| α-helix | 3319-3340 | 22 | |
| α-helix | 3348 | 1 | |
| β-strand | 3349 | 1 | 3 |
| α-helix | 3350 | 1 | |
| α-helix | 3352-3364 | 13 | |
| α-helix | 3366 | 1 | |
| α-helix | 3369-3379 | 11 | |
| β-strand | 3384 | 1 | 3 |
| α-helix | 3385-3405 | 21 | |
| β-strand | 3409-3411 | 3 | 4 |
| α-helix | 3412-3415 | 4 | |
| α-helix | 3417-3420 | 4 | |
| α-helix | 3422-3425 | 4 | |
| β-strand | 3431 | 1 | 5 |
| α-helix | 3432 | 1 | |
| α-helix | 3435-3437 | 3 | |
| β-strand | 3448 | 1 | 5 |
| β-strand | 3449-3452 | 4 | 4 |
| β-strand | 3455-3460 | 6 | 4 |
| β-strand | 3465-3473 | 9 | 4 |
| β-strand | 3478-3484 | 7 | 4 |
| α-helix | 3491-3508 | 18 | |
| α-helix | 3512-3515 | 4 | |
| β-strand | 3526-3530 | 5 | 4 |
| β-strand | 3533-3536 | 4 | 4 |
| α-helix | 3545-3556 | 12 | |
| α-helix | 3562-3574 | 13 | |
| α-helix | 3584-3594 | 11 | |
| α-helix | 3595-3599 | 5 | |
| α-helix | 3605-3612 | 8 | |
| α-helix | 3616-3639 | 24 | |
| β-strand | 3650-3652 | 3 | 6 |
| β-strand | 3659-3661 | 3 | 6 |
| β-strand | 3668-3670 | 3 | 7 |
| α-helix | 3671-3673 | 3 | |
| α-helix | 3678-3680 | 3 | |
| β-strand | 3693-3695 | 3 | 7 |
| α-helix | 3707-3713 | 7 | |
| α-helix | 3717 | 1 | |
| α-helix | 3718-3722 | 5 | |
| α-helix | 3723-3732 | 10 | |
| α-helix | 3740-3755 | 16 | |
| α-helix | 3756-3760 | 5 | |
| α-helix | 3763-3765 | 3 | |
| α-helix | 3766-3786 | 21 | |
| α-helix | 3789-3790 | 2 | |
| α-helix | 3799-3809 | 11 | |
| α-helix | 3811-3815 | 5 | |
| α-helix | 3819-3821 | 3 | |
Chain B: 22 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 7-8 | 2 | |
| β-strand | 9-13 | 5 | 8 |
| β-strand | 18-22 | 5 | 8 |
| β-strand | 30-32 | 3 | 8 |
| β-strand | 36-38 | 3 | 9 |
| α-helix | 57-61 | 5 | |
| β-strand | 67-69 | 3 | 9 |
| β-strand | 72-73 | 2 | 10 |
| β-strand | 76-77 | 2 | 10 |
| α-helix | 80-89 | 10 | |
| α-helix | 90-95 | 6 | |
| β-strand | 104-108 | 5 | 8 |
| α-helix | 114-123 | 10 | |
| α-helix | 124-128 | 5 | |
| β-strand | 132 | 1 | 11 |
| β-strand | 133-137 | 5 | 8 |
| α-helix | 138-144 | 7 | |
| α-helix | 145-147 | 3 | |
| β-strand | 151 | 1 | 12 |
| β-strand | 153-154 | 2 | 13 |
| β-strand | 156 | 1 | 14 |
| β-strand | 161-163 | 3 | 14 |
| β-strand | 166-167 | 2 | 12 |
| β-strand | 170-171 | 2 | 12 |
| α-helix | 173-175 | 3 | |
| β-strand | 177-179 | 3 | 14 |
| α-helix | 183-197 | 15 | |
| α-helix | 204-216 | 13 | |
| α-helix | 224-229 | 6 | |
| β-strand | 239-242 | 4 | 15 |
| β-strand | 248-251 | 4 | 15 |
| α-helix | 254-263 | 10 | |
| α-helix | 275-285 | 11 | |
| α-helix | 288-296 | 9 | |
| β-strand | 299-300 | 2 | 13 |
| α-helix | 310-321 | 12 | |
| α-helix | 336-338 | 3 | |
| α-helix | 339-349 | 11 | |
| β-strand | 350 | 1 | 16 |
| α-helix | 352-356 | 5 | |
| β-strand | 359 | 1 | 11 |
| α-helix | 360-366 | 7 | |
| α-helix | 368-370 | 3 | |
| α-helix | 371-374 | 4 | |
Chain C: 9 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 432-456 | 25 | |
| β-strand | 459-461 | 3 | 26 |
| β-strand | 472-473 | 2 | 29 |
| α-helix | 489-492 | 4 | |
| β-strand | 497-498 | 2 | 29 |
| α-helix | 505-511 | 7 | |
| α-helix | 515-517 | 3 | |
| β-strand | 521-524 | 4 | 24 |
| β-strand | 527-528 | 2 | 24 |
| α-helix | 530-534 | 5 | |
| β-strand | 535-537 | 3 | 25 |
| β-strand | 547 | 1 | 24 |
| β-strand | 552-554 | 3 | 24 |
| β-strand | 557-558 | 2 | 30 |
| β-strand | 563-564 | 2 | 30 |
| β-strand | 567-568 | 2 | 24 |
| α-helix | 603-604 | 2 | |
| β-strand | 605 | 1 | 23 |
| α-helix | 610-619 | 10 | |
| α-helix | 637-639 | 3 | |
| α-helix | 643-664 | 22 | |
Chain E: 31 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 167-173 | 7 | |
| α-helix | 179-182 | 4 | |
| α-helix | 198-200 | 3 | |
| β-strand | 201-207 | 7 | 24 |
| β-strand | 213-215 | 3 | 25 |
| α-helix | 220-228 | 9 | |
| α-helix | 232-235 | 4 | |
| α-helix | 236-238 | 3 | |
| α-helix | 245-269 | 25 | |
| β-strand | 276-278 | 3 | 26 |
| α-helix | 279-281 | 3 | |
| α-helix | 284-288 | 5 | |
| α-helix | 292-331 | 40 | |
| α-helix | 333-335 | 3 | |
| β-strand | 336 | 1 | 16 |
| α-helix | 347-352 | 6 | |
| α-helix | 429-431 | 3 | |
| α-helix | 448-450 | 3 | |
| α-helix | 453-457 | 5 | |
| α-helix | 460-461 | 2 | |
| α-helix | 475-477 | 3 | |
| α-helix | 478-481 | 4 | |
| α-helix | 492-494 | 3 | |
| β-strand | 500-506 | 7 | 24 |
| α-helix | 508-511 | 4 | |
| α-helix | 537-539 | 3 | |
| α-helix | 541-543 | 3 | |
| β-strand | 553 | 1 | 27 |
| α-helix | 555-567 | 13 | |
| α-helix | 572-579 | 8 | |
| α-helix | 586-589 | 4 | |
| α-helix | 596-607 | 12 | |
| α-helix | 620-636 | 17 | |
| β-strand | 645 | 1 | 27 |
| α-helix | 656-658 | 3 | |
| α-helix | 660-685 | 26 | |
| α-helix | 696-698 | 3 | |
| α-helix | 699-712 | 14 | |
Chain F: 11 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 71-73 | 3 | |
| β-strand | 74-77 | 4 | 28 |
| β-strand | 94-97 | 4 | 28 |
| α-helix | 100-102 | 3 | |
| α-helix | 127-130 | 4 | |
| α-helix | 241-253 | 13 | |
| α-helix | 258-264 | 7 | |
| α-helix | 273-289 | 17 | |
| α-helix | 299-307 | 9 | |
| α-helix | 312-326 | 15 | |
| α-helix | 330-347 | 18 | |
| α-helix | 350-364 | 15 | |
| α-helix | 379-390 | 12 | |
Chain G: 19 helices, 22 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 16-18 | 3 | 17 |
| β-strand | 24-27 | 4 | 18 |
| β-strand | 28 | 1 | 17 |
| β-strand | 37-40 | 4 | 18 |
| β-strand | 42-46 | 5 | 19 |
| β-strand | 53 | 1 | 19 |
| α-helix | 58-62 | 5 | |
| β-strand | 68-72 | 5 | 19 |
| α-helix | 82-95 | 14 | |
| β-strand | 105-109 | 5 | 17 |
| α-helix | 115-127 | 13 | |
| β-strand | 133-138 | 6 | 17 |
| α-helix | 139-147 | 9 | |
| β-strand | 152-155 | 4 | 20 |
| β-strand | 162-168 | 7 | 20 |
| β-strand | 171-172 | 2 | 20 |
| α-helix | 174-176 | 3 | |
| β-strand | 178-180 | 3 | 20 |
| α-helix | 184-198 | 15 | |
| β-strand | 208-211 | 4 | 21 |
| β-strand | 214 | 1 | 22 |
| β-strand | 222-224 | 3 | 21 |
| α-helix | 233-251 | 19 | |
| α-helix | 263-269 | 7 | |
| β-strand | 273-276 | 4 | 23 |
| β-strand | 281 | 1 | 22 |
| β-strand | 282-285 | 4 | 23 |
| α-helix | 287-295 | 9 | |
| α-helix | 364-374 | 11 | |
| α-helix | 380-385 | 6 | |
| β-strand | 387-389 | 3 | 20 |
| α-helix | 392-395 | 4 | |
| α-helix | 399-410 | 12 | |
| β-strand | 418-419 | 2 | 20 |
| α-helix | 424-428 | 5 | |
| α-helix | 430-440 | 11 | |
| α-helix | 443-447 | 5 | |
| α-helix | 448 | 1 | |
| β-strand | 449-450 | 2 | 17 |
| α-helix | 451-457 | 7 | |
| α-helix | 460-466 | 7 | |
Chain H: 1 helix, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 403-406 | 4 | |
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Transcription-associated protein | A | protein | 3825 | Komagataella phaffii GS115 | C4QYV4 |
| Actin | B | protein | 376 | Komagataella phaffii GS115 | Q9P4D1 (AlphaFold model) |
| Actin | G | protein | 468 | Komagataella phaffii GS115 | C4QXM9 (AlphaFold model) |
| Chromatin modification-related protein EAF1 | E, H | protein | 1051 | Komagataella phaffii GS115 | C4R7G0 (AlphaFold model) |
| SWR1-complex protein 4 | F | protein | 565 | Komagataella phaffii GS115 | C4R0G7 |
| Enhancer of polycomb-like protein | C | protein | 752 | Komagataella phaffii GS115 | C4R6V1 |
Sequence of entity 1 (A), FASTA
>7ZVW_1 Transcription-associated protein (chains A)
MLHVVQLDDFATRLKAAEDYQSKHSVLSEICDSLETFNAAQDYEYFLKSLIPLFIDVLKE
VPVSFVANSPENKLRNITLEILHRIPANDALQAYSNEIVDTLMDLLKVENELNGILCMKA
ITTLHKTFKASLQEKVHPFIDIVIEIYSNIPQVVEEQFNGNQIDSKENVDSTSRPNSPSF
SSQSDDSKQLAQAMFSFKTLAESPITMVSLYSSYKELAASSLGNFIPHVMKVLSLEVAKQ
AEARKAAEEKGIILVNVCKEITNRANYGEFIIGQVKAASFLAYLFIRRQAQTFLEPYQQA
IPDIIIRLLQDCPSELSAARKELLHATRHILSTDFRKMFIPKIDLLFDLRVLIGEGFTAY
ETLRPLAYSTVADFIHNVRDHLTPAQLWKSVSIYCKNLQDDSLALTVQIMSAKLLLNLIE
KIMRSESKTESRQLLMVIIDAYTKRFKMLNSRYNGIMKQHATYEKEKQEKQNQERLLTNK
LDGTTPSPSDDKKVELIDEDQDVKMEDPTPEISDQETIKGDNDASTEPQDSEQQLADFMS
LQEYLPIQVSVPPEIDLLKDSRYLFKTLMTFLKTIMIGLKNSNPPSSQNHFNAQNWNETA
RGFSNEDINILKSLFRECILALRFFSTSKTSLPASSMKQSFDITGPNLPITSTKEEKDLM
EIFATMFIHIDPASFNEIVREELPFMYKQMLDFASLLHIPQFFLASVITSSSFSGILITF
LKSKLVDLGEVNIIKSNILIRLFKLCFMSVSLFPAANESVILPHLNELILKSLKLSTTAK
EPLVYFYLIRTLFRSIGGGRFENLYKEIMPLLQVLLESLSKLIHEARRPQERDIYVELCL
TVPVRLSVLVPHLSYLMKPLVYALNGSQESVSQGLRTLELCVDNLTAEYFDPIIEPVIDD
VMEALSKHLKPLPYYHQHSHTTLRILGKLGGRNRTFIKPVDNLKTDSELFQNVEAMFKIH
GLPNEVPLSITPGLSAAFSLLTDPRPRIHYRINSFKYISGIFQLFLGATQLPDDYANRLK
ESMDIILEDTIAPDEPLNKLHHFPVKDIAKYDSQMELLVKLLESIFYAVSLQEVREESKA
LIRGTCNHFILLYFNKMVIDKRKFVRKFSVDNHEGNLFLNENCIFDAIIYALSSDNSAVR
SMGLESVQLIYDSCVELFGNIDCALKFAPLNVMCSKFIHCCFEEPYHKKLAGCIGLEMML
NSLDIPMKYFNARQLEIIRALFYVLRDTAPELPCEVTNTAKRLILNSLKEWNKELTRNDV
FSSVFQNLVSSLIVDLPNANEIVRATAQEALRTLSETTQVPIATMISPCKHILLAPIFGK
PLRALPFQMQIGNIDAITFCMGLENSFLEYNEELNRLVQEALALVDAEDESLVSAHRISE
HKTSEQLVRLRVVCIQLLSLAITKPEFAAAQQRSNIRVKILVVFFKSLCGRSIEIIRAAH
GGLKAVIDLKMKLPKELLQNGLRPMLMNLSDHKKLTVASLEALSGLLKLFISYFKVGIGS
KLLDHLLAWAQPRTLQQLGSQDLENNSTVQIIVAILDVFHLLPPTAHKFMNDLMNALLYL
ENNLHRCQYSPFREPLAKFLDRFPDESFEYFFNEFSKREITTRFVYFVGLDSCSSLRAKV
LESLPRVRGLLHQEGSAEEKCVRFSNLVDLCESLAASDKEWIKDKEELLGELLDAGSVCL
TLKRSSNVVSPLYFQVDQGFETLQLLYIEYFKSQPLGHEKVFNFIDKISKEGLPFVLEFD
DFIFNEVVKCQDIPTVQQTLDTIIRMTPQVSSLDARVYLYKRIFLPICIYESEMHGDLSR
LSQTENNELPAWLKSFDSDVWKATGPLVDDYTSTLEDRYRLELMQLTALLIKGAPTALTD
MRKDIIKFSWNYIKLDDNTSKQAAYVVTAYFISRFDTPSELTTRIFVALLRCHQIDTRYL
VKQALELLAPVLSERTNSELDWLKWPRRVLSEDGFNITQVANIYQLIVKFPDLFYPARDH
FIPNIITAMGKLTVMSNTSLENQQLAIDLAELILKWETKLPKSEKLGSAEETEKEKSVSE
DKMDIDVKEETKEDIAERPKAEDQIGGDDSDSSNILTSEDYEVSFAQREACVTFLIRYIC
ISTQRPSENELGKRALNILYELLGPKYWSEVTVKLQFFERFLMSSDLNQPSLLGYCLNAL
EVLAVALKWKPTTWIIENVSYLQKLLEKCLRSDNQDIQEILQKVLGIILEAINKETQGSE
EDEPEEVTNFISLIVNIIGEDLSNMTSVAAGVSLCWTLSLYRPNALDSLLPSIMRTFNKL
CRDHIAISLQGNQPQSGDFANIEFEAKVTTNLLEKILNLCAARISSLDDQRRVFLSLLAQ
LIDRSVDKDMLLKVINIVTEWIFKTDFYPTTKEKAGILGKMMIFDLRGEPELSKKFNQVI
VDIFESKELAHTELTARMETAFLFGTRLSDVSIRKKLMSILSDSLELDIDKRLFYIIKDQ
NWEYLSDYPWLNQALQLLYGSFHLDSPIRLSPEENTLSPLQSITEGLAREKSPVEKAPQN
IIDFVAKHNEFLDSVRSLTAGDILNPLIDISYQSAETIHNAWVVVFPVAYSAIESRYELE
FTRALVKLLFKDYHIRQQDARPNVIKSLLDGVGKCPGLHLPPHLVKYLGSNYNAWYGAIK
LLEELSEGQGIDNQKISDANQDALLEVYMSLQEDDMFYGTWRRRAKYFETNAALSYEQIG
IWDKALQLYEAAQIKARSGVFPFGESEYSLWEDHWIYCAEKLQHWEILTELAKHEGFTDL
LLECGWRGADWIADREPLEQSVKTVMDIPTPRRQIFQTFLALQGFSQQKDTLQDVSRLCD
EGIQLTLRKWNALPQRVTRAHIGLLHTFQQYVELMEASQVYSSLVTTNAQNLDVKSQELK
RVLQAWRERLPNVWDDINIWNDLVTWRQHVFGVINRVYMPFVPVLQQSNGTNNGNSYAYR
GYHEMAWVINRFAHVARKHEMPEVCINQLTKIYTLPNIEIQEAFLKLREQAKCHYQNSSE
LNTGLDVISNTNLVYFATQQKAEFFTLKGMFLAKLNAKDEANQAFATAVQIDLNLPKAWA
EWGFFNDRRFKENPEEIFHAKNAISCYLQAAGLYKDGKTRKLLCRILWLISLDDAAGSLA
KTFEDHHGESPVWYWITFVPQLLTSLSHKEAKIVRHILIQIAKSYPQSLHFQLRTTKEDY
QAIQRQAMAVNRAEEQSSNKQDTADSVLKNTNTPQPQTRTETSGTTAESDKKPSIPPKEE
QGSPQPSRPATTQASPQAQSQENGESSQKHPPEIPTTDSRQPWQDVEEIMGILKTAYPLL
ALSLESLVDQLNQRFKCNADEDAYRLVIVLYNDGVQQMNRVANPREEVKLPAATEASISR
FADSVLPKNIREVFEQDIIACNPNLETYISKLRKWRDCLEEKLDRSYGKADLERVSLHLS
LFHHQKFEDIEIPGQYLLHKDNNNHFIKIERFLPTLDLVRGSNGCYKRMTIRGNDGSLHP
FAVQFPAARHCRREERIFQLFRIFDDALSRKVQSRRRNISLTLPIAVPLSPHIRILNDDK
RYTTLMGIYEEFCRRKGQSRDEPFAYTIQKLRAAFDPRLPKPDIVSVRAEVLASIQSTLV
PSTLLKDYYTEKFSNYENYWLFRKQFTAQYASFIFMTYIMCINSRQPQKIHINEGSGNIW
TSEMLPTKVATGKTHSTAYNNSTLDPAVKAGAPIFYNTESVPFRLTPNIQKFIGEAGLEG
ILSVYILVIANSLSDSEFDMEQYLSLFVRDEVISWFAQQHRASAQTNQLREIVRVNVELL
TKRVLQLNHIPNSQNVATQFVLNLISQAVNPRNLAYTDSAWMAYL
Sequence of entity 2 (B), FASTA
>7ZVW_2 Actin (chains B)
MDGEDVAALVIDNGSGMCKAGYAGDDAPHTVFPSVVGRPRHQGVMVGMGQKDSFVGDEAQ
SKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRLAPEEHPVLLTEAPMNPKSNREKM
TQIMFETFNVPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRID
LAGRDLTDYLMKILSERGYTFSTSAEREIVRDIKEKLCYVALDFDQELQTSSQSSSIEKS
YELPDGQVITIGNERFRAPEALFHPSVLGLEASGIDQTTYNSIMKCDVDVRKELYSNIVM
SGGTTMFPGIAERMQKELTALAPSSMKVKISAPPERKYSVWIGGSILASLGTFQQMWISK
QEYDESGPSIVHLKCF
Sequence of entity 3 (G), FASTA
>7ZVW_3 Actin (chains G)
MATAPQVYGADEINAVVLDASSYRTKIGYGSLDCPILNLPSYYGHQTKDGSEKFIFEENS
MLIPRPDYEIKKIMKDGIIDDFEGAVKQYNYMFDVLKLKPSEQPILVIESTQNEYEKKTA
LLKQLLKENKFVATFLIKNPTCVSFAHGRPNCLVVDLGHDLVTITPILDGISLRKQVLGT
HYAGAFLSQQLRQLLNHKGVEVVPVYKVKSKVPTYFPDEAKFEERKYDFDISESFENFHK
LRILREMKETLLQALPDSETEKLKEQETEEDTRYFEFPNGLNVPFTKYERVRLANSLFNP
SEPYTGESGPNIVVEGFSVETGKIINEDTITSREYVPLRRSKKTDSSSGRRSKDEPTDDK
PRGLTSLVNQALNHLDVDLKPQLANNIILTGATSLIPGVAERLNQELTAMNPGLKVRIHS
SANVIERTCSAWIGGSILSSLGTFHQLWVSENEYDEVGAKKLIMDRFR
Sequence of entity 4 (E, H), FASTA
>7ZVW_4 Chromatin modification-related protein EAF1 (chains E, H)
MSSLDSNVTASSKHDSPKRQPEDGSGTNDDPLQRILNERKRKLAELYCVSRLPLLPISPS
QVSQIGENLMRFLERNDLEQGRQFNITTLTGDKSQKQPPVSKEVSTADQLESPHWPVKED
EETTKDEPPRKKQKTASTSAEPQKATHKESKMTMMHQEVTESEAPTLSSLIRKYAQDEVP
IRPDDPTDRDLNFELLDRNKTIIQALPEIYPHKIADSASLTELYYLTQTFPLAKLLPRSH
KSLTTDAYESALLEGKIAVLYSRIEELKRQRKWSLRQPKRFIDPFTRESPTHWDHLLAEM
KWLSVDIMEERKFKAASCVQLAQAVSDYWTYGKIVCIQRKPLIFLTDEEIKERTVTKVMK
TEVDNENEHDHDDNDIFKDAQEEPRAMDQEQNQPFEENATIDVAKLLERPNPKDEIIPPA
LPTYSMGDYKRLNQNAEPFKLHIGLDDFKKEDLVLVEKLPLSFIFDDNLSDSKKKLSEYE
KAPIAAISTLLAPPEDDEWYKIVIRRDPASELSASLDYQKGLFGASSQRRYNVLKPPKPP
PIKNLELRTPTIWLPQDDKLLIRYVAEYAFNWDIISAHLSARPARAYVANIERRTPWQCF
ERYIQLNDKFQFTDMRGQYAQSAQAWLEAAHKTQSTTKRRISPLGVGIESIQRGHRRLRW
GSMLDAMRKCMRRRENINRSSQVERKHTSDDKRTNVPTPEELSRLKYDRDKAIQEAYMHQ
NSGTFSSARPHTQSSALSPSKGKNAPLPTSAQQTGTHPYTNGIPPKGTLPKTTTPAPGVP
STQPGTPNTRQPQVSSRVATSQNTTPVTNRTGTPNGNRPGPNNSFTQEQLQHFLQAQRHR
QMMQTSAGTPVNKSNVPNRPAGITNTNVTTPANAVSSSTTPSKSAATASQQQPSPSRGIN
LTPAQVNALINQIQAQNPNMSKDQVTKFAVAYIQNLQNQRERSSNGHSTPQVRTVPTPTR
ATAGPPVSASPVTSNASPTTPASLTKEKLDALENSPNLTPQQRQQITLFKAMQARNKMNQ
VANRGQESASASSNLSASPNTDTKQTTDTNK
Sequence of entity 5 (F), FASTA
>7ZVW_5 SWR1-complex protein 4 (chains F)
MSSDILDVLSISGRSNLSNQKKKITKDGPTKKKKQTAMSRELFNLIGQNTPPLAVEKTVK
FKEKLNVNNKPTPWSYVEFSNDARESKDGLKLHHWIKGSSELAKNSPYLFEKYNQKIQIP
SFTKEEYDEFLKDLDLECREREKRDKALKEQEAKEAEKLEKEKENDKERVNGDELGKEED
NASDFVPKKENVNDQILPKIDEPQTNKKDDMESTEDVSKSDSQEVSKDVNPSEEVEASWD
YDETVHLFQLCEKWDLRWPIIVDRYEYDERSMEELKERFYKVSERILRHKYRNVTMDDKT
SLLVQTLSSFDKRRETERKQYLRRLLSRSPTEIAEEESLVIEARKFELAAKKMLTERASL
LRLLDSPQSTGSISQYLTSQGLTQLYNTLMSADRSKRRKVETPTPPQIPPGASSSLHRTS
MDLKRKAAKKIGPNALLENIKATGNSVPPSGNAPQSAAIELINTKMTPEEKEAYGIKIHQ
EKLQPGVSLRSARLPTFKPATQAKIVVVLNELEVSPKPTIPTAKVVAQYDNLLQTINVLL
ETKKQVNKLEVELNLLEGKEEDKES
Sequence of entity 6 (C), FASTA
>7ZVW_6 Enhancer of polycomb-like protein (chains C)
MVLPSAAGARFRQRKISVKQTLQVFKQSDIADLETEDQQRELQKIETGVEKGEEEEEHLQ
RVINAAQAAVISGGKVEKAYIPTPDASQVWKDYDKYYRDKFQPPGTYIRFSATVEETTGC
IYNLDEEDESFLKEVLNKNLANGIKPCTETELEIVLQRFEVVIDKKQPFLAMDPSQILTF
EELHSAALVVDPNSIEEIELSLEKQLGLHPFRTLLDGQRSQLSHRKLAELLRIFGQKIYD
HWKQRRIARHGRPITAQLRFEDSSEKDDSDPYVCFRRREFRQARKTRRTDTQGSERLRKL
HRELKQTRDLLLAVAQREVKRKEAIEVGHEVFQLRCSVKTLKRDLGVKGEEEDLVAHKRK
KVVPTTDEDRKYRKGYNSGNYPNRNQAQAQQQQQQLQQQQISKSGLNPVSIQPYVKLPMS
RIPDMDLITVSTVLNEKDEAINRAVAEKLRQRKESDRGWVNLTDDPFNPFLQFTNPDSIL
EKGHFPYSSIAAALFEVDQSNYFDPEITQLIKDKKPLPRTLCFKDNALTTPLPPSIYEVA
SNNKLDVTAPICKVRKRMGRRGLWIDRKMTVDEPLDEFLDFSTFEKSLDADITDRNSAKS
QQGMNVYDSVDDANSRLRSRFSFDRDVPLFNPVDPSELNQISSQTQSIRFGCMLLTKAYE
QVHQAKQKLFLEQQQHQQKQQQKLLQQRQKVQQKLQQQQQQQQQAQQQNPKSNTNKVVNQ
INNTKSPVKQSKIPSKVSKNISGVTTSAGKGA
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| MG | Magnesium ion | Mg | 2 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
Primary citation
The structure of the NuA4-Tip60 complex reveals the mechanism and importance of long-range chromatin modification. Frechard, A., Faux, C., Hexnerova, R. et al. Nat Struct Mol Biol (2023) 30:1337-1345. DOI 10.1038/s41594-023-01056-x · PubMed
Other PDB entries of the same protein (UniProt C4QYV4), best resolution first:
- 6TB4 3.8 Å, Structure of SAGA bound to TBP
- 5OEJ 5.7 Å, Structure of Tra1 subunit within the chromatin modifying complex SAGA
- 6TBM 20.0 Å, Structure of SAGA bound to TBP, including Spt8 and DUB
Browse structure collections
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