Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation. Determined by electron microscopy at 3.24 Å resolution. Released 22 Mar 2023.
Explore 8BZY in 3D Show helices and sheets RCSB PDB PDBe
8BZY contains 23 α-helices and 12 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 19-22 | 4 | |
| α-helix | 24-53 | 30 | |
| α-helix | 58-85 | 28 | |
| α-helix | 88-115 | 28 | |
| α-helix | 117-118 | 2 | |
| α-helix | 119-123 | 5 | |
| α-helix | 126-150 | 25 | |
| α-helix | 151-159 | 9 | |
| α-helix | 160-163 | 4 | |
| α-helix | 167-198 | 32 | |
| α-helix | 201-229 | 29 | |
| α-helix | 231-234 | 4 | |
| α-helix | 289-303 | 15 | |
| α-helix | 309-316 | 8 | |
| α-helix | 331-335 | 5 | |
| α-helix | 339-366 | 28 | |
| α-helix | 370-392 | 23 | |
| α-helix | 452-483 | 32 | |
| α-helix | 489-513 | 25 | |
| α-helix | 517-519 | 3 | |
| α-helix | 520-545 | 26 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 1 |
| β-strand | 10-13 | 4 | 2 |
| β-strand | 17-24 | 8 | 1 |
| β-strand | 33-39 | 7 | 2 |
| β-strand | 45-50 | 6 | 2 |
| β-strand | 51 | 1 | 3 |
| β-strand | 58 | 1 | 3 |
| α-helix | 62-64 | 3 | |
| β-strand | 68-73 | 6 | 1 |
| β-strand | 78-84 | 7 | 1 |
| α-helix | 88-90 | 3 | |
| β-strand | 92-103 | 12 | 2 |
| β-strand | 106-111 | 6 | 2 |
| β-strand | 115-120 | 6 | 2 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Solute carrier family 40 member 1 | A | protein | 580 | Homo sapiens | Q9NP59 (AlphaFold model) |
| Sybody 3 | B | protein | 146 | synthetic construct |
>8BZY_1 Solute carrier family 40 member 1 (chains A) MSTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLL LTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHE LLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRR IDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGL KEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGW VSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVA FTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESIT PTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQL LQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYF RFAQNTLGNKLFACGPDAKEVRKENQANTSVVALEVLFQG
>8BZY_2 Sybody 3 (chains B) QVQLVESGGGLVQAGGSLRLSCAASGFPVAWNEMRWYRQAPGKEREWVAAIASIGVTTYY ADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNVKDYGMAFWYYDYWGQGTQVTVS AGRAGEQKLISEEDLNSAVDHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| SZU | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-… | C21 H21 F N6 O2 | 1 |
| PLC | Diundecyl phosphatidyl choline | C32 H65 N O8 P | 1 |
Structures of ferroportin in complex with its specific inhibitor vamifeport. Lehmann, E.F., Liziczai, M., Drozdzyk, K. et al. Elife (2023) 12. DOI 10.7554/eLife.83053 · PubMed
Other PDB entries of the same protein (UniProt Q9NP59 (AlphaFold model), which also has an AlphaFold model), best resolution first:
MolViewer shows 8BZY directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.