8CMK: Transportin-3 TNPO3

Transportin-3 TNPO3 in complex with RSY region of CIRBP. Determined by X-ray diffraction at 2.94 Å resolution. Released 6 Mar 2024.

Method
X-ray diffraction
Resolution
2.94 Å
Organism
Homo sapiens
Chains
5
Atoms
14,823
Mol. weight
220.69 kDa
Ligands
TSS
Released
6 Mar 2024

Explore 8CMK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8CMK contains 119 α-helices and 0 β-strands across 5 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 60 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix4-74
α-helix8-2013
α-helix24-3916
α-helix43-5311
α-helix57-7418
α-helix75-773
α-helix80-823
α-helix83-9614
α-helix102-11817
α-helix125-1339
α-helix140-15314
α-helix163-17513
α-helix177-18913
α-helix195-21016
α-helix216-2205
α-helix224-23310
α-helix239-25416
α-helix259-2613
α-helix263-28523
α-helix289-30517
α-helix307-3126
α-helix317-3193
α-helix322-3309
α-helix336-3394
α-helix343-35513
α-helix359-37921
α-helix381-3833
α-helix389-3913
α-helix397-41418
α-helix416-42813
α-helix434-44815
α-helix456-46813
α-helix475-48713
α-helix489-4946
α-helix496-4983
α-helix499-51012
α-helix513-52917
α-helix531-5366
α-helix538-5469
α-helix548-5503
α-helix555-56915
α-helix577-59721
α-helix609-62113
α-helix633-65119
α-helix656-67217
α-helix674-6796
α-helix681-69414
α-helix698-71114
α-helix715-73622
α-helix741-7444
α-helix746-76217
α-helix764-7685
α-helix773-78311
α-helix789-80416
α-helix816-83924
α-helix840-8445
α-helix847-8493
α-helix850-87829
α-helix892-90312
α-helix908-91912
Chain B: 55 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix13-153
α-helix27-3711
α-helix60-7415
α-helix84-9613
α-helix102-11615
α-helix126-1338
α-helix140-15314
α-helix163-18927
α-helix195-21016
α-helix218-2214
α-helix224-23310
α-helix239-25416
α-helix265-27410
α-helix277-2859
α-helix289-31224
α-helix317-3193
α-helix322-3309
α-helix336-3394
α-helix340-3423
α-helix343-35614
α-helix359-37921
α-helix381-3833
α-helix389-3913
α-helix395-41420
α-helix416-42712
α-helix434-44714
α-helix458-46710
α-helix475-48713
α-helix489-4946
α-helix496-4983
α-helix499-51012
α-helix513-52917
α-helix538-5469
α-helix548-5503
α-helix555-56915
α-helix574-59623
α-helix609-62113
α-helix631-6322
α-helix635-65117
α-helix656-67116
α-helix674-6774
α-helix678-69417
α-helix699-71113
α-helix715-73622
α-helix741-7444
α-helix746-76217
α-helix764-7685
α-helix773-78311
α-helix789-80416
α-helix816-83924
α-helix840-8445
α-helix847-8493
α-helix850-87829
α-helix892-90312
α-helix908-91912
Chain C: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix160-1645
Chain D: 2 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix160-1634
α-helix167-1704
Chain E: 1 helix, 0 β-strands
ElementResiduesLengthSheet
α-helix155-1628

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Transportin-3A, Bprotein923Homo sapiensQ9Y5L0 (AlphaFold model)
Cold-inducible RNA-binding proteinC, D, Eprotein35Homo sapiensQ14011 (AlphaFold model)
Sequence of entity 1 (A, B), FASTA
>8CMK_1 Transportin-3 (chains A, B)
MEGAKPTLQLVYQAVQALYHDPDPSGKERASFWLGELQRSVHAWEISDQLLQIRQDVESC
YFAAQTMKMKIQTSFYELPTDSHASLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMP
SWKGCVQTLVEKYSNDVTSLPFLLEILTVLPEEVHSRSLRIGANRRTEIIEDLAFYSSTV
VSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSN
LHEAASDCVCSALYAIENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFT
ELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEV
IHGIFKAYIQRLLHALARHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECF
AQLYSTLKEGNPPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYT
SIELVGEMSEVVDRNPQFLDPVLGYLMKGLAEKPLASAAAKAIHNICSVCRDHMAQHFNG
LLEIARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEP
SNGISSDPTVFLDRLAVIFRHTNPIVENGQTHPCQKVIQEIWPVLSETLNKHRADNRIVE
RCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGMEEGCRQG
LLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTLLRSQVVIPILQWA
IASTTLDHRDANCSVMRFLRDLIHTGVANDHEEDFELRKELIGQVMNQLGQQLVSQLLHT
CCFCLPPYTLPDVAEVLWEIMQVDRPTFCRWLENSLKGLPKETTVGAVTVTHKQLTDFHK
QVTSAEECKQVCWALRDFTRLFR
Sequence of entity 2 (C, D, E), FASTA
>8CMK_2 Cold-inducible RNA-binding protein (chains C, D, E)
SRDYYSSRSQSGGYSDRSSGGSYRDSYDSYATHNE

Ligands and cofactors

IDNameFormulaCopies
TSS2-(1H-indol-3-yl)ethanamineC10 H12 N21

Water and common crystallization additives (PEG) are not listed.

Primary citation

Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3. Zhou, Q., Sagmeister, T., Hutten, S. et al. Nat Commun (2025) 16:4456-4456. DOI 10.1038/s41467-025-59802-2 · PubMed

Other PDB entries of the same protein (UniProt Q9Y5L0 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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