Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R). Determined by electron microscopy at 3.72 Å resolution. Released 7 Jun 2023.
Explore 8EJF in 3D Show helices and sheets RCSB PDB PDBe
8EJF contains 42 α-helices and 63 β-strands across 6 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 277-280 | 4 | 5 |
| β-strand | 285 | 1 | 3 |
| β-strand | 291-294 | 4 | 5 |
| α-helix | 295-298 | 4 | |
| α-helix | 299-302 | 4 | |
| α-helix | 308-326 | 19 | |
| α-helix | 334-344 | 11 | |
| α-helix | 347-358 | 12 | |
| β-strand | 363 | 1 | 6 |
| β-strand | 368-370 | 3 | 2 |
| β-strand | 373-374 | 2 | 1 |
| β-strand | 379-380 | 2 | 1 |
| β-strand | 384-385 | 2 | 2 |
| β-strand | 388-389 | 2 | 6 |
| β-strand | 392-393 | 2 | 6 |
| α-helix | 394-395 | 2 | |
| α-helix | 396-399 | 4 | |
| α-helix | 401-416 | 16 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 67 | 1 | 1 |
| β-strand | 71-72 | 2 | 2 |
| β-strand | 73 | 1 | 3 |
| α-helix | 75-78 | 4 | |
| β-strand | 84-89 | 6 | 4 |
| β-strand | 92-98 | 7 | 4 |
| β-strand | 101-108 | 8 | 4 |
| β-strand | 118 | 1 | 4 |
| α-helix | 120-123 | 4 | |
| α-helix | 133-141 | 9 | |
| β-strand | 154-155 | 2 | 4 |
| β-strand | 164-165 | 2 | 4 |
| α-helix | 183-194 | 12 | |
| α-helix | 199-201 | 3 | |
| β-strand | 219-226 | 8 | 4 |
| β-strand | 237 | 1 | 4 |
| α-helix | 239-245 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Glycoprotein GP1 | A, B, C | protein | 259 | Lassa mammarenavirus | V9VG48 |
| Glycoprotein GP2 | a, b, c | protein | 406 | Lassa mammarenavirus | Q9WXS1 (AlphaFold model), V9VG48 |
>8EJF_1 Glycoprotein GP1 (chains A, B, C) MGQIVTFFQEVPHVIEEVMNIVLIALSILAVLKGLYNIATCGLIGLVTFFLLCGRSCSSN LYKGVYELQSLDLNMETLNMTMPLSCTKNNSHHYIRVGNETGLELTLTNTSLLDHKFCNL SDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKITVQYNLSHSYAGDAARHC GTIANGVLQTFMRMAWGGSYIALDSGCGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIG YLSLLSQRTRDIYISRRRR
>8EJF_2 Glycoprotein GP2 (chains a, b, c) GTFTWTLSDSEGNATPGGYCLTRWMLIEAELKCFGNTAVAKCNEKHDEEFCDMLRLFDFN KQAISRLRSPAQMSIQLINKAVNALINDQLIMKNHLRDIMCIPYCNYSKYWYLNHTVTGR TSLPKCWLVSNGSYLNETHFSDDIEQQADNMITEMLQKEYMDRQGGSGGSGGSGGSGGSE KAAKAEEAARKMEELFKKHKIVAVLRANSVEEAIEKAVAVFAGGVHLIEITFTVPDADTV IKALSVLKEKGAIIGAGTVTSVEQCRKAVESGAEFIVSPHLDEEISQFCKEKGVFYMPGV MTPTELVKAMKLGHDILKLFPGEVVGPEFVKAMKGPFPNVKFVPTGGVDLDNVCEWFDAG VLAVGVGDALVEGDPDEVREKAKEFVEKIRGCTEGSLEWSHPQFEK
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 9 |
Structural conservation of Lassa virus glycoproteins and recognition by neutralizing antibodies. Perrett, H.R., Brouwer, P.J.M., Hurtado, J. et al. Cell Rep (2023) 42:112524-112524. DOI 10.1016/j.celrep.2023.112524 · PubMed
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