8EZB: NHEJ Long-range complex with ATP
NHEJ Long-range complex with ATP. Determined by electron microscopy at 8.9 Å resolution. Released 14 Jun 2023.
- Method
- Electron microscopy
- Resolution
- 8.9 Å
- Organism
- Homo sapiens
- Chains
- 20
- Atoms
- 93,038
- Mol. weight
- 1755.09 kDa
- Ligands
- ATP, MG
- Released
- 14 Jun 2023
Explore 8EZB in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8EZB contains 673 α-helices and 234 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain A: 19 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34 | 1 | |
| β-strand | 35-43 | 9 | 1 |
| α-helix | 46-49 | 4 | |
| α-helix | 59-77 | 19 | |
| β-strand | 82-88 | 7 | 1 |
| β-strand | 94 | 1 | 1 |
| β-strand | 102-109 | 8 | 1 |
| β-strand | 112 | 1 | 2 |
| α-helix | 113-120 | 8 | |
| α-helix | 124-130 | 7 | |
| α-helix | 143-156 | 14 | |
| β-strand | 161-169 | 9 | 1 |
| α-helix | 180-195 | 16 | |
| β-strand | 199-203 | 5 | 1 |
| α-helix | 239-243 | 5 | |
| β-strand | 257-262 | 6 | 3 |
| β-strand | 268-274 | 7 | 3 |
| β-strand | 277 | 1 | 4 |
| α-helix | 282-285 | 4 | |
| β-strand | 286-289 | 4 | 5 |
| β-strand | 295 | 1 | 5 |
| β-strand | 297-298 | 2 | 6 |
| β-strand | 301-304 | 4 | 7 |
| β-strand | 310 | 1 | 7 |
| α-helix | 313-315 | 3 | |
| β-strand | 316 | 1 | 8 |
| β-strand | 318-322 | 5 | 9 |
| β-strand | 325-329 | 5 | 9 |
| α-helix | 333-335 | 3 | |
| β-strand | 344-352 | 9 | 3 |
| β-strand | 366-370 | 5 | 3 |
| α-helix | 378-392 | 15 | |
| β-strand | 394-401 | 8 | 3 |
| α-helix | 407-408 | 2 | |
| β-strand | 409-415 | 7 | 3 |
| β-strand | 432-436 | 5 | 3 |
| α-helix | 440-442 | 3 | |
| β-strand | 443 | 1 | 10 |
| β-strand | 445 | 1 | 11 |
| α-helix | 456-468 | 13 | |
| β-strand | 470 | 1 | 12 |
| α-helix | 475-477 | 3 | |
| α-helix | 481-495 | 15 | |
| α-helix | 511-518 | 8 | |
| α-helix | 522-528 | 7 | |
Chains B and K: 26 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 9-15 | 7 | 13 |
| α-helix | 19-21 | 3 | |
| α-helix | 30-47 | 18 | |
| β-strand | 53-59 | 7 | 13 |
| β-strand | 65 | 1 | 13 |
| β-strand | 77-84 | 8 | 13 |
| α-helix | 88-92 | 5 | |
| α-helix | 93-97 | 5 | |
| α-helix | 107-124 | 18 | |
| β-strand | 130-135 | 6 | 13 |
| α-helix | 147-156 | 10 | |
| β-strand | 160-165 | 6 | 13 |
| α-helix | 199-216 | 18 | |
| α-helix | 217-223 | 7 | |
| β-strand | 224-226 | 3 | 13 |
| α-helix | 227-231 | 5 | |
| β-strand | 243 | 1 | 11 |
| α-helix | 244-246 | 3 | |
| β-strand | 247-251 | 5 | 12 |
| β-strand | 259-268 | 10 | 12 |
| β-strand | 277 | 1 | 9 |
| β-strand | 280 | 1 | 8 |
| β-strand | 289-292 | 4 | 7 |
| β-strand | 295-296 | 2 | 6 |
| β-strand | 297 | 1 | 14 |
| β-strand | 302 | 1 | 14 |
| α-helix | 306-309 | 4 | |
| β-strand | 310-316 | 7 | 5 |
| β-strand | 317 | 1 | 2 |
| β-strand | 319-322 | 4 | 5 |
| α-helix | 325-331 | 7 | |
| β-strand | 340-347 | 8 | 12 |
| α-helix | 348-350 | 3 | |
| β-strand | 360-366 | 7 | 12 |
| α-helix | 367 | 1 | |
| α-helix | 371-382 | 12 | |
| β-strand | 389-395 | 7 | 12 |
| α-helix | 402-403 | 2 | |
| β-strand | 404-413 | 10 | 12 |
| β-strand | 416-423 | 8 | 12 |
| β-strand | 430 | 1 | 4 |
| α-helix | 435-437 | 3 | |
| α-helix | 441-443 | 3 | |
| α-helix | 448-460 | 13 | |
| β-strand | 462 | 1 | 3 |
| α-helix | 479-481 | 3 | |
| α-helix | 483-484 | 2 | |
| α-helix | 485-499 | 15 | |
| α-helix | 504-509 | 6 | |
| α-helix | 510-516 | 7 | |
| α-helix | 520-536 | 17 | |
| α-helix | 548-551 | 4 | |
Chains C and L: 251 helices, 25 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 8-20 | 13 | |
| α-helix | 24-44 | 21 | |
| α-helix | 48-57 | 10 | |
| α-helix | 65-72 | 8 | |
| α-helix | 79-96 | 18 | |
| α-helix | 105-117 | 13 | |
| α-helix | 121-137 | 17 | |
| α-helix | 149-158 | 10 | |
| α-helix | 159-165 | 7 | |
| α-helix | 168-184 | 17 | |
| α-helix | 186-189 | 4 | |
| α-helix | 193-209 | 17 | |
| α-helix | 217-230 | 14 | |
| α-helix | 242-256 | 15 | |
| α-helix | 266-278 | 13 | |
| α-helix | 279-281 | 3 | |
| α-helix | 283-288 | 6 | |
| α-helix | 290-301 | 12 | |
| α-helix | 306-328 | 23 | |
| α-helix | 332-334 | 3 | |
| α-helix | 335-349 | 15 | |
| α-helix | 356-368 | 13 | |
| α-helix | 370-373 | 4 | |
| α-helix | 378-380 | 3 | |
| α-helix | 381-396 | 16 | |
| α-helix | 409-414 | 6 | |
| α-helix | 435-444 | 10 | |
| α-helix | 453-469 | 17 | |
| α-helix | 476-492 | 17 | |
| α-helix | 528-534 | 7 | |
| α-helix | 539-541 | 3 | |
| α-helix | 559-574 | 16 | |
| α-helix | 575-578 | 4 | |
| α-helix | 618-621 | 4 | |
| α-helix | 623-633 | 11 | |
| α-helix | 638-640 | 3 | |
| α-helix | 643-657 | 15 | |
| α-helix | 664-679 | 16 | |
| α-helix | 699-710 | 12 | |
| α-helix | 714-717 | 4 | |
| α-helix | 718-720 | 3 | |
| α-helix | 723-734 | 12 | |
| α-helix | 738-741 | 4 | |
| α-helix | 745-747 | 3 | |
| α-helix | 748-759 | 12 | |
| α-helix | 763-779 | 17 | |
| α-helix | 782-785 | 4 | |
| α-helix | 788-791 | 4 | |
| α-helix | 793-796 | 4 | |
| α-helix | 798-800 | 3 | |
| α-helix | 848-862 | 15 | |
| α-helix | 864-867 | 4 | |
| α-helix | 873-875 | 3 | |
| α-helix | 877-880 | 4 | |
| α-helix | 881-883 | 3 | |
| β-strand | 884 | 1 | 15 |
| β-strand | 893-895 | 3 | 16 |
| β-strand | 904-906 | 3 | 16 |
| α-helix | 907-910 | 4 | |
| α-helix | 911-920 | 10 | |
| α-helix | 924-945 | 22 | |
| α-helix | 954-957 | 4 | |
| α-helix | 959-974 | 16 | |
| α-helix | 978-995 | 18 | |
| α-helix | 1004-1017 | 14 | |
| α-helix | 1023-1041 | 19 | |
| α-helix | 1046-1051 | 6 | |
| α-helix | 1054-1068 | 15 | |
| α-helix | 1072-1086 | 15 | |
| α-helix | 1093-1114 | 22 | |
| α-helix | 1119-1121 | 3 | |
| α-helix | 1123-1145 | 23 | |
| β-strand | 1149 | 1 | 17 |
| α-helix | 1158-1159 | 2 | |
| β-strand | 1163 | 1 | 17 |
| α-helix | 1165-1174 | 10 | |
| α-helix | 1181-1194 | 14 | |
| α-helix | 1195-1197 | 3 | |
| α-helix | 1204-1215 | 12 | |
| α-helix | 1217-1224 | 8 | |
| α-helix | 1238-1241 | 4 | |
| α-helix | 1253-1270 | 18 | |
| α-helix | 1278-1281 | 4 | |
| α-helix | 1288 | 1 | |
| α-helix | 1289-1293 | 5 | |
| α-helix | 1294-1296 | 3 | |
| α-helix | 1297-1301 | 5 | |
| α-helix | 1306-1308 | 3 | |
| α-helix | 1309-1312 | 4 | |
| α-helix | 1324-1349 | 26 | |
| α-helix | 1356-1359 | 4 | |
| α-helix | 1367-1377 | 11 | |
| α-helix | 1379-1381 | 3 | |
| α-helix | 1384-1386 | 3 | |
| α-helix | 1389-1392 | 4 | |
| α-helix | 1394-1407 | 14 | |
| α-helix | 1413-1418 | 6 | |
| α-helix | 1428-1431 | 4 | |
| α-helix | 1433-1435 | 3 | |
| α-helix | 1441-1444 | 4 | |
| α-helix | 1446-1460 | 15 | |
| α-helix | 1464-1467 | 4 | |
| α-helix | 1477-1482 | 6 | |
| α-helix | 1483-1488 | 6 | |
| α-helix | 1505-1518 | 14 | |
| α-helix | 1525-1531 | 7 | |
| β-strand | 1537-1539 | 3 | 18 |
| β-strand | 1552-1554 | 3 | 18 |
| α-helix | 1555-1562 | 8 | |
| α-helix | 1564-1570 | 7 | |
| α-helix | 1571-1573 | 3 | |
| α-helix | 1579-1580 | 2 | |
| α-helix | 1581-1585 | 5 | |
| α-helix | 1595-1606 | 12 | |
| α-helix | 1614-1626 | 13 | |
| α-helix | 1631-1633 | 3 | |
| α-helix | 1639-1655 | 17 | |
| α-helix | 1658-1660 | 3 | |
| α-helix | 1668-1679 | 12 | |
| α-helix | 1686-1694 | 9 | |
| α-helix | 1697-1701 | 5 | |
| α-helix | 1705-1707 | 3 | |
| α-helix | 1708-1721 | 14 | |
| α-helix | 1726-1728 | 3 | |
| α-helix | 1729-1730 | 2 | |
| α-helix | 1734-1753 | 20 | |
| α-helix | 1756-1766 | 11 | |
| α-helix | 1776-1788 | 13 | |
| α-helix | 1792-1806 | 15 | |
| α-helix | 1813-1819 | 7 | |
| α-helix | 1820-1825 | 6 | |
| α-helix | 1826-1828 | 3 | |
| α-helix | 1835-1851 | 17 | |
| α-helix | 1863-1883 | 21 | |
| α-helix | 1887-1889 | 3 | |
| α-helix | 1894-1899 | 6 | |
| α-helix | 1909-1924 | 16 | |
| α-helix | 1934-1955 | 22 | |
| α-helix | 1959-1961 | 3 | |
| α-helix | 1962-1965 | 4 | |
| α-helix | 1977-1981 | 5 | |
| α-helix | 1991-1993 | 3 | |
| α-helix | 2094-2103 | 10 | |
| α-helix | 2122-2128 | 7 | |
| α-helix | 2143-2151 | 9 | |
| α-helix | 2158-2160 | 3 | |
| α-helix | 2162-2172 | 11 | |
| α-helix | 2185-2189 | 5 | |
| α-helix | 2191-2194 | 4 | |
| α-helix | 2210-2218 | 9 | |
| α-helix | 2229-2244 | 16 | |
| α-helix | 2250-2252 | 3 | |
| α-helix | 2253-2261 | 9 | |
| α-helix | 2271-2282 | 12 | |
| α-helix | 2296-2305 | 10 | |
| α-helix | 2306-2308 | 3 | |
| α-helix | 2316-2332 | 17 | |
| α-helix | 2338-2352 | 15 | |
| α-helix | 2357-2369 | 13 | |
| α-helix | 2373-2377 | 5 | |
| α-helix | 2380-2383 | 4 | |
| α-helix | 2391-2403 | 13 | |
| α-helix | 2412-2415 | 4 | |
| α-helix | 2429-2442 | 14 | |
| α-helix | 2443-2445 | 3 | |
| α-helix | 2448-2459 | 12 | |
| α-helix | 2460-2463 | 4 | |
| α-helix | 2467-2484 | 18 | |
| α-helix | 2494-2505 | 12 | |
| α-helix | 2507-2510 | 4 | |
| α-helix | 2515-2525 | 11 | |
| α-helix | 2535-2542 | 8 | |
| α-helix | 2554-2558 | 5 | |
| α-helix | 2562-2565 | 4 | |
| α-helix | 2566-2568 | 3 | |
| β-strand | 2575 | 1 | 19 |
| α-helix | 2594-2602 | 9 | |
| α-helix | 2604-2606 | 3 | |
| β-strand | 2635-2636 | 2 | 20 |
| β-strand | 2772-2773 | 2 | 20 |
| β-strand | 2786 | 1 | 19 |
| α-helix | 2787-2791 | 5 | |
| α-helix | 2792-2794 | 3 | |
| α-helix | 2795-2798 | 4 | |
| α-helix | 2802-2817 | 16 | |
| α-helix | 2820-2822 | 3 | |
| α-helix | 2826-2846 | 21 | |
| α-helix | 2852-2862 | 11 | |
| α-helix | 2866-2870 | 5 | |
| α-helix | 2873-2883 | 11 | |
| α-helix | 2886-2899 | 14 | |
| α-helix | 2917-2933 | 17 | |
| α-helix | 2936-2942 | 7 | |
| α-helix | 2943-2947 | 5 | |
| α-helix | 2951-2961 | 11 | |
| α-helix | 2965-2977 | 13 | |
| α-helix | 2988-3004 | 17 | |
| α-helix | 3008-3017 | 10 | |
| α-helix | 3028-3032 | 5 | |
| α-helix | 3034-3039 | 6 | |
| α-helix | 3041-3053 | 13 | |
| α-helix | 3060-3069 | 10 | |
| α-helix | 3073-3081 | 9 | |
| α-helix | 3083-3092 | 10 | |
| α-helix | 3096-3116 | 21 | |
| α-helix | 3122-3129 | 8 | |
| α-helix | 3132-3146 | 15 | |
| α-helix | 3148-3150 | 3 | |
| α-helix | 3154-3166 | 13 | |
| α-helix | 3176-3197 | 22 | |
| α-helix | 3227-3248 | 22 | |
| α-helix | 3252-3262 | 11 | |
| α-helix | 3271-3287 | 17 | |
| α-helix | 3293-3307 | 15 | |
| α-helix | 3313-3316 | 4 | |
| α-helix | 3320-3343 | 24 | |
| α-helix | 3345-3350 | 6 | |
| α-helix | 3353-3363 | 11 | |
| α-helix | 3370-3393 | 24 | |
| α-helix | 3406-3429 | 24 | |
| α-helix | 3438-3440 | 3 | |
| α-helix | 3441-3455 | 15 | |
| α-helix | 3459-3464 | 6 | |
| α-helix | 3466-3474 | 9 | |
| α-helix | 3479-3487 | 9 | |
| α-helix | 3492-3494 | 3 | |
| α-helix | 3496-3498 | 3 | |
| α-helix | 3499-3503 | 5 | |
| α-helix | 3511-3522 | 12 | |
| α-helix | 3526-3537 | 12 | |
| α-helix | 3546-3560 | 15 | |
| α-helix | 3570-3576 | 7 | |
| α-helix | 3581-3595 | 15 | |
| α-helix | 3603-3617 | 15 | |
| α-helix | 3627-3640 | 14 | |
| α-helix | 3646-3648 | 3 | |
| α-helix | 3656-3670 | 15 | |
| α-helix | 3675-3677 | 3 | |
| β-strand | 3679 | 1 | 21 |
| α-helix | 3680-3683 | 4 | |
| α-helix | 3698-3699 | 2 | |
| β-strand | 3700 | 1 | 22 |
| α-helix | 3701 | 1 | |
| β-strand | 3718 | 1 | 22 |
| β-strand | 3719-3722 | 4 | 23 |
| β-strand | 3725 | 1 | 21 |
| β-strand | 3727-3728 | 2 | 23 |
| β-strand | 3736-3742 | 7 | 23 |
| β-strand | 3747-3754 | 8 | 23 |
| α-helix | 3759-3777 | 19 | |
| α-helix | 3779-3782 | 4 | |
| β-strand | 3793-3797 | 5 | 23 |
| β-strand | 3800-3804 | 5 | 23 |
| β-strand | 3809-3811 | 3 | 24 |
| α-helix | 3812-3817 | 6 | |
| α-helix | 3822-3830 | 9 | |
| α-helix | 3835-3845 | 11 | |
| α-helix | 3853-3861 | 9 | |
| α-helix | 3864-3876 | 13 | |
| α-helix | 3882-3888 | 7 | |
| β-strand | 3891 | 1 | 15 |
| α-helix | 3894-3918 | 25 | |
| α-helix | 3925-3927 | 3 | |
| β-strand | 3928-3931 | 4 | 24 |
| β-strand | 3937-3939 | 3 | 24 |
| α-helix | 3948-3952 | 5 | |
| α-helix | 3965-3970 | 6 | |
| α-helix | 3979-3992 | 14 | |
| α-helix | 3995-4006 | 12 | |
| α-helix | 4013-4020 | 8 | |
| α-helix | 4040-4052 | 13 | |
| α-helix | 4056-4067 | 12 | |
| α-helix | 4074-4082 | 9 | |
| α-helix | 4100-4111 | 12 | |
| α-helix | 4114-4117 | 4 | |
| α-helix | 4122-4124 | 3 | |
Chain F: 5 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-8 | 7 | 25 |
| β-strand | 10 | 1 | 26 |
| β-strand | 18-24 | 7 | 25 |
| α-helix | 28-30 | 3 | |
| β-strand | 31-37 | 7 | 25 |
| β-strand | 42-48 | 7 | 25 |
| α-helix | 49-57 | 9 | |
| α-helix | 61-62 | 2 | |
| α-helix | 65-74 | 10 | |
| β-strand | 84-88 | 5 | 26 |
| β-strand | 94-101 | 8 | 26 |
| β-strand | 104-112 | 9 | 26 |
| β-strand | 114-115 | 2 | 25 |
| α-helix | 119-199 | 81 | |
Chains G and P: 5 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 2-10 | 9 | 27 |
| β-strand | 13-24 | 12 | 27 |
| α-helix | 28-30 | 3 | |
| β-strand | 31-37 | 7 | 27 |
| β-strand | 43-48 | 6 | 27 |
| α-helix | 49-52 | 4 | |
| α-helix | 55-58 | 4 | |
| α-helix | 63-73 | 11 | |
| β-strand | 84-87 | 4 | 28 |
| β-strand | 94-100 | 7 | 28 |
| β-strand | 105-112 | 8 | 28 |
| β-strand | 114-115 | 2 | 27 |
| α-helix | 119-200 | 82 | |
Chain H: 16 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-10 | 9 | |
| α-helix | 11-13 | 3 | |
| β-strand | 14-18 | 5 | 29 |
| β-strand | 21-29 | 9 | 29 |
| β-strand | 33-39 | 7 | 29 |
| β-strand | 44-50 | 7 | 29 |
| α-helix | 51-61 | 11 | |
| α-helix | 69-83 | 15 | |
| β-strand | 94-100 | 7 | 30 |
| β-strand | 103-111 | 9 | 30 |
| β-strand | 116-123 | 8 | 30 |
| β-strand | 124-125 | 2 | 29 |
| α-helix | 126-127 | 2 | |
| α-helix | 128-131 | 4 | |
| α-helix | 132-136 | 5 | |
| α-helix | 137-165 | 29 | |
| α-helix | 166-170 | 5 | |
| α-helix | 180-184 | 5 | |
| α-helix | 186-192 | 7 | |
| α-helix | 193-197 | 5 | |
| α-helix | 198-201 | 4 | |
| α-helix | 208-213 | 6 | |
| α-helix | 215-223 | 9 | |
| α-helix | 297-299 | 3 | |
Chain I: 14 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 2-10 | 9 | |
| α-helix | 12-13 | 2 | |
| β-strand | 14-17 | 4 | 31 |
| β-strand | 22-30 | 9 | 31 |
| β-strand | 33-39 | 7 | 31 |
| β-strand | 44-50 | 7 | 31 |
| α-helix | 51-61 | 11 | |
| α-helix | 69-78 | 10 | |
| β-strand | 94-100 | 7 | 32 |
| β-strand | 103-112 | 10 | 32 |
| β-strand | 115-123 | 9 | 32 |
| β-strand | 124-125 | 2 | 31 |
| α-helix | 126-127 | 2 | |
| α-helix | 128-131 | 4 | |
| α-helix | 132-136 | 5 | |
| α-helix | 137-169 | 33 | |
| α-helix | 182-184 | 3 | |
| α-helix | 186-196 | 11 | |
| α-helix | 198-202 | 5 | |
| α-helix | 208-213 | 6 | |
| α-helix | 215-223 | 9 | |
| α-helix | 297-299 | 3 | |
Chain J: 19 helices, 26 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 34 | 1 | |
| β-strand | 35-43 | 9 | 33 |
| α-helix | 46-49 | 4 | |
| α-helix | 59-77 | 19 | |
| β-strand | 82-88 | 7 | 33 |
| β-strand | 94 | 1 | 33 |
| β-strand | 102-109 | 8 | 33 |
| β-strand | 112 | 1 | 34 |
| α-helix | 113-120 | 8 | |
| α-helix | 124-130 | 7 | |
| α-helix | 143-156 | 14 | |
| β-strand | 161-169 | 9 | 33 |
| α-helix | 180-195 | 16 | |
| β-strand | 199-203 | 5 | 33 |
| α-helix | 239-243 | 5 | |
| β-strand | 257-262 | 6 | 35 |
| β-strand | 268-274 | 7 | 35 |
| β-strand | 277 | 1 | 36 |
| α-helix | 282-285 | 4 | |
| β-strand | 286-289 | 4 | 37 |
| β-strand | 295 | 1 | 37 |
| β-strand | 297-298 | 2 | 38 |
| β-strand | 301-304 | 4 | 39 |
| β-strand | 310 | 1 | 39 |
| α-helix | 313-315 | 3 | |
| β-strand | 316 | 1 | 40 |
| β-strand | 318-322 | 5 | 41 |
| β-strand | 325-329 | 5 | 41 |
| α-helix | 333-335 | 3 | |
| β-strand | 344-352 | 9 | 35 |
| β-strand | 366-370 | 5 | 35 |
| α-helix | 378-392 | 15 | |
| β-strand | 394-401 | 8 | 35 |
| α-helix | 407-408 | 2 | |
| β-strand | 409-415 | 7 | 35 |
| β-strand | 432-436 | 5 | 35 |
| α-helix | 440-442 | 3 | |
| β-strand | 443 | 1 | 42 |
| β-strand | 445 | 1 | 43 |
| α-helix | 456-468 | 13 | |
| β-strand | 470 | 1 | 44 |
| α-helix | 475-477 | 3 | |
| α-helix | 481-494 | 14 | |
| α-helix | 511-518 | 8 | |
| α-helix | 522-528 | 7 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| X-ray repair cross-complementing protein 6 | A, J | protein | 609 | Homo sapiens | P12956 (AlphaFold model) |
| X-ray repair cross-complementing protein 5 | B, K | protein | 732 | Homo sapiens | P13010 (AlphaFold model) |
| DNA-dependent protein kinase catalytic subunit | C, L | protein | 4128 | Homo sapiens | P78527 |
| DNA (31-mer) | D, M | DNA | 31 | Homo sapiens | |
| DNA (30-mer) | E, N | DNA | 30 | Homo sapiens | |
| DNA repair protein XRCC4 | F, G, O, P | protein | 336 | Homo sapiens | Q13426 (AlphaFold model) |
| Non-homologous end-joining factor 1 | H, I | protein | 299 | Homo sapiens | Q9H9Q4 |
| Protein PAXX | S, T | protein | 204 | Homo sapiens | Q9BUH6 |
| DNA ligase 4 | X, Y | protein | 911 | Homo sapiens | P49917 |
Sequence of entity 1 (A, J), FASTA
>8EZB_1 X-ray repair cross-complementing protein 6 (chains A, J)
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
EALTKHFQD
Sequence of entity 2 (B, K), FASTA
>8EZB_2 X-ray repair cross-complementing protein 5 (chains B, K)
MVRSGNKAAVVLCMDVGFTMSNSIPGIESPFEQAKKVITMFVQRQVFAENKDEIALVLFG
TDGTDNPLSGGDQYQNITVHRHLMLPDFDLLEDIESKIQPGSQQADFLDALIVSMDVIQH
ETIGKKFEKRHIEIFTDLSSRFSKSQLDIIIHSLKKCDISLQFFLPFSLGKEDGSGDRGD
GPFRLGGHGPSFPLKGITEQQKEGLEIVKMVMISLEGEDGLDEIYSFSESLRKLCVFKKI
ERHSIHWPCRLTIGSNLSIRIAAYKSILQERVKKTWTVVDAKTLKKEDIQKETVYCLNDD
DETEVLKEDIIQGFRYGSDIVPFSKVDEEQMKYKSEGKCFSVLGFCKSSQVQRRFFMGNQ
VLKVFAARDDEAAAVALSSLIHALDDLDMVAIVRYAYDKRANPQVGVAFPHIKHNYECLV
YVQLPFMEDLRQYMFSSLKNSKKYAPTEAQLNAVDALIDSMSLAKKDEKTDTLEDLFPTT
KIPNPRFQRLFQCLLHRALHPREPLPPIQQHIWNMLNPPAEVTTKSQIPLSKIKTLFPLI
EAKKKDQVTAQEIFQDNHEDGPTAKKLKTEQGGAHFSVSSLAEGSVTSVGSVNPAENFRV
LVKQKKASFEEASNQLINHIEQFLDTNETPYFMKSIDCIRAFREEAIKFSEEQRFNNFLK
ALQEKVEIKQLNHFWEIVVQDGITLITKEEASGSSVTAEEAKKFLAPKDKPSGDTAAVFE
EGGDVDDLLDMI
Sequence of entity 3 (C, L), FASTA
>8EZB_3 DNA-dependent protein kinase catalytic subunit (chains C, L)
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFS
RDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRA
AKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGL
LGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEE
DPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKW
CAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELS
IAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASV
LLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCIS
TVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQM
MDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGV
WMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRL
PLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQ
YKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYI
DRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNL
SSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLL
LAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGN
RTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPA
SIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPD
AQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCL
PSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFY
SLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLAT
TILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLA
DTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYV
DCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLES
VYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE
STFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCY
DAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFEN
LIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEM
SQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTAL
VKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPY
AKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLM
KHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIV
MANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEES
LCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEV
VLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVE
FVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLI
IRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHP
LSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQ
QHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDF
GKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSE
LKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEM
DKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGC
LASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLR
GIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLD
CYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQS
LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVL
LHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWD
DIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM
KMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTV
LKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRIL
ELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFC
DQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESY
SFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTP
VNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFN
DITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIA
GFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSA
CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK
DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL
RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMP
FRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKM
LKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAV
ARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
Sequence of entity 4 (D, M), FASTA
>8EZB_4 DNA (31-MER) (chains D, M)
TCTAAGAACTCTGATGTCAGTAGATTACACT
Sequence of entity 5 (E, N), FASTA
>8EZB_5 DNA (30-MER) (chains E, N)
GTGTAATCTACTGACATCAGAGTTCTTAGA
Sequence of entity 6 (F, G, O, P), FASTA
>8EZB_6 DNA repair protein XRCC4 (chains F, G, O, P)
MERKISRIHLVSEPSITHFLQVSWEKTLESGFVITLTDGHSAWTGTVSESEISQEADDMA
MEKGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVSFRLGSFNLEKVENPA
EVIRELICYCLDTIAENQAKNEHLQKENERLLRDWNDVQGRFEKCVSAKEALETDLYKRF
ILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQ
TDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEKENSR
PDSSLPETSKKEHISAENMSLETLRNSSPEDLFDEI
Sequence of entity 7 (H, I), FASTA
>8EZB_7 Non-homologous end-joining factor 1 (chains H, I)
MEELEQGLLMQPWAWLQLAENSLLAKVFITKQGYALLVSDLQQVWHEQVDTSVVSQRAKE
LNKRLTAPPAAFLCHLDNLLRPLLKDAAHPSEATFSCDCVADALILRVRSELSGLPFYWN
FHCMLASPSLVSQHLIRPLMGMSLALQCQVRELATLLHMKDLEIQDYQESGATLIRDRLK
TEPFEENSFLEQFMIEKLPEACSIGDGKPFVMNLQDLYMAVTTQEVQVGQKHQGAGDPHT
SNSASLQGIDSQCVNQPEQLVSSAPTLSAPEKESTGTSGPLQRPQLSKVKRKKPRGLFS
Sequence of entity 8 (S, T), FASTA
>8EZB_8 Protein PAXX (chains S, T)
MDPLSPPLCTLPPGPEPPRFVCYCEGEESGEGDRGGFNLYVTDAAELWSTCFTPDSLAAL
KARFGLSAAEDITPRFRAACEQQAVALTLQEDRASLTLSGGPSALAFDLSKVPGPEAAPR
LRALTLGLAKRVWSLERRLAAAEETAVSPRKSPRPAGPQLFLPDPDPQRGGPGPGVRRRC
PGESLINPGFKSKKPAGGVDFDET
Sequence of entity 9 (X, Y), FASTA
>8EZB_9 DNA ligase 4 (chains X, Y)
MAASQTSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNHKDV
TDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKLLNYRTPTGTHG
DAGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLIKKSLLQLITQSSA
LEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNVTTDLEKVCRQLHDPSVGLSDISI
TLFSAFKPMLAAIADIEHIEKDMKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTD
QFGASPTEGSLTPFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDL
QTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDALNE
AIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRGGMM
SHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSSILC
GTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLE
QLRGKASGKLASKHLYIGGDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLTNVNKISNIFE
DVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNIILSNKHDV
VKPAWLLECFKTKSFVPWQPRFMIHMCPSTKEHFAREYDCYGDSYFIDTDLNQLKEVFSG
IKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVINDLSTKNEGTRLAI
KALELRFHGAKVVSCLAEGVSHVIIGEDHSRVADFKAFRRTFKRKFKILKESWVTDSIDK
CELQEENQYLI
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 2 |
| MG | Magnesium ion | Mg | 2 |
Primary citation
Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Chen, S., Vogt, A., Lee, L. et al. Sci Adv (2023) 9:eadg2838-eadg2838. DOI 10.1126/sciadv.adg2838 · PubMed
Other PDB entries of the same protein (UniProt P12956 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 8AG4 2.46 Å, Vaccinia C16 protein bound to Ku70/Ku80
- 1JEY 2.5 Å, Crystal Structure of the Ku heterodimer bound to DNA
- 3RZX 2.61 Å, Mouse importin alpha-Ku70 NLS peptide complex
- 7ZYG 2.68 Å, CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
- 1JEQ 2.7 Å, Crystal Structure of the Ku Heterodimer
- 7ZVT 2.74 Å, CryoEM structure of Ku heterodimer bound to DNA
- 6ERH 2.8 Å, Complex of XLF and heterodimer Ku bound to DNA
- 7ZWA 2.8 Å, CryoEM structure of Ku heterodimer bound to DNA and PAXX
- 9CQ3 2.8 Å, The gap-filling complex with Pol mu engaged in the NHEJ pathway
- 9GYF 2.8 Å, Ku70/80 with PAXX peptide mutation K193R
- 9N81 2.8 Å, A gap-filling complex with Pol mu engaged in the NHEJ Pathway
- 6ERG 2.9 Å, Complex of XLF and heterodimer Ku bound to DNA
Browse structure collections
About this viewer
MolViewer shows 8EZB directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.