Crystal Structure of Human CD1b in Complex with Phosphatidylethanolamine C34:1. Determined by X-ray diffraction at 1.6 Å resolution. Released 20 Sept 2023.
Explore 8GLG in 3D Show helices and sheets RCSB PDB PDBe
8GLG contains 14 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 9-20 | 12 | 1 |
| β-strand | 23-32 | 10 | 1 |
| β-strand | 35-41 | 7 | 1 |
| β-strand | 46-49 | 4 | 1 |
| α-helix | 60-84 | 25 | |
| β-strand | 94-104 | 11 | 1 |
| α-helix | 105 | 1 | |
| β-strand | 110-118 | 9 | 1 |
| β-strand | 121-127 | 7 | 1 |
| β-strand | 130-133 | 4 | 1 |
| α-helix | 135-137 | 3 | |
| α-helix | 138-148 | 11 | |
| α-helix | 152-160 | 9 | |
| α-helix | 161-165 | 5 | |
| α-helix | 166-176 | 11 | |
| α-helix | 178-181 | 4 | |
| β-strand | 185 | 1 | 2 |
| β-strand | 188-193 | 6 | 3 |
| β-strand | 201-211 | 11 | 3 |
| β-strand | 212 | 1 | 2 |
| β-strand | 217-222 | 6 | 4 |
| β-strand | 225-226 | 2 | 4 |
| β-strand | 231-232 | 2 | 3 |
| α-helix | 233-235 | 3 | |
| β-strand | 236-238 | 3 | 3 |
| β-strand | 242-252 | 11 | 3 |
| α-helix | 253-255 | 3 | |
| β-strand | 259-264 | 6 | 4 |
| α-helix | 266-268 | 3 | |
| β-strand | 273-276 | 4 | 4 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5 | 1 | 5 |
| α-helix | 6-7 | 2 | |
| β-strand | 8-13 | 6 | 6 |
| β-strand | 23-32 | 10 | 6 |
| β-strand | 33 | 1 | 5 |
| β-strand | 38-43 | 6 | 7 |
| β-strand | 46-47 | 2 | 7 |
| α-helix | 48 | 1 | |
| β-strand | 52-53 | 2 | 6 |
| α-helix | 54-56 | 3 | |
| β-strand | 57-58 | 2 | 6 |
| β-strand | 64-72 | 9 | 6 |
| β-strand | 80-85 | 6 | 7 |
| β-strand | 93-96 | 4 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| T-cell surface glycoprotein CD1b | A | protein | 300 | Homo sapiens | P29016 (AlphaFold model) |
| Beta-2-microglobulin | B | protein | 101 | Homo sapiens | P61769 (AlphaFold model) |
>8GLG_1 T-cell surface glycoprotein CD1b (chains A) HAFQGPTSFHVIQTSSFTNSTWAQTQGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDK EVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGL DFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADL QRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQLGDILPNANW TWYLRATLDVADGEAAGLSCRVKHSSLEGQDIILYWRGSGLNDIFEAQKIEWHEHHHHHH
>8GLG_2 Beta-2-microglobulin (chains B) PKIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSK DWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
| ID | Name | Formula | Copies |
|---|---|---|---|
| CUY | tetracosyl octadecanoate | C42 H84 O2 | 1 |
| NI | Nickel (II) ion | Ni | 1 |
| L9Q | (1S)-2-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl… | C41 H80 N O8 P | 1 |
Water and common crystallization additives (IOD, CL, EDO) are not listed.
CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms. Huang, S., Shahine, A., Cheng, T.Y. et al. Cell (2023) 186:4583-4596.e13. DOI 10.1016/j.cell.2023.08.022 · PubMed
Other PDB entries of the same protein (UniProt P29016 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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