8I79: KCTD7

Cryo-EM structure of KCTD7 in complex with Cullin3. Determined by electron microscopy at 2.8 Å resolution. Released 26 Jul 2023.

Method
Electron microscopy
Resolution
2.8 Å
Organisms
Mus musculus, Homo sapiens
Chains
10
Atoms
16,293
Mol. weight
391.47 kDa
Released
26 Jul 2023

Explore 8I79 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8I79 contains 133 α-helices and 40 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 8 β-strands

ElementResiduesLengthSheet
α-helix47-504
β-strand52-5763
β-strand60-6563
α-helix66-694
α-helix76-805
β-strand8913
α-helix941
β-strand95-9733
α-helix104-1129
α-helix119-1213
α-helix122-13211
α-helix135-1428
α-helix145-15713
α-helix163-18119
β-strand185-19284
β-strand230-23234
α-helix241-25414
β-strand258-26364
β-strand281-28774
Chain B: 17 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix101-12222
α-helix124-1252
α-helix126-1305
α-helix131-1333
α-helix139-15113
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22721
α-helix230-25122
α-helix257-26913
Chain C: 18 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix101-12222
α-helix124-1252
α-helix126-1305
α-helix131-1333
α-helix139-1479
α-helix148-1525
α-helix155-17420
α-helix180-19213
α-helix199-2013
α-helix202-2065
α-helix207-22721
α-helix230-25122
α-helix257-26610
Chain D: 9 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand52-5765
β-strand60-6565
α-helix66-694
α-helix76-805
β-strand8915
α-helix941
β-strand95-9735
α-helix104-1129
α-helix122-13211
α-helix135-1428
α-helix145-15713
α-helix163-18119
β-strand185-19286
β-strand230-23236
α-helix241-25414
β-strand258-26366
β-strand281-28776
Chain E: 18 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix101-12222
α-helix124-1252
α-helix126-1305
α-helix131-1333
α-helix136-1383
α-helix139-15113
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22721
α-helix230-25122
α-helix257-26610
Chains F and G: 8 helices, 8 β-strands
ElementResiduesLengthSheet
β-strand52-5761
β-strand60-6561
α-helix66-694
α-helix76-805
β-strand8911
β-strand95-9731
α-helix104-1129
α-helix122-13211
α-helix135-1428
α-helix145-15713
α-helix163-18119
β-strand185-19282
β-strand230-23232
α-helix241-25414
β-strand258-26362
β-strand281-28772
Chain H: 17 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-945
α-helix101-12222
α-helix124-1252
α-helix126-1305
α-helix131-1333
α-helix139-15113
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22317
α-helix230-25122
α-helix257-26913
Chain I: 9 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix47-504
β-strand52-5769
β-strand60-6569
α-helix66-694
α-helix76-805
β-strand8919
β-strand95-9739
α-helix104-1129
α-helix122-13211
α-helix135-1428
α-helix145-15713
α-helix163-18119
β-strand185-192810
β-strand230-232310
α-helix241-25414
β-strand258-263610
β-strand281-287710

1 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
BTB/POZ domain-containing protein KCTD7A, D, F, G, Iprotein297Mus musculusQ8BJK1 (AlphaFold model)
Cullin-3B, C, E, H, Jprotein376Homo sapiensQ13618 (AlphaFold model)
Sequence of entity 1 (A, D, F, G, I), FASTA
>8I79_1 BTB/POZ domain-containing protein KCTD7 (chains A, D, F, G, I)
DYKDDDDKMVVVTGREPDSRHSDGAMSSSEAEDDFLEPATPTATQAGHGLPLLPQEFPEV
VPLNIGGAHFTTRLSTLRRYEDTMLAAMFSGRHYIPTDSEGRYFIDRDGTHFGDVLNFLR
SGDLPPREHVRAVYKEAQYYAIGPLLEQLENMQPLKGEKVRQAFLGLMPYYKDHLERIVE
IARLRAVQRKARFAKLKVCVFKEEMPITPYECPLLNSLRFERSESDGQLFEHHCEVDVSF
GPWEAVADVYDLLHCLVTDLSAQGLTVDHQCIGVCDKHLVNHYYCKRPIYEFKITWW
Sequence of entity 2 (B, C, E, H, J), FASTA
>8I79_2 Cullin-3 (chains B, C, E, H, J)
MHHHHHHGSPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEK
LYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ
QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI
LGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCL
DKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKT
MCECMSSYLREQGKALVSEEGEGKNPVDYRQGLDDLKSRFDRFLLESFNNDRLFKQTIAG
DFEYFLNLNSRSPEYL

Primary citation

Structural basis for the ubiquitination of G protein beta gamma subunits by KCTD5/Cullin3 E3 ligase. Jiang, W., Wang, W., Kong, Y. et al. Sci Adv (2023) 9:eadg8369-eadg8369. DOI 10.1126/sciadv.adg8369 · PubMed

Browse structure collections

About this viewer

MolViewer shows 8I79 directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.