8IUE: DNA-directed RNA polymerase III subunit RPC1

RNA polymerase III pre-initiation complex melting complex 1. Determined by electron microscopy at 4.1 Å resolution. Released 24 May 2023.

Method: Electron microscopy
Resolution: 4.1 Å
Organism: Homo sapiens
Chains: 25
Atoms: 57,927
Mol. weight: 1614.63 kDa
Ligands: ZN, SF4, MG
Released: 24 May 2023

Explore 8IUE in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8IUE contains 331 α-helices and 322 β-strands across 23 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 8 helices, 2 β-strands

Element	Residues	Length	Sheet
α-helix	5-20	16
α-helix	27-33	7
α-helix	49-63	15
α-helix	64-66	3
α-helix	72-87	16
α-helix	96	1
β-strand	97-100	4	88
α-helix	106-116	11
α-helix	120-132	13
β-strand	135-138	4	88

Chain 3: 21 helices, 24 β-strands

Element	Residues	Length	Sheet
α-helix	23-24	2
α-helix	30-31	2
β-strand	32-34	3	89
β-strand	38-39	2	89
β-strand	42-43	2	90
α-helix	44-46	3
α-helix	47-53	7
α-helix	77-89	13
α-helix	99-105	7
α-helix	128-142	15
α-helix	155-161	7
α-helix	171-173	3
β-strand	174	1	91
α-helix	175-176	2
β-strand	180-187	8	88
β-strand	203-207	5	88
β-strand	211	1	92
α-helix	212-218	7
α-helix	222-225	4
α-helix	237-239	3
α-helix	243-246	4
β-strand	250-252	3	88
β-strand	257-260	4	93
α-helix	271-279	9
α-helix	287-288	2
β-strand	289-292	4	93
β-strand	297	1	92
α-helix	298-300	3
β-strand	302-303	2	90
β-strand	308-313	6	88
β-strand	317-322	6	88
β-strand	326-328	3	88
β-strand	336	1	91
β-strand	345	1	88
α-helix	351-352	2
β-strand	353	1	94
α-helix	354	1
β-strand	361	1	94
β-strand	364-367	4	95
β-strand	378-379	2	95
α-helix	381-388	8
β-strand	389	1	96
β-strand	395	1	96
β-strand	400-403	4	95
α-helix	407-409	3

Chain 4: 23 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	164-170	7
α-helix	186-221	36
α-helix	225-246	22
α-helix	252-254	3
α-helix	263-265	3
α-helix	266-270	5
α-helix	277-282	6
α-helix	283-287	5
α-helix	302-312	11
α-helix	317-324	8
α-helix	330-340	11
α-helix	352-364	13
β-strand	366	1	97
β-strand	369	1	97
α-helix	372-378	7
α-helix	387-391	5
β-strand	399	1	98
α-helix	408-411	4
α-helix	414-418	5
α-helix	425-428	4
β-strand	433	1	98
α-helix	436-447	12
α-helix	460-467	8
α-helix	478-481	4
α-helix	488-498	11
α-helix	505-509	5
α-helix	510-512	3

Chain A: 70 helices, 60 β-strands

Element	Residues	Length	Sheet
β-strand	4-5	2	1
β-strand	13-21	9	2
α-helix	25-31	7
β-strand	35	1	3
β-strand	38	1	4
β-strand	42	1	5
α-helix	49	1
β-strand	50	1	5
α-helix	51	1
β-strand	54	1	4
α-helix	58-60	3
α-helix	68-69	2
β-strand	84-92	9	3
α-helix	98-107	10
β-strand	108	1	6
β-strand	115	1	6
α-helix	119-129	11
α-helix	136-152	17
β-strand	155	1	7
β-strand	162	1	7
β-strand	166-168	3	8
β-strand	174-176	3	8
α-helix	186-187	2
α-helix	188-194	7
α-helix	198-203	6
α-helix	205-207	3
β-strand	216-218	3	8
α-helix	220-228	9
α-helix	232-234	3
α-helix	236-238	3
α-helix	247-249	3
β-strand	252-257	6	3
β-strand	266-268	3	9
β-strand	273-276	4	9
α-helix	278-299	22
α-helix	303-321	19
α-helix	341-345	5
α-helix	351	1
α-helix	352-357	6
β-strand	359-360	2	10
β-strand	364-371	8	11
β-strand	379-383	5	11
α-helix	384-387	4
β-strand	391-395	5	12
α-helix	401-410	10
β-strand	418-422	5	12
β-strand	429-431	3	12
α-helix	437-442	6
β-strand	449-453	5	12
β-strand	459-463	5	11
α-helix	470-472	3
β-strand	473-481	9	11
β-strand	486-488	3	11
α-helix	490-492	3
α-helix	493-496	4
β-strand	504-508	5	11
α-helix	513-521	9
β-strand	524	1	11
β-strand	530	1	13
β-strand	537	1	13
β-strand	541	1	14
α-helix	546-552	7
β-strand	558-559	2	15
α-helix	561-569	9
α-helix	574-578	5
α-helix	583-586	4
β-strand	588	1	16
β-strand	592	1	17
β-strand	594	1	16
β-strand	595-596	2	15
α-helix	597-605	9
β-strand	617-620	4	18
β-strand	637-640	4	18
β-strand	645-647	3	18
β-strand	656	1	14
α-helix	663-671	9
α-helix	673-694	22
β-strand	697	1	19
α-helix	700-702	3
α-helix	704-706	3
α-helix	707-732	26
α-helix	738-739	2
α-helix	744-770	27
α-helix	776-783	8
α-helix	789-792	4
α-helix	793-797	5
α-helix	808-810	3
α-helix	828-831	4
α-helix	844-878	35
β-strand	883-884	2	20
β-strand	890-891	2	20
β-strand	897-899	3	20
α-helix	902-904	3
β-strand	907	1	21
α-helix	909-911	3
α-helix	921-931	11
α-helix	942-953	12
α-helix	963-987	25
α-helix	998-1002	5
α-helix	1008-1024	17
β-strand	1026	1	21
α-helix	1027-1028	2
α-helix	1033-1046	14
α-helix	1067-1075	9
β-strand	1085-1089	5	22
α-helix	1095-1105	11
β-strand	1108-1109	2	23
α-helix	1110-1113	4
β-strand	1114-1121	8	24
β-strand	1126-1132	7	24
α-helix	1134-1139	6
α-helix	1146-1152	7
β-strand	1165-1167	3	24
β-strand	1172-1175	4	24
α-helix	1189-1195	7
β-strand	1200-1202	3	23
β-strand	1210-1214	5	22
β-strand	1223-1227	5	22
α-helix	1232-1237	6
β-strand	1241-1248	8	22
α-helix	1251-1276	26
α-helix	1284-1294	11
α-helix	1305-1311	7
α-helix	1315-1321	7
α-helix	1324-1334	11
β-strand	1338-1339	2	2
α-helix	1343-1349	7
α-helix	1356-1359	4
β-strand	1361-1364	4	1
α-helix	1372-1377	6

Chain B: 47 helices, 80 β-strands

Element	Residues	Length	Sheet
α-helix	19-21	3
α-helix	26-28	3
α-helix	29-34	6
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
β-strand	64-65	2	25
β-strand	75-81	7	25
β-strand	90	1	26
β-strand	93	1	26
α-helix	99-105	7
β-strand	110-113	4	27
β-strand	114-120	7	25
β-strand	125-127	3	25
β-strand	134-137	4	27
α-helix	138-139	2
α-helix	152-157	6
β-strand	169-171	3	28
β-strand	174-178	5	28
β-strand	180-184	5	29
α-helix	185	1
β-strand	189-193	5	30
β-strand	199-206	8	30
β-strand	211-217	7	30
β-strand	224-226	3	30
β-strand	230	1	31
β-strand	234-235	2	30
α-helix	236-242	7
α-helix	248-255	8
α-helix	259-274	16
α-helix	280-289	10
β-strand	291	1	31
α-helix	307-311	5
α-helix	312-316	5
α-helix	329-345	17
α-helix	357-359	3
β-strand	360-363	4	29
α-helix	365-391	27
α-helix	399-400	2
α-helix	402-405	4
α-helix	408-421	14
β-strand	424-426	3	32
β-strand	431-433	3	32
β-strand	437-439	3	28
α-helix	445-451	7
β-strand	454-456	3	29
α-helix	471-472	2
α-helix	473-475	3
β-strand	479	1	33
β-strand	493-495	3	29
β-strand	496	1	33
β-strand	501-502	2	34
α-helix	509-517	9
β-strand	521	1	35
α-helix	528-532	5
β-strand	536-541	6	35
β-strand	544-550	7	35
α-helix	552-565	14
β-strand	573-577	5	35
β-strand	582-586	5	35
β-strand	592-598	7	34
β-strand	599-600	2	36
β-strand	603-604	2	36
α-helix	608-616	9
α-helix	621-626	6
β-strand	630-634	5	34
α-helix	635-640	6
β-strand	643-644	2	34
β-strand	656-657	2	34
α-helix	661-664	4
α-helix	669-671	3
α-helix	675-677	3
α-helix	680-690	11
β-strand	693	1	37
β-strand	708-712	5	38
β-strand	716	1	39
β-strand	721	1	40
α-helix	723-728	6
α-helix	730-732	3
β-strand	737-743	7	41
β-strand	744	1	19
β-strand	754-758	5	41
α-helix	759-763	5
β-strand	769-779	11	38
β-strand	781	1	42
β-strand	787	1	42
β-strand	789-790	2	43
β-strand	795-796	2	44
β-strand	801-802	2	44
β-strand	809	1	45
β-strand	814	1	46
β-strand	815	1	45
α-helix	816	1
β-strand	820-821	2	38
β-strand	825-828	4	46
β-strand	830-833	4	43
β-strand	851-853	3	43
β-strand	856-858	3	46
β-strand	864-873	10	38
β-strand	879-889	11	38
β-strand	896-898	3	41
β-strand	905-911	7	41
β-strand	918	1	47
β-strand	927-929	3	41
α-helix	933-937	5
α-helix	940-955	16
β-strand	960	1	40
α-helix	969-979	11
β-strand	986-987	2	41
β-strand	990	1	47
β-strand	997	1	47
β-strand	1002-1011	10	41
β-strand	1012	1	37
α-helix	1016-1019	4
β-strand	1021-1023	3	11
β-strand	1028	1	48
β-strand	1046-1047	2	10
α-helix	1049-1058	10
α-helix	1061-1065	5
α-helix	1066-1070	5
β-strand	1074-1080	7	49
β-strand	1086-1087	2	49
β-strand	1092	1	50
β-strand	1097	1	50
β-strand	1101-1107	7	49
α-helix	1108-1119	12
β-strand	1123-1130	8	2

Chain C: 14 helices, 23 β-strands

Element	Residues	Length	Sheet
α-helix	3-12	10
β-strand	13-15	3	51
β-strand	16	1	52
β-strand	21	1	52
β-strand	33	1	17
α-helix	42-48	7
β-strand	50-57	8	51
β-strand	60-66	7	51
α-helix	70-82	13
β-strand	86-94	9	53
α-helix	103-111	9
β-strand	115	1	54
α-helix	119-121	3
α-helix	124-126	3
β-strand	138-145	8	53
β-strand	147-148	2	55
α-helix	159-162	4
β-strand	163-164	2	55
β-strand	167-169	3	56
β-strand	174-176	3	53
α-helix	181-184	4
α-helix	186	1
β-strand	192	1	54
β-strand	198-201	4	56
β-strand	207-217	11	53
α-helix	223-225	3
β-strand	228-237	10	51
β-strand	240-241	2	57
β-strand	246	1	58
α-helix	248-256	9
β-strand	262-266	5	58
β-strand	271-275	5	58
α-helix	278-280	3
α-helix	292-294	3
β-strand	297-298	2	57
β-strand	300-312	13	51
α-helix	318-343	26

Chain D: 9 helices, 1 β-strand

Element	Residues	Length	Sheet
β-strand	3-10	8	1
α-helix	13-29	17
α-helix	33-38	6
α-helix	41-55	15
α-helix	63-73	11
α-helix	74-76	3
α-helix	80-89	10
α-helix	95	1
α-helix	96-100	5
α-helix	112-121	10

Chain E: 10 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	5-23	19
α-helix	30-33	4
α-helix	37-43	7
β-strand	58-62	5	59
β-strand	71-75	5	59
β-strand	81-82	2	60
α-helix	84-97	14
β-strand	101-106	6	59
β-strand	109-110	2	60
α-helix	112-119	8
β-strand	126-131	6	59
α-helix	134-136	3
β-strand	147-150	4	61
α-helix	153-163	11
α-helix	171	1
β-strand	172-173	2	61
α-helix	178-183	6
α-helix	185-186	2
β-strand	190-196	7	61
β-strand	202-209	8	61

15 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1390	Homo sapiens	O14802 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1133	Homo sapiens	Q9NW08 (AlphaFold model)
DNA-directed RNA polymerases I and III subunit RPAC1	C	protein	346	Homo sapiens	O15160 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC9	D	protein	148	Homo sapiens	O75575 (AlphaFold model)
DNA-directed RNA polymerases I, II, and III subunit RPABC1	E	protein	210	Homo sapiens	P19388
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Homo sapiens	P61218
DNA-directed RNA polymerase III subunit RPC8	G	protein	204	Homo sapiens	Q9Y535
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Homo sapiens	P52434
DNA-directed RNA polymerase III subunit RPC10	I	protein	108	Homo sapiens	Q9Y2Y1
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Homo sapiens	P62875
DNA-directed RNA polymerases I and III subunit RPAC2	K	protein	133	Homo sapiens	P0DPB6
DNA-directed RNA polymerases I, II, and III subunit RPABC4	L	protein	58	Homo sapiens	P53803

13 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8IUE_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM
GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE
EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK
TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM
NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG
AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR
VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF
IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV
KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA
AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI
FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK
NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG
YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM
ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS
GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF
IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC
CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD
KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI
STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL
RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV
VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI
EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD
TNEFHIPLVT

Sequence of entity 2 (B), FASTA

>8IUE_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
ANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYT
RGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILI
QEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIF
KAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG
PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNK
RLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAIS
TGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLC
PSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVF
LNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK
KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIE
PFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMV
KTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLK
RYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPL
EGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSR
HGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHY
GTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKM
HARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVC
GQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE

Sequence of entity 3 (C), FASTA

>8IUE_3 DNA-directed RNA polymerases I and III subunit RPAC1 (chains C)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 4 (D), FASTA

>8IUE_4 DNA-directed RNA polymerase III subunit RPC9 (chains D)
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRH
QSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTV
TSILPAEPEAEQKKNTNSNVAMDEEDPA

Sequence of entity 5 (E), FASTA

>8IUE_5 DNA-directed RNA polymerases I, II, and III subunit RPABC1 (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQSGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>8IUE_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIITD

Sequence of entity 7 (G), FASTA

>8IUE_7 DNA-directed RNA polymerase III subunit RPC8 (chains G)
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

Sequence of entity 8 (H), FASTA

>8IUE_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>8IUE_9 DNA-directed RNA polymerase III subunit RPC10 (chains I)
MLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Sequence of entity 10 (J), FASTA

>8IUE_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>8IUE_11 DNA-directed RNA polymerases I and III subunit RPAC2 (chains K)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Sequence of entity 12 (L), FASTA

>8IUE_12 DNA-directed RNA polymerases I, II, and III subunit RPABC4 (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	8
SF4	Iron/sulfur cluster	Fe4 S4	1
MG	Magnesium ion	Mg	1

Primary citation

Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Hou, H., Jin, Q., Ren, Y. et al. Cell Res (2023) 33:565-568. DOI 10.1038/s41422-023-00819-x · PubMed

Other PDB entries of the same protein (UniProt O14802 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AE1 2.8 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 1
9K39 2.8 Å, Human RNA Polymerase III de novo transcribing complex 8 (TC8)
7D58 2.9 Å, cryo-EM structure of human RNA polymerase III in elongating state
9K36 2.9 Å, Human RNA Polymerase III de novo transcribing complex 12 (TC12)
9K2G 3.0 Å, Human RNA Polymerase III de novo transcribing complex 13 (TC13)
9K3U 3.0 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)
7AE3 3.1 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 3
7D59 3.1 Å, cryo-EM structure of human RNA polymerase III in apo state
9K38 3.1 Å, Human RNA Polymerase III de novo transcribing complex 6 (TC6)
9FSO 3.28 Å, Human RNA Polymerase III Class III Open Pre-initiation Complex 1 (OC1)
7A6H 3.3 Å, Cryo-EM structure of human apo RNA Polymerase III
9LXN 3.3 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)(without 3'dATP)

Browse structure collections

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