8IYJ: Cilia- and flagella-associated protein 95

Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm. Determined by electron microscopy at 3.5 Å resolution. Released 5 Jul 2023.

Method: Electron microscopy
Resolution: 3.5 Å
Organism: Mus musculus
Chains: 576
Atoms: 1,650,085
Mol. weight: 27904.74 kDa
Ligands: GDP, MG, GTP
Released: 5 Jul 2023

Explore 8IYJ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8IYJ contains 10,605 α-helices and 7,636 β-strands across 576 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 0: 3 helices, 0 β-strands

Element	Residues	Length
α-helix	31-34	4
α-helix	51-57	7
α-helix	91-100	10

Chain 1: 28 helices, 9 β-strands

Element	Residues	Length	Sheet
α-helix	360-363	4
α-helix	364-374	11
α-helix	378-381	4
β-strand	406	1	70
α-helix	416-420	5
α-helix	426-434	9
α-helix	437-444	8
α-helix	479-485	7
α-helix	488-495	8
β-strand	499-501	3	71
α-helix	502-511	10
β-strand	514	1	72
β-strand	517	1	72
α-helix	532-533	2
β-strand	534	1	73
α-helix	538-541	4
α-helix	545-550	6
α-helix	562-582	21
α-helix	586-593	8
β-strand	601	1	74
α-helix	603-612	10
α-helix	619-629	11
β-strand	637	1	74
α-helix	639-646	8
α-helix	656-659	4
α-helix	689-691	3
β-strand	693-694	2	75
β-strand	702-703	2	75
α-helix	704-709	6
α-helix	721-726	6
α-helix	750-752	3
α-helix	769-773	5
α-helix	777-781	5
α-helix	785-789	5
α-helix	794-804	11
α-helix	810-823	14
α-helix	831-846	16

Chain 2: 19 helices, 4 β-strands

Element	Residues	Length	Sheet
α-helix	275-276	2
β-strand	284	1	154
α-helix	288-290	3
α-helix	294-298	5
α-helix	304-305	2
α-helix	312-318	7
β-strand	325	1	155
α-helix	338-340	3
α-helix	353-357	5
α-helix	360-363	4
α-helix	364-374	11
α-helix	378-381	4
α-helix	401-403	3
α-helix	416-419	4
α-helix	426-434	9
α-helix	437-444	8
α-helix	452-454	3
β-strand	468	1	156
α-helix	479-485	7
α-helix	488-495	8
β-strand	499-501	3	157
α-helix	502-510	9
α-helix	523-526	4

Chain 3: 4 helices, 0 β-strands

Element	Residues	Length
α-helix	34-82	49
α-helix	84-118	35
α-helix	123-159	37
α-helix	163-484	322

Chain 4: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	359-492	134

Chain 5: 21 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	27-34	8	394
β-strand	39-48	10	394
β-strand	53-57	5	394
β-strand	66-70	5	394
α-helix	76-78	3
β-strand	84-87	4	395
β-strand	90-93	4	395
β-strand	96-97	2	394
α-helix	100-105	6
β-strand	110-117	8	396
α-helix	119-124	6
α-helix	125-134	10
β-strand	138-145	8	396
α-helix	149-155	7
α-helix	156-159	4
α-helix	165-172	8
β-strand	177-185	9	396
α-helix	187-195	9
α-helix	200-206	7
α-helix	211-214	4
α-helix	230-240	11
α-helix	250	1
β-strand	251	1	396
β-strand	258-263	6	396
α-helix	265-269	5
α-helix	273-281	9
β-strand	286-293	8	396
α-helix	297-303	7
β-strand	308	1	397
β-strand	311	1	397
α-helix	314-323	10
β-strand	326-332	7	396
α-helix	340-344	5
α-helix	349-355	7
α-helix	360-363	4
β-strand	373-375	3	396
α-helix	381-387	7
α-helix	388-392	5

Chain 6: 24 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	26-34	9	479
β-strand	39-48	10	479
β-strand	53-58	6	479
β-strand	63-70	8	479
α-helix	76-78	3
β-strand	84-87	4	480
β-strand	90-93	4	480
β-strand	96-97	2	479
α-helix	100-105	6
β-strand	110-114	5	481
α-helix	116	1
β-strand	117	1	481
α-helix	118	1
α-helix	119-121	3
α-helix	125-135	11
β-strand	138-144	7	481
β-strand	145	1	482
α-helix	149-155	7
α-helix	158-160	3
α-helix	165-172	8
β-strand	178-185	8	481
α-helix	187-195	9
α-helix	200-205	6
α-helix	211-214	4
β-strand	224	1	481
α-helix	230-240	11
α-helix	250	1
β-strand	251	1	482
β-strand	258-263	6	481
α-helix	265-269	5
α-helix	273-282	10
β-strand	286-293	8	481
α-helix	297-303	7
α-helix	304-306	3
β-strand	311	1	483
α-helix	314-321	8
β-strand	326-332	7	481
α-helix	336-344	9
α-helix	349-355	7
α-helix	360-362	3
β-strand	374-375	2	481
α-helix	381-387	7
α-helix	388-392	5

Chain 7: 6 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	51-57	7
α-helix	91-100	10
α-helix	154-158	5
α-helix	166-169	4
α-helix	171-176	6
β-strand	198	1	558
α-helix	211-218	8

565 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Cilia- and flagella-associated protein 95	0, 7	protein	228	Mus musculus	Q9CQC3 (AlphaFold model)
EF-hand domain-containing family member B	1, 2	protein	853	Mus musculus	Q8CDU5 (AlphaFold model)
Cilia- and flagella-associated protein 53	3, 4	protein	514	Mus musculus	Q9D439 (AlphaFold model)
Nucleoside diphosphate kinase 7	5, 6, j1	protein	395	Mus musculus	Q9QXL8 (AlphaFold model)
Cilia- and flagella-associated protein 107	8	protein	196	Mus musculus	Q4KKZ1
Cilia- and flagella-associated protein 141	A, N1	protein	101	Mus musculus	Q9D9D9
Tektin-1	A0, A1, A2, A3, A4, A5	protein	418	Mus musculus	Q9DAJ2
Tubulin alpha-3 chain	AA, AC, AE, AG, AI, AK, AM, AO, BC, BE, BG, BI, BK, BM, BO, CC, CE, CG, CI, CK, CM, CO, CQ, DC, DE, DG, DI, DK, DM, DO, DQ, EA, EC, EE, EG, EI, EK, EM, EO, FA, FC, FE, FG, FI, FK, FM, FO, GA, GC, GE, GG, GI, GK, GM, GO, HA, HC, HE, HG, HI, HK, HM, HO, IA, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, JO, JQ, KA, KC, KE, KG, KI, KK, KM, KO, LA, LC, LE, LG, LI, LK, LM, LO, MA, MC, ME, MG, MI, MK, MM, MO, NA, NC, NE, NG, NI, NK, NM, NO, OA, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SA, SC, SE, SG, SI, SK, SM, TA, TC, TE, TG, TI, TK, TM, UA, UC, UE, UG, UI, UK, UM, UO, VA, VC, VE, VG, VI, VK, VM, VO, WA, WC, WE, WG, WI, WK, WM, WO	protein	450	Mus musculus	P05214
Tubulin beta-4B chain	AB, AD, AF, AH, AJ, AL, AN, AP, BB, BD, BF, BH, BJ, BL, BN, BP, CB, CD, CF, CH, CJ, CL, CN, CP, DB, DD, DF, DH, DJ, DL, DN, DP, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, HP, IB, ID, IF, IH, IJ, IL, IN, IP, JB, JD, JF, JH, JJ, JL, JN, JP, KB, KD, KF, KH, KJ, KL, KN, KP, LB, LD, LF, LH, LJ, LL, LN, LP, MB, MD, MF, MH, MJ, ML, MN, MP, NB, ND, NF, NH, NJ, NL, NN, NP, OB, OD, OF, OH, OJ, OL, ON, OP, PB, PD, PF, PH, PJ, PL, PN, PP, QB, QD, QF, QH, QJ, QL, QN, QP, RD, RF, RH, RJ, RL, RN, RP, SB, SD, SF, SH, SJ, SL, SN, TB, TD, TF, TH, TJ, TL, TN, UB, UD, UF, UH, UJ, UL, UN, VB, VD, VF, VH, VJ, VL, VN, WB, WD, WF, WH, WJ, WL, WN, WP	protein	445	Mus musculus	P68372
Meiosis-specific nuclear structural protein 1	B, C	protein	491	Mus musculus	Q61884
Tektin-2	B0, B1, B2, B3, B4, B5, R0, R1, R2, R3, R4, R5	protein	430	Mus musculus	Q922G7
Tektin-3	C0, C1, C2, C3, C4, C5, C6, S0, S1, S2, S3, S4, S5, S6, S7, S8, S9	protein	490	Mus musculus	Q6X6Z7

37 more molecules are not listed.

Sequence of entity 1 (0, 7), FASTA

>8IYJ_1 Cilia- and flagella-associated protein 95 (chains 0, 7)
MGTFDSQCHECFESKERWYEIGPTDLLERKGSLTLRSHHKKYSEPVLVYSWHRNREAFPK
DYDIESLETVKNLCMSTYKRFGSDSPRWMSEAREQMAQVLVNKDLVEKKKTGLLDEETLC
PGILERDPELPPTGFRDVPMESPPDPRKPCFSTTYSEDFTPQYEYPPPACPRREEYSIVH
RKCRSQFTDLNGSKRLGINTWHDESGIYANSEAKQKLYALARNPIVPF

Sequence of entity 2 (1, 2), FASTA

>8IYJ_2 EF-hand domain-containing family member B (chains 1, 2)
MCSFVRVGSPKPLQTSASPLEMSSLRRTRAPEISELGLTPEQKDDIRDRVLRGSKSPTEL
GFDLRLEQDRKWRERMGSSEAKSPPCHALGVGLERHTISGTPTEMGNLGLHKGSAFQGSK
PLGVLPGRVGPENKGLPPRLRYGGTLHPPFSTVHASPLAAESRRRPLAWGSAWTDAVVEK
QPVVGLELRKEPEKEPTCVVMNPYPEMPPKEVDIGLPQTQESDEAKNTEPLIGLVREPSE
CPFAQQPEEKKEPGSTEPGVEPPGNIRPIYSGKFFDRVPCWPSAGKVKPVGYRVATCLTE
KLPRLMTPPEAKKYFNFRYPPAGAERVFYGRANDPQIAPYLTHGLRSKISIPMGSLINPQ
PITTFQQKIKDKKESIYFSHQRAPLGKSHDQTPGLPKGMDVINTTLGTPTIRELSVRDTV
NPSKSFEDVLKEGQEGHDLYTVSHNDYFAGEAKNRKYNPASFHRFNLYGIPTPHFNDGRT
MAKALHWLHELQMERGAKIVSKRVDDFKEKFQHKLGKVLDPIAETMNVPPGHTFGSCLHP
EEYGAGDLIHYRSPDEYLRGKDHQRAVVAAARHHLKKFNHQNFDTLQVAFRHYDKKGDGV
IDRAELHEACVQANLHLDKMLLDHLFDYCDVDQDGLINYLEFANFLNWKDRIPLKEHEKR
VVVKGKKPDCENVTDTSMGEAEPSLLINPEDIVPKEPGSSEETLRTIQRPGDKVSHQYKT
TSSEINAVVGAVPSMCHPIFGVPTIRSDISAPRIRRVSDMNNYGDEGNAYSLLHPSIFSQ
KGVFERDFFKTRSKEEISDILTNIGVKLSKEEFENVWNLASKKHQRGEVCVETIRNVLDE
LLHADLVKCKTAM

Sequence of entity 3 (3, 4), FASTA

>8IYJ_3 Cilia- and flagella-associated protein 53 (chains 3, 4)
MYSQQFGTVPREFKGPTPKAVIIRAKPPKAQRAEQHLKRIQRSYHKYHTTLASIKSNEEN
RLKCDWIQRNNHKTFDSLVQARVQDAMQGFVINTEERRNKLRELLASEENEYFSEMQLKG
ETIEEKKDKMRERTKLLREKKEKERQEFVAEKLDQQFRERCEELRTKLASIHEKKVVEER
NAQIEFNKELKRQKLVEEHLFARLWEEDRLAKERREAQEEKRQRELVQNTRLGLDAQVTS
IQAQRQGARRMKEEEARILEQNKAQIKREDEQEKLQKQKRRQETRSSLKKAVQDKIESMQ
REYREDLDLNMKLVGRALQDLQDEADKKKQKREEMGREQKIYNDYLMQRREEEKAQEKEL
NRLLEDIKAKKLAEKDRELALQRAARKQLMNEVMNTRKLQVQERLQRKLREQEELALHEQ
RISESLKVLHQEDMEDFARRCALAEEYRNQLQMQIAHQQQAREAEKEEERQEFEAGLAAN
KACLDKIQRILSENQALSQNVHPMRRGYPDKPPL

Sequence of entity 4 (5, 6, j1), FASTA

>8IYJ_4 Nucleoside diphosphate kinase 7 (chains 5, 6, j1)
MRACQQGRSSSLVSPYMAPKNQSERFAFIAEWYDPNASLLRRYELLFYPVDGSVEMHDVK
NRRTFLKRTKYEDLRLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPD
AVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAM
EILRDDAICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELF
FPSSGGCGPANTAKFTNCTCCIIKPHAISEGMLGKNLIAIRDACFGMSAIQMFNLDRANV
EEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNPTKTFREFCGPADPEIARHLRPETL
RAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILDN

Sequence of entity 5 (8), FASTA

>8IYJ_5 Cilia- and flagella-associated protein 107 (chains 8)
MAMLSTSVVPEAFSTPGWQIEKKYSTKVLLGNWVEERGKFTKAIDHTPQCIYRKEYVPMP
DHRPDFVSRWYSKSKMEGLPYKHLITHHQEPSHRYLISTYDDHYNRHNYNPGLPALRTWN
GQKLLWLPEKSDFPLVAPPTNYGLLEQLQQKWLASKTSLKESIYTTSYPRLPVCAMSRRE
HAIPVPHPRLQPIPRF

Sequence of entity 6 (A, N1), FASTA

>8IYJ_6 Cilia- and flagella-associated protein 141 (chains A, N1)
MSAEKMTKLEENLQRAVALKKTVDRWRNFHIHCMWQTTLDQRRNLFAALRMKDTKEQELA
LSNKQLLVVRQAALHELFEKEYQQYQQELNQMGKAFYEERL

Sequence of entity 7 (A0, A1, A2, A3, A4, A5), FASTA

>8IYJ_7 Tektin-1 (chains A0, A1, A2, A3, A4, A5)
MAKLLQSPPRFLPEEWYIANKSQYHRAEAQRSQSERLVAESQRLVEEIEKTTRKSQSDVN
KKLEQRLEEVRFWKKELDDKLEQLVNQTDDLLTYKTRLERSLESYKEPLHITEKCLEYRE
KRVGIDLVHDVVEQELQKEADIIHGVMNLLIRTLEESTEQIRLNRSAKYNLEKDLRDKFT
AITIDDVCFSLNNNSPNINFSEKVVRIEPNSVSLEDWLDFSNANVEKADKQLNNSTALKT
LVDQILSQTANDLRRQCEVVDEAFINGLKETKDARNKLADHLAKVMEEIASQEKNIMALE
NAITQQEGPAKVAHTRLETRTHRPNVELCRDIAQYRLIKEIQEINHNVARLKETLAQAQT
QLKALYRRQLALQEEIQVKENTIYIDQVLCMEMRKSIPPRDGDDHGAWEGGIRAEAIC

Sequence of entity 8 (AA, AC, AE, AG, AI, AK, AM, AO, BC, BE, BG, BI, BK, BM, BO, CC, CE, CG, CI, CK, CM, CO, CQ, DC, DE, DG, DI, DK, DM, DO, DQ, EA, EC, EE, EG, EI, EK, EM, EO, FA, FC, FE, FG, FI, FK, FM, FO, GA, GC, GE, GG, GI, GK, GM, GO, HA, HC, HE, HG, HI, HK, HM, HO, IA, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, JO, JQ, KA, KC, KE, KG, KI, KK, KM, KO, LA, LC, LE, LG, LI, LK, LM, LO, MA, MC, ME, MG, MI, MK, MM, MO, NA, NC, NE, NG, NI, NK, NM, NO, OA, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SA, SC, SE, SG, SI, SK, SM, TA, TC, TE, TG, TI, TK, TM, UA, UC, UE, UG, UI, UK, UM, UO, VA, VC, VE, VG, VI, VK, VM, VO, WA, WC, WE, WG, WI, WK, WM, WO), FASTA

>8IYJ_8 Tubulin alpha-3 chain (chains AA, AC, AE, AG, AI, AK, AM, AO, BC, BE, BG, BI, BK, BM, BO, CC, CE, CG, CI, CK, CM, CO, CQ, DC, DE, DG, DI, DK, DM, DO, DQ, EA, EC, EE, EG, EI, EK, EM, EO, FA, FC, FE, FG, FI, FK, FM, FO, GA, GC, GE, GG, GI, GK, GM, GO, HA, HC, HE, HG, HI, HK, HM, HO, IA, IC, IE, IG, II, IK, IM, IO, JC, JE, JG, JI, JK, JM, JO, JQ, KA, KC, KE, KG, KI, KK, KM, KO, LA, LC, LE, LG, LI, LK, LM, LO, MA, MC, ME, MG, MI, MK, MM, MO, NA, NC, NE, NG, NI, NK, NM, NO, OA, OC, OE, OG, OI, OK, OM, OO, PC, PE, PG, PI, PK, PM, PO, QC, QE, QG, QI, QK, QM, QO, RC, RE, RG, RI, RK, RM, RO, SA, SC, SE, SG, SI, SK, SM, TA, TC, TE, TG, TI, TK, TM, UA, UC, UE, UG, UI, UK, UM, UO, VA, VC, VE, VG, VI, VK, VM, VO, WA, WC, WE, WG, WI, WK, WM, WO)
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY

Sequence of entity 9 (AB, AD, AF, AH, AJ, AL, AN, AP, BB, BD, BF, BH, BJ, BL, BN, BP, CB, CD, CF, CH, CJ, CL, CN, CP, DB, DD, DF, DH, DJ, DL, DN, DP, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, HP, IB, ID, IF, IH, IJ, IL, IN, IP, JB, JD, JF, JH, JJ, JL, JN, JP, KB, KD, KF, KH, KJ, KL, KN, KP, LB, LD, LF, LH, LJ, LL, LN, LP, MB, MD, MF, MH, MJ, ML, MN, MP, NB, ND, NF, NH, NJ, NL, NN, NP, OB, OD, OF, OH, OJ, OL, ON, OP, PB, PD, PF, PH, PJ, PL, PN, PP, QB, QD, QF, QH, QJ, QL, QN, QP, RD, RF, RH, RJ, RL, RN, RP, SB, SD, SF, SH, SJ, SL, SN, TB, TD, TF, TH, TJ, TL, TN, UB, UD, UF, UH, UJ, UL, UN, VB, VD, VF, VH, VJ, VL, VN, WB, WD, WF, WH, WJ, WL, WN, WP), FASTA

>8IYJ_9 Tubulin beta-4B chain (chains AB, AD, AF, AH, AJ, AL, AN, AP, BB, BD, BF, BH, BJ, BL, BN, BP, CB, CD, CF, CH, CJ, CL, CN, CP, DB, DD, DF, DH, DJ, DL, DN, DP, EB, ED, EF, EH, EJ, EL, EN, FB, FD, FF, FH, FJ, FL, FN, GB, GD, GF, GH, GJ, GL, GN, HB, HD, HF, HH, HJ, HL, HN, HP, IB, ID, IF, IH, IJ, IL, IN, IP, JB, JD, JF, JH, JJ, JL, JN, JP, KB, KD, KF, KH, KJ, KL, KN, KP, LB, LD, LF, LH, LJ, LL, LN, LP, MB, MD, MF, MH, MJ, ML, MN, MP, NB, ND, NF, NH, NJ, NL, NN, NP, OB, OD, OF, OH, OJ, OL, ON, OP, PB, PD, PF, PH, PJ, PL, PN, PP, QB, QD, QF, QH, QJ, QL, QN, QP, RD, RF, RH, RJ, RL, RN, RP, SB, SD, SF, SH, SJ, SL, SN, TB, TD, TF, TH, TJ, TL, TN, UB, UD, UF, UH, UJ, UL, UN, VB, VD, VF, VH, VJ, VL, VN, WB, WD, WF, WH, WJ, WL, WN, WP)
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Sequence of entity 10 (B, C), FASTA

>8IYJ_10 Meiosis-specific nuclear structural protein 1 (chains B, C)
MATKKRALSFSEKHQKLVDEKFRKSLNIQVMNKLERQAKNQVVQNENDEKVERQRFLRVL
QNEQFELDMEEAIQKAEANKMLRDRQLEQEERLANELARLKHESLKDKKMRQQVRENSIE
LRELEQKLKAAYMNKERAAQIVEKDAMKYEQMKRDAEIERIMMEEHDRLLKEESAKQERR
NKERAQYYLDLEKQLEDQERRKQEAYEQLLKEKLMIDEIVRKIYEEDQVERQQKLEKKNA
IQKYIEEFQRAQDFWRQKKREEMEEENRKIIEFANIQEQREGERMARVHEIEEKRVQRQN
LLMKQLEETLRQRDDLEQVRQELYQEEQAEIIKLKVKEEAELRLRRQREMKQDFEDQMAL
KELILQAAKEEEETFKKAMLAKFAEDDRIELMNAQKQRMKQLEHKRAVEKLIEERRSQFL
ADKQRELEELQLQQRRQGCINEIIEEERLRLLKEHAAKLLGYLPKGVFKREDDVDMLGEE
FRKAYQKRDGV

Sequence of entity 11 (B0, B1, B2, B3, B4, B5, R0, R1, R2, R3, R4, R5), FASTA

>8IYJ_11 Tektin-2 (chains B0, B1, B2, B3, B4, B5, R0, R1, R2, R3, R4, R5)
MATLSFKPSERYRLSDWRTNSYLLSTNAERQRDASHQIRQEARILRNETNNQIVWDEHDN
RTRLAERIDTVNRWKETLDKCLTDLDAEIDSLAQAKESAEQNLQAKNLPLDVAIECLTLR
ESRRDIDVVRDPVEEELLKEVEVIEATKKVLQEKISQAFQHLCLLQEIRQQLNSDHRDKM
ETLEIDRGCLSLNLTSPNISLKVNPTRIPKDSTTLQQWDEFTRFNKNRAEAEMKASIELR
EAIALAIAQTNNELDAQRVATEFTFRKRLREMESFYSELKWQEKNTLEEIAELQGDIRRL
EEDLRRKMMNLKLAHTRLESRTYRSNVELCRDQTQYGLIDEVHQLEATINTMKQKLAQTQ
NALDALFKHLARIQADIACKTNTLLLDTKCMDTRRKLTVPAEKFVPQVDTFTRTTNRTLS
PLKICQLELT

Sequence of entity 12 (C0, C1, C2, C3, C4, C5, C6, S0, S1, S2, S3, S4, S5, S6, S7, S8, S9), FASTA

>8IYJ_12 Tektin-3 (chains C0, C1, C2, C3, C4, C5, C6, S0, S1, S2, S3, S4, S5, S6, S7, S8, S9)
MELLGSTLTATYAHPPPASASFLPAIGTITSSYKDRFPHRNLTHSLSLPWRPNTYYKTAY
NYPTLAPYSSRSQRVCESTMLPFVSNRTTFFTRYTPDDWYRSNLVSFQESNSSRHNSERL
RVDTSRLIQDKYQQIRKTQAHSTQNLGERVNDLAFWKSEITHELDEMIGETNALTDIKRR
LERGLIETEGPLQVSRECLFHREKRMGIDLVHDEAEKELLAEVDTILCCQERMRQHLDKA
NAQLASDRSAQHELEKDLSDKQAALRIDDKCQHLRNTSEGVSYFRGVERVDATVSVPETW
AKFTDDNVLRSQSERAASAKLREETENLLIVTANEMWNQFNKVNLAFTNRIAETVDAKNK
IHTHLTKTLQEIFQIEMTIESIKKAIKEKSAFLKVAQTRLDERTRRPNVELCRDMAQLRL
VNEVYEVDETIQTLQQRLRDSEDTLQSLAHTKATLEHDLAVKANTLYIDQEKCMSMRNSY
PSTLRLVGYC

Ligands and cofactors

ID	Name	Formula	Copies
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	176
MG	Magnesium ion	Mg	178
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	178

Primary citation

Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou, L., Liu, H., Liu, S. et al. Cell (2023) 186:2897-2910.e19. DOI 10.1016/j.cell.2023.05.009 · PubMed

Other PDB entries of the same protein (UniProt Q9CQC3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9V10 3.7 Å, Cryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm
8I7R 6.5 Å, In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat
8TO0 7.7 Å, 48-nm repeating structure of doublets from mouse sperm flagella

Browse structure collections

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