8P4B: DNA-directed RNA polymerase II subunit RPB1

Name: PDB 8P4B: Structural insights into human co-transcriptional capping - structure 2
Published: 2023-08-16
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structural insights into human co-transcriptional capping - structure 2. Determined by electron microscopy at 3.2 Å resolution. Released 16 Aug 2023.

Method: Electron microscopy
Resolution: 3.2 Å
Organisms: Sus scrofa, unidentified, Homo sapiens
Chains: 16
Atoms: 35,383
Mol. weight: 611.92 kDa
Ligands: MG, ZN
Released: 16 Aug 2023

Explore 8P4B in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8P4B contains 185 α-helices and 246 β-strands across 13 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 72 helices, 68 β-strands

Element	Residues	Length	Sheet
β-strand	15	1	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	26-27	2
α-helix	28-34	7
β-strand	43	1	4
β-strand	47	1	5
β-strand	52	1	5
β-strand	56	1	4
β-strand	86-94	9	6
α-helix	100-109	10
α-helix	124-132	9
α-helix	137-148	12
β-strand	190-194	5	7
β-strand	197-201	5	7
β-strand	214-215	2	7
α-helix	218-226	9
α-helix	230-236	7
α-helix	245-247	3
β-strand	250-255	6	6
α-helix	256	1
β-strand	264	1	8
β-strand	272	1	8
α-helix	275-296	22
α-helix	302-318	17
α-helix	326-328	3
β-strand	329	1	9
α-helix	331-333	3
α-helix	334	1
β-strand	335	1	9
α-helix	336	1
α-helix	339-342	4
α-helix	349-353	5
β-strand	357-358	2	10
β-strand	362-369	8	11
β-strand	377-380	4	11
α-helix	382-385	4
β-strand	389-393	5	12
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	12
β-strand	426-428	3	12
β-strand	445-449	5	12
α-helix	450	1
β-strand	455-459	5	11
β-strand	469-476	8	11
β-strand	482-484	3	11
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	11
α-helix	509-518	10
β-strand	520	1	11
α-helix	521-524	4
β-strand	526	1	13
β-strand	533	1	13
α-helix	541-548	8
β-strand	554-555	2	14
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	15
α-helix	576-577	2
β-strand	579-581	3	16
β-strand	585	1	16
β-strand	586-587	2	14
α-helix	588-595	8
β-strand	602-603	2	17
α-helix	612-615	4
β-strand	629-630	2	17
β-strand	635-637	3	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	18
α-helix	689-692	4
α-helix	697-721	25
α-helix	725-728	4
α-helix	733-759	27
α-helix	765-770	6
α-helix	778-781	4
α-helix	782-786	5
β-strand	789-790	2	19
β-strand	793	1	20
β-strand	796	1	20
β-strand	822-823	2	19
α-helix	833-868	36
β-strand	872-873	2	21
β-strand	879-880	2	21
β-strand	886-888	3	21
α-helix	891-893	3
β-strand	896	1	22
β-strand	902-905	4	23
α-helix	913-920	8
α-helix	927-931	5
β-strand	934	1	24
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	23
α-helix	983-993	11
β-strand	1002	1	24
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1077	16
β-strand	1080	1	22
α-helix	1081-1082	2
α-helix	1087-1096	10
α-helix	1098-1100	3
α-helix	1121-1128	8
β-strand	1140-1142	3	25
β-strand	1143	1	26
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	27
α-helix	1166-1169	4
β-strand	1170-1177	8	28
α-helix	1189-1194	6
β-strand	1210-1216	7	28
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1245-1247	3	28
β-strand	1256-1259	4	28
α-helix	1283-1294	12
β-strand	1299	1	27
β-strand	1307-1310	4	25
β-strand	1319	1	29
β-strand	1331	1	29
β-strand	1335-1338	4	25
β-strand	1352	1	26
α-helix	1362-1368	7
α-helix	1371-1388	18
α-helix	1395-1404	10
α-helix	1426-1429	4
α-helix	1437-1445	9
β-strand	1448-1449	2	2
α-helix	1455-1459	5
β-strand	1472-1475	4	30
α-helix	1477-1480	4
β-strand	1484	1	31

Chain B: 52 helices, 78 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	84	1	32
β-strand	87-93	7	32
β-strand	97-98	2	33
β-strand	106-107	2	33
α-helix	108-109	2
α-helix	110-116	7
β-strand	121-133	13	32
β-strand	139-153	15	32
β-strand	155	1	34
α-helix	168-173	6
β-strand	185-187	3	34
β-strand	190-193	4	34
β-strand	196-200	5	35
α-helix	201	1
β-strand	206-208	3	36
β-strand	215-223	9	36
β-strand	233-240	8	36
β-strand	256-259	4	36
β-strand	263	1	37
β-strand	266-268	3	36
α-helix	269-276	8
α-helix	282-286	5
α-helix	295-305	11
α-helix	306-308	3
α-helix	314-323	10
β-strand	325	1	37
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-377	20
α-helix	382-384	3
β-strand	391-394	4	35
α-helix	396-423	28
α-helix	431-434	4
α-helix	437-450	14
β-strand	453	1	38
β-strand	463	1	38
β-strand	468-469	2	34
α-helix	470	1
α-helix	475-482	8
β-strand	484-486	3	35
α-helix	503-505	3
β-strand	523-525	3	35
β-strand	531-532	2	39
α-helix	539-545	7
β-strand	551-552	2	40
β-strand	565-569	5	40
β-strand	572-577	6	40
α-helix	584-593	10
β-strand	602-605	4	40
β-strand	612-615	4	40
β-strand	621-627	7	39
β-strand	628	1	41
β-strand	633	1	41
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	39
α-helix	667-671	5
β-strand	675-676	2	39
α-helix	679-682	4
β-strand	695-696	2	39
α-helix	700-703	4
α-helix	708-710	3
α-helix	714-716	3
β-strand	717	1	42
α-helix	719-728	10
β-strand	732	1	43
β-strand	748-751	4	44
β-strand	755	1	45
β-strand	759-760	2	46
α-helix	764-767	4
β-strand	776-782	7	47
β-strand	783	1	18
β-strand	794-797	4	47
α-helix	798-803	6
β-strand	808-817	10	44
β-strand	827-829	3	48
β-strand	837	1	48
β-strand	853	1	49
α-helix	854-855	2
β-strand	859	1	44
β-strand	865-867	3	49
β-strand	869-872	4	48
β-strand	889-891	3	48
α-helix	893	1
β-strand	894-895	2	49
α-helix	896-897	2
β-strand	903-911	9	44
β-strand	917-927	11	44
β-strand	934-936	3	50
β-strand	942-944	3	50
β-strand	945-949	5	47
β-strand	956	1	51
β-strand	965-967	3	47
α-helix	969-971	3
α-helix	972-975	4
β-strand	977	1	42
α-helix	978-993	16
α-helix	996	1
β-strand	997-998	2	46
α-helix	1008-1016	9
β-strand	1025-1026	2	47
β-strand	1029	1	51
α-helix	1035	1
β-strand	1036	1	51
α-helix	1037	1
α-helix	1040	1
β-strand	1041-1048	8	47
β-strand	1049-1050	2	50
β-strand	1051	1	43
β-strand	1060	1	11
β-strand	1067	1	52
β-strand	1074	1	52
α-helix	1075	1
β-strand	1085-1086	2	10
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1113-1119	7	1
β-strand	1125	1	1
β-strand	1127-1129	3	53
β-strand	1134-1136	3	53
β-strand	1146-1152	7	1
α-helix	1153-1164	12
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain C: 10 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	54
β-strand	18-24	7	54
α-helix	28-40	13
β-strand	44-55	12	55
α-helix	61-69	9
β-strand	74	1	56
α-helix	78-81	4
β-strand	99-106	8	55
α-helix	112	1
β-strand	113-116	4	57
α-helix	117-119	3
β-strand	121-122	2	55
β-strand	128	1	56
β-strand	149-153	5	57
β-strand	158-168	11	55
α-helix	174-176	3
β-strand	179-186	8	54
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	54
α-helix	241-270	30

Chain D: 9 helices, 1 β-strand

Element	Residues	Length	Sheet
α-helix	29	1
β-strand	30-31	2	30
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 12 helices, 10 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26-27	2	58
α-helix	30-33	4
α-helix	37-44	8
β-strand	61-64	4	58
β-strand	71-75	5	58
α-helix	85-96	12
β-strand	101-106	6	58
α-helix	109-111	3
α-helix	112-120	9
β-strand	128-131	4	58
α-helix	134-136	3
α-helix	139-141	3
β-strand	147-150	4	59
α-helix	151-152	2
α-helix	153-163	11
α-helix	167-169	3
β-strand	172-173	2	60
α-helix	178-183	6
β-strand	191-196	6	59
β-strand	202-207	6	59
β-strand	208-209	2	60

Chain F: 3 helices, 5 β-strands

Element	Residues	Length	Sheet
β-strand	56-57	2	61
α-helix	59-74	16
α-helix	77-78	2
β-strand	79	1	31
α-helix	89-99	11
β-strand	104-109	6	30
β-strand	115-119	5	30
β-strand	124-125	2	61

Chain G: 4 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	30
α-helix	15-17	3
α-helix	22-34	13
β-strand	38-39	2	30
β-strand	43-54	12	30
α-helix	56-57	2
β-strand	58-59	2	30
α-helix	60	1
β-strand	66-77	12	30
β-strand	83-92	10	69
β-strand	96-101	6	69
β-strand	104-109	6	69
β-strand	118-120	3	70
β-strand	127-129	3	70
β-strand	136-137	2	70
β-strand	142-153	12	69
β-strand	156-162	7	69
β-strand	170	1	69

Chain H: 0 helices, 14 β-strands

Element	Residues	Length	Sheet
β-strand	6-14	9	62
β-strand	25-32	8	62
β-strand	38-44	7	62
β-strand	55-61	7	62
β-strand	65	1	63
β-strand	74	1	15
β-strand	83	1	63
β-strand	90	1	62
β-strand	91-92	2	16
β-strand	93-101	9	62
β-strand	112-118	7	62
β-strand	121-126	6	62
β-strand	139-142	4	62
β-strand	145-148	4	62

5 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase II subunit RPB1	A	protein	1970	Sus scrofa	P11414 (AlphaFold model)
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa	I3LCH3 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7 (AlphaFold model)
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa	F1RKE4
RNA polymerase II subunit K	L	protein	58	Sus scrofa	A0A4X1TRS6
DNA (5'-d(papgpcpgpgpcpgpgpapgpcpcpapgpcpapgpgpgpapgpcptpg)-3')	N	DNA	24	unidentified
RNA (5'-r(pgpupapapcpcpgpgpapgpapgpgpgpapapcpcpcpapcpu)-3')	P	RNA	22	unidentified

4 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>8P4B_1 DNA-directed RNA polymerase II subunit RPB1 (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>8P4B_2 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>8P4B_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (E), FASTA

>8P4B_4 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 5 (F), FASTA

>8P4B_5 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 6 (H), FASTA

>8P4B_6 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 7 (I), FASTA

>8P4B_7 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 8 (J), FASTA

>8P4B_8 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 9 (K), FASTA

>8P4B_9 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 10 (L), FASTA

>8P4B_10 RNA polymerase II subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Sequence of entity 11 (N), FASTA

>8P4B_11 DNA (5'-D(P*AP*GP*CP*GP*GP*CP*GP*GP*AP*GP*CP*CP*AP*GP*CP*AP*GP*GP*GP*AP*GP*CP*TP*G)-3') (chains N)
AGCGGCGGAGCCAGCAGGGAGCTG

Sequence of entity 12 (P), FASTA

>8P4B_12 RNA (5'-R(P*GP*UP*AP*AP*CP*CP*GP*GP*AP*GP*AP*GP*GP*GP*AP*AP*CP*CP*CP*AP*CP*U)-3') (chains P)
GUAACCGGAGAGGGAACCCACU

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8

Primary citation

Structural insights into human co-transcriptional capping. Garg, G., Dienemann, C., Farnung, L. et al. Mol Cell (2023) 83:2464-2477.e5. DOI 10.1016/j.molcel.2023.06.002 · PubMed

Other PDB entries of the same protein (UniProt P11414 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7OO3 2.8 Å, Pol II-CSB-CSA-DDB1-UVSSA (Structure1)
8OEW 2.8 Å, Structure of the mammalian Pol II-Elongin complex, lacking the ELOA latch (composite…
8OEV 2.86 Å, Structure of the mammalian Pol II-SPT6-Elongin complex, lacking ELOA latch (composite…
7OOP 2.9 Å, Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3)
7OPD 3.0 Å, Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 5)
8OEU 3.04 Å, Structure of the mammalian Pol II-SPT6 complex (composite structure, Structure 4)
8OF0 3.05 Å, Structure of the mammalian Pol II-SPT6-Elongin complex, Structure 1
7B0Y 3.6 Å, Structure of a transcribing RNA polymerase II-U1 snRNP complex
8P4D 3.6 Å, Structural insights into human co-transcriptional capping - structure 4
8P4C 3.8 Å, Structural insights into human co-transcriptional capping - structure 3
8P4E 3.9 Å, Structural insights into human co-transcriptional capping - structure 5
8P4F 4.0 Å, Structural insights into human co-transcriptional capping - structure 6

Browse structure collections

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