Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297. Determined by electron microscopy at 2.1 Å resolution. Released 20 Mar 2024.
Explore 8P7L in 3D Show helices and sheets RCSB PDB PDBe
8P7L contains 17 α-helices and 11 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 280-285 | 6 | |
| α-helix | 290-295 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 12-20 | 9 | 1 |
| β-strand | 24-31 | 8 | 1 |
| β-strand | 36-43 | 8 | 1 |
| α-helix | 57-66 | 10 | |
| β-strand | 74 | 1 | 2 |
| α-helix | 75-76 | 2 | |
| β-strand | 77-83 | 7 | 1 |
| β-strand | 86-92 | 7 | 1 |
| β-strand | 96-97 | 2 | 2 |
| α-helix | 98-103 | 6 | |
| α-helix | 111-130 | 20 | |
| β-strand | 133-134 | 2 | 3 |
| α-helix | 140-142 | 3 | |
| β-strand | 143-145 | 3 | 2 |
| β-strand | 152-153 | 2 | 2 |
| β-strand | 160-161 | 2 | 3 |
| α-helix | 181-184 | 4 | |
| α-helix | 193-208 | 16 | |
| α-helix | 218-229 | 12 | |
| α-helix | 240-242 | 3 | |
| α-helix | 257-260 | 4 | |
| α-helix | 266-275 | 10 | |
| α-helix | 286-290 | 5 | |
| α-helix | 293-296 | 4 | |
| α-helix | 300-303 | 4 | |
| α-helix | 304-306 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| CDK-activating kinase assembly factor MAT1 | H | protein | 328 | Homo sapiens | P51948 (AlphaFold model) |
| Cyclin-dependent kinase 7 | J | protein | 379 | Homo sapiens | P50613 (AlphaFold model) |
>8P7L_1 CDK-activating kinase assembly factor MAT1 (chains H) MGSSHHHHHHENLYFQSNAMDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVR GAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEE VEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQR RLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPV TFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQ DLAGGYTSSLACHRALQDAFSGLFWQPS
>8P7L_2 Cyclin-dependent kinase 7 (chains J) SNAYSPTSPSYAPTAPAYSPTSPSGGSGSGSSGMALDVKSRAKRYEKLDFLGEGQFATVY KARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNI SLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDE NGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELL LRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDD LLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAI KRKRTEALEQGGLPKKLIF
| ID | Name | Formula | Copies |
|---|---|---|---|
| WD9 | 2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazo… | C23 H28 N8 O | 1 |
High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Cushing, V.I., Koh, A.F., Feng, J. et al. Nat Commun (2024) 15:2265-2265. DOI 10.1038/s41467-024-46375-9 · PubMed
Other PDB entries of the same protein (UniProt P51948 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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