8S0F: H. sapiens OC1M
H. sapiens OC1M bound to double stranded DNA. Determined by electron microscopy at 4.1 Å resolution. Released 2 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 4.1 Å
- Organisms
- Homo sapiens, synthetic construct
- Chains
- 14
- Atoms
- 40,819
- Mol. weight
- 980.88 kDa
- Ligands
- AGS, ZN, MG
- Released
- 2 Oct 2024
Explore 8S0F in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8S0F contains 267 α-helices and 157 β-strands across 12 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain 2: 32 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 189-205 | 17 | |
| α-helix | 214-225 | 12 | |
| β-strand | 229-233 | 5 | 7 |
| α-helix | 234-240 | 7 | |
| α-helix | 242-250 | 9 | |
| α-helix | 252-270 | 19 | |
| α-helix | 272-275 | 4 | |
| β-strand | 282-286 | 5 | 7 |
| β-strand | 291 | 1 | 8 |
| α-helix | 294-296 | 3 | |
| α-helix | 299-301 | 3 | |
| β-strand | 305-315 | 11 | 8 |
| β-strand | 319-320 | 2 | 8 |
| β-strand | 372-379 | 8 | 8 |
| α-helix | 386 | 1 | |
| α-helix | 390-392 | 3 | |
| β-strand | 393-399 | 7 | 8 |
| α-helix | 400-402 | 3 | |
| β-strand | 411-422 | 12 | 8 |
| α-helix | 424-430 | 7 | |
| β-strand | 435-446 | 12 | 8 |
| α-helix | 450-455 | 6 | |
| α-helix | 458-468 | 11 | |
| α-helix | 473-479 | 7 | |
| α-helix | 489-500 | 12 | |
| β-strand | 505 | 1 | 9 |
| α-helix | 507-509 | 3 | |
| β-strand | 513 | 1 | 9 |
| β-strand | 519-523 | 5 | 10 |
| α-helix | 529-539 | 11 | |
| β-strand | 543-546 | 4 | 10 |
| β-strand | 551 | 1 | 11 |
| α-helix | 553-556 | 4 | |
| β-strand | 559-562 | 4 | 12 |
| β-strand | 569-572 | 4 | 12 |
| α-helix | 575-578 | 4 | |
| β-strand | 583-586 | 4 | 10 |
| α-helix | 589-591 | 3 | |
| α-helix | 594-606 | 13 | |
| β-strand | 608-613 | 6 | 13 |
| β-strand | 616-621 | 6 | 13 |
| β-strand | 625-630 | 6 | 10 |
| α-helix | 643-646 | 4 | |
| α-helix | 651-656 | 6 | |
| β-strand | 659-663 | 5 | 10 |
| α-helix | 669-685 | 17 | |
| α-helix | 713-716 | 4 | |
| α-helix | 717-730 | 14 | |
| β-strand | 734 | 1 | 14 |
| α-helix | 740-755 | 16 | |
| α-helix | 764-780 | 17 | |
| β-strand | 785 | 1 | 14 |
| α-helix | 788-804 | 17 | |
| α-helix | 808-817 | 10 | |
| α-helix | 819-822 | 4 | |
Chain 3: 20 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 282-290 | 9 | |
| α-helix | 294-301 | 8 | |
| α-helix | 311-322 | 12 | |
| β-strand | 327-328 | 2 | 36 |
| β-strand | 334-335 | 2 | 36 |
| β-strand | 340-345 | 6 | 37 |
| α-helix | 352-361 | 10 | |
| β-strand | 365-367 | 3 | 37 |
| α-helix | 375-378 | 4 | |
| β-strand | 381-384 | 4 | 38 |
| β-strand | 391-394 | 4 | 38 |
| α-helix | 397-400 | 4 | |
| β-strand | 405-409 | 5 | 37 |
| α-helix | 411-413 | 3 | |
| α-helix | 416-428 | 13 | |
| β-strand | 430-435 | 6 | 39 |
| β-strand | 438-443 | 6 | 39 |
| β-strand | 447-452 | 6 | 37 |
| α-helix | 465-469 | 5 | |
| α-helix | 473-478 | 6 | |
| β-strand | 481-485 | 5 | 37 |
| α-helix | 491-506 | 16 | |
| β-strand | 545 | 1 | 40 |
| α-helix | 546-548 | 3 | |
| α-helix | 556-559 | 4 | |
| α-helix | 562 | 1 | |
| β-strand | 563 | 1 | 40 |
| α-helix | 564 | 1 | |
| α-helix | 565-577 | 13 | |
| β-strand | 581 | 1 | 41 |
| α-helix | 584-599 | 16 | |
| α-helix | 600-603 | 4 | |
| β-strand | 608-609 | 2 | 42 |
| α-helix | 615-631 | 17 | |
| β-strand | 636 | 1 | 41 |
| α-helix | 639-653 | 15 | |
| β-strand | 654-655 | 2 | 42 |
Chain 4: 20 helices, 23 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 192-203 | 12 | |
| β-strand | 207-211 | 5 | 15 |
| α-helix | 212-218 | 7 | |
| α-helix | 220-228 | 9 | |
| α-helix | 230-248 | 19 | |
| β-strand | 259-263 | 5 | 15 |
| α-helix | 271-273 | 3 | |
| α-helix | 276-278 | 3 | |
| β-strand | 282-292 | 11 | 16 |
| β-strand | 296-306 | 11 | 16 |
| β-strand | 312-316 | 5 | 16 |
| β-strand | 318 | 1 | 17 |
| β-strand | 321 | 1 | 17 |
| β-strand | 337-339 | 3 | 16 |
| β-strand | 345-354 | 10 | 16 |
| β-strand | 370-375 | 6 | 16 |
| α-helix | 376-378 | 3 | |
| β-strand | 387-395 | 9 | 16 |
| β-strand | 415-422 | 8 | 16 |
| α-helix | 443-453 | 11 | |
| α-helix | 458-465 | 8 | |
| α-helix | 474-485 | 12 | |
| β-strand | 506-510 | 5 | 18 |
| α-helix | 516-526 | 11 | |
| β-strand | 531-534 | 4 | 18 |
| β-strand | 546-549 | 4 | 19 |
| β-strand | 556-559 | 4 | 19 |
| α-helix | 562-565 | 4 | |
| β-strand | 570-574 | 5 | 18 |
| α-helix | 581-593 | 13 | |
| β-strand | 595-600 | 6 | 20 |
| β-strand | 603-608 | 6 | 20 |
| β-strand | 612-617 | 6 | 18 |
| α-helix | 631-634 | 4 | |
| α-helix | 638-643 | 6 | |
| β-strand | 646-650 | 5 | 18 |
| α-helix | 656-668 | 13 | |
| α-helix | 681-697 | 17 | |
| β-strand | 701 | 1 | 21 |
| α-helix | 704-720 | 17 | |
| α-helix | 731-747 | 17 | |
| β-strand | 752 | 1 | 21 |
| α-helix | 755-770 | 16 | |
Chain 5: 13 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 317-326 | 10 | |
| α-helix | 331-338 | 8 | |
| α-helix | 347-358 | 12 | |
| β-strand | 363-364 | 2 | 2 |
| β-strand | 370-371 | 2 | 2 |
| β-strand | 376-381 | 6 | 3 |
| α-helix | 388-397 | 10 | |
| β-strand | 401-404 | 4 | 3 |
| β-strand | 441-444 | 4 | 3 |
| β-strand | 483-488 | 6 | 3 |
| α-helix | 508-511 | 4 | |
| β-strand | 516-520 | 5 | 3 |
| α-helix | 526-543 | 18 | |
| α-helix | 553-555 | 3 | |
| α-helix | 556-569 | 14 | |
| β-strand | 573 | 1 | 4 |
| α-helix | 576-600 | 25 | |
| α-helix | 610-626 | 17 | |
| β-strand | 631 | 1 | 4 |
| α-helix | 634-644 | 11 | |
| α-helix | 645-649 | 5 | |
| α-helix | 650-651 | 2 | |
Chain 6: 33 helices, 30 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-36 | 16 | |
| α-helix | 46-52 | 7 | |
| β-strand | 60-64 | 5 | 22 |
| α-helix | 65-71 | 7 | |
| α-helix | 73-81 | 9 | |
| α-helix | 83-99 | 17 | |
| β-strand | 111-115 | 5 | 22 |
| β-strand | 120-121 | 2 | 23 |
| α-helix | 123-125 | 3 | |
| α-helix | 128-130 | 3 | |
| β-strand | 135-144 | 10 | 23 |
| β-strand | 148-157 | 10 | 23 |
| β-strand | 164-169 | 6 | 23 |
| β-strand | 199-209 | 11 | 23 |
| α-helix | 215-216 | 2 | |
| β-strand | 223-229 | 7 | 23 |
| α-helix | 230-232 | 3 | |
| β-strand | 241-251 | 11 | 23 |
| β-strand | 295-304 | 10 | 23 |
| α-helix | 331-341 | 11 | |
| α-helix | 346-354 | 9 | |
| α-helix | 362-373 | 12 | |
| β-strand | 378-379 | 2 | 24 |
| α-helix | 384 | 1 | |
| β-strand | 385-386 | 2 | 24 |
| α-helix | 387 | 1 | |
| β-strand | 392-396 | 5 | 25 |
| α-helix | 403-412 | 10 | |
| β-strand | 416-420 | 5 | 25 |
| β-strand | 424 | 1 | 20 |
| α-helix | 426-429 | 4 | |
| β-strand | 431-436 | 6 | 26 |
| β-strand | 441-446 | 6 | 26 |
| α-helix | 448-451 | 4 | |
| β-strand | 455-460 | 6 | 25 |
| α-helix | 467-478 | 12 | |
| β-strand | 481-486 | 6 | 11 |
| β-strand | 489-494 | 6 | 11 |
| β-strand | 497-503 | 7 | 25 |
| α-helix | 516-519 | 4 | |
| α-helix | 524-528 | 5 | |
| β-strand | 532-536 | 5 | 25 |
| α-helix | 542-557 | 16 | |
| α-helix | 569-580 | 12 | |
| α-helix | 584 | 1 | |
| β-strand | 585-586 | 2 | 27 |
| α-helix | 587 | 1 | |
| α-helix | 588-602 | 15 | |
| α-helix | 618-634 | 17 | |
| β-strand | 639-640 | 2 | 27 |
| α-helix | 642-654 | 13 | |
| β-strand | 656-657 | 2 | 25 |
| α-helix | 661-663 | 3 | |
| β-strand | 664 | 1 | 28 |
| β-strand | 715 | 1 | 28 |
| α-helix | 717-735 | 19 | |
| β-strand | 744 | 1 | 29 |
| α-helix | 745-755 | 11 | |
| α-helix | 756-758 | 3 | |
| α-helix | 763-779 | 17 | |
| α-helix | 780-784 | 5 | |
| β-strand | 787-790 | 4 | 29 |
| β-strand | 810-813 | 4 | 29 |
Chain 7: 18 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 321-327 | 7 | |
| α-helix | 332-339 | 8 | |
| α-helix | 348-359 | 12 | |
| α-helix | 366-368 | 3 | |
| β-strand | 377-381 | 5 | 30 |
| α-helix | 387-397 | 11 | |
| β-strand | 401-405 | 5 | 30 |
| β-strand | 440-445 | 6 | 30 |
| α-helix | 447-449 | 3 | |
| α-helix | 452-464 | 13 | |
| β-strand | 466 | 1 | 31 |
| β-strand | 479 | 1 | 31 |
| β-strand | 482-488 | 7 | 30 |
| α-helix | 501-505 | 5 | |
| α-helix | 509-514 | 6 | |
| β-strand | 517-521 | 5 | 30 |
| α-helix | 527-543 | 17 | |
| α-helix | 552-555 | 4 | |
| α-helix | 556-567 | 12 | |
| β-strand | 572 | 1 | 32 |
| α-helix | 578-594 | 17 | |
| α-helix | 603-619 | 17 | |
| β-strand | 624 | 1 | 32 |
| α-helix | 627-642 | 16 | |
| α-helix | 657-666 | 10 | |
| β-strand | 674-676 | 3 | 33 |
| α-helix | 677-686 | 10 | |
| α-helix | 691-703 | 13 | |
| β-strand | 708-709 | 2 | 33 |
| β-strand | 715-717 | 3 | 33 |
Chain 8: 13 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 188-208 | 21 | |
| β-strand | 215 | 1 | 5 |
| α-helix | 216-227 | 12 | |
| α-helix | 233-242 | 10 | |
| α-helix | 244-246 | 3 | |
| β-strand | 247-252 | 6 | 5 |
| β-strand | 268-273 | 6 | 5 |
| α-helix | 276-278 | 3 | |
| α-helix | 283-284 | 2 | |
| α-helix | 288-307 | 20 | |
| α-helix | 343-346 | 4 | |
| α-helix | 420-437 | 18 | |
| α-helix | 442-468 | 27 | |
| β-strand | 472-474 | 3 | 6 |
| α-helix | 475-485 | 11 | |
| α-helix | 492-505 | 14 | |
| β-strand | 510-515 | 6 | 6 |
| β-strand | 518-523 | 6 | 6 |
| α-helix | 529-543 | 15 | |
Chain A: 25 helices, 7 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 487-494 | 8 | |
| α-helix | 505-507 | 3 | |
| α-helix | 508-523 | 16 | |
| β-strand | 528-534 | 7 | 43 |
| α-helix | 540-556 | 17 | |
| β-strand | 563-569 | 7 | 43 |
| α-helix | 570-572 | 3 | |
| α-helix | 579-587 | 9 | |
| α-helix | 594-606 | 13 | |
| α-helix | 613 | 1 | |
| β-strand | 614-620 | 7 | 43 |
| α-helix | 622-625 | 4 | |
| α-helix | 631-638 | 8 | |
| α-helix | 639-641 | 3 | |
| α-helix | 643-645 | 3 | |
| β-strand | 647-653 | 7 | 43 |
| α-helix | 658-662 | 5 | |
| α-helix | 665-671 | 7 | |
| β-strand | 675-678 | 4 | 43 |
| α-helix | 679-682 | 4 | |
| α-helix | 683-693 | 11 | |
| α-helix | 702-715 | 14 | |
| α-helix | 719-734 | 16 | |
| α-helix | 748-758 | 11 | |
| α-helix | 763-768 | 6 | |
| α-helix | 772-788 | 17 | |
| β-strand | 793 | 1 | 44 |
| α-helix | 795-809 | 15 | |
| α-helix | 811-815 | 5 | |
| α-helix | 816-828 | 13 | |
| β-strand | 845 | 1 | 44 |
| α-helix | 851-859 | 9 | |
4 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Origin recognition complex subunit 2 | B | protein | 577 | Homo sapiens | Q13416 (AlphaFold model) |
| DNA (39-mer) | X | DNA | 39 | synthetic construct | |
| DNA (39-mer) | Y | DNA | 39 | synthetic construct | |
| DNA replication licensing factor MCM5 | 5 | protein | 734 | Homo sapiens | P33992 (AlphaFold model) |
| DNA replication factor Cdt1 | 8 | protein | 546 | Homo sapiens | Q9H211 (AlphaFold model) |
| DNA replication licensing factor MCM2 | 2 | protein | 904 | Homo sapiens | P49736 (AlphaFold model) |
| DNA replication licensing factor MCM4 | 4 | protein | 863 | Homo sapiens | P33991 |
| DNA replication licensing factor MCM6 | 6 | protein | 821 | Homo sapiens | Q14566 |
| DNA replication licensing factor MCM7 | 7 | protein | 719 | Homo sapiens | P33993 |
| Origin recognition complex subunit 3 | C | protein | 711 | Homo sapiens | Q9UBD5 |
| DNA replication licensing factor MCM3 | 3 | protein | 810 | Homo sapiens | P25205 |
| Origin recognition complex subunit 1 | A | protein | 861 | Homo sapiens | Q13415 |
2 more molecules are not listed.
Sequence of entity 1 (B), FASTA
>8S0F_1 Origin recognition complex subunit 2 (chains B)
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED
DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS
VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE
SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV
EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK
WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL
DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL
IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV
LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR
DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
Sequence of entity 2 (X), FASTA
>8S0F_2 DNA (39-mer) (chains X)
GCATGCATGCATGCTGCATGCATGCATGCGCATGCATGC
Sequence of entity 3 (Y), FASTA
>8S0F_3 DNA (39-mer) (chains Y)
GCATGCATGCGCATGCATGCATGCAGCATGCATGCATGC
Sequence of entity 4 (5), FASTA
>8S0F_4 DNA replication licensing factor MCM5 (chains 5)
MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELK
RHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEV
LQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLT
NIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGE
MPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQ
VDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGG
SRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMR
DPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNS
RCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLH
VSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDS
DRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGV
EGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGE
IQHRMQRKVLYRLK
Sequence of entity 5 (8), FASTA
>8S0F_5 DNA replication factor Cdt1 (chains 8)
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRD
QARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTI
SELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPG
LPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIK
TVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQ
KLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTA
QEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQ
DLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACA
RMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQT
RAEEGL
Sequence of entity 6 (2), FASTA
>8S0F_6 DNA replication licensing factor MCM2 (chains 2)
MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTE
GPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQR
DREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGH
SVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAR
EHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQL
HLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGP
FEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHN
NYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFAS
IAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVS
SRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSI
HEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDIL
CVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVL
KKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARI
HLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLV
AEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMI
LQQF
Sequence of entity 7 (4), FASTA
>8S0F_7 DNA replication licensing factor MCM4 (chains 4)
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGS
AQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKE
EENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMA
VNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQ
EAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPED
MPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIH
YRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGI
LLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSA
VGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAK
AGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDR
RLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKI
GSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGI
VDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMF
EEALRALADDDFLTVTGKTVRLL
Sequence of entity 8 (6), FASTA
>8S0F_8 DNA replication licensing factor MCM6 (chains 6)
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNT
LVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTR
HKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNIC
RNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGD
KCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLA
CCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHG
NDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTS
GKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQ
TISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDEC
NEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKH
LRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVE
TPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEY
CRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRL
THYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED
Sequence of entity 9 (7), FASTA
>8S0F_9 DNA replication licensing factor MCM7 (chains 7)
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDP
ELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVR
SPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVA
TYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEH
SDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEA
HRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVG
GVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLR
DSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNA
RCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYV
HQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATY
TSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADV
IFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
Sequence of entity 10 (C), FASTA
>8S0F_10 Origin recognition complex subunit 3 (chains C)
MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENER
LQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGS
LTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYS
MDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQH
LHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPF
KINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSN
NQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLH
KFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFK
SYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKELR
RSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALH
TALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAE
KMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC
Sequence of entity 11 (3), FASTA
>8S0F_11 DNA replication licensing factor MCM3 (chains 3)
GEMAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKN
EKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTS
CFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKD
EENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVV
GTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQ
LAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYV
LCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMD
RTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSR
FDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQED
QQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLR
SQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVL
EKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMP
QVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEE
PFSSVEIQAALSKMQDDNQVMVSEGIIFLI
Sequence of entity 12 (A), FASTA
>8S0F_12 Origin recognition complex subunit 1 (chains A)
MAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTEIHIQIGQFVLIEGDDD
ENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHLLGRKPGAQEIFWYDYPAC
DSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSWNEKKFRPLSSELFAELNKPQ
ESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSASKSRQTPTHPLTPRARKRLELG
NLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSKRSQPDKLQTLSPALKAPEKTRETG
LSYTEDDKKASPEHRIILRTRIAASKTIDIREERTLTPISGGQRSSVVPSVILKPENIKK
RDAKEAKAQNEATSTPHRIRRKSSVLTMNRIRQQLRFLGNSKSDQEEKEILPAAEISDSS
SDEEEASTPPLPRRAPRTVSRNLRSSLKSSLHTLTKVPKKSLKPRTPRCAAPQIRSRSLA
AQEPASVLEEARLRLHVSAVPESLPCREQEFQDIYNFVESKLLDHTGGCMYISGVPGTGK
TATVHEVIRCLQQAAQANDVPPFQYIEVNGMKLTEPHQVYVQILQKLTGQKATANHAAEL
LAKQFCTRGSPQETTVLLVDELDLLWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPE
RIMMNRVSSRLGLTRMCFQPYTYSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDAR
RCLDICRRATEICEFSQQKPDSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRA
ILAEFRRSGLEEATFQQIYSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRND
LLLRVRLNVSQDDVLYALKDE
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| AGS | Phosphothiophosphoric acid-adenylate ester | C10 H16 N5 O12 P3 S | 5 |
| ZN | Zinc ion | Zn | 1 |
| MG | Magnesium ion | Mg | 5 |
Primary citation
MCM double hexamer loading visualized with human proteins. Weissmann, F., Greiwe, J.F., Puhringer, T. et al. Nature (2024) 636:499-508. DOI 10.1038/s41586-024-08263-6 · PubMed
Other PDB entries of the same protein (UniProt Q13416 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5C8H 2.01 Å, Crystal structure of ORC2 C-terminal domain
- 11RL 2.8 Å, CryoEM structure of the human origin recognition complex with DNA and CDC6 protein
- 7JPO 3.2 Å, ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH
- 7JPQ 3.5 Å, ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5
- 8S0D 3.6 Å, H. sapiens MCM bound to double stranded DNA and ORC1-6
- 7JPP 3.7 Å, ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain
- 7CTE 3.8 Å, Human Origin Recognition Complex, ORC2-5
- 8S0E 3.8 Å, H. sapiens OCCM bound to double stranded DNA
- 7JPR 4.0 Å, ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation
- 8S0C 4.0 Å, H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
- 7JPS 4.4 Å, ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core
- 7CTF 4.8 Å, Human origin recognition complex 1-5 State II
Browse structure collections
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