8SUP: PDB entry 8SUP
Structure of the 48S translation initiation complex assembled on the encephalomyocarditis virus IRES. Determined by electron microscopy at 3.1 Å resolution. Released 18 Mar 2026.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organisms
- Oryctolagus cuniculus, Encephalomyocarditis virus, Homo sapiens
- Chains
- 47
- Atoms
- 106,317
- Mol. weight
- 1893.88 kDa
- Ligands
- ZN
- Released
- 18 Mar 2026
Explore 8SUP in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8SUP contains 393 α-helices and 271 β-strands across 44 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 5 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 47 | 1 | 34 |
| β-strand | 50 | 1 | 12 |
| α-helix | 52-61 | 10 | |
| α-helix | 62-64 | 3 | |
| β-strand | 68 | 1 | 35 |
| α-helix | 70-76 | 7 | |
| β-strand | 79 | 1 | 34 |
| α-helix | 81-94 | 14 | |
| β-strand | 97-101 | 5 | 35 |
| β-strand | 108-111 | 4 | 35 |
| α-helix | 112-113 | 2 | |
Chain A: 2 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 35-42 | 8 | 33 |
| β-strand | 46-50 | 5 | 33 |
| β-strand | 57-60 | 4 | 33 |
| α-helix | 64-67 | 4 | |
| β-strand | 76-78 | 3 | 33 |
| β-strand | 80-81 | 2 | 33 |
| β-strand | 88-90 | 3 | 33 |
| α-helix | 98-106 | 9 | |
Chain b: 5 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 20-22 | 3 | 38 |
| β-strand | 29-31 | 3 | 38 |
| β-strand | 36-43 | 8 | 39 |
| α-helix | 50-56 | 7 | |
| β-strand | 57 | 1 | 83 |
| α-helix | 62-65 | 4 | |
| β-strand | 66-73 | 8 | 39 |
| α-helix | 75-80 | 6 | |
| α-helix | 91-93 | 3 | |
| α-helix | 97-99 | 3 | |
Chain B: 13 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-8 | 3 | |
| α-helix | 13-21 | 9 | |
| β-strand | 25 | 1 | 36 |
| α-helix | 32-34 | 3 | |
| β-strand | 38-42 | 5 | 36 |
| β-strand | 46-49 | 4 | 36 |
| α-helix | 51-66 | 16 | |
| α-helix | 71-73 | 3 | |
| β-strand | 74-78 | 5 | 37 |
| α-helix | 81-83 | 3 | |
| α-helix | 84-94 | 11 | |
| α-helix | 96 | 1 | |
| β-strand | 97-100 | 4 | 37 |
| α-helix | 103-104 | 2 | |
| β-strand | 121-124 | 4 | 37 |
| α-helix | 131-139 | 9 | |
| β-strand | 144-149 | 6 | 37 |
| β-strand | 159-163 | 5 | 37 |
| α-helix | 168-186 | 19 | |
| α-helix | 204-206 | 3 | |
| α-helix | 207-216 | 10 | |
Chain c: 2 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 12-17 | 6 | |
| β-strand | 32-36 | 5 | 43 |
| β-strand | 43-47 | 5 | 43 |
| β-strand | 55 | 1 | 44 |
| β-strand | 62 | 1 | 44 |
| β-strand | 64-65 | 2 | 45 |
| β-strand | 72-73 | 2 | 45 |
| α-helix | 74 | 1 | |
| β-strand | 78 | 1 | 43 |
| β-strand | 81 | 1 | 43 |
Chain C: 9 helices, 13 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 24-27 | 4 | |
| β-strand | 28-34 | 7 | 40 |
| β-strand | 43-50 | 8 | 40 |
| α-helix | 51-52 | 2 | |
| β-strand | 53 | 1 | 41 |
| β-strand | 56 | 1 | 41 |
| α-helix | 58-63 | 6 | |
| β-strand | 66-70 | 5 | 40 |
| α-helix | 71-74 | 4 | |
| β-strand | 82-91 | 10 | 40 |
| β-strand | 95-105 | 11 | 40 |
| α-helix | 107-113 | 7 | |
| β-strand | 120-128 | 9 | 40 |
| β-strand | 134-142 | 9 | 40 |
| β-strand | 143 | 1 | 42 |
| α-helix | 158-177 | 20 | |
| α-helix | 181-188 | 8 | |
| α-helix | 192-199 | 8 | |
| β-strand | 207 | 1 | 42 |
| β-strand | 211 | 1 | 40 |
| β-strand | 215-219 | 5 | 40 |
| α-helix | 225-232 | 8 | |
Chain d: 1 helix, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 10-21 | 12 | 50 |
| β-strand | 27-34 | 8 | 50 |
| β-strand | 41-47 | 7 | 50 |
| β-strand | 55-58 | 4 | 50 |
| α-helix | 63-65 | 3 | |
Chain D: 9 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 65-71 | 7 | |
| α-helix | 78-84 | 7 | |
| α-helix | 91-97 | 7 | |
| β-strand | 103-115 | 13 | 46 |
| β-strand | 120-131 | 12 | 46 |
| β-strand | 137 | 1 | 47 |
| β-strand | 140-144 | 5 | 46 |
| α-helix | 147-160 | 14 | |
| β-strand | 163 | 1 | 47 |
| β-strand | 168 | 1 | 48 |
| β-strand | 179 | 1 | 48 |
| β-strand | 184-188 | 5 | 49 |
| β-strand | 191-196 | 6 | 49 |
| β-strand | 204-205 | 2 | 49 |
| α-helix | 208-215 | 8 | |
| β-strand | 222-227 | 6 | 49 |
| α-helix | 233-245 | 13 | |
| α-helix | 253-255 | 3 | |
| α-helix | 265-268 | 4 | |
| α-helix | 270-276 | 7 | |
36 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Eukaryotic translation initiation factor 3 subunit A | o | protein | 1362 | Oryctolagus cuniculus | G1SMZ5 |
| Eukaryotic translation initiation factor 3 subunit C | p | protein | 843 | Oryctolagus cuniculus | A0A5F9CMJ3 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit E | q | protein | 445 | Oryctolagus cuniculus | G1SUC8 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit F | r | protein | 364 | Oryctolagus cuniculus | G1SLC2 (AlphaFold model) |
| Eukaryotic translation initiation factor 3 subunit H | s | protein | 352 | Oryctolagus cuniculus | G1ST95 |
| Eukaryotic translation initiation factor 3 subunit K | t | protein | 218 | Oryctolagus cuniculus | G1T3L2 |
| Eukaryotic translation initiation factor 3 subunit L | u | protein | 564 | Oryctolagus cuniculus | G1SED9 |
| Eukaryotic translation initiation factor 3 subunit M | v | protein | 374 | Oryctolagus cuniculus | G1SLW8 |
| 18S rRNA | 2 | RNA | 1870 | Oryctolagus cuniculus | |
| Emcv mRNA | 3 | RNA | 89 | Encephalomyocarditis virus | |
| Eukaryotic translation initiation factor 1A, X-chromosomal | A | protein | 144 | Homo sapiens | P47813 |
| uS2 (SA) | B | protein | 295 | Oryctolagus cuniculus | G1TLT8 |
35 more molecules are not listed.
Sequence of entity 1 (o), FASTA
>8SUP_1 Eukaryotic translation initiation factor 3 subunit A (chains o)
MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVD
LRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKLAEEKTEAAKEESQQMVLDIEDLDN
IQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQ
AFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSA
ISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLY
HLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLG
LQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEK
EPELQQYVPQLQSNTILRLLQQVAQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDL
QVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPA
HILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAE
LQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIED
LEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIK
DMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFE
ERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEE
LREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGEDPLSRRDSRWGDRDSEGTWR
KGPEADSEWRRGPPEKEWRRGEGRDDERSHRRDEERPRRVGDDEDRESSLRPDDDRTLRR
GMEDDRGPRRGPDEERFSRRGLEDERPSWRSTDDDRPPRRIGEEDRGSWRHAEDDRPPRR
GLDDDRGSWRTADEDRGPRRMMDEDRGPRRGGADDERPSWRSADDDRGPRRGIDDDRGPR
RGLDDDRGPWRNADDDRIPRRGADDDRGPWRNMDDDRMSRRADDDRISRRGEDSRPGPWR
PFVKPGGWREKEKAREESWGPPRESRPPEEREWERERDRDNPDREENDKDPERERDRERD
GDREERFRRPRDEGGWRRGPAEEASSWRDSSRRDDRDRDDRRRERDDRRDLRDRRDLRDD
RDRRGPPLRSERDEVSSWRRADDRKDDRAEERDPPRRVPPPVLSRDRDRDRDRDRDRDRE
REREREREGEKEKTSWRAEKDRESLRRTKNETDEDGWTTVRR
Sequence of entity 2 (p), FASTA
>8SUP_2 Eukaryotic translation initiation factor 3 subunit C (chains p)
MKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKM
NKNNAKALSTLRQKIRKYNRDFESHITNYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDG
VSAAAFLKKKAEAPSGESRKFLKKMEDEDEDSEDSEDDEEWDTGSTSSDSDSEEEEGKQT
ALASRFLKKAPTTEEDKKAAEKKREDKAKKKHDRKSKRLDEEEEDNEGGEWERVRGGVPL
VKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIASENNLGEGV
IVKIKFNIIASLYDYNPNLATYMKPEMWQKCLDCINELMDILFANPNIFVGENILEESEN
LQNVDQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYL
EEKGTTEEICRVYLRRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMER
LCKYIYAKDRTDRIRTCAILCHIYHHYLHSRWYQARDLMLMSHLQDNIQHADPPVQILYN
RTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQ
VPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPP
ESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRT
YLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPT
AQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQ
TAY
Sequence of entity 3 (q), FASTA
>8SUP_3 Eukaryotic translation initiation factor 3 subunit E (chains q)
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKN
LYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADK
HGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQ
NWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQP
QYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLY
VNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKL
NMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAM
NIEKKLNQNSRSEAPNWATQDSGFY
Sequence of entity 4 (r), FASTA
>8SUP_4 Eukaryotic translation initiation factor 3 subunit F (chains r)
MATPAVSASAPPATPAATPAAAAAPASAPAAAPAPTPAPAPAAAPAAGAAPAAAADPAAA
AAAAGTGQTPASAQAPAQTSAPSLPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGA
ARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWY
ATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTSMGVPGRTMGVMFT
PLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDV
LSGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEK
LVNL
Sequence of entity 5 (s), FASTA
>8SUP_5 Eukaryotic translation initiation factor 3 subunit H (chains s)
MASRKEGTGSGGTSSSSATGVVGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGT
EVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWY
QSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEK
DFSPEALKKANITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLG
KNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEED
LSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
Sequence of entity 6 (t), FASTA
>8SUP_6 Eukaryotic translation initiation factor 3 subunit K (chains t)
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAF
FQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQA
LDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDSQLKMWMSKYGWS
ADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
Sequence of entity 7 (u), FASTA
>8SUP_7 Eukaryotic translation initiation factor 3 subunit L (chains u)
MSYPADDYESEAVYDPYAYPSDYDMHTGDPKQDLAYERQYEQQTYQVIPEVIRNFIQYFH
KTVSDLIDQKVYELQASRVSSDVIDQKVYEIQDIYENSWTKLTERFFKNTPWPEAETIAP
QVGNDAVFLILYKELYYRHIYAKVSGGPSLAQRFESYYNYCNLFNYILNADGPAPLELPN
QWLWDIIDEFIYQFQSFSQYRCKTAKKSEEEIDFLRSNPKIWNVHSVLNVLHSLVDKSNI
NRQLEVYTSGGDPESVAGEYGRHSLYKMLGYFSLVGLLRLHSLLGDYYQAIKVLENIELN
KKSMYSRVPECQVTTYYYVGFAYLMMRRYQDAIRVFANILLYIQRTKSMFQRTTYKYEMI
NKQNEQMHALLAIALTMYPMRIDESIHLQLREKYGDKMLRMQKGDPQVYEELFSYSCPKF
LSPVVPNYDSVHPNYHKEPFLQQLKVFSDEVQQQAQLSTIRSFLKLYTTMPVAKLAGFLD
LTEQEFRIQLLVFKHKMKNLVWTSGISALDGEFQSASEVDFYIDKDMIHIADTKVARRYG
DFFIRQIHKFEELNRTLKKMGQRP
Sequence of entity 8 (v), FASTA
>8SUP_8 Eukaryotic translation initiation factor 3 subunit M (chains v)
MSVPAFIDISEEDQAAELRAYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKEDDKDV
ESVMNSVVSLLLILEPDKQEALIESLCEKLVKFREGERPSLRLQLLSNLFHGMDKNTPVR
YTVYCSLIKVAASCGAIQYIPTELDQVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDA
ASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFDHLLTLKPVKFLEGELIHDL
LTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQE
LQIGADDVEAFVIDAVRTKMVYCKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLNAWKQN
LNKVKNSLLSLSDT
Sequence of entity 9 (2), FASTA
>8SUP_9 18S rRNA (chains 2)
UACCUGGUUGAUCCUGCCAGUAGCAUAUGCUUGUCUCAAAGAUUAAGCCAUGCAUGUCUA
AGUACGCACGGCCGGUACAGUGAAACUGCGAAUGGCUCAUUAAAUCAGUUAUGGUUCCUU
UGGUCGCUCGCUCCUCUCCUACUUGGAUAACUGUGGUAAUUCUAGAGCUAAUACAUGCCG
ACGGGCGCUGACCCCCUUCGCGGGGGGGAUGCGUGCAUUUAUCAGAUCAAAACCAACCCG
GUCAGCCUCCCCCCGGCCCCGGCCGGGGGGGUGGGCGCCGGCGGCUUUGGUGACUCUAGA
UAACCUCGGGCCGAUCGCACGCCCUCCGUGGCGGCGACGACCCAUUCGAACGUCUGCCCU
AUCAACUUUCGAUGGUAGUCGCCGUGCCUACCAUGGUGACCACGGGUGACGGGGAAUCAG
GGUUCGAUUCCGGAGAGGGAGCCUGAGAAACGGCUACCACAUCCAAGGAAGGCAGCAGGC
GCGCAAAUUACCCACUCCCGACCCGGGGAGGUAGUGACGAAAAAUAACAAUACAGGACUC
UUUCGAGGCCCUGUAAUUGGAAUGAGUCCACUUUAAAUCCUUUAACGAGGAUCCAUUGGA
GGGCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAAUAGCGUAUAUUAAAGUUG
CUGCAGUUAAAAAGCUCGUAGUUGGAUCUUGGGAGCGGGCGGGCGGUCCGCCGCGAGGCG
AGCCACCGCCCGUCCCCGCCCCUUGCCUCUCGGCGCCCCCUCGAUGCUCUUAGCUGAGUG
UCCCGCGGGGCCCGAAGCGUUUACUUUGAAAAAAUUAGAGUGUUCAAAGCAGGCCCGAGC
CGCCUGGAUACCGCAGCUAGGAAUAAUGGAAUAGGACCGCGGUUCUAUUUUGUUGGUUUU
CGGAACUGAGGCCAUGAUUAAGAGGGACGGCCGGGGGCAUUCGUAUUGCGCCGCUAGAGG
UGAAAUUCUUGGACCGGCGCAAGACGGACCAGAGCGAAAGCAUUUGCCAAGAAUGUUUUC
AUUAAUCAAGAACGAAAGUCGGAGGUUCGAAGACGAUCAGAUACCGUCGUAGUUCCGACC
AUAAACGAUGCCGACCGGCGAUGCGGCGGCGUUAUUCCCAUGACCCGCCGGGCAGCUUCC
GGGAAACCAAAGUCUUUGGGUUCCGGGGGGAGUAUGGUUGCAAAGCUGAAACUUAAAGGA
AUUUGGCGAAGGGCACCACCAGGAGUGGAGCCUGCGGCUUAAUUUGACUCAACACGGGAA
ACCUCACCCGGCCCGGACACGGACAGGAUUGACAGAUUGAUAGCUCUUUCUCGAUUCCGU
GGGUGGUGGUGCAUGGCCGUUCUUAGUUGGUGGAGCGAUUUGUCUGGUUAAUUCCGAUAA
CGAACGAGACUCUGGCAUGCUAACUAGUUACGCGACCCCCGAGCGGUCGGCGUCCCCCAA
CUUCUUAGAGGGACAAGUGGCGUUCAGCCACCCGAGAUUGAGCAAUAACAGGUCUGUGAU
GCCCUUAGAUGUCCGGGGCUGCACGCGCGCUACACUGACUGGCUCAGCGUGUGCCUACCC
UACGCCGGCAGGCGCGGGUAACCCGUUGAACCCCAUUCGUGAUGGGGAUCGGGGAUUGCA
AUUAUUCCCCAUGAACGAGGAAUUCCCAGUAAGUGCGGGUCAUAAGCUUGCGUUGAUUAA
GUCCCUGCCCUUUGUACACACCGCCCGUCGCUACUACCGAUUGGAUGGUUUAGUGAGGCC
CUCGGAUCGGCCCCGCCGGGGUCGGCCCACGGCCCUGGCGGAGCGCUGAGAAGACGGUCG
AACUUGACUAUCUAGAGGAAGUAAAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGA
AGGAUCAUUA
Sequence of entity 10 (3), FASTA
>8SUP_10 EMCV mRNA (chains 3)
CCUUUGCAGGCAGCGGAACCCCCCACCUGGCGACAGGUGCCUCUGCGGCCAAAAGCCACG
UGUAUAAGAUACACCUGCAAAGGAAUAUG
Sequence of entity 11 (A), FASTA
>8SUP_11 Eukaryotic translation initiation factor 1A, X-chromosomal (chains A)
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCH
IRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDT
FGPGDDDEIQFDDIGDDDEDIDDI
Sequence of entity 12 (B), FASTA
>8SUP_12 uS2 (SA) (chains B)
MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQTAFREPR
LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGTTTEWS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
Primary citation
The mechanism of ribosomal recruitment during translation initiation on the Type 2 encephalomyocarditis virus IRES. Bhattacharjee, S., Abaeva, I.S., Brown, Z.P. et al. EMBO J (2026). DOI 10.1038/s44318-026-00735-x · PubMed
Other PDB entries of the same protein (UniProt G1SMZ5), best resolution first:
- 9H74 2.9 Å, Late-stage 48S Initiation Complex with eIF3 (LS48S-eIF3 IC) guided by the trans-RNA
- 6W2T 3.36 Å, Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small…
- 6W2S 3.47 Å, Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small…
- 5A5T 6.0 Å, Structure of mammalian eIF3 in the context of the 43S preinitiation complex
Browse structure collections
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