Human VPS29/VPS35L Complex (Locally refined map). Determined by electron microscopy at 3.2 Å resolution. Released 1 Nov 2023.
Explore 8SYM in 3D Show helices and sheets RCSB PDB PDBe
8SYM contains 24 α-helices and 21 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 8 | 1 | 1 |
| α-helix | 9-10 | 2 | |
| α-helix | 13-20 | 8 | |
| β-strand | 21 | 1 | 2 |
| β-strand | 25-26 | 2 | 3 |
| β-strand | 29 | 1 | 4 |
| β-strand | 31 | 1 | 4 |
| α-helix | 583-596 | 14 | |
| β-strand | 601 | 1 | 5 |
| α-helix | 608-618 | 11 | |
| α-helix | 627-642 | 16 | |
| β-strand | 644 | 1 | 5 |
| α-helix | 650-663 | 14 | |
| α-helix | 668-688 | 21 | |
| α-helix | 695-711 | 17 | |
| α-helix | 712-714 | 3 | |
| α-helix | 718-733 | 16 | |
| α-helix | 738-751 | 14 | |
| α-helix | 752-754 | 3 | |
| β-strand | 758-761 | 4 | 6 |
| β-strand | 764-767 | 4 | 6 |
| α-helix | 769-782 | 14 | |
| α-helix | 786-789 | 4 | |
| α-helix | 796-807 | 12 | |
| α-helix | 816-831 | 16 | |
| α-helix | 846-849 | 4 | |
| α-helix | 854-881 | 28 | |
| α-helix | 884-901 | 18 | |
| β-strand | 902 | 1 | 1 |
| α-helix | 907-922 | 16 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-10 | 6 | 3 |
| α-helix | 24-29 | 6 | |
| β-strand | 37-40 | 4 | 3 |
| α-helix | 47-54 | 8 | |
| β-strand | 59-62 | 4 | 3 |
| β-strand | 76-81 | 6 | 2 |
| β-strand | 84-89 | 6 | 2 |
| α-helix | 100-110 | 11 | |
| β-strand | 114-117 | 4 | 2 |
| β-strand | 124-127 | 4 | 2 |
| β-strand | 132-135 | 4 | 2 |
| α-helix | 150-152 | 3 | |
| β-strand | 153-160 | 8 | 3 |
| β-strand | 163-172 | 10 | 3 |
| β-strand | 175-184 | 10 | 3 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| VPS35 endosomal protein-sorting factor-like | A | protein | 963 | Homo sapiens | Q7Z3J2 (AlphaFold model) |
| Vacuolar protein sorting-associated protein 29 | B | protein | 205 | Homo sapiens | Q9UBQ0 (AlphaFold model) |
>8SYM_1 VPS35 endosomal protein-sorting factor-like (chains A) MAVFPWHSRNRNYKAEFASCRLEAVPLEFGDYHPLKPITVTESKTKKVNRKGSTSSTSSS SSSSVVDPLSSVLDGTDPLSMFAATADPAALAAAMDSSRRKRDRDDNSVVGSDFEPWTNK RGEILARYTTTEKLSINLFMGSEKGKAGTATLAMSEKVRTRLEELDDFEEGSQKELLNLT QQDYVNRIEELNQSLKDAWASDQKVKALKIVIQCSKLLSDTSVIQFYPSKFVLITDILDT FGKLVYERIFSMCVDSRSVLPDHFSPENANDTAKETCLNWFFKIASIRELIPRFYVEASI LKCNKFLSKTGISECLPRLTCMIRGIGDPLVSVYARAYLCRVGMEVAPHLKETLNKNFFD FLLTFKQIHGDTVQNQLVVQGVELPSYLPLYPPAMDWIFQCISYHAPEALLTEMMERCKK LGNNALLLNSVMSAFRAEFIATRSMDFIGMIKECDESGFPKHLLFRSLGLNLALADPPES DRLQILNEAWKVITKLKNPQDYINCAEVWVEYTCKHFTKREVNTVLADVIKHMTPDRAFE DSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQKESVRVEVCKCIMDAFIKHQQEP TKDPVILNALLHVCKTMHDSVNALTLEDEKRMLSYLINGFIKMVSFGRDFEQQLSFYVES RSMFCNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAYCFITIPSLAGIFT RLNLYLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEFLCNFF STLLIVPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHI DKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSLGLSFFNSILA HGDLRNNKLNQLSVNLWHLAQRHGCADTRTMVKTLEYIKKQSKQPDMTHLTELALRLPLQ TRT
>8SYM_2 Vacuolar protein sorting-associated protein 29 (chains B) MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDV HIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHT HKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVER IEYKKPENLYFQGGGSGGSHHHHHH
Structural organization of the retriever-CCC endosomal recycling complex. Boesch, D.J., Singla, A., Han, Y. et al. Nat Struct Mol Biol (2024) 31:910-924. DOI 10.1038/s41594-023-01184-4 · PubMed
Other PDB entries of the same protein (UniProt Q7Z3J2 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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