8TMU: HLA-B*73:01

HLA-B*73:01 bound to a 10mer peptide in complex with KIR2DL2. Determined by X-ray diffraction at 2.9 Å resolution. Released 18 Dec 2024.

Method: X-ray diffraction
Resolution: 2.9 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,761
Mol. weight: 70.69 kDa
Ligands: NAG
Released: 18 Dec 2024

Explore 8TMU in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8TMU contains 17 α-helices and 54 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
α-helix	15-17	3
α-helix	20	1
β-strand	21-28	8	1
β-strand	32-37	6	1
β-strand	46-47	2	1
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-164	6
α-helix	165-174	10
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-193	8	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chain B: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	4	1	5
α-helix	5-6	2
β-strand	7-12	6	6
β-strand	22-31	10	6
β-strand	32	1	5
β-strand	37-42	6	7
β-strand	45-46	2	7
β-strand	51-52	2	6
β-strand	56-57	2	6
β-strand	63-71	9	6
β-strand	79-84	6	7
β-strand	92-95	4	7

Chain C: 6 helices, 25 β-strands

Element	Residues	Length	Sheet
α-helix	5-8	4
β-strand	9-13	5	8
β-strand	17-19	3	9
β-strand	25-29	5	8
β-strand	30	1	10
β-strand	36-41	6	11
β-strand	47-52	6	11
α-helix	53	1
β-strand	54-56	3	10
β-strand	59-61	3	10
β-strand	63-65	3	8
α-helix	71-73	3
β-strand	75-82	8	11
α-helix	92-96	5
β-strand	97-99	3	11
β-strand	100-102	3	9
β-strand	109-113	5	12
β-strand	117-119	3	13
β-strand	123-130	8	12
β-strand	136-141	6	14
β-strand	145-151	7	14
β-strand	154	1	12
β-strand	160-168	9	12
β-strand	173-180	8	14
β-strand	181	1	15
β-strand	184	1	15
β-strand	187	1	9
α-helix	191-194	4
β-strand	195-197	3	14
β-strand	198-200	3	13
α-helix	201-203	3

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA-B*73:01	A	protein	277	Homo sapiens	A0A583ZBV1 (AlphaFold model)
Beta-2-microglobulin	B	protein	101	Homo sapiens	P61769 (AlphaFold model)
Killer cell immunoglobulin-like receptor 2DL2	C	protein	225	Homo sapiens	P43627 (AlphaFold model)
KP1	E	protein	10	Homo sapiens	Q96AG3 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8TMU_1 HLA-B*73:01 (chains A)
MGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTQFVRFDSDAASPREEPRAPWIEQEGPEY
WDRNTQICKAKAQTDRVGLRNLRGYYNQSEDGSHTWQTMYGCDMGPDGRLLRGYNQFAYD
GKDYIALNEDLRSWTAADTAAQITQRKWEAARVAEQLRAYLEGECVEWLRRHLENGKETL
QRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDG
TFQKWAAVVVPSGQEQRYTCHVQHEGLQEPLTLRWKP

Sequence of entity 2 (B), FASTA

>8TMU_2 Beta-2-microglobulin (chains B)
MGIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSK
DWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>8TMU_3 Killer cell immunoglobulin-like receptor 2DL2 (chains C)
HEGVHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVS
KANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLA
GESVTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGS
FRDSPYEWSNSSDPLLVSVIGNPSNSWPSPTEPSSKTGNPRHLHL

Sequence of entity 4 (E), FASTA

>8TMU_4 KP1 (chains E)
NRFAGFGIGL

Ligands and cofactors

ID	Name	Formula	Copies
NAG	2-acetamido-2-deoxy-beta-D-glucopyranose	C8 H15 N O6	2

Water and common crystallization additives (PEG, GOL) are not listed.

Primary citation

Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2. Ross, P., Hilton, H.G., Lodwick, J. et al. J Biol Chem (2025) 301:110542-110542. DOI 10.1016/j.jbc.2025.110542 · PubMed

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