Ghanaian virus fusion glycoprotein (GhV F). Determined by electron microscopy at 2.9 Å resolution. Released 1 May 2024.
Explore 8TVB in 3D Show helices and sheets RCSB PDB PDBe
8TVB contains 66 α-helices and 81 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 126-129 | 4 | |
| α-helix | 130-132 | 3 | |
| β-strand | 134-145 | 12 | 1 |
| α-helix | 147-148 | 2 | |
| β-strand | 149-156 | 8 | 2 |
| α-helix | 162-164 | 3 | |
| α-helix | 173-196 | 24 | |
| β-strand | 197-199 | 3 | 3 |
| β-strand | 209-212 | 4 | 3 |
| α-helix | 213-216 | 4 | |
| β-strand | 218-220 | 3 | 4 |
| α-helix | 221-240 | 20 | |
| α-helix | 241-243 | 3 | |
| α-helix | 244-248 | 5 | |
| β-strand | 254-258 | 5 | 2 |
| α-helix | 259 | 1 | |
| β-strand | 264-269 | 6 | 2 |
| α-helix | 272-274 | 3 | |
| α-helix | 275-279 | 5 | |
| α-helix | 280-282 | 3 | |
| α-helix | 288-310 | 23 | |
| β-strand | 322-323 | 2 | 2 |
| α-helix | 324-327 | 4 | |
| α-helix | 328-331 | 4 | |
| α-helix | 335-342 | 8 | |
| α-helix | 349-354 | 6 | |
| β-strand | 359-366 | 8 | 2 |
| β-strand | 371-378 | 8 | 2 |
| β-strand | 381-394 | 14 | 1 |
| β-strand | 397-398 | 2 | 5 |
| β-strand | 403-406 | 4 | 5 |
| β-strand | 411-415 | 5 | 1 |
| β-strand | 418-422 | 5 | 1 |
| α-helix | 424-426 | 3 | |
| β-strand | 427-429 | 3 | 1 |
| β-strand | 433-436 | 4 | 1 |
| β-strand | 441-442 | 2 | 1 |
| α-helix | 446-452 | 7 | |
| α-helix | 456-458 | 3 | |
| β-strand | 461-463 | 3 | 5 |
| β-strand | 472-475 | 4 | 6 |
| β-strand | 478-481 | 4 | 6 |
| β-strand | 488-490 | 3 | 7 |
| β-strand | 496 | 1 | 7 |
| β-strand | 506-508 | 3 | 6 |
| β-strand | 515-518 | 4 | 7 |
| β-strand | 521-524 | 4 | 7 |
| α-helix | 534-536 | 3 | |
| β-strand | 544 | 1 | 5 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Fusion glycoprotein F0,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | A, B, C | protein | 886 | Henipavirus ghanaense, Thermotoga maritima MSB8 | I0E092 (AlphaFold model), Q9WXS1 (AlphaFold model) |
>8TVB_1 Fusion glycoprotein F0,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (chains A, B, C) MKKKTDNPTISKRGHNHSRGIKSRALLRETDNYSNGLIVENLVRNCHHPSKNNLNYTKTQ KRDSTIPYRVEERKGHYPKIKHLIDKSYKHIKRGKRRNGHNGNIITIILLLILILKTQMS EGAIHYETLSKIGLIKGITREYKVKGTPSSKDIVIKLIPNVTGLNKCTNISMENYKEQLD KILIPINNIIELYANSTKSAPGNARFAGVIIAGVALGVAAAAQITAGIALHEARQNAERI NLLKDSISATNNAVAELQEATGGIVNVITGMQDYINTNLVPQIDKLQCSQIKTALDISLS QYYSEILTVFGPNLQNPVTTSMSIQAISQSFGGNIDLLLNLLGYTANDLLDLLESKSITG QITYINLEHYFMVIRVYYPIMTTISNAYVQELIKISFNVDGSEWVSLVPSYILIRNSYLS NIDISECLITKNSVICRHDFAMPMSYTLKECLTGDTEKCPREAVVTSYVPRFAISGGVIY ANCLSTTCQCYQTGKVIAQDGSQTLMMIDNQTCSIVRIEEILISTGKYLGSQEYNTMHVS VGNPVFTDKLDITSQISNINQSIEQSKFYLDKSKAILDKINLNLIGMKQIEDKIEEILSK IYHIENEIARIKKLIGEAPGGIEGRGGSGSGGSGGSGSEKAAKAEEAARKMEELFKKHKI VAVLRANSVEEAIEKAVAVFAGGVHLIEITFTVPDADTVIKALSVLKEKGAIIGAGTVTS VEQARKAVESGAEFIVSPHLDEEISQFAKEKGVFYMPGVMTPTELVKAMKLGHTILKLFP GEVVGPQFVKAMKGPFPNVKFVPTGGVNLDNVAEWFKAGVLAVGVGSALVKGTPDEVREK AKAFVEKIRGATEGGSGGSHHHHHHGSGGGSGLNDIFEAQKIEWHE
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 12 |
Structure and design of Langya virus glycoprotein antigens. Wang, Z., McCallum, M., Yan, L. et al. Proc Natl Acad Sci U S A (2024) 121:e2314990121-e2314990121. DOI 10.1073/pnas.2314990121 · PubMed
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