8U80: BTB/POZ domain-containing protein KCTD5

KCTD5/Cullin3/Gbeta1gamma2 Complex: Local Refinment of KCTD5(BTB)/Cullin3(NTD). Determined by electron microscopy at 3.6 Å resolution. Released 11 Oct 2023.

Method
Electron microscopy
Resolution
3.6 Å
Organism
Homo sapiens
Chains
10
Atoms
19,260
Mol. weight
353.3 kDa
Released
11 Oct 2023

Explore 8U80 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8U80 contains 167 α-helices and 22 β-strands across 10 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain C1: 28 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix29-4416
α-helix49-513
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix96-983
α-helix101-12222
α-helix124-1285
α-helix130-1345
α-helix139-1479
α-helix148-1525
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22519
α-helix230-25122
α-helix254-2563
α-helix257-2659
α-helix266-2705
α-helix273-2775
α-helix284-2907
α-helix293-30311
α-helix309-32921
α-helix338-3425
α-helix344-35815
α-helix364-37815
Chain C2: 27 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix29-4618
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix101-12222
α-helix124-13411
α-helix136-1383
α-helix139-1479
α-helix148-1525
α-helix155-17319
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22519
α-helix230-25021
α-helix254-2563
α-helix257-2648
α-helix265-2695
α-helix270-2723
α-helix273-2775
α-helix284-2907
α-helix293-30311
α-helix309-32921
α-helix338-3425
α-helix344-35815
α-helix364-37815
Chain C3: 25 helices, 2 β-strands
ElementResiduesLengthSheet
α-helix27-4519
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-945
α-helix101-12222
α-helix130-1345
α-helix139-1479
α-helix148-1525
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22721
α-helix230-25122
α-helix254-2563
α-helix257-2659
α-helix266-2705
α-helix273-2764
β-strand27917
β-strand28217
α-helix284-2907
α-helix293-30311
α-helix309-32921
α-helix338-3425
α-helix344-35815
α-helix364-37815
Chain C4: 29 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix29-4517
α-helix49-513
α-helix54-6613
α-helix70-8415
α-helix85-895
α-helix90-956
α-helix101-12222
α-helix124-1296
α-helix131-1344
α-helix136-1383
α-helix139-1479
α-helix148-1525
α-helix155-17319
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22519
α-helix230-25021
α-helix254-2563
α-helix257-2659
α-helix266-2705
α-helix273-2775
α-helix284-2907
α-helix293-30311
α-helix309-32921
α-helix338-3425
α-helix344-35815
α-helix364-3696
α-helix371-3788
Chain C5: 27 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix29-4517
α-helix49-513
α-helix54-6613
α-helix70-8415
α-helix85-906
α-helix91-955
α-helix101-12222
α-helix126-1294
α-helix131-1344
α-helix139-1479
α-helix148-1525
α-helix155-17420
α-helix180-19314
α-helix199-2013
α-helix202-2065
α-helix207-22519
α-helix230-25021
α-helix254-2563
α-helix257-2648
α-helix265-2706
α-helix273-2775
α-helix284-2907
α-helix293-30311
α-helix309-32921
α-helix338-3425
α-helix344-35815
α-helix364-37815
Chain K1: 5 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand45-5061
β-strand53-5861
α-helix59-624
α-helix69-746
β-strand83-8422
β-strand89-9022
β-strand91-9221
α-helix99-10810
α-helix119-12911
α-helix132-14918
Chain K2: 6 helices, 3 β-strands
ElementResiduesLengthSheet
β-strand45-4843
α-helix50-523
β-strand55-5843
α-helix59-624
α-helix69-746
β-strand9013
α-helix99-10810
α-helix119-12911
α-helix132-14918
Chain K3: 5 helices, 4 β-strands
ElementResiduesLengthSheet
β-strand45-5064
β-strand53-5864
α-helix59-624
α-helix69-746
β-strand8314
β-strand90-9234
α-helix96-10813
α-helix119-12911
α-helix132-15019

2 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
BTB/POZ domain-containing protein KCTD5K1, K2, K3, K4, K5protein234Homo sapiensQ9NXV2 (AlphaFold model)
Cullin-3C1, C2, C3, C4, C5protein381Homo sapiensQ13618 (AlphaFold model)
Sequence of entity 1 (K1, K2, K3, K4, K5), FASTA
>8U80_1 BTB/POZ domain-containing protein KCTD5 (chains K1, K2, K3, K4, K5)
MAENHCELLSPARGGIGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQ
TLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEE
GVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRVLQCQEEELTQMVSTMSDGWK
FEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKILQERGSRM
Sequence of entity 2 (C1, C2, C3, C4, C5), FASTA
>8U80_2 Cullin-3 (chains C1, C2, C3, C4, C5)
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN
AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR
DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR
INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY
KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
NNDRLFKQTIAGDFEYFLNLN

Primary citation

Structure and dynamics of a pentameric KCTD5/CUL3/G beta gamma E3 ubiquitin ligase complex. Nguyen, D.M., Rath, D.H., Devost, D. et al. Proc Natl Acad Sci U S A (2024) 121:e2315018121-e2315018121. DOI 10.1073/pnas.2315018121 · PubMed

Other PDB entries of the same protein (UniProt Q9NXV2 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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