8USC: Nub1/Fat10-processing human 26S proteasome
Nub1/Fat10-processing human 26S proteasome. Determined by electron microscopy at 3.1 Å resolution. Released 6 Nov 2024.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organism
- Homo sapiens
- Chains
- 28
- Atoms
- 70,061
- Mol. weight
- 1212.35 kDa
- Ligands
- ADP, ZN, ATP, MG
- Released
- 6 Nov 2024
Explore 8USC in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
8USC contains 466 α-helices and 273 β-strands across 28 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 19 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 5-10 | 6 | |
| α-helix | 18-30 | 13 | |
| α-helix | 36-45 | 10 | |
| α-helix | 54-66 | 13 | |
| α-helix | 73-87 | 15 | |
| α-helix | 90-103 | 14 | |
| α-helix | 111-122 | 12 | |
| α-helix | 131-141 | 11 | |
| α-helix | 151-161 | 11 | |
| α-helix | 170-182 | 13 | |
| α-helix | 190-206 | 17 | |
| α-helix | 220-224 | 5 | |
| α-helix | 232-242 | 11 | |
| α-helix | 247-255 | 9 | |
| α-helix | 265-282 | 18 | |
| β-strand | 291 | 1 | 24 |
| α-helix | 293-299 | 7 | |
| α-helix | 307-317 | 11 | |
| β-strand | 323 | 1 | 25 |
| β-strand | 324-325 | 2 | 26 |
| β-strand | 331 | 1 | 24 |
| β-strand | 332 | 1 | 25 |
| α-helix | 343-370 | 28 | |
| α-helix | 372-375 | 4 | |
Chain A: 25 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-24 | 5 | |
| α-helix | 27-35 | 9 | |
| α-helix | 42-63 | 22 | |
| α-helix | 67-69 | 3 | |
| β-strand | 70 | 1 | 30 |
| α-helix | 75-78 | 4 | |
| α-helix | 83-89 | 7 | |
| β-strand | 93-101 | 9 | 31 |
| β-strand | 111-114 | 4 | 31 |
| β-strand | 120-123 | 4 | 31 |
| β-strand | 125 | 1 | 31 |
| α-helix | 131-133 | 3 | |
| β-strand | 139-143 | 5 | 31 |
| β-strand | 149-152 | 4 | 31 |
| α-helix | 154-156 | 3 | |
| α-helix | 159-163 | 5 | |
| β-strand | 165 | 1 | 32 |
| α-helix | 174-176 | 3 | |
| α-helix | 181-191 | 11 | |
| α-helix | 193-196 | 4 | |
| α-helix | 199-202 | 4 | |
| β-strand | 211-215 | 5 | 32 |
| α-helix | 222-231 | 10 | |
| β-strand | 237-240 | 4 | 32 |
| β-strand | 249 | 1 | 33 |
| α-helix | 252-266 | 15 | |
| β-strand | 271-275 | 5 | 32 |
| α-helix | 294-306 | 13 | |
| β-strand | 316-321 | 6 | 32 |
| α-helix | 324-326 | 3 | |
| α-helix | 329-332 | 4 | |
| β-strand | 339-342 | 4 | 32 |
| α-helix | 348-358 | 11 | |
| β-strand | 364 | 1 | 34 |
| α-helix | 370-375 | 6 | |
| α-helix | 382-398 | 17 | |
| β-strand | 404 | 1 | 34 |
| α-helix | 406-413 | 8 | |
| α-helix | 414-418 | 5 | |
| α-helix | 419-421 | 3 | |
| α-helix | 426-429 | 4 | |
| β-strand | 432 | 1 | 35 |
Chain b: 8 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-9 | 6 | 27 |
| β-strand | 13 | 1 | 28 |
| α-helix | 14-16 | 3 | |
| α-helix | 25-43 | 19 | |
| β-strand | 48-52 | 5 | 27 |
| β-strand | 55 | 1 | 29 |
| β-strand | 62-65 | 4 | 27 |
| α-helix | 68-75 | 8 | |
| β-strand | 82 | 1 | 28 |
| β-strand | 84 | 1 | 29 |
| α-helix | 86-97 | 12 | |
| α-helix | 105 | 1 | |
| β-strand | 106-113 | 8 | 27 |
| α-helix | 121-134 | 14 | |
| β-strand | 138-142 | 5 | 27 |
| α-helix | 151-160 | 10 | |
| β-strand | 170-172 | 3 | 27 |
| α-helix | 181-185 | 5 | |
Chain B: 23 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-46 | 2 | |
| β-strand | 47 | 1 | 36 |
| α-helix | 49-51 | 3 | |
| α-helix | 59-84 | 26 | |
| α-helix | 92-103 | 12 | |
| β-strand | 107-115 | 9 | 31 |
| β-strand | 120-124 | 5 | 31 |
| β-strand | 130-135 | 6 | 31 |
| α-helix | 136 | 1 | |
| β-strand | 149-153 | 5 | 31 |
| β-strand | 159-162 | 4 | 31 |
| β-strand | 163 | 1 | 30 |
| α-helix | 169-172 | 4 | |
| β-strand | 175 | 1 | 37 |
| β-strand | 178 | 1 | 36 |
| α-helix | 184-186 | 3 | |
| α-helix | 191-197 | 7 | |
| α-helix | 198-202 | 5 | |
| α-helix | 203-206 | 4 | |
| α-helix | 208-214 | 7 | |
| α-helix | 216-219 | 4 | |
| β-strand | 221-225 | 5 | 37 |
| α-helix | 232-242 | 11 | |
| β-strand | 246-250 | 5 | 37 |
| α-helix | 262-276 | 15 | |
| β-strand | 280-284 | 5 | 37 |
| α-helix | 288-291 | 4 | |
| β-strand | 292 | 1 | 38 |
| α-helix | 293-294 | 2 | |
| α-helix | 300-316 | 17 | |
| β-strand | 325-331 | 7 | 37 |
| β-strand | 337 | 1 | 38 |
| α-helix | 339-342 | 4 | |
| β-strand | 349-352 | 4 | 37 |
| α-helix | 354-356 | 3 | |
| α-helix | 358-368 | 11 | |
| β-strand | 374 | 1 | 39 |
| α-helix | 381-384 | 4 | |
| α-helix | 392-408 | 17 | |
| β-strand | 414 | 1 | 39 |
| α-helix | 416-427 | 12 | |
| β-strand | 439 | 1 | 40 |
Chain c: 13 helices, 9 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26 | 1 | 8 |
| β-strand | 30-34 | 5 | 9 |
| α-helix | 35-48 | 14 | |
| β-strand | 54-60 | 7 | 9 |
| β-strand | 66-74 | 9 | 9 |
| α-helix | 84-86 | 3 | |
| α-helix | 89-102 | 14 | |
| β-strand | 107-114 | 8 | 9 |
| α-helix | 124-136 | 13 | |
| β-strand | 141-145 | 5 | 9 |
| β-strand | 157-162 | 6 | 9 |
| α-helix | 165-169 | 5 | |
| β-strand | 176 | 1 | 8 |
| α-helix | 186-188 | 3 | |
| α-helix | 189-193 | 5 | |
| α-helix | 196-199 | 4 | |
| β-strand | 200-208 | 9 | 9 |
| α-helix | 211-218 | 8 | |
| α-helix | 222-224 | 3 | |
| α-helix | 225-229 | 5 | |
| α-helix | 234-260 | 27 | |
| α-helix | 280-308 | 29 | |
Chain C: 23 helices, 17 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 22-67 | 46 | |
| α-helix | 69-70 | 2 | |
| β-strand | 71-79 | 9 | 31 |
| β-strand | 84-89 | 6 | 31 |
| β-strand | 94-99 | 6 | 31 |
| α-helix | 105-107 | 3 | |
| β-strand | 114-116 | 3 | 31 |
| β-strand | 123-125 | 3 | 31 |
| α-helix | 128-130 | 3 | |
| α-helix | 136-138 | 3 | |
| α-helix | 148-150 | 3 | |
| α-helix | 155-165 | 11 | |
| α-helix | 167-170 | 4 | |
| α-helix | 172-178 | 7 | |
| α-helix | 180-183 | 4 | |
| β-strand | 185-189 | 5 | 41 |
| α-helix | 196-205 | 10 | |
| β-strand | 210 | 1 | 41 |
| β-strand | 213-214 | 2 | 41 |
| β-strand | 223 | 1 | 42 |
| α-helix | 226-240 | 15 | |
| β-strand | 244-249 | 6 | 41 |
| β-strand | 256 | 1 | 43 |
| α-helix | 257-259 | 3 | |
| α-helix | 268-280 | 13 | |
| α-helix | 285-286 | 2 | |
| β-strand | 289-295 | 7 | 41 |
| α-helix | 298-300 | 3 | |
| β-strand | 301 | 1 | 43 |
| β-strand | 313-316 | 4 | 41 |
| α-helix | 318-320 | 3 | |
| α-helix | 322-332 | 11 | |
| β-strand | 337-338 | 2 | 44 |
| α-helix | 339 | 1 | |
| α-helix | 344-349 | 6 | |
| α-helix | 357-372 | 16 | |
| β-strand | 377-378 | 2 | 44 |
| α-helix | 380-390 | 11 | |
| α-helix | 399-402 | 4 | |
| β-strand | 405 | 1 | 45 |
Chain d: 17 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 83-103 | 21 | |
| α-helix | 109-126 | 18 | |
| α-helix | 138-155 | 18 | |
| α-helix | 156-158 | 3 | |
| α-helix | 161-177 | 17 | |
| α-helix | 186-202 | 17 | |
| α-helix | 205-214 | 10 | |
| α-helix | 217-221 | 5 | |
| α-helix | 224-237 | 14 | |
| α-helix | 241-247 | 7 | |
| α-helix | 248-250 | 3 | |
| α-helix | 254-278 | 25 | |
| β-strand | 281-283 | 3 | 73 |
| α-helix | 284-290 | 7 | |
| α-helix | 296-305 | 10 | |
| α-helix | 308-310 | 3 | |
| β-strand | 315-317 | 3 | 73 |
| α-helix | 319-322 | 4 | |
| α-helix | 333-347 | 15 | |
Chain D: 15 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 40-82 | 43 | |
| β-strand | 87-97 | 11 | 31 |
| β-strand | 100-105 | 6 | 31 |
| β-strand | 110-113 | 4 | 31 |
| β-strand | 115 | 1 | 31 |
| β-strand | 129-133 | 5 | 31 |
| β-strand | 139-142 | 4 | 31 |
| α-helix | 143-145 | 3 | |
| α-helix | 171-177 | 7 | |
| α-helix | 178-182 | 5 | |
| α-helix | 183-186 | 4 | |
| α-helix | 188-194 | 7 | |
| β-strand | 201-205 | 5 | 46 |
| α-helix | 212-221 | 10 | |
| β-strand | 226-230 | 5 | 46 |
| α-helix | 243-256 | 14 | |
| β-strand | 260-266 | 7 | 46 |
| α-helix | 280-296 | 17 | |
| β-strand | 305-311 | 7 | 46 |
| β-strand | 329-332 | 4 | 46 |
| α-helix | 334-336 | 3 | |
| α-helix | 340-349 | 10 | |
| α-helix | 361-364 | 4 | |
| α-helix | 372-388 | 17 | |
| α-helix | 396-407 | 12 | |
| α-helix | 413-415 | 3 | |
20 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Proteasome subunit alpha type-2 | H | protein | 234 | Homo sapiens | P25787 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 6 | Y | protein | 389 | Homo sapiens | Q15008 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 2 | f | protein | 908 | Homo sapiens | Q13200 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 11 | X | protein | 422 | Homo sapiens | O00231 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 1 | U | protein | 953 | Homo sapiens | Q99460 |
| 26S proteasome non-ATPase regulatory subunit 7 | Z | protein | 324 | Homo sapiens | P51665 |
| 26S proteasome non-ATPase regulatory subunit 13 | a | protein | 376 | Homo sapiens | Q9UNM6 |
| 26S proteasome non-ATPase regulatory subunit 4 | b | protein | 377 | Homo sapiens | P55036 |
| 26S proteasome regulatory subunit 7 | A | protein | 433 | Homo sapiens | P35998 |
| 26S proteasome regulatory subunit 4 | B | protein | 440 | Homo sapiens | P62191 |
| 26S protease regulatory subunit 8 | C | protein | 406 | Homo sapiens | P62195 |
| 26S proteasome regulatory subunit 6B | D | protein | 418 | Homo sapiens | P43686 |
16 more molecules are not listed.
Sequence of entity 1 (H), FASTA
>8USC_1 Proteasome subunit alpha type-2 (chains H)
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
Sequence of entity 2 (Y), FASTA
>8USC_2 26S proteasome non-ATPase regulatory subunit 6 (chains Y)
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKS
LDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGA
LTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRL
KVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKV
IKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPD
SKNWQYQETIKKGDLLLNRVQKLSRVINM
Sequence of entity 3 (f), FASTA
>8USC_3 26S proteasome non-ATPase regulatory subunit 2 (chains f)
MEEGGRDKAPVQPQQSPAAAPGGTDEKPSGKERRDAGDKDKEQELSEEDKQLQDELEMLV
ERLGEKDTSLYRPALEELRRQIRSSTTSMTSVPKPLKFLRPHYGKLKEIYENMAPGENKR
FAADIISVLAMTMSGERECLKYRLVGSQEELASWGHEYVRHLAGEVAKEWQELDDAEKVQ
REPLLTLVKEIVPYNMAHNAEHEACDLLMEIEQVDMLEKDIDENAYAKVCLYLTSCVNYV
PEPENSALLRCALGVFRKFSRFPEALRLALMLNDMELVEDIFTSCKDVVVQKQMAFMLGR
HGVFLELSEDVEEYEDLTEIMSNVQLNSNFLALARELDIMEPKVPDDIYKTHLENNRFGG
SGSQVDSARMNLASSFVNGFVNAAFGQDKLLTDDGNKWLYKNKDHGMLSAAASLGMILLW
DVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLG
SIFGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQ
TIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANTLVDVCAY
AGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALI
AMGEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPE
VSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGKGTLTLCP
YHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPL
PVSVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVIL
RKNPNYDL
Sequence of entity 4 (X), FASTA
>8USC_4 26S proteasome non-ATPase regulatory subunit 11 (chains X)
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
Sequence of entity 5 (U), FASTA
>8USC_5 26S proteasome non-ATPase regulatory subunit 1 (chains U)
MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFA
ALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPE
GEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYS
LKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKED
NLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETE
EKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV
RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEAL
QLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLG
LGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQ
HEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIR
RLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICC
AGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDK
HDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLS
LAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAK
KKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRY
QPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
Sequence of entity 6 (Z), FASTA
>8USC_6 26S proteasome non-ATPase regulatory subunit 7 (chains Z)
MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
KEDKEKDKDKEKSDVKKEEKKEKK
Sequence of entity 7 (a), FASTA
>8USC_7 26S proteasome non-ATPase regulatory subunit 13 (chains a)
MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT
Sequence of entity 8 (b), FASTA
>8USC_8 26S proteasome non-ATPase regulatory subunit 4 (chains b)
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV
LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN
EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA
DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA
ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF
GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA
SQATKDGKKDKKEEDKK
Sequence of entity 9 (A), FASTA
>8USC_9 26S proteasome regulatory subunit 7 (chains A)
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
Sequence of entity 10 (B), FASTA
>8USC_10 26S proteasome regulatory subunit 4 (chains B)
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL
Sequence of entity 11 (C), FASTA
>8USC_11 26S protease regulatory subunit 8 (chains C)
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Sequence of entity 12 (D), FASTA
>8USC_12 26S proteasome regulatory subunit 6B (chains D)
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 3 |
| ZN | Zinc ion | Zn | 1 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 3 |
| MG | Magnesium ion | Mg | 5 |
Primary citation
NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome. Arkinson, C., Dong, K.C., Gee, C.L. et al. Nat Struct Mol Biol (2025) 32:1752-1765. DOI 10.1038/s41594-025-01527-3 · PubMed
Other PDB entries of the same protein (UniProt P25787 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5LE5 1.8 Å, Native human 20S proteasome at 1.8 Angstrom
- 9TMN 1.85 Å, Human sperm 20S proteasome complex isolated from native source
- 5LEY 1.9 Å, Human 20S proteasome complex with Oprozomib at 1.9 Angstrom
- 5LF4 1.99 Å, Human 20S proteasome complex with Delanzomib at 2.0 Angstrom
- 5LF1 2.0 Å, Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom
- 5LF7 2.0 Å, Human 20S proteasome complex with Ixazomib at 2.0 Angstrom
- 8UD9 2.04 Å, Structure of human constitutive 20S proteasome complexed with the inhibitor TDI-8304
- 5LF6 2.07 Å, Human 20S proteasome complex with Z-LLY-ketoaldehyde at 2.1 Angstrom
- 5LF3 2.1 Å, Human 20S proteasome complex with Bortezomib at 2.1 Angstrom
- 8BZL 2.14 Å, Human 20S Proteasome in complex with peptide activator peptide BLM42
- 5LEZ 2.19 Å, Human 20S proteasome complex with Oprozomib in Mg-Acetate at 2.2 Angstrom
- 5LEX 2.2 Å, Native human 20S proteasome in Mg-Acetate at 2.2 Angstrom
Browse structure collections
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