Cryo-EM structure of human invariant chain in complex with HLA-DR15. Determined by electron microscopy at 3.03 Å resolution. Released 8 May 2024.
Explore 8VRW in 3D Show helices and sheets RCSB PDB PDBe
8VRW contains 27 α-helices and 99 β-strands across 9 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 5-10 | 6 | 1 |
| β-strand | 13-15 | 3 | 2 |
| β-strand | 19-20 | 2 | 2 |
| β-strand | 23-26 | 4 | 1 |
| β-strand | 29-35 | 7 | 1 |
| β-strand | 40-43 | 4 | 1 |
| α-helix | 46-49 | 4 | |
| α-helix | 56-76 | 21 | |
| β-strand | 85 | 1 | 3 |
| β-strand | 88-93 | 6 | 4 |
| β-strand | 98 | 1 | 5 |
| β-strand | 101 | 1 | 5 |
| β-strand | 103-112 | 10 | 4 |
| β-strand | 113 | 1 | 3 |
| β-strand | 118-123 | 6 | 6 |
| β-strand | 126-128 | 3 | 6 |
| β-strand | 133-134 | 2 | 4 |
| β-strand | 138 | 1 | 4 |
| β-strand | 145-153 | 9 | 4 |
| β-strand | 161-166 | 6 | 6 |
| β-strand | 174-178 | 5 | 6 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 7-8 | 2 | 2 |
| β-strand | 9-18 | 10 | 1 |
| β-strand | 23-32 | 10 | 1 |
| β-strand | 35-41 | 7 | 1 |
| α-helix | 55-63 | 9 | |
| α-helix | 65-74 | 10 | |
| α-helix | 75-80 | 6 | |
| α-helix | 81-86 | 6 | |
| α-helix | 87-91 | 5 | |
| β-strand | 95 | 1 | 7 |
| β-strand | 99-104 | 6 | 8 |
| β-strand | 114-122 | 9 | 8 |
| β-strand | 123 | 1 | 7 |
| β-strand | 129-133 | 5 | 9 |
| β-strand | 136-138 | 3 | 9 |
| β-strand | 143-144 | 2 | 8 |
| β-strand | 155-162 | 8 | 8 |
| β-strand | 172-175 | 4 | 9 |
| α-helix | 183 | 1 | |
| β-strand | 184-186 | 3 | 9 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 63-95 | 33 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| HLA class II histocompatibility antigen, DR alpha chain | A, D, G | protein | 288 | Homo sapiens | P01903 (AlphaFold model) |
| HLA class II histocompatibility antigen, DRB1 beta chain | B, E, H | protein | 300 | Homo sapiens | P01911 (AlphaFold model) |
| HLA class II histocompatibility antigen gamma chain | C, F, I | protein | 308 | Homo sapiens | P04233 (AlphaFold model) |
>8VRW_1 HLA class II histocompatibility antigen, DR alpha chain (chains A, D, G) MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVD MAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNS PVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLP STEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENVVCALGLTVGLVGIIIGTIFIIK GLRKSNAAERRGPLAAALEVLFQGPGAAEDQVDPRLIDGKHHHHHHHH
>8VRW_2 HLA class II histocompatibility antigen, DRB1 beta chain (chains B, E, H) MVCLKLPGGSCMTALTVTLMVLSSPLALSGDTRPRFLWQPKRECHFFNGTERVRFLDRYF YNQEESVRFDSDVGEFRAVTELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVVESFTV QRRVQPKVTVYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQNG DWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRARSESAQSKMLSGVGGFVLGLL FLGAGLFIYFRNQKGHSGLQPTGFLSAAALEVLFQGPGAAEDQVDPRLIDGKHHHHHHHH
>8VRW_3 HLA class II histocompatibility antigen gamma chain (chains C, F, I) MDYKDDDDAGTSRHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGA LYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMR MATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRH LKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSF RPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTK QDLGPVPM
Structural insights into human MHC-II association with invariant chain. Wang, N., Waghray, D., Caveney, N.A. et al. Proc Natl Acad Sci U S A (2024) 121:e2403031121-e2403031121. DOI 10.1073/pnas.2403031121 · PubMed
Other PDB entries of the same protein (UniProt P01903 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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