8XFZ: HLA-A/L1-2

The structure of HLA-A/L1-2. Determined by X-ray diffraction at 2.32 Å resolution. Released 10 Jul 2024.

Method: X-ray diffraction
Resolution: 2.32 Å
Organisms: Homo sapiens, Human papillomavirus
Chains: 3
Atoms: 3,218
Mol. weight: 44.77 kDa
Released: 10 Jul 2024

Explore 8XFZ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8XFZ contains 13 α-helices and 30 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 10 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-14	12	1
β-strand	18-28	11	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-195	10	3
β-strand	198-208	11	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-224	3	4
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-250	10	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-273	4	4

Chain B: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
α-helix	46	1
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
HLA class I heavy chain	A	protein	274	Homo sapiens	A0A0G2JPD3 (AlphaFold model)
Beta-2-microglobulin	B	protein	99	Homo sapiens	P61769 (AlphaFold model)
Major capsid protein L1	C	protein	9	Human papillomavirus	P03101 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>8XFZ_1 HLA class I heavy chain (chains A)
GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DRNTRNVKAHSQTDRANLGTLRGYYNQSEDGSHTIQRMYGCDVGPDGRFLRGYQQDAYDG
KDYIALNEDLRSWTAADMAAQITQRKWETAHEAEQWRAYLEGRCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWASVVVPSGQEQRYTCHVQHEGLPKPLTLRW

Sequence of entity 2 (B), FASTA

>8XFZ_2 Beta-2-microglobulin (chains B)
IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDW
SFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>8XFZ_3 Major capsid protein L1 (chains C)
YVARTNIYY

Primary citation

Uncommon P1 Anchor-featured Viral T Cell Epitope Preference within HLA-A*2601 and HLA-A*0101 Individuals. Zhang, J., Yue, C., Lin, Y. et al. Immunohorizons (2024) 8:415-430. DOI 10.4049/immunohorizons.2400026 · PubMed

Other PDB entries of the same protein (UniProt A0A0G2JPD3 (AlphaFold model), which also has an AlphaFold model), best resolution first:

8XES 1.78 Å, The structure of HLA-A/L1-1
8XG2 1.84 Å, The structure of HLA-A/Pep14
8XKC 2.18 Å, The structure of HLA-A/Pep16

Browse structure collections

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