8ZHC: Large ribosomal subunit protein uL2A

pre-frameshift complex of yeast 80S ribosome with eRF1 and mRNA of WNV. Determined by electron microscopy at 2.3 Å resolution. Released 21 May 2025.

Method
Electron microscopy
Resolution
2.3 Å
Organisms
Saccharomyces cerevisiae S288C, Homo sapiens, West Nile virus
Chains
82
Atoms
204,434
Mol. weight
3105.32 kDa
Released
21 May 2025

Explore 8ZHC in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8ZHC contains 512 α-helices and 507 β-strands across 74 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain eR: 14 helices, 17 β-strands

ElementResiduesLengthSheet
α-helix7-2519
β-strand2819
β-strand34-39610
α-helix45-5915
α-helix65-8319
α-helix88-892
β-strand93-98610
β-strand110-114510
β-strand124-128510
β-strand13019
α-helix134-1418
β-strand146-151611
β-strand155-161711
β-strand166-173811
α-helix187-21327
β-strand214-215212
β-strand218-219212
β-strand224-228511
α-helix234-2385
α-helix244-2474
β-strand250-255611
α-helix260-27011
α-helix272-29524
α-helix305-31410
β-strand321-323313
β-strand329-330214
α-helix370-3712
β-strand372-373214
α-helix374-3785
β-strand390-392313
α-helix397-40610
Chain La: 4 helices, 6 β-strands
ElementResiduesLengthSheet
α-helix12-209
α-helix37-437
β-strand55-5841
β-strand67-6931
β-strand70-7452
β-strand79-88102
β-strand94-9962
α-helix101-1033
β-strand104-10851
α-helix113-12210
Chain Lb: 5 helices, 5 β-strands
ElementResiduesLengthSheet
β-strand9-1246
β-strand22-2986
β-strand40-4896
α-helix49-524
α-helix61-655
β-strand69-7576
α-helix77-793
β-strand82-8656
α-helix104-12320
α-helix133-1353
Chain Lc: 8 helices, 8 β-strands
ElementResiduesLengthSheet
α-helix3-53
α-helix7-104
α-helix42-487
β-strand531128
α-helix65-684
β-strand72-74315
α-helix75-806
α-helix84-929
β-strand99-1002102
β-strand101-103316
α-helix104-1074
β-strand111-113315
β-strand124-127416
β-strand129-130215
α-helix132-1409
β-strand144-147416
Chain Ld: 3 helices, 0 β-strands
ElementResiduesLengthSheet
α-helix12-165
α-helix23-264
α-helix37-5721
Chain LD: 12 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix6-94
α-helix10-123
α-helix29-313
α-helix35-384
β-strand40-501120
α-helix511
β-strand57-64820
α-helix651
β-strand71-77720
α-helix781
β-strand79121
β-strand83122
β-strand87-91520
β-strand103123
α-helix104-1063
β-strand112-114324
β-strand116125
β-strand126125
β-strand134-140724
β-strand145-149524
β-strand155-159524
β-strand163123
β-strand165-166224
β-strand169121
α-helix174-1763
α-helix182-1909
α-helix201-2033
β-strand224-225226
α-helix229-2302
β-strand237-238226
Chain Le: 4 helices, 4 β-strands
ElementResiduesLengthSheet
α-helix10-2011
β-strand22-25434
α-helix27-3610
β-strand41-44434
α-helix50-6314
β-strand66-69434
α-helix74-807
β-strand89-94634
Chain LE: 15 helices, 18 β-strands
ElementResiduesLengthSheet
α-helix27-282
α-helix32-354
α-helix40-412
β-strand43129
β-strand45-591530
β-strand71-801030
α-helix82-832
β-strand84-961331
β-strand98-105831
α-helix112-1165
α-helix134-1363
α-helix144-15310
β-strand157-163731
α-helix166-1683
β-strand178-182531
β-strand183129
α-helix188-19710
β-strand202-203231
α-helix205-2073
β-strand214-220730
α-helix221-2233
β-strand225-227332
α-helix229-2335
α-helix235-2395
β-strand268-270332
β-strand274-2861330
α-helix3071
β-strand311133
β-strand315133
β-strand321-325530
β-strand335-340630
β-strand356-359430
α-helix373-3808

66 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
25S rRNA (3393-mer)LARNA3393Saccharomyces cerevisiae S288C
5S rRNA (121-mer)LBRNA121Saccharomyces cerevisiae S288C
5.8S rRNA (158-mer)LCRNA158Saccharomyces cerevisiae S288C
Large ribosomal subunit protein uL2ALDprotein251Saccharomyces cerevisiae S288CP0CX45 (AlphaFold model)
Large ribosomal subunit protein uL3LEprotein386Saccharomyces cerevisiae S288CP14126 (AlphaFold model)
Large ribosomal subunit protein uL4ALFprotein361Saccharomyces cerevisiae S288CP10664 (AlphaFold model)
Large ribosomal subunit protein uL18LGprotein294Saccharomyces cerevisiae S288CP26321 (AlphaFold model)
Large ribosomal subunit protein eL6BLHprotein175Saccharomyces cerevisiae S288CP05739
Large ribosomal subunit protein uL30ALIprotein222Saccharomyces cerevisiae S288CP05737
Large ribosomal subunit protein eL8ALJprotein233Saccharomyces cerevisiae S288CP17076
Large ribosomal subunit protein uL6ALKprotein191Saccharomyces cerevisiae S288CP05738
Large ribosomal subunit protein uL16LLprotein218Saccharomyces cerevisiae S288CP41805

70 more molecules are not listed.

Sequence of entity 1 (LA), FASTA
>8ZHC_1 25S rRNA (3393-MER) (chains LA)
UUGACCUCAAAUCAGGUAGGAGUACCCGCUGAACUUAAGCAUAUCAAUAAGCGGAGGAAA
AGAAACCAACCGGGAUUGCCUUAGUAACGGCGAGUGAAGCGGCAAAAGCUCAAAUUUGAA
AUCUGGUACCUUCGGUGCCCGAGUUGUAAUUUGGAGAGGGCAACUUUGGGGCCGUUCCUU
GUCUAUGUUCCUUGGAACAGGACGUCAUAGAGGGUGAGAAUCCCGUGUGGCGAGGAGUGC
GGUUCUUUGUAAAGUGCCUUCGAAGAGUCGAGUUGUUUGGGAAUGCAGCUCUAAGUGGGU
GGUAAAUUCCAUCUAAAGCUAAAUAUUGGCGAGAGACCGAUAGCGAACAAGUACAGUGAU
GGAAAGAUGAAAAGAACUUUGAAAAGAGAGUGAAAAAGUACGUGAAAUUGUUGAAAGGGA
AGGGCAUUUGAUCAGACAUGGUGUUUUGUGCCCUCUGCUCCUUGUGGGUAGGGGAAUCUC
GCAUUUCACUGGCCAGCAUCAGUUUUGGUGGCAGGAUAAAUCCAUAGGAAUGUAGCUUGC
CUCGGUAAGUAUUAUAGCCUGUGGGAAUACUGCCAGCUGGGACUGAGGACUGCGACGUAA
GUCAAGGAUGCUGGCAUAAUGGUUAUAUGCCGCCCGUCUUGAAACACGGACCAAGGAGUC
UAACGUCUAUGCGAGUGUUUGGGUGUAAAACCCAUACGCGUAAUGAAAGUGAACGUAGGU
UGGGGCCUCGCAAGAGGUGCACAAUCGACCGAUCCUGAUGUCUUCGGAUGGAUUUGAGUA
AGAGCAUAGCUGUUGGGACCCGAAAGAUGGUGAACUAUGCCUGAAUAGGGUGAAGCCAGA
GGAAACUCUGGUGGAGGCUCGUAGCGGUUCUGACGUGCAAAUCGAUCGUCGAAUUUGGGU
AUAGGGGCGAAAGACUAAUCGAACCAUCUAGUAGCUGGUUCCUGCCGAAGUUUCCCUCAG
GAUAGCAGAAGCUCGUAUCAGUUUUAUGAGGUAAAGCGAAUGAUUAGAGGUUCCGGGGUC
GAAAUGACCUUGACCUAUUCUCAAACUUUAAAUAUGUAAGAAGUCCUUGUUACUUAAUUG
AACGUGGACAUUUGAAUGAAGAGCUUUUAGUGGGCCAUUUUUGGUAAGCAGAACUGGCGA
UGCGGGAUGAACCGAACGUAGAGUUAAGGUGCCGGAAUACACGCUCAUCAGACACCACAA
AAGGUGUUAGUUCAUCUAGACAGCCGGACGGUGGCCAUGGAAGUCGGAAUCCGCUAAGGA
GUGUGUAACAACUCACCGGCCGAAUGAACUAGCCCUGAAAAUGGAUGGCGCUCAAGCGUG
UUACCUAUACUCUACCGUCAGGGUUGAUAUGAUGCCCUGACGAGUAGGCAGGCGUGGAGG
UCAGUGACGAAGCCUAGACCGUAAGGUCGGGUCGAACGGCCUCUAGUGCAGAUCUUGGUG
GUAGUAGCAAAUAUUCAAAUGAGAACUUUGAAGACUGAAGUGGGGAAAGGUUCCACGUCA
ACAGCAGUUGGACGUGGGUUAGUCGAUCCUAAGAGAUGGGGAAGCUCCGUUUCAAAGGCC
UGAUUUUAUGCAGGCCACCAUCGAAAGGGAAUCCGGUUAAGAUUCCGGAACCUGGAUAUG
GAUUCUUCACGGUAACGUAACUGAAUGUGGAGACGUCGGCGCGAGCCCUGGGAGGAGUUA
UCUUUUCUUCUUAACAGCUUAUCACCCCGGAAUUGGUUUAUCCGGAGAUGGGGUCUUAUG
GCUGGAAGAGGCCAGCACCUUUGCUGGCUCCGGUGCGCUUGUGACGGCCCGUGAAAAUCC
ACAGGAAGGAAUAGUUUUCAUGCCAGGUCGUACUGAUAACCGCAGCAGGUCUCCAAGGUG
AACAGCCUCUAGUUGAUAGAAUAAUGUAGAUAAGGGAAGUCGGCAAAAUAGAUCCGUAAC
UUCGGGAUAAGGAUUGGCUCUAAGGGUCGGGUAGUGAGGGCCUUGGUCAGACGCAGCGGG
CGUGCUUGUGGACUGCUUGGUGGGGCUUGCUCUGCUAGGCGGACUACUUGCGUGCCUUGU
UGUAGACGGCCUUGGUAGGUCUCUUGUAGACCGUCGCUUGCUACAAUUAACGAUCAACUU
AGAACUGGUACGGACAAGGGGAAUCUGACUGUCUAAUUAAAACAUAGCAUUGCGAUGGUC
AGAAAGUGAUGUUGACGCAAUGUGAUUUCUGCCCAGUGCUCUGAAUGUCAAAGUGAAGAA
AUUCAACCAAGCGCGGGUAAACGGCGGGAGUAACUAUGACUCUCUUAAGGUAGCCAAAUG
CCUCGUCAUCUAAUUAGUGACGCGCAUGAAUGGAUUAACGAGAUUCCCACUGUCCCUAUC
UACUAUCUAGCGAAACCACAGCCAAGGGAACGGGCUUGGCAGAAUCAGCGGGGAAAGAAG
ACCCUGUUGAGCUUGACUCUAGUUUGACAUUGUGAAGAGACAUAGAGGGUGUAGAAUAAG
UGGGAGCUUCGGCGCCAGUGAAAUACCACUACCUUUAUAGUUUCUUUACUUAUUCAAUGA
AGCGGAGCUGGAAUUCAUUUUCCACGUUCUAGCAUUCAAGGUCCCAUUCGGGGCUGAUCC
GGGUUGAAGACAUUGUCAGGUGGGGAGUUUGGCUGGGGCGGCACAUCUGUUAAACGAUAA
CGCAGAUGUCCUAAGGGGGGCUCAUGGAGAACAGAAAUCUCCAGUAGAACAAAAGGGUAA
AAGCCCCCUUGAUUUUGAUUUUCAGUGUGAAUACAAACCAUGAAAGUGUGGCCUAUCGAU
CCUUUAGUCCCUCGGAAUUUGAGGCUAGAGGUGCCAGAAAAGUUACCACAGGGAUAACUG
GCUUGUGGCAGUCAAGCGUUCAUAGCGACAUUGCUUUUUGAUUCUUCGAUGUCGGCUCUU
CCUAUCAUACCGAAGCAGAAUUCGGUAAGCGUUGGAUUGUUCACCCACUAAUAGGGAACG
UGAGCUGGGUUUAGACCGUCGUGAGACAGGUUAGUUUUACCCUACUGAUGAAUGUUACCG
CAAUAGUAAUUGAACUUAGUACGAGAGGAACAGUUCAUUCGGAUAAUUGGUUUUUGCGGC
UGUCUGAUCAGGCAUUGCCGCGAAGCUACCAUCCGCUGGAUUAUGGCUGAACGCCUCUAA
GUCAGAAUCCAUGCUAGAACGCGGUGAUUUCUUUGCUCCACACAAUAUAGAUGGAUACGA
AUAAGGCGUCCUUGUGGCGUCGCUGAACCAUAGCAGGCUAGCAACGGUGCACUUGGCGGA
AAGGCCUUGGGUGCUUGCUGGCGAAUUGCAAUGUCAUUUUGCGUGGGGAUAAAUCAUUUG
UAUACGACUUAGAUGUACAACGGGGUAUUGUAAGCAGUAGAGUAGCCUUGUUGUUACGAU
CUGCUGAGAUUAAGCCUUUGUUGUCUGAUUUGU
Sequence of entity 2 (LB), FASTA
>8ZHC_2 5S rRNA (121-MER) (chains LB)
GGUUGCGGCCAUAUCUACCAGAAAGCACCGUUUCCCGUCCGAUCAACUGUAGUUAAGCUG
GUAAGAGCCUGACCGAGUAGUGUAGUGGGUGACCAUACGCGAAACUCAGGUGCUGCAAUC
U
Sequence of entity 3 (LC), FASTA
>8ZHC_3 5.8S rRNA (158-MER) (chains LC)
AAACUUUCAACAACGGAUCUCUUGGUUCUCGCAUCGAUGAAGAACGCAGCGAAAUGCGAU
ACGUAAUGUGAAUUGCAGAAUUCCGUGAAUCAUCGAAUCUUUGAACGCACAUUGCGCCCC
UUGGUAUUCCAGGGGGCAUGCCUGUUUGAGCGUCAUUU
Sequence of entity 4 (LD), FASTA
>8ZHC_4 Large ribosomal subunit protein uL2A (chains LD)
GRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHDSGRGAPLAKV
VFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPG
DRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKVISSDARGVIGVIAGGGRVDKPLLK
AGRAFHKYRLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAAR
RTGLLRGSQKT
Sequence of entity 5 (LE), FASTA
>8ZHC_5 Large ribosomal subunit protein uL3 (chains LE)
SHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKAGMTTIVRDLD
RPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKN
WYKSKKKAFTKYSAKYAQDGAGIERELARIKKYASVVRVLVHTQIRKTPLAQKKAHLAEI
QLNGGSISEKVDWAREHFEKTVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRK
THRGLRKVACIGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDRT
KKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKALEEVSLKWIDT
ASKFGKGRFQTPAEKHAFMGTLKKDL
Sequence of entity 6 (LF), FASTA
>8ZHC_6 Large ribosomal subunit protein uL4A (chains LF)
SRPQVTVHSLTGEATANALPLPAVFSAPIRPDIVHTVFTSVNKNKRQAYAVSEKAGHQTS
AESWGTGRAVARIPRVGGGGTGRSGQGAFGNMCRGGRMFAPTKTWRKWNVKVNHNEKRYA
TASAIAATAVASLVLARGHRVEKIPEIPLVVSTDLESIQKTKEAVAALKAVGAHSDLLKV
LKSKKLRAGKGKYRNRRWTQRRGPLVVYAEDNGIVKALRNVPGVETANVASLNLLQLAPG
AHLGRFVIWTEAAFTKLDQVWGSETVASSKVGYTLPSHIISTSDVTRIINSSEIQSAIRP
AGQATQKRTHVLKKNPLKNKQVLLRLNPYAKVFAAEKLGSKKAEKTGTKPAAVFTETLKH
D
Sequence of entity 7 (LG), FASTA
>8ZHC_7 Large ribosomal subunit protein uL18 (chains LG)
QKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVVRFTNKDIICQ
IISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGLLIARRTLQKLGLDETYKGVE
EVEGEYELTEAVEDGPRPFKVFLDIGLQRTTTGARVFGALKGASDGGLYVPHSENRFPGW
DFETEEIDPELLRSYIFGGHVSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSA
HEAIRADPAFKPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ
Sequence of entity 8 (LH), FASTA
>8ZHC_8 Large ribosomal subunit protein eL6B (chains LH)
TAQQAPKWYPSEDVAAPKKTRKAVRPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDN
TLLVTGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANL
FPEQQTKEIKTERVEDQKVVDKALLAEIKKTPLLKQYLSASFSLKNGDKPHLLKF
Sequence of entity 9 (LI), FASTA
>8ZHC_9 Large ribosomal subunit protein uL30A (chains LI)
AEQVAAERAARKAANKEKRAIILERNAAYQKEYETAERNIIQAKRDAKAAGSYYVEAQHK
LVFVVRIKGINKIPPKPRKVLQLLRLTRINSGTFVKVTKATLELLKLIEPYVAYGYPSYS
TIRQLVYKRGFGKINKQRVPLSDNAIIEANLGKYGILSIDDLIHEIITVGPHFKQANNFL
WPFKLSNPSGGWGVPRKFKHFIQGGSFGNREEFINKLVKSMN
Sequence of entity 10 (LJ), FASTA
>8ZHC_10 Large ribosomal subunit protein eL8A (chains LJ)
NPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPPTIAQFQYTLD
RNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGKSKQDASPKPYAVKYGLNHVVALI
ENKKAKLVLIANDVDPIELVVFLPALCKKMGVPYAIVKGKARLGTLVNQKTSAVAALTEV
RAEDEAALAKLVSTIDANFADKYDEVKKHWGGGILGNKAQAKMDKRAKNSDSA
Sequence of entity 11 (LK), FASTA
>8ZHC_11 Large ribosomal subunit protein uL6A (chains LK)
MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNG
GRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGD
KKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIY
VSHKGFITEDL
Sequence of entity 12 (LL), FASTA
>8ZHC_12 Large ribosomal subunit protein uL16 (chains LL)
ARRPARCYRYQKNKPYPKSRYNRAVPDSKIRIYDLGKKKATVDEFPLCVHLVSNELEQLS
SEALEAARICANKYMTTVSGRDAFHLRVRVHPFHVLRINKMLSCAGADRLQQGMRGAWGK
PHGLAARVDIGQIIFSVRTKDSNKDVVVEGLRRARYKFPGQQKIILSKKWGFTNLDRPEY
LKKREAGEVKDDGAFVKFLSKKGSLENNIREFPEYFAA

Primary citation

Flexibilities and conservations in the structural basis of viral -1 programmed ribosomal frameshifting. Wu, M., Wan, X., Zhou, H. et al. To be published.

Other PDB entries of the same protein (UniProt P0CX45 (AlphaFold model), which also has an AlphaFold model), best resolution first:

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