9A0U: Docking model of HLA class I with HLA class II

Docking model of HLA class I with HLA class II. Released 4 Jun 2021.

Chains

8

Atoms

6,332

Mol. weight

103.62 kDa

Released

4 Jun 2021

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Molecules and chains

>9A0U_1 CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A*0201) (ALPHA CHAIN) (chains A)
GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYW
DGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG
KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYLEGTCVEWLRRYLENGKETLQ
RTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT
FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWE

>9A0U_2 BETA 2-MICROGLOBULIN (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

>9A0U_3 INFLUENZA A MATRIX PROTEIN M1 (RESIDUES 58-66) (chains C)
GILGFVFTL

>9A0U_4 GLY residue (chains D, H)
G

>9A0U_5 HLA class II histocompatibility antigen, DR alpha chain (chains E)
KEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALA
NIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTW
LRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEF

>9A0U_6 HLA class II histocompatibility antigen, DRB1-4 beta chain (chains F)
DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVTELGRPDAEYW
NSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTVYPAKTQPLQHHNLLVCSVNG
FYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSLT
SPLTVEWRASSAD

>9A0U_7 Alpha-enolase (chains G)
KRIAKAVNEKSCNC

Primary citation

Extracellular crosslinking mass spectrometry reveals HLA class I - HLA class II interactions on the cell surface. Armony G, Heck AJR, Wu W. Mol Immunol (2021) 136:16-25. DOI 10.1016/j.molimm.2021.05.010 · PubMed

Related structures

Other PDB entries of the same protein (UniProt P04439 (AlphaFold model), which also has an AlphaFold model), best resolution first:

• 3MRE 1.1 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with EBV bmlf1-280-288…
• 3D25 1.3 Å, Crystal structure of HA-1 minor histocompatibility antigen bound to human class I MHC…
• 3MRG 1.3 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCV NS3-1073-1081…
• 6JOZ 1.35 Å, Crystal structure of BRLF peptide from EBV in complex with HLA-A1101.
• 5C0G 1.37 Å, HLA-A02 carrying YLGGPDFPTI
• 5N1Y 1.39 Å, HLA-A02 carrying MVWGPDPLYV
• 1I4F 1.4 Å, Crystal structure of HLA-A*0201/MAGE-A4-peptide complex
• 1OGA 1.4 Å, A structural basis for immunodominant human T-cell receptor recognition.
• 3MRB 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with HCMV pp65-495-503…
• 3MRK 1.4 Å, Crystal Structure of MHC class I HLA-A2 molecule complexed with AFP137 nonapeptide
• 6J2A 1.4 Å, The structure of HLA-A*3003/NP44
• 1X7Q 1.45 Å, Crystal structure of HLA-A*1101 with sars nucleocapsid peptide

Browse structure collections

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