Crystal Structure of Inhibitor 5c in Complex with Prefusion RSV F Glycoprotein. Determined by X-ray diffraction at 2.07 Å resolution. Released 10 Jul 2024.
Explore 9BJM in 3D Show helices and sheets RCSB PDB PDBe
9BJM contains 20 α-helices and 26 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 29-33 | 5 | 1 |
| β-strand | 38-49 | 12 | 1 |
| β-strand | 51-60 | 10 | 2 |
| α-helix | 75-97 | 23 | |
| α-helix | 138-141 | 4 | |
| α-helix | 149-158 | 10 | |
| α-helix | 163-170 | 8 | |
| β-strand | 176-180 | 5 | 2 |
| β-strand | 186-194 | 9 | 2 |
| α-helix | 195-198 | 4 | |
| α-helix | 199-203 | 5 | |
| α-helix | 217-239 | 23 | |
| β-strand | 243-244 | 2 | 2 |
| α-helix | 247-248 | 2 | |
| α-helix | 254-262 | 9 | |
| α-helix | 268-275 | 8 | |
| α-helix | 278-283 | 6 | |
| β-strand | 286-293 | 8 | 2 |
| β-strand | 296-305 | 10 | 2 |
| β-strand | 308-318 | 11 | 1 |
| β-strand | 321-322 | 2 | 3 |
| β-strand | 333-336 | 4 | 3 |
| β-strand | 340-345 | 6 | 1 |
| β-strand | 348-352 | 5 | 1 |
| α-helix | 355-357 | 3 | |
| β-strand | 359-361 | 3 | 1 |
| β-strand | 364-368 | 5 | 1 |
| α-helix | 369-371 | 3 | |
| β-strand | 373-375 | 3 | 1 |
| α-helix | 377-380 | 4 | |
| α-helix | 381-384 | 4 | |
| β-strand | 394-398 | 5 | 3 |
| β-strand | 404-407 | 4 | 4 |
| β-strand | 411-416 | 6 | 4 |
| β-strand | 422-425 | 4 | 5 |
| β-strand | 431-434 | 4 | 5 |
| α-helix | 435-436 | 2 | |
| β-strand | 438-443 | 6 | 4 |
| β-strand | 449-452 | 4 | 5 |
| β-strand | 455-458 | 4 | 5 |
| α-helix | 459-460 | 2 | |
| β-strand | 465-469 | 5 | 1 |
| α-helix | 474-477 | 4 | |
| α-helix | 480-482 | 3 | |
| β-strand | 487-491 | 5 | 3 |
| α-helix | 492-515 | 24 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Prefusion RSV F (DS-CAV1),Envelope glycoprotein | A | protein | 568 | human respiratory syncytial virus, Human immunodeficiency virus 1 | M1E1E4 (AlphaFold model), W8RJF9 |
>9BJM_1 Prefusion RSV F (DS-CAV1),Envelope glycoprotein (chains A) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIE LSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLN NAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVCKVLHLEGEVNKIKSALLSTNKAVVS LSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSISNIETVIEFQQKNNRLLEITREFSVN AGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYV VQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKV QSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKT KCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDP LVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLL STFLGGLVPRGSHHHHHHSAWSHPQFEK
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1APZ | 1'-{[5-chloro-1-(4,4,4-trifluorobutyl)-1H-1,3-benzimidazol-2-yl]methyl}-1-(meth… | C23 H22 Cl F3 N4 O3 S | 1 |
Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections. Kesteleyn, B., Herschke, F., Darville, N. et al. J Med Chem (2024) 67:10986-11002. DOI 10.1021/acs.jmedchem.4c00514 · PubMed
Other PDB entries of the same protein (UniProt M1E1E4 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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