9BMG: Cytoplasmic dynein 1 heavy chain 1

State-2 of full-length human dynein-1 in 5mM ATPVi. Determined by electron microscopy at 2.86 Å resolution. Released 23 Apr 2025.

Method
Electron microscopy
Resolution
2.86 Å
Organism
Homo sapiens
Chains
1
Atoms
23,712
Mol. weight
535.04 kDa
Ligands
MG, ADP, ATP, AOV
Released
23 Apr 2025

Explore 9BMG in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9BMG contains 154 α-helices and 72 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 154 helices, 72 β-strands

ElementResiduesLengthSheet
α-helix1458-147013
β-strand147411
α-helix14751
β-strand1476-148052
β-strand1484-148852
α-helix1490-150920
α-helix1511-15133
α-helix1517-155337
α-helix1557-15604
α-helix1562-158423
β-strand158711
α-helix1588-15925
α-helix1597-161317
α-helix1616-162510
α-helix1627-16315
α-helix1634-16429
α-helix1647-16504
β-strand1663-166643
β-strand1672-167763
β-strand1683-169193
α-helix1698-172730
α-helix1735-174410
α-helix1747-176822
α-helix1778-179720
α-helix1802-182827
α-helix1836-18394
β-strand1842-184654
α-helix1853-18553
β-strand1857-186154
β-strand1864-186744
α-helix1878-18803
α-helix1883-189715
β-strand1901-190555
α-helix1912-192211
β-strand1927-193155
α-helix1938-195114
β-strand1954-195855
α-helix1960-19623
α-helix1965-198521
α-helix1995-19973
β-strand1998-200146
β-strand2004-200746
β-strand2013-201865
α-helix2030-20334
β-strand2036-204055
α-helix2046-205712
α-helix2062-207918
α-helix2090-211829
α-helix2124-21296
α-helix2133-214513
α-helix2154-216411
α-helix2176-218813
α-helix2201-221616
β-strand2219-222357
α-helix2230-224516
β-strand2249-225467
α-helix2256-22583
α-helix2261-22655
β-strand2266-226838
β-strand2275-227738
α-helix2279-228911
α-helix2294-22963
β-strand2298-230477
α-helix2309-23124
α-helix2313-23153
α-helix2316-23194
β-strand2324-232639
β-strand2332-233439
α-helix2335-23362
β-strand2339-234577
α-helix2353-23564
β-strand2360-236347
α-helix2371-238414
α-helix2411-242313
α-helix2432-244211
α-helix2451-247525
α-helix2480-24823
α-helix2483-250220
α-helix2508-252114
α-helix2534-25363
β-strand2537-2539310
β-strand2545-2547310
α-helix2548-25514
α-helix2559-25613
α-helix2572-258615
β-strand2591-2594411
α-helix2601-26099
β-strand2615-2620611
α-helix2628-263811
β-strand2639-2644612
β-strand2647-2652612
β-strand2658-2663611
α-helix2670-26712
α-helix2678-268811
β-strand2691-2694412
β-strand2699-2703512
β-strand2706-2712711
α-helix2722-27243
α-helix2725-27284
β-strand2733-2735311
α-helix2737-27404
α-helix2741-275515
α-helix2756-27583
α-helix2760-27656
α-helix2766-278318
α-helix2796-281015
α-helix2818-283316
α-helix2840-285718
α-helix2863-28664
β-strand2873-2874213
β-strand2882-2883213
α-helix2886-290318
α-helix2913-292614
β-strand2932-2936514
α-helix2943-295311
α-helix29561
β-strand2957-2959314
α-helix2969-298416
β-strand2990-2995614
α-helix2996-29983
α-helix3002-301413
α-helix3024-304017
α-helix3047-306115
β-strand3062-3068714
α-helix3073-30819
α-helix3084-30874
β-strand3089-3093514
α-helix3099-310911
α-helix3139-316325
α-helix3173-324169
α-helix3450-348132
α-helix3483-349412
α-helix3496-35016
α-helix3503-351614
α-helix3522-353817
α-helix3549-35535
α-helix3556-35649
α-helix3571-35799
β-strand3586-3590515
α-helix3595-36039
β-strand3610-3613415
α-helix3619-362911
β-strand3632-3636515
α-helix3638-36403
α-helix3643-36453
α-helix3646-36505
β-strand3653116
β-strand3661-3664416
β-strand3667-3670416
β-strand3676-3681615
α-helix3690-36956
β-strand3696-3700515
α-helix3705-372016
α-helix3722-375534
α-helix3764-379835
α-helix3802-381716
α-helix3818-38203
α-helix3829-384012
α-helix3852-387221
α-helix3877-38793
α-helix3880-389415
α-helix3902-39109
α-helix3929-393810
α-helix3948-39536
α-helix3957-39615
α-helix3966-39694
α-helix3982-399615
α-helix3998-40003
α-helix4001-401313
α-helix4019-40224
α-helix4024-40252
α-helix4027-40293
α-helix4030-40345
β-strand4041-4043317
β-strand4045118
α-helix4052-406110
β-strand4066-4070517
α-helix4074-409017
β-strand4093-4097517
α-helix4099-41013
α-helix4103-411412
β-strand4123-4127517
α-helix4136-41416
β-strand4143-4144217
β-strand4147118
α-helix4153-416311
α-helix4166-41694
α-helix4176-419217
α-helix4193-41953
α-helix4197-42004
α-helix4209-422618
α-helix4235-42373
α-helix4240-42467
α-helix4247-42515
α-helix4259-427214
α-helix4275-42784
β-strand4283119
α-helix42941
β-strand4295119
α-helix4296-42972
α-helix4302-43109
α-helix4318-43203
α-helix4325-43284
α-helix4329-434517
α-helix4375-439016
α-helix4396-44005
α-helix4402-44054
α-helix4408-443831
α-helix4446-445611
α-helix4459-44613
α-helix4475-449723
α-helix4500-45056
β-strand4509-4510220
α-helix4511-45133
α-helix4518-453215
β-strand4539-4546820
β-strand4559-4561320
β-strand4564-4566321
β-strand4568-4571421
β-strand4574-4577421
β-strand4583-4584221
β-strand4587-4594820
β-strand4604-4610721
β-strand4618-4626921
α-helix4632-46376
β-strand4641-4643321

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cytoplasmic dynein 1 heavy chain 1Aprotein4646Homo sapiensQ14204
Sequence of entity 1 (A), FASTA
>9BMG_1 Cytoplasmic dynein 1 heavy chain 1 (chains A)
MSEPGGGGGEDGSAGLEVSAVQNVADVSVLQKHLRKLVPLLLEDGGEAPAALEAALEEKS
ALEQMRKFLSDPQVHTVLVERSTLKEDVGDEGEEEKEFISYNINIDIHYGVKSNSLAFIK
RTPVIDADKPVSSQLRVLTLSEDSPYETLHSFISNAVAPFFKSYIRESGKADRDGDKMAP
SVEKKIAELEMGLLHLQQNIEIPEISLPIHPMITNVAKQCYERGEKPKVTDFGDKVEDPT
FLNQLQSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESPEVLLT
LDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLLSATELDKIRQALVAI
FTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKVLGTRKLMHVAYEEFEKVMVACFEVF
QTWDDEYEKLQVLLRDIVKRKREENLKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVI
VRVLRPQVTAVAQQNQGEVPEPQDMKVAEVLFDAADANAIEEVNLAYENVKEVDGLDVSK
EGTEAWEAAMKRYDERIDRVETRITARLRDQLGTAKNANEMFRIFSRFNALFVRPHIRGA
IREYQTQLIQRVKDDIESLHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTA
YMKRVEDVLGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIFTI
ESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKAHQANQLYPFAIS
LIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAEGIALVWESYKLDPYVQRLAETV
FNFQEKVDDLLIIEEKIDLEVRSLETCMYDHKTFSEILNRVQKAVDDLNLHSYSNLPIWV
NKLDMEIERILGVRLQAGLRAWTQVLLGQAEDKAEVDMDTDAPQVSHKPGGEPKIKNVVH
ELRITNQVIYLNPPIEECRYKLYQEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYR
NALTRMPDGPVALEESYSAVMGIVSEVEQYVKVWLQYQCLWDMQAENIYNRLGEDLNKWQ
ALLVQIRKARGTFDNAETKKEFGPVVIDYGKVQSKVNLKYDSWHKEVLSKFGQMLGSNMT
EFHSQISKSRQELEQHSVDTASTSDAVTFITYVQSLKRKIKQFEKQVELYRNGQRLLEKQ
RFQFPPSWLYIDNIEGEWGAFNDIMRRKDSAIQQQVANLQMKIVQEDRAVESRTTDLLTD
WEKTKPVTGNLRPEEALQALTIYEGKFGRLKDDREKCAKAKEALELTDTGLLSGSEERVQ
VALEELQDLKGVWSELSKVWEQIDQMKEQPWVSVQPRKLRQNLDALLNQLKSFPARLRQY
ASYEFVQRLLKGYMKINMLVIELKSEALKDRHWKQLMKRLHVNWVVSELTLGQIWDVDLQ
KNEAIVKDVLLVAQGEMALEEFLKQIREVWNTYELDLVNYQNKCRLIRGWDDLFNKVKEH
INSVSAMKLSPYYKVFEEDALSWEDKLNRIMALFDVWIDVQRRWVYLEGIFTGSADIKHL
LPVETQRFQSISTEFLALMKKVSKSPLVMDVLNIQGVQRSLERLADLLGKIQKALGEYLE
RERSSFPRFYFVGDEDLLEIIGNSKNVAKLQKHFKKMFAGVSSIILNEDNSVVLGISSRE
GEEVMFKTPVSITEHPKINEWLTLVEKEMRVTLAKLLAESVTEVEIFGKATSIDPNTYIT
WIDKYQAQLVVLSAQIAWSENVETALSSMGGGGDAAPLHSVLSNVEVTLNVLADSVLMEQ
PPLRRRKLEHLITELVHQRDVTRSLIKSKIDNAKSFEWLSQMRFYFDPKQTDVLQQLSIQ
MANAKFNYGFEYLGVQDKLVQTPLTDRCYLTMTQALEARLGGSPFGPAGTGKTESVKALG
HQLGRFVLVFNCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERMLSAVSQQVQCIQE
ALREHSNPNYDKTSAPITCELLNKQVKVSPDMAIFITMNPGYAGRSNLPDNLKKLFRSLA
MTKPDRQLIAQVMLYSQGFRTAEVLANKIVPFFKLCDEQLSSQSHYDFGLRALKSVLVSA
GNVKRERIQKIKREKEERGEAVDEGEIAENLPEQEILIQSVCETMVPKLVAEDIPLLFSL
LSDVFPGVQYHRGEMTALREELKKVCQEMYLTYGDGEEVGGMWVEKVLQLYQITQINHGL
MMVGPSGSGKSMAWRVLLKALERLEGVEGVAHIIDPKAISKDHLYGTLDPNTREWTDGLF
THVLRKIIDSVRGELQKRQWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLSLPPNVR
IMFEVQDLKYATLATVSRCGMVWFSEDVLSTDMIFNNFLARLRSIPLDEGEDEAQRRRKG
KEDEGEEAASPMLQIQRDAATIMQPYFTSNGLVTKALEHAFQLEHIMDLTRLRCLGSLFS
MLHQACRNVAQYNANHPDFPMQIEQLERYIQRYLVYAILWSLSGDSRLKMRAELGEYIRR
ITTVPLPTAPNIPIIDYEVSISGEWSPWQAKVPQIEVETHKVAAPDVVVPTLDTVRHEAL
LYTWLAEHKPLVLCGPPGSGKTMTLFSALRALPDMEVVGLNFSSATTPELLLKTFDHYCE
YRRTPNGVVLAPVQLGKWLVLFCDEINLPDMDKYGTQRVISFIRQMVEHGGFYRTSDQTW
VKLERIQFVGACNPPTDPGRKPLSHRFLRHVPVVYVDYPGPASLTQIYGTFNRAMLRLIP
SLRTYAEPLTAAMVEFYTMSQERFTQDTQPHYIYSPREMTRWVRGIFEALRPLETLPVEG
LIRIWAHEALRLFQDRLVEDEERRWTDENIDTVALKHFPNIDREKAMSRPILYSNWLSKD
YIPVDQEELRDYVKARLKVFYEEELDVPLVLFNEVLDHVLRIDRIFRQPQGHLLLIGVSG
AGKTTLSRFVAWMNGLSVYQIKVHRKYTGEDFDEDLRTVLRRSGCKNEKIAFIMDESNVL
DSGFLERMNTLLANGEVPGLFEGDEYATLMTQCKEGAQKEGLMLDSHEELYKWFTSQVIR
NLHVVFTMNPSSEGLKDRAATSPALFNRCVLNWFGDWSTEALYQVGKEFTSKMDLEKPNY
IVPDYMPVVYDKLPQPPSHREAIVNSCVFVHQTLHQANARLAKRGGRTMAITPRHYLDFI
NHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRIKSQELEVKNAAANDKL
KKMVKDQQEAEKKKVMSQEIQEQLHKQQEVIADKQMSVKEDLDKVEPAVIEAQNAVKSIK
KQHLVEVRSMANPPAAVKLALESICLLLGESTTDWKQIRSIIMRENFIPTIVNFSAEEIS
DAIREKMKKNYMSNPSYNYEIVNRASLACGPMVKWAIAQLNYADMLKRVEPLRNELQKLE
DDAKDNQQKANEVEQMIRDLEASIARYKEEYAVLISEAQAIKADLAAVEAKVNRSTALLK
SLSAERERWEKTSETFKNQMSTIAGDCLLSAAFIAYAGYFDQQMRQNLFTTWSHHLQQAN
IQFRTDIARTEYLSNADERLRWQASSLPADDLCTENAIMLKRFNRYPLIIDPSGQATEFI
MNEYKDRKITRTSFLDDAFRKNLESALRFGNPLLVQDVESYDPVLNPVLNREVRRTGGRV
LITLGDQDIDLSPSFVIFLSTRDPTVEFPPDLCSRVTFVNFTVTRSSLQSQCLNEVLKAE
RPDVDEKRSDLLKLQGEFQLRLRQLEKSLLQALNEVKGRILDDDTIITTLENLKREAAEV
TRKVEETDIVMQEVETVSQQYLPLSTACSSIYFTMESLKQIHFLYQYSLQFFLDIYHNVL
YENPNLKGVTDHTQRLSIITKDLFQVAFNRVARGMLHQDHITFAMLLARIKLKGTVGEPT
YDAEFQHFLRGNEIVLSAGSTPRIQGLTVEQAEAVVRLSCLPAFKDLIAKVQADEQFGIW
LDSSSPEQTVPYLWSEETPATPIGQAIHRLLLIQAFRPDRLLAMAHMFVSTNLGESFMSI
MEQPLDLTHIVGTEVKPNTPVLMCSVPGYDASGHVEDLAAEQNTQITSIAIGSAEGFNQA
DKAINTAVKSGRWVMLKNVHLAPGWLMQLEKKLHSLQPHACFRLFLTMEINPKVPVNLLR
AGRIFVFEPPPGVKANMLRTFSSIPVSRICKSPNERARLYFLLAWFHAIIQERLRYAPLG
WSKKYEFGESDLRSACDTVDTWLDDTAKGRQNISPDKIPWSALKTLMAQSIYGGRVDNEF
DQRLLNTFLERLFTTRSFDSEFKLACKVDGHKDIQMPDGIRREEFVQWVELLPDTQTPSW
LGLPNNAERVLLTTQGVDMISKMLKMQMLEDEDDLAYAETEKKTRTDSTSDGRPAWMRTL
HTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGAKLLQDVRQDLADVVQVCEG
KKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSDFSERIKQLQNISLAAASGG
AKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCLEVNVTTSQGATLDACSFGV
TGLKLQGATCNNNKLSLSNAISTALPLTQLRWVKQTNTEKKASVVTLPVYLNFTRADLIF
TVDFEIATKEDPRSFYERGVAVLCTE

Ligands and cofactors

IDNameFormulaCopies
MGMagnesium ionMg2
ADPAdenosine-5'-diphosphateC10 H15 N5 O10 P22
ATPAdenosine-5'-triphosphateC10 H16 N5 O13 P31
AOVADP orthovanadateC10 H17 N5 O14 P2 V1

Primary citation

The mechanochemical cycle of reactive full-length human dynein 1. Chai, P., Yang, J., Geohring, I.C. et al. Nat Struct Mol Biol (2025) 32:1383-1395. DOI 10.1038/s41594-025-01543-3 · PubMed

Other PDB entries of the same protein (UniProt Q14204), best resolution first:

Browse structure collections

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