IkappaBzeta ankyrin repeat domain:NF-kappaB p50 homodimer complex at 2.0 Angstrom resolution. Determined by X-ray diffraction at 2.0 Å resolution. Released 7 Aug 2024.
Explore 9BOR in 3D Show helices and sheets RCSB PDB PDBe
9BOR contains 26 α-helices and 22 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 417-428 | 12 | |
| α-helix | 447-454 | 8 | |
| α-helix | 457-469 | 13 | |
| α-helix | 483-489 | 7 | |
| α-helix | 493-501 | 9 | |
| α-helix | 516-523 | 8 | |
| α-helix | 526-537 | 12 | |
| α-helix | 555-570 | 16 | |
| α-helix | 579-601 | 23 | |
| α-helix | 616-622 | 7 | |
| α-helix | 626-633 | 8 | |
| α-helix | 638-641 | 4 | |
| α-helix | 652-658 | 7 | |
| α-helix | 659 | 1 | |
| α-helix | 661 | 1 | |
| α-helix | 665-674 | 10 | |
| α-helix | 689-692 | 4 | |
| α-helix | 693-694 | 2 | |
| α-helix | 697-707 | 11 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 250-253 | 4 | 1 |
| β-strand | 257-259 | 3 | 2 |
| β-strand | 265-270 | 6 | 1 |
| β-strand | 278-285 | 8 | 2 |
| β-strand | 291-295 | 5 | 2 |
| β-strand | 297 | 1 | 1 |
| α-helix | 300-302 | 3 | |
| β-strand | 303-304 | 2 | 1 |
| β-strand | 308-312 | 5 | 1 |
| α-helix | 313-316 | 4 | |
| β-strand | 325-333 | 9 | 2 |
| β-strand | 339 | 1 | 2 |
| α-helix | 340-342 | 3 | |
| β-strand | 343-348 | 6 | 2 |
| α-helix | 357-361 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 250-253 | 4 | 3 |
| β-strand | 257-259 | 3 | 4 |
| β-strand | 265-270 | 6 | 3 |
| β-strand | 278-284 | 7 | 4 |
| β-strand | 292-295 | 4 | 4 |
| β-strand | 297 | 1 | 3 |
| α-helix | 300-302 | 3 | |
| β-strand | 303-304 | 2 | 3 |
| β-strand | 308-312 | 5 | 3 |
| α-helix | 313-316 | 4 | |
| β-strand | 325-333 | 9 | 4 |
| β-strand | 339 | 1 | 4 |
| α-helix | 340-342 | 3 | |
| β-strand | 343-348 | 6 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| NF-kappa-B inhibitor zeta | A | protein | 315 | Homo sapiens | Q9BYH8 (AlphaFold model) |
| Nuclear factor NF-kappa-B p50 subunit | B, C | protein | 132 | Mus musculus | P25799 (AlphaFold model) |
>9BOR_1 NF-kappa-B inhibitor zeta (chains A) MGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVL ARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEK GHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQE LLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVN AKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIR RILKGKSIQQRAPPY
>9BOR_2 Nuclear factor NF-kappa-B p50 subunit (chains B, C) ASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVH RQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKL MPNFSDSFGGGS
| ID | Name | Formula | Copies |
|---|---|---|---|
| HT3 | (2R,3S)-heptane-1,2,3-triol | C7 H16 O3 | 1 |
Structural and biochemical analyses of the nuclear I kappa B zeta protein in complex with the NF-kappa B p50 homodimer. Zhu, N., Rogers, W.E., Heidary, D.K. et al. Genes Dev (2024) 38:528-535. DOI 10.1101/gad.351892.124 · PubMed
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