9BV1: M2A Midnolin-Proteasome
M2A Midnolin-Proteasome (translocating). Determined by electron microscopy at 3.1 Å resolution. Released 11 Jun 2025.
- Method
- Electron microscopy
- Resolution
- 3.1 Å
- Organism
- Homo sapiens
- Chains
- 40
- Atoms
- 90,308
- Mol. weight
- 1523.93 kDa
- Ligands
- ZN, ATP, MG, ADP
- Released
- 11 Jun 2025
Explore 9BV1 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9BV1 contains 508 α-helices and 462 β-strands across 40 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 22 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-14 | 12 | |
| α-helix | 21-31 | 11 | |
| α-helix | 37-45 | 9 | |
| α-helix | 55-59 | 5 | |
| α-helix | 60-64 | 5 | |
| α-helix | 65 | 1 | |
| α-helix | 73-85 | 13 | |
| α-helix | 90-103 | 14 | |
| α-helix | 108-125 | 18 | |
| α-helix | 128-140 | 13 | |
| α-helix | 150-166 | 17 | |
| α-helix | 169-182 | 14 | |
| α-helix | 190-205 | 16 | |
| α-helix | 220-222 | 3 | |
| α-helix | 231-241 | 11 | |
| α-helix | 245-255 | 11 | |
| α-helix | 259-263 | 5 | |
| α-helix | 265-283 | 19 | |
| α-helix | 286-288 | 3 | |
| β-strand | 290-292 | 3 | 20 |
| α-helix | 293-298 | 6 | |
| α-helix | 307-317 | 11 | |
| β-strand | 320-325 | 6 | 20 |
| β-strand | 330-336 | 7 | 20 |
| α-helix | 343-370 | 28 | |
Chain A: 22 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 27-33 | 7 | |
| α-helix | 42-63 | 22 | |
| β-strand | 72 | 1 | 65 |
| α-helix | 73-74 | 2 | |
| α-helix | 82-87 | 6 | |
| α-helix | 93 | 1 | |
| β-strand | 94-96 | 3 | 66 |
| β-strand | 100 | 1 | 67 |
| α-helix | 102-105 | 4 | |
| β-strand | 111-115 | 5 | 67 |
| β-strand | 119-123 | 5 | 67 |
| β-strand | 125 | 1 | 66 |
| β-strand | 140-142 | 3 | 66 |
| β-strand | 149-152 | 4 | 66 |
| α-helix | 154-156 | 3 | |
| α-helix | 159-164 | 6 | |
| β-strand | 165 | 1 | 68 |
| α-helix | 169-170 | 2 | |
| α-helix | 182-196 | 15 | |
| α-helix | 198-204 | 7 | |
| β-strand | 212-215 | 4 | 68 |
| α-helix | 222-232 | 11 | |
| β-strand | 236-240 | 5 | 68 |
| α-helix | 252-266 | 15 | |
| β-strand | 270-275 | 6 | 68 |
| α-helix | 290-292 | 3 | |
| α-helix | 293-306 | 14 | |
| β-strand | 308 | 1 | 69 |
| β-strand | 310 | 1 | 69 |
| β-strand | 315-321 | 7 | 68 |
| α-helix | 329-332 | 4 | |
| β-strand | 341-342 | 2 | 68 |
| α-helix | 344-346 | 3 | |
| α-helix | 348-359 | 12 | |
| β-strand | 364 | 1 | 70 |
| α-helix | 370-376 | 7 | |
| α-helix | 382-397 | 16 | |
| β-strand | 404 | 1 | 70 |
| α-helix | 406-413 | 8 | |
| α-helix | 414-418 | 5 | |
Chain b: 8 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-11 | 8 | 44 |
| α-helix | 14-17 | 4 | |
| α-helix | 25-42 | 18 | |
| β-strand | 48-54 | 7 | 44 |
| β-strand | 59-65 | 7 | 44 |
| α-helix | 69-76 | 8 | |
| α-helix | 86-99 | 14 | |
| β-strand | 106-112 | 7 | 44 |
| α-helix | 121-133 | 13 | |
| β-strand | 137-142 | 6 | 44 |
| α-helix | 146-161 | 16 | |
| β-strand | 170-172 | 3 | 44 |
| α-helix | 179-184 | 6 | |
| α-helix | 187-190 | 4 | |
Chain B: 18 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 59-84 | 26 | |
| α-helix | 95-102 | 8 | |
| β-strand | 107-111 | 5 | 75 |
| β-strand | 112-116 | 5 | 66 |
| β-strand | 120-124 | 5 | 66 |
| β-strand | 130-134 | 5 | 66 |
| β-strand | 135 | 1 | 75 |
| β-strand | 139 | 1 | 65 |
| β-strand | 149-152 | 4 | 75 |
| β-strand | 159-161 | 3 | 75 |
| α-helix | 169-172 | 4 | |
| α-helix | 184-186 | 3 | |
| α-helix | 191-201 | 11 | |
| α-helix | 203-206 | 4 | |
| α-helix | 212-214 | 3 | |
| α-helix | 217-219 | 3 | |
| β-strand | 221-225 | 5 | 76 |
| α-helix | 234-242 | 9 | |
| β-strand | 246-251 | 6 | 76 |
| α-helix | 262-276 | 15 | |
| β-strand | 280-285 | 6 | 76 |
| α-helix | 287-289 | 3 | |
| β-strand | 292 | 1 | 77 |
| α-helix | 300-316 | 17 | |
| β-strand | 325-331 | 7 | 76 |
| β-strand | 337 | 1 | 77 |
| α-helix | 339-342 | 4 | |
| β-strand | 349-352 | 4 | 76 |
| α-helix | 354-356 | 3 | |
| α-helix | 358-370 | 13 | |
| α-helix | 382-385 | 4 | |
| α-helix | 392-408 | 17 | |
| α-helix | 416-426 | 11 | |
| β-strand | 439 | 1 | 78 |
Chain c: 13 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26 | 1 | 49 |
| β-strand | 30-34 | 5 | 50 |
| α-helix | 35-46 | 12 | |
| β-strand | 54-61 | 8 | 50 |
| β-strand | 66-74 | 9 | 50 |
| α-helix | 84-86 | 3 | |
| α-helix | 89-102 | 14 | |
| β-strand | 107-114 | 8 | 50 |
| α-helix | 124-136 | 13 | |
| β-strand | 142-145 | 4 | 50 |
| β-strand | 157-162 | 6 | 50 |
| α-helix | 163-164 | 2 | |
| α-helix | 165-169 | 5 | |
| β-strand | 176 | 1 | 49 |
| β-strand | 181 | 1 | 51 |
| β-strand | 183 | 1 | 51 |
| α-helix | 189-193 | 5 | |
| α-helix | 196-199 | 4 | |
| β-strand | 200-208 | 9 | 50 |
| α-helix | 211-218 | 8 | |
| α-helix | 222-224 | 3 | |
| α-helix | 225-229 | 5 | |
| α-helix | 234-265 | 32 | |
| α-helix | 279-308 | 30 | |
Chain C: 19 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 19-67 | 49 | |
| β-strand | 71-78 | 8 | 75 |
| β-strand | 84-89 | 6 | 75 |
| β-strand | 94-98 | 5 | 75 |
| α-helix | 105-107 | 3 | |
| β-strand | 113-117 | 5 | 75 |
| β-strand | 123-126 | 4 | 75 |
| α-helix | 127-130 | 4 | |
| α-helix | 133-136 | 4 | |
| β-strand | 139 | 1 | 83 |
| α-helix | 148-150 | 3 | |
| α-helix | 155-170 | 16 | |
| α-helix | 172-178 | 7 | |
| α-helix | 180-183 | 4 | |
| β-strand | 185-189 | 5 | 83 |
| α-helix | 196-206 | 11 | |
| β-strand | 210-215 | 6 | 83 |
| α-helix | 227-240 | 14 | |
| β-strand | 244-249 | 6 | 83 |
| α-helix | 267-280 | 14 | |
| β-strand | 289-295 | 7 | 83 |
| α-helix | 303-306 | 4 | |
| β-strand | 313-316 | 4 | 83 |
| α-helix | 318-320 | 3 | |
| α-helix | 323-333 | 11 | |
| β-strand | 338 | 1 | 84 |
| α-helix | 339 | 1 | |
| α-helix | 344-350 | 7 | |
| α-helix | 356-372 | 17 | |
| β-strand | 378 | 1 | 84 |
| α-helix | 380-390 | 11 | |
| α-helix | 399-403 | 5 | |
| β-strand | 405 | 1 | 85 |
Chain d: 15 helices, 0 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 84-101 | 18 | |
| α-helix | 110-125 | 16 | |
| α-helix | 139-158 | 20 | |
| α-helix | 161-177 | 17 | |
| α-helix | 183-184 | 2 | |
| α-helix | 189-202 | 14 | |
| α-helix | 205-214 | 10 | |
| α-helix | 219-222 | 4 | |
| α-helix | 227-238 | 12 | |
| α-helix | 241-246 | 6 | |
| α-helix | 259-277 | 19 | |
| α-helix | 284-290 | 7 | |
| α-helix | 296-298 | 3 | |
| α-helix | 317-320 | 4 | |
| α-helix | 332-347 | 16 | |
Chain D: 14 helices, 11 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 40-82 | 43 | |
| β-strand | 88-97 | 10 | 75 |
| β-strand | 100-105 | 6 | 75 |
| β-strand | 110-113 | 4 | 75 |
| β-strand | 115 | 1 | 75 |
| β-strand | 128-132 | 5 | 75 |
| β-strand | 139-142 | 4 | 75 |
| α-helix | 164-166 | 3 | |
| α-helix | 171-181 | 11 | |
| α-helix | 183-186 | 4 | |
| α-helix | 189-194 | 6 | |
| β-strand | 202-205 | 4 | 86 |
| α-helix | 213-221 | 9 | |
| β-strand | 227-230 | 4 | 86 |
| α-helix | 232-235 | 4 | |
| α-helix | 243-256 | 14 | |
| β-strand | 260-264 | 5 | 86 |
| α-helix | 267-269 | 3 | |
| α-helix | 280-296 | 17 | |
| β-strand | 305-311 | 7 | 86 |
| β-strand | 330-332 | 3 | 86 |
| α-helix | 334-336 | 3 | |
| α-helix | 338-351 | 14 | |
| α-helix | 372-388 | 17 | |
| α-helix | 396-408 | 13 | |
32 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 26S proteasome non-ATPase regulatory subunit 1 | U | protein | 953 | Homo sapiens | Q99460 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 3 | V | protein | 534 | Homo sapiens | O43242 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 12 | W | protein | 456 | Homo sapiens | O00232 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 11 | X | protein | 422 | Homo sapiens | O00231 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 6 | Y | protein | 389 | Homo sapiens | Q15008 |
| 26S proteasome non-ATPase regulatory subunit 7 | Z | protein | 324 | Homo sapiens | P51665 |
| 26S proteasome non-ATPase regulatory subunit 13 | a | protein | 376 | Homo sapiens | Q9UNM6 |
| 26S proteasome non-ATPase regulatory subunit 4 | b | protein | 377 | Homo sapiens | P55036 |
| 26S proteasome non-ATPase regulatory subunit 14 | c | protein | 310 | Homo sapiens | O00487 |
| 26S proteasome non-ATPase regulatory subunit 8 | d | protein | 350 | Homo sapiens | P48556 |
| 26S proteasome complex subunit SEM1 | e | protein | 70 | Homo sapiens | P60896 |
| 26S proteasome regulatory subunit 7 | A | protein | 433 | Homo sapiens | P35998 |
21 more molecules are not listed.
Sequence of entity 1 (U), FASTA
>9BV1_1 26S proteasome non-ATPase regulatory subunit 1 (chains U)
MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFA
ALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPE
GEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYS
LKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKED
NLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETE
EKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV
RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEAL
QLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLG
LGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQ
HEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIR
RLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICC
AGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDK
HDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLS
LAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAK
KKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRY
QPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
Sequence of entity 2 (V), FASTA
>9BV1_2 26S proteasome non-ATPase regulatory subunit 3 (chains V)
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
Sequence of entity 3 (W), FASTA
>9BV1_3 26S proteasome non-ATPase regulatory subunit 12 (chains W)
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
Sequence of entity 4 (X), FASTA
>9BV1_4 26S proteasome non-ATPase regulatory subunit 11 (chains X)
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
Sequence of entity 5 (Y), FASTA
>9BV1_5 26S proteasome non-ATPase regulatory subunit 6 (chains Y)
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKS
LDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGA
LTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRL
KVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKV
IKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPD
SKNWQYQETIKKGDLLLNRVQKLSRVINM
Sequence of entity 6 (Z), FASTA
>9BV1_6 26S proteasome non-ATPase regulatory subunit 7 (chains Z)
MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
KEDKEKDKDKEKSDVKKEEKKEKK
Sequence of entity 7 (a), FASTA
>9BV1_7 26S proteasome non-ATPase regulatory subunit 13 (chains a)
MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT
Sequence of entity 8 (b), FASTA
>9BV1_8 26S proteasome non-ATPase regulatory subunit 4 (chains b)
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV
LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN
EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA
DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA
ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF
GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA
SQATKDGKKDKKEEDKK
Sequence of entity 9 (c), FASTA
>9BV1_9 26S proteasome non-ATPase regulatory subunit 14 (chains c)
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
Sequence of entity 10 (d), FASTA
>9BV1_10 26S proteasome non-ATPase regulatory subunit 8 (chains d)
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAA
SRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLK
LVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKE
QLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGS
YNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMT
DYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
Sequence of entity 11 (e), FASTA
>9BV1_11 26S proteasome complex subunit SEM1 (chains e)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS
Sequence of entity 12 (A), FASTA
>9BV1_12 26S proteasome regulatory subunit 7 (chains A)
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ZN | Zinc ion | Zn | 1 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 4 |
| MG | Magnesium ion | Mg | 4 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
Primary citation
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma. Nardone, C., Gao, J., Seo, H.S. et al. Mol Cell (2025) 85:2597-2609.e11. DOI 10.1016/j.molcel.2025.05.030 · PubMed
Other PDB entries of the same protein (UniProt Q99460 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 5V1Y 1.42 Å, Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex
- 6OI4 1.76 Å, RPN13 (19-132)-RPN2 (940-952) pY950-Ub complex
- 5V1Z 2.0 Å, Crystal structure of the RPN13 PRU-RPN2 (932-953)-ubiquitin complex
- 9K53 2.5 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1
- 8USD 2.7 Å, Rpn1/Nub1UBL-focused alignment of the non-substrate-engaged human 26S proteasome
- 8USB 2.73 Å, Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1
- 9MBP 2.75 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT1 at top of spiral…
- 9NKG 2.8 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
- 9E8I 2.87 Å, Human proteasome in resting state conformation bound to TXNL1 in Forward conformation
- 9BV3 2.9 Å, M1B Midnolin-Proteasome
- 9E8H 2.9 Å, Human proteasome in resting state conformation bound to TXNL1 in backward conformation
- 9K4J 2.9 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state EA1.0
Browse structure collections
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