9BV3: M1B Midnolin-Proteasome
M1B Midnolin-Proteasome. Determined by electron microscopy at 2.9 Å resolution. Released 11 Jun 2025.
- Method
- Electron microscopy
- Resolution
- 2.9 Å
- Organism
- Homo sapiens
- Chains
- 40
- Atoms
- 88,575
- Mol. weight
- 1530.51 kDa
- Ligands
- ADP, MG, ATP
- Released
- 11 Jun 2025
Explore 9BV3 in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9BV3 contains 524 α-helices and 466 β-strands across 40 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 19 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 3-14 | 12 | |
| α-helix | 19-31 | 13 | |
| α-helix | 37-46 | 10 | |
| α-helix | 55-67 | 13 | |
| α-helix | 73-85 | 13 | |
| α-helix | 90-103 | 14 | |
| α-helix | 108-125 | 18 | |
| α-helix | 129-143 | 15 | |
| α-helix | 152-166 | 15 | |
| α-helix | 169-182 | 14 | |
| α-helix | 190-206 | 17 | |
| α-helix | 214-218 | 5 | |
| α-helix | 234-241 | 8 | |
| α-helix | 245-250 | 6 | |
| α-helix | 252-255 | 4 | |
| α-helix | 265-283 | 19 | |
| β-strand | 290-292 | 3 | 22 |
| α-helix | 293-300 | 8 | |
| α-helix | 304-317 | 14 | |
| β-strand | 320-325 | 6 | 22 |
| β-strand | 330-336 | 7 | 22 |
| α-helix | 343-370 | 28 | |
Chain A: 25 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 45-63 | 19 | |
| β-strand | 72 | 1 | 62 |
| α-helix | 73-74 | 2 | |
| α-helix | 75-77 | 3 | |
| α-helix | 80-89 | 10 | |
| β-strand | 93-94 | 2 | 63 |
| β-strand | 97 | 1 | 64 |
| β-strand | 98-102 | 5 | 65 |
| β-strand | 110-115 | 6 | 65 |
| β-strand | 119-123 | 5 | 65 |
| α-helix | 131-133 | 3 | |
| β-strand | 139 | 1 | 64 |
| β-strand | 142-143 | 2 | 63 |
| β-strand | 153 | 1 | 64 |
| α-helix | 154-156 | 3 | |
| α-helix | 159-162 | 4 | |
| β-strand | 165 | 1 | 66 |
| α-helix | 169-170 | 2 | |
| α-helix | 174-176 | 3 | |
| α-helix | 181-196 | 16 | |
| α-helix | 199-202 | 4 | |
| β-strand | 212-215 | 4 | 66 |
| α-helix | 222-232 | 11 | |
| β-strand | 236-241 | 6 | 66 |
| α-helix | 242-245 | 4 | |
| α-helix | 253-266 | 14 | |
| β-strand | 270-275 | 6 | 66 |
| α-helix | 277-279 | 3 | |
| α-helix | 293-306 | 14 | |
| β-strand | 308 | 1 | 67 |
| β-strand | 310 | 1 | 67 |
| β-strand | 315-321 | 7 | 66 |
| α-helix | 329-332 | 4 | |
| β-strand | 341-342 | 2 | 66 |
| α-helix | 344-346 | 3 | |
| α-helix | 348-359 | 12 | |
| β-strand | 364 | 1 | 68 |
| α-helix | 370-376 | 7 | |
| α-helix | 382-398 | 17 | |
| β-strand | 404 | 1 | 68 |
| α-helix | 406-413 | 8 | |
| α-helix | 414-418 | 5 | |
| α-helix | 419-423 | 5 | |
| α-helix | 426-429 | 4 | |
Chain b: 8 helices, 6 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-11 | 8 | 45 |
| α-helix | 14-17 | 4 | |
| α-helix | 25-42 | 18 | |
| β-strand | 48-54 | 7 | 45 |
| β-strand | 59-65 | 7 | 45 |
| α-helix | 69-76 | 8 | |
| α-helix | 87-98 | 12 | |
| β-strand | 106-112 | 7 | 45 |
| α-helix | 121-133 | 13 | |
| β-strand | 137-143 | 7 | 45 |
| α-helix | 150-161 | 12 | |
| β-strand | 169-173 | 5 | 45 |
| α-helix | 181-184 | 4 | |
| α-helix | 187-190 | 4 | |
Chain B: 23 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 60-85 | 26 | |
| α-helix | 92-103 | 12 | |
| β-strand | 106-117 | 12 | 63 |
| β-strand | 120-124 | 5 | 63 |
| β-strand | 130-133 | 4 | 63 |
| β-strand | 135 | 1 | 63 |
| β-strand | 139 | 1 | 62 |
| β-strand | 149-153 | 5 | 63 |
| β-strand | 159-162 | 4 | 63 |
| α-helix | 167-168 | 2 | |
| α-helix | 169-174 | 6 | |
| β-strand | 175 | 1 | 73 |
| α-helix | 184-186 | 3 | |
| α-helix | 191-197 | 7 | |
| α-helix | 198-202 | 5 | |
| α-helix | 203-206 | 4 | |
| α-helix | 208-214 | 7 | |
| α-helix | 217-219 | 3 | |
| β-strand | 221-225 | 5 | 73 |
| α-helix | 232-242 | 11 | |
| β-strand | 246-251 | 6 | 73 |
| α-helix | 252-255 | 4 | |
| α-helix | 262-276 | 15 | |
| β-strand | 280-285 | 6 | 73 |
| α-helix | 287-289 | 3 | |
| α-helix | 302-316 | 15 | |
| α-helix | 321-322 | 2 | |
| β-strand | 325-331 | 7 | 73 |
| α-helix | 334-336 | 3 | |
| α-helix | 339-342 | 4 | |
| β-strand | 350-352 | 3 | 73 |
| α-helix | 354-356 | 3 | |
| α-helix | 358-369 | 12 | |
| β-strand | 374 | 1 | 74 |
| α-helix | 382-385 | 4 | |
| α-helix | 392-408 | 17 | |
| β-strand | 414 | 1 | 74 |
| α-helix | 416-425 | 10 | |
Chain c: 11 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 26 | 1 | 49 |
| β-strand | 30-33 | 4 | 50 |
| α-helix | 35-45 | 11 | |
| β-strand | 54-60 | 7 | 50 |
| β-strand | 66-74 | 9 | 50 |
| α-helix | 89-101 | 13 | |
| β-strand | 107-114 | 8 | 50 |
| α-helix | 124-136 | 13 | |
| β-strand | 141-145 | 5 | 50 |
| β-strand | 151 | 1 | 51 |
| β-strand | 154 | 1 | 51 |
| β-strand | 157-162 | 6 | 50 |
| α-helix | 163-164 | 2 | |
| α-helix | 165-169 | 5 | |
| β-strand | 176 | 1 | 49 |
| α-helix | 189-194 | 6 | |
| β-strand | 196 | 1 | 50 |
| β-strand | 200-207 | 8 | 50 |
| α-helix | 213-219 | 7 | |
| α-helix | 225-229 | 5 | |
| α-helix | 230-233 | 4 | |
| α-helix | 234-263 | 30 | |
| α-helix | 280-308 | 29 | |
Chain C: 27 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 20-65 | 46 | |
| α-helix | 69-70 | 2 | |
| β-strand | 71-79 | 9 | 63 |
| β-strand | 84-89 | 6 | 63 |
| β-strand | 94-99 | 6 | 63 |
| α-helix | 100 | 1 | |
| α-helix | 105-107 | 3 | |
| β-strand | 112-116 | 5 | 63 |
| β-strand | 122-126 | 5 | 63 |
| α-helix | 127 | 1 | |
| α-helix | 129-132 | 4 | |
| α-helix | 133-141 | 9 | |
| α-helix | 143-145 | 3 | |
| α-helix | 155-161 | 7 | |
| α-helix | 162-166 | 5 | |
| α-helix | 167-170 | 4 | |
| α-helix | 174-178 | 5 | |
| α-helix | 181-183 | 3 | |
| β-strand | 185-189 | 5 | 80 |
| α-helix | 196-207 | 12 | |
| β-strand | 210-214 | 5 | 80 |
| α-helix | 218-220 | 3 | |
| α-helix | 221-224 | 4 | |
| α-helix | 231-233 | 3 | |
| α-helix | 234-240 | 7 | |
| β-strand | 244-249 | 6 | 80 |
| α-helix | 268-280 | 13 | |
| β-strand | 289-295 | 7 | 80 |
| α-helix | 303-306 | 4 | |
| β-strand | 313-316 | 4 | 80 |
| α-helix | 318 | 1 | |
| α-helix | 320 | 1 | |
| α-helix | 322-333 | 12 | |
| β-strand | 338 | 1 | 81 |
| α-helix | 339 | 1 | |
| α-helix | 344-350 | 7 | |
| α-helix | 356-372 | 17 | |
| β-strand | 378 | 1 | 81 |
| α-helix | 380-390 | 11 | |
Chain d: 16 helices, 2 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 84-104 | 21 | |
| α-helix | 110-123 | 14 | |
| α-helix | 140 | 1 | |
| α-helix | 141-146 | 6 | |
| α-helix | 147-158 | 12 | |
| α-helix | 161-177 | 17 | |
| α-helix | 187-202 | 16 | |
| α-helix | 205-214 | 10 | |
| α-helix | 217-221 | 5 | |
| α-helix | 224-238 | 15 | |
| α-helix | 241-250 | 10 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-277 | 21 | |
| β-strand | 282-283 | 2 | 55 |
| α-helix | 285-291 | 7 | |
| α-helix | 296-304 | 9 | |
| β-strand | 315-316 | 2 | 55 |
| α-helix | 332-347 | 16 | |
Chain D: 22 helices, 16 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 40-51 | 12 | |
| α-helix | 52-57 | 6 | |
| α-helix | 58-79 | 22 | |
| α-helix | 80-82 | 3 | |
| β-strand | 87-95 | 9 | 63 |
| β-strand | 100-105 | 6 | 63 |
| β-strand | 110-115 | 6 | 63 |
| α-helix | 121-123 | 3 | |
| β-strand | 128-132 | 5 | 63 |
| β-strand | 139-142 | 4 | 63 |
| α-helix | 151-153 | 3 | |
| α-helix | 164-167 | 4 | |
| α-helix | 171-177 | 7 | |
| α-helix | 178-182 | 5 | |
| α-helix | 184-194 | 11 | |
| β-strand | 205 | 1 | 82 |
| α-helix | 212-222 | 11 | |
| β-strand | 226-231 | 6 | 83 |
| α-helix | 232-235 | 4 | |
| α-helix | 244-256 | 13 | |
| β-strand | 260-265 | 6 | 83 |
| α-helix | 267-269 | 3 | |
| β-strand | 272 | 1 | 84 |
| α-helix | 281-297 | 17 | |
| β-strand | 305-309 | 5 | 83 |
| β-strand | 311 | 1 | 82 |
| α-helix | 314-316 | 3 | |
| β-strand | 317 | 1 | 84 |
| β-strand | 332 | 1 | 82 |
| α-helix | 334-336 | 3 | |
| α-helix | 338-350 | 13 | |
| β-strand | 354 | 1 | 85 |
| α-helix | 361-364 | 4 | |
| α-helix | 372-388 | 17 | |
| β-strand | 391 | 1 | 21 |
| β-strand | 394 | 1 | 85 |
| α-helix | 396-406 | 11 | |
| α-helix | 415-417 | 3 | |
32 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Midnolin | y | protein | 567 | Homo sapiens | Q504T8 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 1 | U | protein | 953 | Homo sapiens | Q99460 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 3 | V | protein | 534 | Homo sapiens | O43242 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 12 | W | protein | 456 | Homo sapiens | O00232 (AlphaFold model) |
| 26S proteasome non-ATPase regulatory subunit 11 | X | protein | 422 | Homo sapiens | O00231 |
| 26S proteasome non-ATPase regulatory subunit 6 | Y | protein | 389 | Homo sapiens | Q15008 |
| 26S proteasome non-ATPase regulatory subunit 7 | Z | protein | 324 | Homo sapiens | P51665 |
| 26S proteasome non-ATPase regulatory subunit 13 | a | protein | 376 | Homo sapiens | Q9UNM6 |
| 26S proteasome non-ATPase regulatory subunit 4 | b | protein | 377 | Homo sapiens | P55036 |
| 26S proteasome non-ATPase regulatory subunit 14 | c | protein | 310 | Homo sapiens | O00487 |
| 26S proteasome non-ATPase regulatory subunit 8 | d | protein | 350 | Homo sapiens | P48556 |
| 26S proteasome complex subunit SEM1 | e | protein | 70 | Homo sapiens | P60896 |
21 more molecules are not listed.
Sequence of entity 1 (y), FASTA
>9BV3_1 Midnolin (chains y)
MDYKDDDDKDYKDDDDKGGGGSGGGGFETSLYKKAGLATMEKVLVETSYPSQTTRLPPIT
YTGRFSLEPAPNSGNTLWPEPLFSLVSGLVSMTNPPASSSEPQPGGARSCRRGAPGGACE
LGPAAEAAPMSLAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLS
SGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALESLTETQVSDFLSGRSPLTL
ALRVGDHMMFVQLQLAAQHAPLQHRHVLAAAAAAAAARGDPSIASPVSSPCRPVSSAARV
PPVPTSPSPASPSPITAGSFRSHAASTTCPEQMDCSPTASSSASPGASTTSTPGASPAPR
SRKPGAVIESFVNHAPGVFSGTFSGTLHPNCQDSSGRPRRDIGTILQILNDLLSATRHYQ
GMPPSLAQLRCHAQCSPASPAPDLAPRTTSCEKLTAAPSASLLQGQSQIRMCKPPGDRLR
QTENRATRCKVERLQLLLQQKRLRRKARRDARGPYHWSPSRKAGRSDSSSSGGGGSPSEA
SGLGLDFEDSVWKPEANPDIKSEFVVA
Sequence of entity 2 (U), FASTA
>9BV3_2 26S proteasome non-ATPase regulatory subunit 1 (chains U)
MITSAAGIISLLDEDEPQLKEFALHKLNAVVNDFWAEISESVDKIEVLYEDEGFRSRQFA
ALVASKVFYHLGAFEESLNYALGAGDLFNVNDNSEYVETIIAKCIDHYTKQCVENADLPE
GEKKPIDQRLEGIVNKMFQRCLDDHKYKQAIGIALETRRLDVFEKTILESNDVPGMLAYS
LKLCMSLMQNKQFRNKVLRVLVKIYMNLEKPDFINVCQCLIFLDDPQAVSDILEKLVKED
NLLMAYQICFDLYESASQQFLSSVIQNLRTVGTPIASVPGSTNTGTVPGSEKDSDSMETE
EKTSSAFVGKTPEASPEPKDQTLKMIKILSGEMAIELHLQFLIRNNNTDLMILKNTKDAV
RNSVCHTATVIANSFMHCGTTSDQFLRDNLEWLARATNWAKFTATASLGVIHKGHEKEAL
QLMATYLPKDTSPGSAYQEGGGLYALGLIHANHGGDIIDYLLNQLKNASNDIVRHGGSLG
LGLAAMGTARQDVYDLLKTNLYQDDAVTGEAAGLALGLVMLGSKNAQAIEDMVGYAQETQ
HEKILRGLAVGIALVMYGRMEEADALIESLCRDKDPILRRSGMYTVAMAYCGSGNNKAIR
RLLHVAVSDVNDDVRRAAVESLGFILFRTPEQCPSVVSLLSESYNPHVRYGAAMALGICC
AGTGNKEAINLLEPMTNDPVNYVRQGALIASALIMIQQTEITCPKVNQFRQLYSKVINDK
HDDVMAKFGAILAQGILDAGGHNVTISLQSRTGHTHMPSVVGVLVFTQFWFWFPLSHFLS
LAYTPTCVIGLNKDLKMPKVQYKSNCKPSTFAYPAPLEVPKEKEKEKVSTAVLSITAKAK
KKEKEKEKKEEEKMEVDEAEKKEEKEKKKEPEPNFQLLDNPARVMPAQLKVLTMPETCRY
QPFKPLSIGGIIILKDTSEDIEELVEPVAAHGPKIEEEEQEPEPPEPFEYIDD
Sequence of entity 3 (V), FASTA
>9BV3_3 26S proteasome non-ATPase regulatory subunit 3 (chains V)
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
Sequence of entity 4 (W), FASTA
>9BV3_4 26S proteasome non-ATPase regulatory subunit 12 (chains W)
MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDM
VSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPI
KLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKK
ERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTEKLKLKYYNLMIQLDQHEGSY
LSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFDNEQSDLVHRISGDKKLEEIP
KYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKRWKDLKNRVVE
HNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ
Sequence of entity 5 (X), FASTA
>9BV3_5 26S proteasome non-ATPase regulatory subunit 11 (chains X)
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKT
GQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSE
KRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHAL
SNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYD
SIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLA
DFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKAD
VERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKK
LT
Sequence of entity 6 (Y), FASTA
>9BV3_6 26S proteasome non-ATPase regulatory subunit 6 (chains Y)
MPLENLEEEGLPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRDNNMAPYYEALCKS
LDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGA
LTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRL
KVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKV
IKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMR
IHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPD
SKNWQYQETIKKGDLLLNRVQKLSRVINM
Sequence of entity 7 (Z), FASTA
>9BV3_7 26S proteasome non-ATPase regulatory subunit 7 (chains Z)
MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
KEDKEKDKDKEKSDVKKEEKKEKK
Sequence of entity 8 (a), FASTA
>9BV3_8 26S proteasome non-ATPase regulatory subunit 13 (chains a)
MKDVPGFLQQSQNSGPGQPAVWHRLEELYTKKLWHQLTLQVLDFVQDPCFAQGDGLIKLY
ENFISEFEHRVNPLSLVEIILHVVRQMTDPNVALTFLEKTREKVKSSDEAVILCKTAIGA
LKLNIGDLQVTKETIEDVEEMLNNLPGVTSVHSRFYDLSSKYYQTIGNHASYYKDALRFL
GCVDIKDLPVSEQQERAFTLGLAGLLGEGVFNFGELLMHPVLESLRNTDRQWLIDTLYAF
NSGNVERFQTLKTAWGQQPDLAANEAQLLRKIQLLCLMEMTFTRPANHRQLTFEEIAKSA
KITVNEVELLVMKALSVGLVKGSIDEVDKRVHMTWVQPRVLDLQQIKGMKDRLEFWCTDV
KSMEMLVEHQAHDILT
Sequence of entity 9 (b), FASTA
>9BV3_9 26S proteasome non-ATPase regulatory subunit 4 (chains b)
MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV
LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN
EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA
DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA
ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF
GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA
SQATKDGKKDKKEEDKK
Sequence of entity 10 (c), FASTA
>9BV3_10 26S proteasome non-ATPase regulatory subunit 14 (chains c)
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
Sequence of entity 11 (d), FASTA
>9BV3_11 26S proteasome non-ATPase regulatory subunit 8 (chains d)
MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAA
SRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLK
LVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKE
QLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGS
YNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMT
DYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
Sequence of entity 12 (e), FASTA
>9BV3_12 26S proteasome complex subunit SEM1 (chains e)
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 2 |
| MG | Magnesium ion | Mg | 5 |
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 4 |
Primary citation
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma. Nardone, C., Gao, J., Seo, H.S. et al. Mol Cell (2025) 85:2597-2609.e11. DOI 10.1016/j.molcel.2025.05.030 · PubMed
Other PDB entries of the same protein (UniProt Q504T8 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9VEH 2.0 Å, The MIDN Catch-IRF4 (A8M) fusion protein
- 9VE3 2.1 Å, The MIDN Catch-IRF4 (V2L) fusion protein
- 9VE7 2.15 Å, The MIDN Catch-IRF4 (A8V) fusion protein
- 8VQP 2.52 Å, Crystal Structure Analysis of EGR1-MIDN
- 9VE4 2.55 Å, The MIDN Catch-IRF4 fusion protein
- 9MBP 2.75 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT1 at top of spiral…
- 9NKG 2.8 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
- 9VE6 2.8 Å, The MIDN Catch-IRF4 (F6Y) fusion protein
- 9MBO 2.83 Å, Focused refinement of RPN1 and the C-terminal helix of midnolin in the substrate-engaged…
- 9VE8 2.85 Å, The MIDN Catch-IRF4 (A8L) fusion protein
- 9NKI 2.94 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB MIDN_UBL state…
- 21IK 2.99 Å, The MIDN Catch-IRF4 (V2T) fusion protein
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