9C6O: Merbecovirus MOW15-22 Spike glycoprotein RBD

Merbecovirus MOW15-22 Spike glycoprotein RBD bound to the P. davyi ACE2. Determined by electron microscopy at 2.77 Å resolution. Released 5 Mar 2025.

Method
Electron microscopy
Resolution
2.77 Å
Organisms
Merbecovirus, Pteronotus davyi
Chains
2
Atoms
6,086
Mol. weight
127.05 kDa
Ligands
NAG
Released
5 Mar 2025

Explore 9C6O in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9C6O contains 50 α-helices and 20 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 40 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix22-5231
α-helix57-8125
α-helix86-883
α-helix92-10211
α-helix111-12616
β-strand129-13244
β-strand135-14174
α-helix142-1443
α-helix146-1527
α-helix156-16611
α-helix167-1715
α-helix175-19117
α-helix197-2015
α-helix202-2054
β-strand20715
α-helix211-2133
β-strand21515
α-helix219-24931
α-helix2591
β-strand260-26126
α-helix262-2643
α-helix274-2763
α-helix277-2804
α-helix287-2893
α-helix292-2976
α-helix302-31615
α-helix319-3224
α-helix325-3284
β-strand33017
β-strand345-34847
β-strand354-35747
α-helix365-38218
α-helix388-3903
α-helix398-40912
α-helix413-4186
α-helix426-4283
α-helix431-44414
α-helix448-46316
α-helix468-4703
α-helix471-48212
β-strand485-48626
α-helix498-5003
α-helix502-5054
α-helix512-53019
α-helix537-5393
α-helix546-55611
α-helix564-5729
α-helix580-5856
α-helix587-59610
Chain B: 10 helices, 11 β-strands
ElementResiduesLengthSheet
α-helix387-3893
α-helix396-3983
β-strand400-40341
α-helix411-4144
β-strand419-42681
β-strand442-44761
α-helix453-4564
α-helix464-4685
β-strand477-48481
β-strand497-508122
β-strand518-52582
α-helix528-5292
α-helix533-5353
α-helix536-54813
β-strand552-55762
β-strand56213
α-helix5671
β-strand56813
α-helix569-5702
β-strand571-57882
β-strand586-59381

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
MOW15-22 rbdBprotein320MerbecovirusA0ABF7PQ93
Pteronotus davyi ACE2 ectodomainAprotein768Pteronotus davyiQ56H28 (AlphaFold model)
Sequence of entity 1 (B), FASTA
>9C6O_1 MOW15-22 RBD (chains B)
MGILPSPGMPALLSLVSLLSVLLMGCVAETGTYSVSSFEAKPQGSFIESVYEGNECDFTK
LFIGQVPQPYEFGRLVFTNCNYNFTKLLSYFQVNTFQCQKVTPESIATGCYSSLTVDWFA
YRVEDKSDLLPGSSSDLQRFNYKPTYSNPTCLISAYTNLVPLGGVNPTNYTTLTNCYGCV
DKDPANPWGDQICIPEFVTEVEPGFRPKPSCARVGLEGHISGNDTYSAIVTNGELDSTGD
PIWRKGVALTKQPIDSSRADLAFFVSVQIDAQSSSVCPLGAPKLVPRGSSSGGSGLNDIF
EAQKIEWHEGGSHHHHHHHH
Sequence of entity 2 (A), FASTA
>9C6O_2 Pteronotus davyi ACE2 ectodomain (chains A)
MPMGSLQPLATLYLLGMLVASVLAQILTEDEKAKEFLEKFDLEAEKLYHQSSLASWNYNT
NITEENVKKMNEADREWSTFYENMTKIAKNYNLSQITDDKVKRQLQALQQNGLSEDENKR
LNNILNEMSTIYSTGKVCKPNNPQQCLLLATGLEDIMQYSKDYDERLWAWEGWRSQVGKQ
LRPLYEKYVDLKNEMAREKNYEDYGDYWRGDYETDGKEDYAYSRNQLIDDVERTFEEIKP
LYEHLHAYVRTKLMDAYPSRISPTGCLPAHLLGDMWGRFWTNLYDLTVPYGEKPTIDVTA
AMINQSWDAEKIFKEAEKFFMSVGLFNMTQGFWNNSMLTKPDDGREVVCHPTAWDLGNND
FRIKMCTKVTMDDFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSAATP
KHLKDLGLLAQNYPEDYETEINFLLKQALNIVGTLPFTYMLEKWRWMVFKGQIPKDQWTK
KWWEMKRDIVGVVEPVPHDETYCDAASLFHVANDYSFIRYYTRTIFQFQFQEALCRTAQH
TGPLHKCDISNSTAAGEKLLKMLELGKSQPWTFALENIVGERKINVRPLLDYFRPLFNWL
KEQNSNSFVGWRTDWSPYVDQSIKVRISLKSALGDKAYEWNDNEMYFFQSSVAYAMRVYF
SNFKNQTTPFGVENVQVRNLKPRVSFNFFVTSPKNVSDIIPRSEVVEAIRMSRGRINDAF
RLDDNSLEFLGLVPRGSSSGGSGLNDIFEAQKIEWHEGGSHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O67

Primary citation

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses. Ma, C.B., Liu, C., Park, Y.J. et al. Cell (2025) 188:1693. DOI 10.1016/j.cell.2024.12.031 · PubMed

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