9CB3: E2F1-Cyclin F Interface

E2F1-Cyclin F Interface. Determined by electron microscopy at 3.47 Å resolution. Released 12 Feb 2025.

Method
Electron microscopy
Resolution
3.47 Å
Organism
Homo sapiens
Chains
3
Atoms
4,995
Mol. weight
91.92 kDa
Released
12 Feb 2025

Explore 9CB3 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9CB3 contains 45 α-helices and 2 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 37 helices, 0 β-strands

ElementResiduesLengthSheet
α-helix32-343
α-helix37-437
α-helix44-463
α-helix49-557
α-helix60-689
α-helix70-745
α-helix85-873
α-helix88-969
α-helix100-11213
α-helix123-14018
α-helix149-1524
α-helix1541
α-helix1561
α-helix164-17815
α-helix184-19512
α-helix200-21617
α-helix219-23012
α-helix237-25317
α-helix257-2659
α-helix276-28712
α-helix297-3015
α-helix308-32316
α-helix328-34417
α-helix349-3513
α-helix352-36615
α-helix374-3796
α-helix387-40014
α-helix410-4189
α-helix425-43612
α-helix443-4464
α-helix449-46315
α-helix472-4787
α-helix486-49712
α-helix512-5165
α-helix520-5223
α-helix525-5273
α-helix533-5408
Chain B: 8 helices, 2 β-strands
ElementResiduesLengthSheet
β-strand711
β-strand1311
α-helix18-214
α-helix25-3410
α-helix52-6413
α-helix87-926
α-helix97-11014
α-helix116-12813
α-helix132-1387
α-helix147-15610

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Cyclin-FAprotein636Homo sapiensP41002 (AlphaFold model)
S-phase kinase-associated protein 1Bprotein163Homo sapiensP63208 (AlphaFold model)
E2F1 peptideCprotein13Homo sapiensQ01094 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9CB3_1 Cyclin-F (chains A)
MGSGGVVHCRCAKCFCYPTKRRIRRRPRNLTILSLPEDVLFHILKWLSVEDILAVRAVHS
QLKDLVDNHASVWACASFQELWPSPGNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSD
EARAEVNGLKASRFFSLAERLNVGAAPFIWLFIRPPWSVSGSCCKAVVHESLRAECQLQR
THKASILHCLGRVLSLFEDEEKQQQAHDLFEEAAHQGCLTSSYLLWESDRRTDVSDPGRC
LHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQAVSKQQVFS
VQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGIACM
VICTRFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKEVLLTL
VPVELRTQHLCSFLCELSLLHTSLSAYAPARLAAAALLLARLTHGQTQPWTTQLWDLTGF
SYEDLIPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKRYGEISQEEVLSYSQLCAAL
GVTQDSPDPPTFLSTGEIHAFLSSPSGRRTKRKRENSLQEDRGSFVTTPTAELSSQEETL
LGSFLDWSLDCCSGYEGDQESEGEKEGDVTAPSGIL
Sequence of entity 2 (B), FASTA
>9CB3_2 S-phase kinase-associated protein 1 (chains B)
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ
WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC
KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
Sequence of entity 3 (C), FASTA
>9CB3_3 E2F1 peptide (chains C)
GRPPVKRRLDLET

Primary citation

Structural mechanism for the recognition of E2F1 by the ubiquitin ligase adaptor Cyclin F. Ngoi, P., Wang, X., Putta, S. et al. Proc Natl Acad Sci U S A (2025) 122:e2501057122-e2501057122. DOI 10.1073/pnas.2501057122 · PubMed

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