Crystal structure of human respiratory syncytial virus NS1 bound to human MED25 ACID. Determined by X-ray diffraction at 2.53 Å resolution. Released 9 Apr 2025.
Explore 9CCV in 3D Show helices and sheets RCSB PDB PDBe
9CCV contains 8 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 6-15 | 10 | 1 |
| β-strand | 18-30 | 13 | 1 |
| α-helix | 34-42 | 9 | |
| β-strand | 44-51 | 8 | 1 |
| β-strand | 54-61 | 8 | 1 |
| α-helix | 69-71 | 3 | |
| β-strand | 74-80 | 7 | 1 |
| β-strand | 86-97 | 12 | 1 |
| β-strand | 110-115 | 6 | 1 |
| α-helix | 116-118 | 3 | |
| α-helix | 119-133 | 15 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 399-409 | 11 | 2 |
| β-strand | 424-433 | 10 | 2 |
| β-strand | 447-454 | 8 | 2 |
| α-helix | 455-461 | 7 | |
| α-helix | 462-466 | 5 | |
| β-strand | 468-475 | 8 | 2 |
| α-helix | 480-493 | 14 | |
| β-strand | 494-499 | 6 | 2 |
| β-strand | 510-516 | 7 | 2 |
| β-strand | 521-527 | 7 | 2 |
| α-helix | 530-541 | 12 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Non-structural protein 1 | A | protein | 141 | Human respiratory syncytial virus A | P0DOE9 |
| Mediator of RNA polymerase II transcription subunit 25 | B | protein | 185 | Homo sapiens | Q71SY5 (AlphaFold model) |
>9CCV_1 Non-structural protein 1 (chains A) GHMGSNSLSMIKVRLQNLFDNDEVALLKITCYTDKLIHLTNALAKAVIHTIKLNGIVFVH VITSSDICPNNNIVVKSNFTTMPVLQNGGYIWEMMELTHCSQPNGLIDDNCEIKFSKKLS DSTMTNYMNQLSELLGFDLNP
>9CCV_2 Mediator of RNA polymerase II transcription subunit 25 (chains B) MGSSHHHHHHSSGLVPRGSHIENLYFQGHMLGGQQSVSNKLLAWSGVLEWQEKPKPASVD ANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNK DLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIR QVITN
Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25. Kalita, P., Khatavkar, O., Uwase, G. et al. Nat Commun (2025) 16:2883-2883. DOI 10.1038/s41467-025-58216-4 · PubMed
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