9D32: HKU5 RBD

Structure of the HKU5 RBD bound to the P. abramus ACE2 receptor. Determined by electron microscopy at 3.1 Å resolution. Released 19 Feb 2025.

Method
Electron microscopy
Resolution
3.1 Å
Organisms
Pipistrellus abramus, Pipistrellus bat coronavirus HKU5
Chains
2
Atoms
6,130
Mol. weight
120.6 kDa
Ligands
NAG, ZN
Released
19 Feb 2025

Explore 9D32 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9D32 contains 49 α-helices and 24 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 38 helices, 9 β-strands

ElementResiduesLengthSheet
α-helix21-5131
α-helix56-8025
α-helix85-873
α-helix93-1008
α-helix104-1074
α-helix111-12818
β-strand131-13331
β-strand141-14331
α-helix144-1518
α-helix157-17014
α-helix176-19217
α-helix198-2036
α-helix204-2063
β-strand20812
β-strand21612
α-helix221-25030
α-helix2601
β-strand261-26223
α-helix263-2653
α-helix275-2773
α-helix278-2814
α-helix288-2903
α-helix293-2986
α-helix303-31614
α-helix324-3296
β-strand33114
β-strand346-34944
β-strand355-35844
α-helix365-38319
α-helix389-3913
α-helix399-41113
α-helix414-4207
α-helix431-44515
α-helix446-4483
α-helix449-46416
α-helix469-4713
α-helix472-4798
α-helix480-4845
β-strand486-48723
α-helix499-5013
α-helix503-5064
α-helix513-53119
α-helix538-5403
α-helix547-55711
α-helix565-5739
α-helix581-5866
α-helix588-59811
Chain B: 11 helices, 15 β-strands
ElementResiduesLengthSheet
β-strand40015
α-helix401-4044
α-helix405-4073
β-strand409-41356
β-strand41717
α-helix424-4263
β-strand428-43586
α-helix439-4424
β-strand44718
β-strand449-45686
α-helix459-4646
α-helix4721
α-helix473-4775
β-strand486-49276
α-helix493-4942
β-strand50015
α-helix501-5033
β-strand505-516129
β-strand519-52249
α-helix525-5262
α-helix534-5374
β-strand546-54949
β-strand553-56199
β-strand567-57596
β-strand58318
β-strand58417

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Angiotensin-converting enzymeAprotein768Pipistrellus abramusC7ECT9 (AlphaFold model)
Spike glycoproteinBprotein267Pipistrellus bat coronavirus HKU5A3EXD0 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9D32_1 Angiotensin-converting enzyme (chains A)
MPMGSLQPLATLYLLGMLVASVLAQYTTEEEARRFLVKFNHEAENLSHESALASWDYNTN
ITDENAKKMNEADNKWSDFYKEQSKIAQGFPLQEIKDPIIKLQLQILQQNGSSVLTAEKR
KRLSTILTTMSTIYSTGKVCNPNNPQQCFTLSGLEDIMEKSKDYHERLWVWEGWRSEVGK
QLRPLYEEYVELKNEMARGNNYKDYGDYWRGDYETEGEKGYNYSRNYLMEDVDRIFLEIK
PLYEQLHAYVRAKLMKAYPSHISPTGCLPAHLLGDMWGRFWTNLYNLTVPLEKEPNIDVT
DTMKKQSWDAEKIFKEAEKFYSSVGLPNMTPGFWRDSMLTEPSDGRQVVCHPTAWDLGKN
DFRIKMCTKVTMDDFLTAHHEMGHIQYDMAYANQSYLLRNGANEGFHEAVGEVMSLSVAT
PKHLKGMGLLPSDFSENNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFEGKIPKEQWM
EKWWEMKREIVGVVEPLPHDETYCDPASLFHVANDYSFIRYFTRTILEFQFQEALCRTAK
HQGPLHKCDISNSTEAGKKLNDMLKLGKSTPWTYALEKIAETKEMDAKPLLNYFNPLFRW
LKEQNGNSVGWSVDSSPYSNQSIKVRISLKSALGEKAYEWNENEMYLFQSSVAYAMRVYF
LKAKNESIPFRAEDVRVSDEKKRVSFKFFVTSPTNMSDIIPRSEVEDAIRMSRSRINDAF
RLDDNTLEFLGLVPRGSSSGGSGLNDIFEAQKIEWHEGGSHHHHHHHH
Sequence of entity 2 (B), FASTA
>9D32_2 Spike glycoprotein (chains B)
MGILPSPGMPALLSLVSLLSVLLMGCVAETGTQECDFTPMLTGTPPPIYNFKRLVFTNCN
YNLTKLLSLFQVSEFSCHQVSPSSLATGCYSSLTVDYFAYSTDMSSYLQPGSAGEIVQFN
YKQDFSNPTCRVLATVPQNLTTITKPSNYAYLTECYKTSAYGKNYLYNAPGGYTPCLSLA
SRGFSTKYQSHSDGELTTTGYIYPVTGNLQMAFIISVQYGTDTNSVCPMQLVPRGSSSGG
SGLNDIFEAQKIEWHEGGSHHHHHHHH

Ligands and cofactors

IDNameFormulaCopies
NAG2-acetamido-2-deoxy-beta-D-glucopyranoseC8 H15 N O68
ZNZinc ionZn1

Primary citation

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses. Park, Y.J., Liu, C., Lee, J. et al. Cell (2025) 188:1711-1728.e21. DOI 10.1016/j.cell.2024.12.032 · PubMed

Other PDB entries of the same protein (UniProt C7ECT9 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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