9D43: Unliganded yeast Exportin Msn5

Cryo-EM structure of unliganded yeast Exportin Msn5. Determined by electron microscopy at 3.39 Å resolution. Released 19 Mar 2025.

Method
Electron microscopy
Resolution
3.39 Å
Organism
Saccharomyces cerevisiae
Chains
1
Atoms
9,754
Mol. weight
143.07 kDa
Released
19 Mar 2025

Explore 9D43 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9D43 contains 77 α-helices and 4 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 77 helices, 4 β-strands

ElementResiduesLengthSheet
α-helix6-1712
α-helix22-3716
α-helix42-5211
α-helix57-7317
α-helix80-9516
α-helix103-12018
α-helix123-1264
α-helix131-1377
α-helix142-1509
α-helix154-16916
α-helix170-1745
α-helix177-1815
α-helix183-19412
α-helix197-2037
α-helix210-2134
α-helix221-23414
α-helix237-25014
α-helix256-2627
α-helix264-2729
α-helix277-29216
α-helix298-31013
α-helix312-32211
α-helix335-34713
α-helix348-3547
α-helix361-37313
α-helix378-3836
α-helix385-3939
α-helix398-4014
α-helix406-41611
α-helix428-4358
α-helix439-46325
α-helix465-48117
α-helix486-4894
α-helix499-52426
α-helix530-55122
α-helix557-57418
α-helix575-5773
α-helix579-59113
α-helix604-62623
α-helix630-6323
α-helix635-64410
α-helix650-66718
α-helix673-68513
α-helix686-6894
α-helix691-6966
α-helix700-7078
α-helix709-71911
β-strand73111
α-helix732-7332
α-helix734-75017
α-helix753-76311
α-helix771-78414
α-helix788-80114
α-helix806-8094
α-helix812-8143
α-helix815-8228
β-strand84911
α-helix850-87829
α-helix880-8834
α-helix887-89610
β-strand89912
β-strand90612
α-helix912-9187
α-helix919-9235
α-helix924-9285
α-helix935-95925
α-helix969-9724
α-helix979-100224
α-helix1019-102810
α-helix1031-104616
α-helix1051-106313
α-helix1064-10663
α-helix1072-10776
α-helix1078-10825
α-helix1083-10864
α-helix1087-10915
α-helix1100-111718
α-helix1119-112911
α-helix1134-11429
α-helix1147-116519
α-helix1176-119722

Molecules and chains

MoleculeChainsTypeLengthOrganismUniProt
Protein MSN5Aprotein1230Saccharomyces cerevisiaeP52918 (AlphaFold model)
Sequence of entity 1 (A), FASTA
>9D43_1 Protein MSN5 (chains A)
MDSTGASQIVSALDVIYSPKSNNSQRQEAQKFLDEVKLCSESPFWGYEIALQNPTNSILK
YFGLGLLDHAVKKNWNDYDEGKRVALRKWVMELNFGVQDYDTRYIKEKLATLWVEVAKRT
WGEALKQTNPTEEQLLTSWVDMDNNLFELWNINQSSRELALIIFRILFEDVFLLDDLIVL
KRMTVIQPLCVMIVCPIEVFAIKYKFSDKWTKFKANEEGWFSVWIPELNNALQQNNSEYI
IRLLETLKTCLNWPLTEVIVRNDVLSSLLTCLSSNIPRAQSMALDSIHILLTRPYSNESH
YQMTIDRVFDNMDLLDSVYESLLFDPTDDIDETKYPIIKKFVDMISCLYVCVPKIKETNG
QIQKYFKLVLKTTYNPSLIVSGLTLDLWCTCLRNDEYLPKLEKYVIPDLLQFAADALVYY
EQIDGHISKKFAEIDFQSKSEFQTFCSTYRKRIRDIIRLISCVELDLTYDWLNNRLNNYF
SSPFGQQVLSSTFLDHKLEPYLGALSQYMIVECFINGCIRWKIWYPTGDDYDEKLDSILQ
KLEILSNQLIALNLREPLLLKKQIQNFALFLTMLKDNVLFTLLEKIITSATMDYPEINLE
ERGAESDAVRDLRYACGIELNRMALLMPESLKKIYPDLESVIARIMPNLSYHEKISFKSF
LLIIVLKSSLDMKEERFAAIVDPELLAWSDKTTVVGLSDLHWFMERLGIVQIAEYFQRRD
IDENSDLLSIPIDDEGKELKSELTKRWQSLFPVRATRMFIHYSMQSIKTDEEFKMLQDLW
RPRIVPILPYITRLLYQLQSYHDPDNWKGLPTVVQSFVKYSTIERFWEAGASNKSKDEFI
DEHMKAMQTLRDFADSVGHIIRYTREYTLLVLSAISSLGSVFYLLDESPDLLLNSIAIFK
PGSNEISPGVSTHGWKHIMNIAIRPILKGCPKDCLGKFMPAFLPKLFEILDLLLCQKWSS
HMNDMDMNPVPTDDDQMTEEILEENLLRQLTTVVVRIVIDCVGQGNANPNSAKSRLNNHQ
MEMRKIIFNDLNTLAPFLKLLNHLISFKDTKCSFNSILVMKCCLTSVLNQNNTVDEYFTF
EVMKNLLLNVLCNSAFKDSFHEALYAFTVIFLTLCKEYPSARAFLFEISNGYNIDELYRN
LRSVDEYKTQRALMIDFIDWVKSTSGKEDGNVDHAGDERKRQEKREAILKKANERLIKKN
KENGDMLDDPNIEDGAVGNLFDDNENLYFQ

Primary citation

Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5. Fung, H.Y.J., Mittal, S.R., Niesman, A.B. et al. Nat Commun (2025) 16:2580-2580. DOI 10.1038/s41467-025-57752-3 · PubMed

Other PDB entries of the same protein (UniProt P52918 (AlphaFold model), which also has an AlphaFold model), best resolution first:

Browse structure collections

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