9E8I: Human proteasome in resting state conformation
Human proteasome in resting state conformation bound to TXNL1 in Forward conformation. Determined by electron microscopy at 2.87 Å resolution. Released 4 Dec 2024.
- Method
- Electron microscopy
- Resolution
- 2.87 Å
- Organism
- Homo sapiens
- Chains
- 27
- Atoms
- 71,304
- Mol. weight
- 1213.78 kDa
- Ligands
- ATP, ADP, ZN, MG
- Released
- 4 Dec 2024
Explore 9E8I in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9E8I contains 511 α-helices and 281 β-strands across 27 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 25 helices, 3 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 6-13 | 8 | |
| α-helix | 19-30 | 12 | |
| α-helix | 34-45 | 12 | |
| α-helix | 58-59 | 2 | |
| α-helix | 60-64 | 5 | |
| α-helix | 68-70 | 3 | |
| α-helix | 73-86 | 14 | |
| α-helix | 90-103 | 14 | |
| α-helix | 108-125 | 18 | |
| α-helix | 128-144 | 17 | |
| α-helix | 150-166 | 17 | |
| α-helix | 169-182 | 14 | |
| α-helix | 190-206 | 17 | |
| α-helix | 213-217 | 5 | |
| α-helix | 220-225 | 6 | |
| α-helix | 231-242 | 12 | |
| α-helix | 245-250 | 6 | |
| α-helix | 252-255 | 4 | |
| α-helix | 259-263 | 5 | |
| α-helix | 265-283 | 19 | |
| α-helix | 286-288 | 3 | |
| β-strand | 290-292 | 3 | 58 |
| α-helix | 293-299 | 7 | |
| α-helix | 304-306 | 3 | |
| α-helix | 307-317 | 11 | |
| β-strand | 320-325 | 6 | 58 |
| β-strand | 330-336 | 7 | 58 |
| α-helix | 343-370 | 28 | |
Chain A: 26 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 42-62 | 21 | |
| β-strand | 72 | 1 | 1 |
| α-helix | 73-74 | 2 | |
| α-helix | 75-77 | 3 | |
| α-helix | 80-89 | 10 | |
| β-strand | 93-102 | 10 | 2 |
| β-strand | 110-115 | 6 | 2 |
| β-strand | 119-125 | 7 | 2 |
| α-helix | 131-133 | 3 | |
| β-strand | 139-142 | 4 | 2 |
| β-strand | 149-152 | 4 | 2 |
| α-helix | 154-156 | 3 | |
| α-helix | 159-162 | 4 | |
| β-strand | 165 | 1 | 3 |
| α-helix | 174-176 | 3 | |
| α-helix | 181-191 | 11 | |
| α-helix | 193-196 | 4 | |
| α-helix | 199-202 | 4 | |
| β-strand | 211-215 | 5 | 3 |
| α-helix | 222-232 | 11 | |
| β-strand | 236-241 | 6 | 3 |
| α-helix | 242-245 | 4 | |
| α-helix | 252-265 | 14 | |
| β-strand | 270-275 | 6 | 3 |
| α-helix | 277-279 | 3 | |
| β-strand | 282 | 1 | 4 |
| α-helix | 283-284 | 2 | |
| β-strand | 287 | 1 | 5 |
| β-strand | 289 | 1 | 5 |
| α-helix | 293-306 | 14 | |
| β-strand | 315-321 | 7 | 3 |
| α-helix | 324-326 | 3 | |
| β-strand | 327 | 1 | 4 |
| β-strand | 339-342 | 4 | 3 |
| α-helix | 344-346 | 3 | |
| α-helix | 348-358 | 11 | |
| β-strand | 364 | 1 | 6 |
| α-helix | 370-375 | 6 | |
| α-helix | 382-398 | 17 | |
| β-strand | 404 | 1 | 6 |
| α-helix | 406-413 | 8 | |
| α-helix | 414-418 | 5 | |
| α-helix | 419-421 | 3 | |
| α-helix | 426-432 | 7 | |
Chain b: 9 helices, 5 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 4-10 | 7 | 61 |
| α-helix | 14-17 | 4 | |
| α-helix | 25-43 | 19 | |
| β-strand | 48-53 | 6 | 61 |
| β-strand | 60-65 | 6 | 61 |
| α-helix | 69-76 | 8 | |
| α-helix | 86-98 | 13 | |
| β-strand | 106-112 | 7 | 61 |
| α-helix | 121-133 | 13 | |
| β-strand | 138-141 | 4 | 61 |
| α-helix | 146-149 | 4 | |
| α-helix | 152-161 | 10 | |
| α-helix | 173-174 | 2 | |
| α-helix | 180-182 | 3 | |
Chain B: 24 helices, 14 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 37-38 | 2 | |
| α-helix | 45-47 | 3 | |
| α-helix | 59-85 | 27 | |
| α-helix | 92-103 | 12 | |
| β-strand | 107-114 | 8 | 2 |
| β-strand | 120-124 | 5 | 2 |
| β-strand | 130-135 | 6 | 2 |
| β-strand | 139 | 1 | 1 |
| α-helix | 141-143 | 3 | |
| β-strand | 149-153 | 5 | 2 |
| β-strand | 159-162 | 4 | 2 |
| α-helix | 165-168 | 4 | |
| α-helix | 169-174 | 6 | |
| β-strand | 175 | 1 | 9 |
| α-helix | 184-186 | 3 | |
| α-helix | 191-201 | 11 | |
| α-helix | 203-206 | 4 | |
| α-helix | 209-214 | 6 | |
| α-helix | 217-219 | 3 | |
| β-strand | 221-225 | 5 | 9 |
| α-helix | 232-241 | 10 | |
| β-strand | 246-251 | 6 | 9 |
| α-helix | 252-255 | 4 | |
| α-helix | 262-276 | 15 | |
| β-strand | 280-285 | 6 | 9 |
| α-helix | 289-292 | 4 | |
| α-helix | 302-316 | 15 | |
| α-helix | 321-322 | 2 | |
| β-strand | 325-331 | 7 | 9 |
| β-strand | 349-352 | 4 | 9 |
| α-helix | 354-356 | 3 | |
| α-helix | 358-368 | 11 | |
| β-strand | 374 | 1 | 10 |
| α-helix | 380-384 | 5 | |
| α-helix | 392-408 | 17 | |
| β-strand | 414 | 1 | 10 |
| α-helix | 415 | 1 | |
| α-helix | 416-426 | 11 | |
Chain c: 17 helices, 10 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 25-26 | 2 | 62 |
| β-strand | 30-34 | 5 | 63 |
| α-helix | 35-47 | 13 | |
| β-strand | 54-63 | 10 | 63 |
| β-strand | 66-74 | 9 | 63 |
| α-helix | 75-77 | 3 | |
| α-helix | 84-87 | 4 | |
| α-helix | 89-99 | 11 | |
| α-helix | 100-102 | 3 | |
| β-strand | 107-114 | 8 | 63 |
| α-helix | 124-136 | 13 | |
| β-strand | 141-151 | 11 | 63 |
| β-strand | 154-162 | 9 | 63 |
| α-helix | 163-164 | 2 | |
| α-helix | 165-169 | 5 | |
| β-strand | 175-176 | 2 | 62 |
| α-helix | 181-183 | 3 | |
| α-helix | 186-188 | 3 | |
| α-helix | 189-193 | 5 | |
| β-strand | 196 | 1 | 63 |
| β-strand | 200-208 | 9 | 63 |
| α-helix | 211-217 | 7 | |
| α-helix | 225-229 | 5 | |
| α-helix | 230-233 | 4 | |
| α-helix | 234-263 | 30 | |
| α-helix | 269-272 | 4 | |
| α-helix | 280-308 | 29 | |
Chain C: 26 helices, 12 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 21-66 | 46 | |
| α-helix | 69-70 | 2 | |
| β-strand | 71-80 | 10 | 2 |
| β-strand | 84-89 | 6 | 2 |
| β-strand | 93-99 | 7 | 2 |
| β-strand | 113-116 | 4 | 2 |
| β-strand | 123-126 | 4 | 2 |
| α-helix | 127-129 | 3 | |
| α-helix | 133-141 | 9 | |
| α-helix | 143-145 | 3 | |
| α-helix | 148-150 | 3 | |
| α-helix | 155-161 | 7 | |
| α-helix | 162-166 | 5 | |
| α-helix | 167-170 | 4 | |
| α-helix | 172-178 | 7 | |
| α-helix | 181-183 | 3 | |
| β-strand | 185-189 | 5 | 11 |
| α-helix | 196-206 | 11 | |
| α-helix | 209 | 1 | |
| β-strand | 210-213 | 4 | 11 |
| α-helix | 221-224 | 4 | |
| α-helix | 231-233 | 3 | |
| α-helix | 234-239 | 6 | |
| β-strand | 244-249 | 6 | 11 |
| α-helix | 268-282 | 15 | |
| β-strand | 289-295 | 7 | 11 |
| α-helix | 303-306 | 4 | |
| β-strand | 313-316 | 4 | 11 |
| α-helix | 318-320 | 3 | |
| α-helix | 322-332 | 11 | |
| α-helix | 333-335 | 3 | |
| β-strand | 338 | 1 | 12 |
| α-helix | 339 | 1 | |
| α-helix | 344-349 | 6 | |
| α-helix | 356-372 | 17 | |
| β-strand | 378 | 1 | 12 |
| α-helix | 380-387 | 8 | |
| α-helix | 388-393 | 6 | |
Chain d: 15 helices, 4 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 87-103 | 17 | |
| α-helix | 109-125 | 17 | |
| α-helix | 138-157 | 20 | |
| α-helix | 161-176 | 16 | |
| α-helix | 183-185 | 3 | |
| α-helix | 188-201 | 14 | |
| α-helix | 205-213 | 9 | |
| α-helix | 217-222 | 6 | |
| α-helix | 224-238 | 15 | |
| α-helix | 241-246 | 6 | |
| α-helix | 254-256 | 3 | |
| α-helix | 257-278 | 22 | |
| β-strand | 279 | 1 | 56 |
| β-strand | 281-283 | 3 | 64 |
| α-helix | 286-290 | 5 | |
| α-helix | 297-306 | 10 | |
| β-strand | 310 | 1 | 64 |
| β-strand | 315-317 | 3 | 64 |
| α-helix | 332-347 | 16 | |
Chain D: 21 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 40-79 | 40 | |
| α-helix | 80-83 | 4 | |
| α-helix | 84 | 1 | |
| α-helix | 86 | 1 | |
| β-strand | 87-94 | 8 | 2 |
| β-strand | 100-105 | 6 | 2 |
| β-strand | 110-115 | 6 | 2 |
| α-helix | 121-123 | 3 | |
| β-strand | 128-133 | 6 | 2 |
| β-strand | 139-142 | 4 | 2 |
| α-helix | 171-177 | 7 | |
| α-helix | 178-182 | 5 | |
| α-helix | 183-186 | 4 | |
| α-helix | 188-194 | 7 | |
| β-strand | 201-205 | 5 | 13 |
| α-helix | 212-221 | 10 | |
| β-strand | 226-231 | 6 | 13 |
| α-helix | 232-234 | 3 | |
| α-helix | 242-256 | 15 | |
| β-strand | 260-265 | 6 | 13 |
| α-helix | 267-269 | 3 | |
| β-strand | 272 | 1 | 14 |
| α-helix | 280-297 | 18 | |
| β-strand | 305-311 | 7 | 13 |
| α-helix | 314-316 | 3 | |
| β-strand | 317 | 1 | 14 |
| α-helix | 319-322 | 4 | |
| β-strand | 329-332 | 4 | 13 |
| α-helix | 338-349 | 12 | |
| β-strand | 354 | 1 | 15 |
| α-helix | 361-364 | 4 | |
| α-helix | 372-388 | 17 | |
| β-strand | 391 | 1 | 16 |
| β-strand | 394 | 1 | 15 |
| α-helix | 396-407 | 12 | |
| α-helix | 415-417 | 3 | |
19 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| 26S proteasome regulatory subunit 7 | A | protein | 433 | Homo sapiens | P35998 (AlphaFold model) |
| 26S proteasome regulatory subunit 4 | B | protein | 440 | Homo sapiens | P62191 (AlphaFold model) |
| 26S protease regulatory subunit 8 | C | protein | 406 | Homo sapiens | P62195 (AlphaFold model) |
| 26S proteasome regulatory subunit 6B | D | protein | 418 | Homo sapiens | P43686 (AlphaFold model) |
| 26S protease regulatory subunit 10B | E | protein | 389 | Homo sapiens | P62333 |
| 26S proteasome regulatory subunit 6A | F | protein | 439 | Homo sapiens | P17980 |
| Proteasome subunit alpha type-6 | G | protein | 246 | Homo sapiens | P60900 |
| Proteasome subunit alpha type-2 | H | protein | 234 | Homo sapiens | P25787 |
| Proteasome subunit alpha type-4 | I | protein | 261 | Homo sapiens | P25789 |
| Proteasome subunit alpha type-7 | J | protein | 248 | Homo sapiens | O14818 |
| Proteasome subunit alpha type-5 | K | protein | 241 | Homo sapiens | P28066 |
| Proteasome subunit alpha type-1 | L | protein | 263 | Homo sapiens | P25786 |
15 more molecules are not listed.
Sequence of entity 1 (A), FASTA
>9E8I_1 26S proteasome regulatory subunit 7 (chains A)
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKIN
ELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAK
FVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGC
KEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRV
IGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTML
ELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHAR
SMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSY
AKFSATPRYMTYN
Sequence of entity 2 (B), FASTA
>9E8I_2 26S proteasome regulatory subunit 4 (chains B)
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRL
KLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNH
AIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAP
QETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVA
NQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSG
GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKT
KKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFK
KSKENVLYKKQEGTPEGLYL
Sequence of entity 3 (C), FASTA
>9E8I_3 26S protease regulatory subunit 8 (chains C)
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLR
EELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDS
YTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGI
AQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMARE
HAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDI
LDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVK
GVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Sequence of entity 4 (D), FASTA
>9E8I_4 26S proteasome regulatory subunit 6B (chains D)
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Sequence of entity 5 (E), FASTA
>9E8I_5 26S protease regulatory subunit 10B (chains E)
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKALQSVGQIVGEV
LKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVY
NMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGK
TLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGG
RRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIH
IDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD
FVVQEDFMKAVRKVADSKKLESKLDYKPV
Sequence of entity 6 (F), FASTA
>9E8I_6 26S proteasome regulatory subunit 6A (chains F)
MNLLPNIESPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVL
RVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGK
CAVIKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDER
PTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARAC
AAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEK
AGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEE
ARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDY
MEGILEVQAKKKANLQYYA
Sequence of entity 7 (G), FASTA
>9E8I_7 Proteasome subunit alpha type-6 (chains G)
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKL
LDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIAD
ISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLE
KKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLV
ALAERD
Sequence of entity 8 (H), FASTA
>9E8I_8 Proteasome subunit alpha type-2 (chains H)
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
Sequence of entity 9 (I), FASTA
>9E8I_9 Proteasome subunit alpha type-4 (chains I)
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVF
FSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQA
YTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYK
EGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKH
EEEEAKAEREKKEKEQKEKDK
Sequence of entity 10 (J), FASTA
>9E8I_10 Proteasome subunit alpha type-7 (chains J)
MSYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGVRGRDIVVLGVEKKSVAKLQDERTVR
KICALDDNVCMAFAGLTADARIVINRARVECQSHRLTVEDPVTVEYITRYIASLKQRYTQ
SNGRRPFGISALIVGFDFDGTPRLYQTDPSGTYHAWKANAIGRGAKSVREFLEKNYTDEA
IETDDLTIKLVIKALLEVVQSGGKNIELAVMRRDQSLKILNPEEIEKYVAEIEKEKEENE
KKKQKKAS
Sequence of entity 11 (K), FASTA
>9E8I_11 Proteasome subunit alpha type-5 (chains K)
MFLTRSEYDRGVNTFSPEGRLFQVEYAIEAIKLGSTAIGIQTSEGVCLAVEKRITSPLME
PSSIEKIVEIDAHIGCAMSGLIADAKTLIDKARVETQNHWFTYNETMTVESVTQAVSNLA
LQFGEEDADPGAMSRPFGVALLFGGVDEKGPQLFHMDPSGTFVQCDARAIGSASEGAQSS
LQEVYHKSMTLKEAIKSSLIILKQVMEEKLNATNIELATVQPGQNFHMFTKEELEEVIKD
I
Sequence of entity 12 (L), FASTA
>9E8I_12 Proteasome subunit alpha type-1 (chains L)
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
Ligands and cofactors
| ID | Name | Formula | Copies |
|---|
| ATP | Adenosine-5'-triphosphate | C10 H16 N5 O13 P3 | 5 |
| ADP | Adenosine-5'-diphosphate | C10 H15 N5 O10 P2 | 1 |
| ZN | Zinc ion | Zn | 1 |
| MG | Magnesium ion | Mg | 6 |
Primary citation
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1. Arkinson, C., Gee, C.L., Zhang, Z. et al. Nat Struct Mol Biol (2025) 32:2403-2415. DOI 10.1038/s41594-025-01695-2 · PubMed
Other PDB entries of the same protein (UniProt P35998 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9K53 2.5 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state ED2.1
- 8USD 2.7 Å, Rpn1/Nub1UBL-focused alignment of the non-substrate-engaged human 26S proteasome
- 8USB 2.73 Å, Non-substrate-engaged human 26S proteasome with Nub1/FAT10 bound to Rpn1
- 9MBP 2.75 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT1 at top of spiral…
- 9PDL 2.76 Å, Nub1/Fat10-processing human 26S proteasome with Rpt5 at top of spiral staircase (AAA+…
- 9NKG 2.8 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB-MIDN (Composite map)
- 9BV3 2.9 Å, M1B Midnolin-Proteasome
- 9E8H 2.9 Å, Human proteasome in resting state conformation bound to TXNL1 in backward conformation
- 9K4J 2.9 Å, Structure of substrate-engaged human 26S proteasome RP-CP subcomplex in state EA1.0
- 9NKF 2.9 Å, Structure of human substrate-free 26S proteasome in the presence of ATPgS and…
- 9U3L 2.91 Å, Substrate-engaged human 26S proteasome bound to midnolin with RPT2 at top of spiral…
- 9NKI 2.94 Å, Structure of substrate engaged MIDN-bound human 26S proteasome, EB MIDN_UBL state…
Browse structure collections
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