9FSQ: DNA-directed RNA polymerase III subunit RPC1

RNA Polymerase III Class III Melting Pre-Initiation Complex (MC). Determined by electron microscopy at 3.51 Å resolution. Released 15 Jan 2025.

Method: Electron microscopy
Resolution: 3.51 Å
Organism: Homo sapiens
Chains: 25
Atoms: 56,541
Mol. weight: 1149.06 kDa
Ligands: SF4, MG, ZN
Released: 15 Jan 2025

Explore 9FSQ in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9FSQ contains 340 α-helices and 325 β-strands across 23 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 77 helices, 63 β-strands

Element	Residues	Length	Sheet
β-strand	5	1	1
β-strand	14-21	8	2
α-helix	25-31	7
β-strand	35	1	3
β-strand	38	1	4
β-strand	42	1	5
α-helix	49	1
β-strand	50	1	5
α-helix	51	1
β-strand	54	1	4
β-strand	84-87	4	3
α-helix	95-106	12
α-helix	119-130	12
α-helix	136-151	16
β-strand	155	1	6
β-strand	162	1	6
β-strand	166-170	5	7
β-strand	173-176	4	7
α-helix	177-179	3
α-helix	186-187	2
α-helix	188-194	7
α-helix	195-197	3
α-helix	198-203	6
α-helix	208-213	6
β-strand	216-218	3	7
α-helix	220-227	8
α-helix	234-237	4
α-helix	247-250	4
β-strand	254-257	4	3
α-helix	260-262	3
α-helix	278-298	21
α-helix	303-321	19
α-helix	330-332	3
α-helix	341-345	5
α-helix	351-356	6
β-strand	360	1	8
β-strand	364-368	5	9
β-strand	369-371	3	10
β-strand	379-383	5	9
α-helix	384-387	4
β-strand	391-395	5	11
α-helix	396	1
α-helix	401-410	10
β-strand	418-422	5	11
β-strand	429-430	2	11
α-helix	432-434	3
α-helix	439-442	4
β-strand	446	1	12
β-strand	448	1	12
β-strand	449-453	5	11
α-helix	454	1
β-strand	459-463	5	9
α-helix	470-472	3
β-strand	473-481	9	9
β-strand	486-488	3	10
α-helix	490-492	3
α-helix	493-496	4
β-strand	504-508	5	9
α-helix	513-523	11
β-strand	524	1	9
β-strand	530	1	13
β-strand	537	1	13
β-strand	541	1	14
α-helix	546-552	7
α-helix	561-568	8
α-helix	569-571	3
α-helix	574-578	5
α-helix	583-585	3
β-strand	588	1	15
β-strand	592	1	16
β-strand	594	1	15
α-helix	597-605	9
β-strand	616-618	3	17
β-strand	639-641	3	17
β-strand	644-645	2	17
α-helix	652-655	4
β-strand	656	1	14
α-helix	663-671	9
α-helix	673-694	22
α-helix	700-703	4
α-helix	707-732	26
α-helix	744-770	27
α-helix	771-772	2
α-helix	776-782	7
α-helix	789-796	8
β-strand	804	1	18
β-strand	807	1	18
α-helix	808-811	4
β-strand	813	1	19
β-strand	816	1	19
α-helix	828-831	4
α-helix	844-879	36
β-strand	883-884	2	20
β-strand	890-891	2	20
β-strand	897-899	3	20
β-strand	907	1	21
α-helix	909-911	3
β-strand	914	1	22
β-strand	917	1	22
α-helix	921-931	11
α-helix	938-940	3
α-helix	942-953	12
α-helix	956-959	4
α-helix	963-986	24
α-helix	998-1002	5
α-helix	1008-1023	16
β-strand	1026	1	21
α-helix	1033-1047	15
α-helix	1067-1075	9
β-strand	1084-1087	4	23
β-strand	1091	1	24
α-helix	1100-1103	4
α-helix	1111-1113	3
β-strand	1122	1	25
β-strand	1125	1	25
β-strand	1128-1131	4	26
α-helix	1134-1140	7
α-helix	1146-1152	7
α-helix	1162-1164	3
β-strand	1165-1169	5	26
β-strand	1172-1175	4	26
α-helix	1186-1190	5
β-strand	1207	1	27
β-strand	1225-1228	4	23
β-strand	1229	1	27
α-helix	1232-1237	6
α-helix	1243-1245	3
β-strand	1247-1248	2	23
α-helix	1251-1257	7
α-helix	1260-1278	19
α-helix	1284-1294	11
α-helix	1305-1311	7
α-helix	1315-1321	7
α-helix	1327-1334	8
β-strand	1337-1339	3	2
α-helix	1343-1348	6
α-helix	1356-1358	3
β-strand	1361-1364	4	1
α-helix	1372-1376	5
α-helix	1382-1384	3

Chain B: 54 helices, 83 β-strands

Element	Residues	Length	Sheet
α-helix	26-28	3
α-helix	29-36	8
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
β-strand	64-66	3	28
β-strand	74-81	8	28
β-strand	87-88	2	29
β-strand	94-95	2	29
α-helix	99-105	7
β-strand	110-119	10	28
β-strand	121	1	30
β-strand	123	1	30
β-strand	127-137	11	28
α-helix	152-155	4
β-strand	169-171	3	31
β-strand	174-178	5	31
β-strand	180	1	32
β-strand	182-184	3	33
β-strand	190-193	4	34
β-strand	199-206	8	34
β-strand	211-217	7	34
β-strand	224-226	3	34
β-strand	230	1	35
β-strand	234-235	2	34
α-helix	236-243	8
α-helix	248-255	8
α-helix	259-265	7
α-helix	266-269	4
α-helix	270-274	5
α-helix	280-289	10
β-strand	291	1	35
α-helix	304-308	5
α-helix	309-316	8
α-helix	329-344	16
α-helix	357-359	3
β-strand	360-362	3	33
α-helix	365-395	31
α-helix	399-400	2
α-helix	402-405	4
α-helix	409-421	13
β-strand	423	1	36
β-strand	426	1	37
β-strand	431	1	37
β-strand	434	1	36
β-strand	437-439	3	31
α-helix	445-452	8
β-strand	454-455	2	32
α-helix	473-475	3
β-strand	479	1	38
β-strand	494-495	2	32
β-strand	496	1	38
β-strand	501-502	2	39
α-helix	509-515	7
β-strand	521	1	40
α-helix	523-525	3
α-helix	529-532	4
β-strand	536-541	6	40
β-strand	544-550	7	40
α-helix	552-565	14
β-strand	573-577	5	40
β-strand	582-586	5	40
β-strand	592-593	2	39
β-strand	594-598	5	41
β-strand	599-600	2	42
β-strand	603-604	2	42
α-helix	608-616	9
α-helix	621-626	6
β-strand	630-633	4	41
α-helix	635-638	4
β-strand	643-644	2	41
β-strand	656-657	2	41
α-helix	661-664	4
α-helix	668-671	4
α-helix	675-677	3
α-helix	680-687	8
β-strand	708-712	5	43
β-strand	716	1	44
β-strand	720-721	2	45
α-helix	724-727	4
α-helix	730-732	3
β-strand	736	1	44
β-strand	737-743	7	46
β-strand	754-758	5	46
α-helix	759-763	5
β-strand	769-779	11	43
β-strand	781	1	47
β-strand	787	1	47
β-strand	789-790	2	48
α-helix	791-794	4
β-strand	795	1	49
β-strand	802	1	49
α-helix	804-806	3
β-strand	814	1	50
α-helix	819	1
β-strand	820-821	2	43
β-strand	826-828	3	50
β-strand	830-833	4	48
α-helix	848-850	3
β-strand	851-853	3	48
β-strand	856-857	2	50
β-strand	864-873	10	43
β-strand	879-889	11	43
β-strand	896-898	3	46
β-strand	905-911	7	46
α-helix	913-915	3
β-strand	918	1	51
β-strand	927-929	3	46
α-helix	931-933	3
α-helix	934-937	4
α-helix	940-953	14
α-helix	957-958	2
β-strand	959-960	2	45
α-helix	969-977	9
β-strand	986-987	2	46
β-strand	990	1	51
β-strand	997	1	51
α-helix	998	1
α-helix	1001	1
β-strand	1002-1011	10	46
α-helix	1016-1018	3
β-strand	1021-1023	3	9
β-strand	1028-1029	2	52
β-strand	1035	1	52
β-strand	1046	1	8
α-helix	1049-1058	10
α-helix	1062-1065	4
α-helix	1066-1070	5
β-strand	1076-1080	5	53
β-strand	1085-1086	2	53
β-strand	1088	1	54
β-strand	1091	1	54
β-strand	1092	1	55
β-strand	1097	1	55
β-strand	1101-1105	5	53
α-helix	1108-1119	12
β-strand	1123-1129	7	2

Chain C: 30 helices, 18 β-strands

Element	Residues	Length	Sheet
α-helix	3-16	14
α-helix	19-31	13
β-strand	34-35	2	56
α-helix	36-43	8
α-helix	47-59	13
β-strand	63-67	5	56
α-helix	69-71	3
β-strand	73-77	5	56
α-helix	80-83	4
α-helix	85-87	3
α-helix	88-98	11
α-helix	101-113	13
β-strand	116-117	2	57
α-helix	118-128	11
α-helix	129-131	3
α-helix	141-153	13
β-strand	157-159	3	57
α-helix	160-161	2
β-strand	162	1	58
α-helix	163-165	3
α-helix	174-175	2
β-strand	181	1	58
α-helix	190-192	3
α-helix	198-200	3
β-strand	234-237	4	57
α-helix	239-258	20
α-helix	261-275	15
β-strand	284	1	59
α-helix	285-287	3
β-strand	288-289	2	60
α-helix	290-296	7
α-helix	305-316	12
β-strand	323-324	2	61
β-strand	333-334	2	60
β-strand	335-336	2	61
β-strand	337	1	59
α-helix	338-371	34
α-helix	377-384	8
α-helix	391-400	10
β-strand	405-406	2	62
β-strand	409-410	2	63
α-helix	417-419	3
β-strand	420-421	2	63
β-strand	424-425	2	62
α-helix	428-472	45
α-helix	484-488	5
α-helix	493-495	3
α-helix	496-530	35

Chain D: 8 helices, 7 β-strands

Element	Residues	Length	Sheet
α-helix	109-110	2
α-helix	112-123	12
α-helix	133-135	3
α-helix	148-150	3
α-helix	250-260	11
β-strand	265-270	6	64
α-helix	318-320	3
β-strand	324-332	9	64
α-helix	333-335	3
β-strand	337-341	5	64
β-strand	344-350	7	64
β-strand	356-364	9	65
β-strand	370-378	9	65
β-strand	381-387	7	64
α-helix	389-395	7

Chain E: 19 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	64
β-strand	14-17	4	64
β-strand	25-34	10	65
α-helix	43	1
β-strand	44-50	7	65
β-strand	55-61	7	65
β-strand	69	1	66
α-helix	71-81	11
β-strand	99-106	8	65
β-strand	114-120	7	64
β-strand	123-128	6	64
β-strand	132-137	6	65
α-helix	140-153	14
α-helix	184-187	4
α-helix	189-191	3
α-helix	193-202	10
α-helix	204-205	2
β-strand	206-211	6	65
α-helix	216-222	7
α-helix	223-225	3
α-helix	242-249	8
α-helix	278-288	11
β-strand	291-292	2	67
α-helix	294-301	8
α-helix	309-317	9
β-strand	318-321	4	67
β-strand	324-327	4	67
α-helix	329-332	4
β-strand	338	1	68
β-strand	347	1	68
α-helix	350-362	13
β-strand	365-366	2	69
α-helix	371-375	5
α-helix	379-389	11
β-strand	390-392	3	69
β-strand	398-400	3	69
α-helix	407-409	3
α-helix	413-430	18

Chain F: 17 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	16-28	13
β-strand	33-34	2	70
α-helix	35-41	7
α-helix	47-60	14
β-strand	63-68	6	70
β-strand	71-76	6	70
α-helix	90-101	12
α-helix	103-105	3
β-strand	107-108	2	71
α-helix	109-116	8
α-helix	120-132	13
β-strand	136-140	5	71
β-strand	148-152	5	71
α-helix	156-157	2
α-helix	165-170	6
α-helix	174-198	25
α-helix	203-208	6
α-helix	213-220	8
α-helix	233-243	11
α-helix	260-265	6
α-helix	281-284	4
α-helix	286-289	4
α-helix	308-315	8

Chain G: 5 helices, 0 β-strands

Element	Residues	Length
α-helix	45-49	5
α-helix	52-67	16
α-helix	76-79	4
α-helix	89-92	4
α-helix	103-105	3

Chain H: 4 helices, 13 β-strands

Element	Residues	Length	Sheet
β-strand	2-13	12	1
α-helix	15-19	5
α-helix	22-34	13
β-strand	37-39	3	1
β-strand	43-54	12	1
β-strand	58	1	1
β-strand	66-77	12	1
α-helix	79-80	2
β-strand	84-93	10	72
β-strand	96-100	5	72
β-strand	107-109	3	72
β-strand	128	1	73
β-strand	140	1	73
β-strand	148-157	10	72
β-strand	184-189	6	72
β-strand	196	1	72
α-helix	198-200	3

15 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase III subunit RPC1	A	protein	1390	Homo sapiens	O14802 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC2	B	protein	1133	Homo sapiens	Q9NW08 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC3	C	protein	534	Homo sapiens	Q9BUI4 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC4	D	protein	398	Homo sapiens	P05423 (AlphaFold model)
DNA-directed RNA polymerase III subunit RPC5	E	protein	708	Homo sapiens	Q9NVU0
DNA-directed RNA polymerase III subunit RPC6	F	protein	316	Homo sapiens	Q9H1D9
DNA-directed RNA polymerase III subunit RPC7	G	protein	223	Homo sapiens	O15318
DNA-directed RNA polymerase III subunit RPC8	H	protein	204	Homo sapiens	Q9Y535
DNA-directed RNA polymerase III subunit RPC9	I	protein	148	Homo sapiens	O75575
DNA-directed RNA polymerase III subunit RPC10	J	protein	108	Homo sapiens	Q9Y2Y1
DNA-directed RNA polymerases I and III subunit RPAC1	K	protein	346	Homo sapiens	O15160
DNA-directed RNA polymerases I and III subunit RPAC2	L	protein	133	Homo sapiens	P0DPB6

13 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9FSQ_1 DNA-directed RNA polymerase III subunit RPC1 (chains A)
MVKEQFRETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRM
GTSEKDRPCETCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTCCHIMLSQE
EKKQFLDYLKRPGLTYLQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEKYK
TNKKVVDPIVSNFLQSFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLLLM
NPEAGKPSDLILTRLLVPPLCIRPSVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG
AKTQMIMEDWDFLQLQCALYINSELSGIPLNMAPKKWTRGFVQRLKGKQGRFRGNLSGKR
VDFSGRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANF
IQQRHTQMKRFLKYGNREKMAQELKYGDIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV
KPHRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIA
AIQDFLTGAYLLTLKDTFFDRAKACQIIASILVGKDEKIKVRLPPPTILKPVTLWTGKQI
FSVILRPSDDNPVRANLRTKGKQYCGKGEDLCANDSYVTIQNSELMSGSMDKGTLGSGSK
NNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAG
YKKCDEYIEALNTGKLQQQPGCTAEETLEALILKELSVIRDHAGSACLRELDKSNSPLTM
ALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKGFVANSFYS
GLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDIIQF
IYGGDGLDPAAMEGKDEPLEFKRVLDNIKAVFPCPSEPALSKNELILTTESIMKKSEFLC
CQDSFLQEIKKFIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCRD
KYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIINASKAI
STPIITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEEVFLPDDCFILVKLSLERIRLL
RLEVNAETVRYSICTSKLRVKPGDVAVHGEAVVCVTPRENSKSSMYYVLQFLKEDLPKVV
VQGIPEVSRAVIHIDEQSGKEKYKLLVEGDNLRAVMATHGVKGTRTTSNNTYEVEKTLGI
EAARTTIINEIQYTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLAS
FEKTADHLFDAAYFGQKDSVCGVSECIIMGIPMNIGTGLFKLLHKADRDPNPPKRPLIFD
TNEFHIPLVT

Sequence of entity 2 (B), FASTA

>9FSQ_2 DNA-directed RNA polymerase III subunit RPC2 (chains B)
MDVLAEEFGNLTPEQLAAPIPTVEEKWRLLPAFLKVKGLVKQHIDSFNYFINVEIKKIMK
ANEKVTSDADPMWYLKYLNIYVGLPDVEESFNVTRPVSPHECRLRDMTYSAPITVDIEYT
RGSQRIIRNALPIGRMPIMLRSSNCVLTGKTPAEFAKLNECPLDPGGYFIVKGVEKVILI
QEQLSKNRIIVEADRKGAVGASVTSSTHEKKSRTNMAVKQGRFYLRHNTLSEDIPIVIIF
KAMGVESDQEIVQMIGTEEHVMAAFGPSLEECQKAQIFTQMQALKYIGNKVRRQRMWGGG
PKKTKIEEARELLASTILTHVPVKEFNFRAKCIYTAVMVRRVILAQGDNKVDDRDYYGNK
RLELAGQLLSLLFEDLFKKFNSEMKKIADQVIPKQRAAQFDVVKHMRQDQITNGMVNAIS
TGNWSLKRFKMDRQGVTQVLSRLSYISALGMMTRISSQFEKTRKVSGPRSLQPSQWGMLC
PSDTPEGEACGLVKNLALMTHITTDMEDGPIVKLASNLGVEDVNLLCGEELSYPNVFLVF
LNGNILGVIRDHKKLVNTFRLMRRAGYINEFVSISTNLTDRCVYISSDGGRLCRPYIIVK
KQKPAVTNKHMEELAQGYRNFEDFLHESLVEYLDVNEENDCNIALYEHTINKDTTHLEIE
PFTLLGVCAGLIPYPHHNQSPRNTYQCAMGKQAMGTIGYNQRNRIDTLMYLLAYPQKPMV
KTKTIELIEFEKLPAGQNATVAVMSYSGYDIEDALVLNKASLDRGFGRCLVYKNAKCTLK
RYTNQTFDKVMGPMLDAATRKPIWRHEILDADGICSPGEKVENKQVLVNKSMPTVTQIPL
EGSNVPQQPQYKDVPITYKGATDSYIEKVMISSNAEDAFLIKMLLRQTRRPEIGDKFSSR
HGQKGVCGLIVPQEDMPFCDSGICPDIIMNPHGFPSRMTVGKLIELLAGKAGVLDGRFHY
GTAFGGSKVKDVCEDLVRHGYNYLGKDYVTSGITGEPLEAYIYFGPVYYQKLKHMVLDKM
HARARGPRAVLTRQPTEGRSRDGGLRLGEMERDCLIGYGASMLLLERLMISSDAFEVDVC
GQCGLLGYSGWCHYCKSSCHVSSLRIPYACKLLFQELQSMNIIPRLKLSKYNE

Sequence of entity 3 (C), FASTA

>9FSQ_3 DNA-directed RNA polymerase III subunit RPC3 (chains C)
MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQH
NLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSA
VVKKVADRLTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTL
VINEKDMYLVPKLSLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLD
RFHQHFRDQAIVSAVANRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVG
YNISKQVLDQYLTLLADDPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGS
RCARIFRLVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRT
FYLYTVNILSAARMLLHRCYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAE
EAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMKRQ

Sequence of entity 4 (D), FASTA

>9FSQ_4 DNA-directed RNA polymerase III subunit RPC4 (chains D)
MSEGNAAGEPSTPGGPRPLLTGARGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTP
NIISRKIKEEPKEEVTVKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKK
GNWDKTVDVSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFLDDPGLRNDTRNMPVQL
PLAHSGWLFKEENDEPDVKPWLAGPKEEDMEVDIPAVKVKEEPRDEEEEAKMKAPPKAAR
KTPGLPKDVSVAELLRELSLTKEEELLFLQLPDTLPGQPPTQDIKPIKTEVQGEDGQVVL
IKQEKDREAKLAENACTLADLTEGQVGKLLIRKSGRVQLLLGKVTLDVTMGTACSFLQEL
VSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR

Sequence of entity 5 (E), FASTA

>9FSQ_5 DNA-directed RNA polymerase III subunit RPC5 (chains E)
MANEEDDPVVQEIDVYLAKSLAEKLYLFQYPVRPASMTYDDIPHLSAKIKPKQQKVELEM
AIDTLNPNYCRSKGEQIALNVDGACADETSTYSSKLMDKQTFCSSQTTSNTSRYAAALYR
QGELHLTPLHGILQLRPSFSYLDKADAKHREREAANEAGDSSQDEAEDDVKQITVRFSRP
ESEQARQRRVQSYEFLQKKHAEEPWVHLHYYGLRDSRSEHERQYLLCPGSSGVENTELVK
SPSEYLMMLMPPSQEEEKDKPVAPSNVLSMAQLRTLPLADQIKILMKNVKVMPFANLMSL
LGPSIDSVAVLRGIQKVAMLVQGNWVVKSDILYPKDSSSPHSGVPAEVLCRGRDFVMWKF
TQSRWVVRKEVATVTKLCAEDVKDFLEHMAVVRINKGWEFILPYDGEFIKKHPDVVQRQH
MLWTGIQAKLEKVYNLVKETMPKKPDAQSGPAGLVCGDQRIQVAKTKAQQNHALLERELQ
RRKEQLRVPAVPPGVRIKEEPVSEEGEEDEEQEAEEEPMDTSPSGLHSKLANGLPLGRAA
GTDSFNGHPPQGCASTPVARELKAFVEATFQRQFVLTLSELKRLFNLHLASLPPGHTLFS
GISDRMLQDTVLAAGCKQILVPFPPQTAASPDEQKVFALWESGDMSDQHRQVLLEIFSKN
YRVRRNMIQSRLTQECGEDLSKQEVDKVLKDCCVSYGGMWYLKGTVQS

Sequence of entity 6 (F), FASTA

>9FSQ_6 DNA-directed RNA polymerase III subunit RPC6 (chains F)
MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSM
GQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPL
TEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVL
NQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILN
TLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGG
EISPSNCIYMTEWLEF

Sequence of entity 7 (G), FASTA

>9FSQ_7 DNA-directed RNA polymerase III subunit RPC7 (chains G)
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLAL
KQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAG
PKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDD
DAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY

Sequence of entity 8 (H), FASTA

>9FSQ_8 DNA-directed RNA polymerase III subunit RPC8 (chains H)
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN

Sequence of entity 9 (I), FASTA

>9FSQ_9 DNA-directed RNA polymerase III subunit RPC9 (chains I)
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRH
QSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTV
TSILPAEPEAEQKKNTNSNVAMDEEDPA

Sequence of entity 10 (J), FASTA

>9FSQ_10 DNA-directed RNA polymerase III subunit RPC10 (chains J)
MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWE
NVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

Sequence of entity 11 (K), FASTA

>9FSQ_11 DNA-directed RNA polymerases I and III subunit RPAC1 (chains K)
MAASQAVEEMRSRVVLGEFGVRNVHTTDFPGNYSGYDDAWDQDRFEKNFRVDVVHMDENS
LEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPIHADPR
LFEYRNQGDEEGTEIDTLQFRLQVRCTRNPHAAKDSSDPNELYVNHKVYTRHMTWIPLGN
QADLFPEGTIRPVHDDILIAQLRPGQEIDLLMHCVKGIGKDHAKFSPVATASYRLLPDIT
LLEPVEGEAAEELSRCFSPGVIEVQEVQGKKVARVANPRLDTFSREIFRNEKLKKVVRLA
RVRDHYIFSVESTGVLPPDVLVSEAIKVLMGKCRRFLDELDAVQMD

Sequence of entity 12 (L), FASTA

>9FSQ_12 DNA-directed RNA polymerases I and III subunit RPAC2 (chains L)
MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIM
KNPEVEFCGYTTTHPSESKINLRIQTRGTLPAVEPFQRGLNELMNVCQHVLDKFEASIKD
YKDQKASRNESTF

Ligands and cofactors

ID	Name	Formula	Copies
SF4	Iron/sulfur cluster	Fe4 S4	1
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	9

Primary citation

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters. Shah, S.Z., Perry, T.N., Graziadei, A. et al. Nat Commun (2025) 16:141-141. DOI 10.1038/s41467-024-55553-8 · PubMed

Other PDB entries of the same protein (UniProt O14802 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7AE1 2.8 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 1
9K39 2.8 Å, Human RNA Polymerase III de novo transcribing complex 8 (TC8)
7D58 2.9 Å, cryo-EM structure of human RNA polymerase III in elongating state
9K36 2.9 Å, Human RNA Polymerase III de novo transcribing complex 12 (TC12)
9K2G 3.0 Å, Human RNA Polymerase III de novo transcribing complex 13 (TC13)
9K3U 3.0 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)
7AE3 3.1 Å, Cryo-EM structure of human RNA Polymerase III elongation complex 3
7D59 3.1 Å, cryo-EM structure of human RNA polymerase III in apo state
9K38 3.1 Å, Human RNA Polymerase III de novo transcribing complex 6 (TC6)
9FSO 3.28 Å, Human RNA Polymerase III Class III Open Pre-initiation Complex 1 (OC1)
7A6H 3.3 Å, Cryo-EM structure of human apo RNA Polymerase III
9LXN 3.3 Å, Human RNA Polymerase III de novo transcribing complex 5 (TC5)(without 3'dATP)

Browse structure collections

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