9G3Z: Open gamma-Tubulin Ring Complex from Pig Brain
Structure of the Open gamma-Tubulin Ring Complex from Pig Brain. Determined by electron microscopy at 4.3 Å resolution. Released 2 Oct 2024.
- Method
- Electron microscopy
- Resolution
- 4.3 Å
- Organisms
- Sus scrofa, Homo sapiens
- Chains
- 34
- Atoms
- 78,332
- Mol. weight
- 2626.34 kDa
- Released
- 2 Oct 2024
Explore 9G3Z in 3D
Show helices and sheets
RCSB PDB
PDBe
Secondary structure: helices and β-sheets
9G3Z contains 879 α-helices and 351 β-strands across 34 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
Chain a: 27 helices, 15 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-10 | 6 | 19 |
| α-helix | 11-29 | 19 | |
| β-strand | 31 | 1 | 20 |
| α-helix | 36 | 1 | |
| β-strand | 37 | 1 | 20 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-51 | 4 | |
| β-strand | 52-54 | 3 | 21 |
| α-helix | 55 | 1 | |
| β-strand | 60-62 | 3 | 21 |
| β-strand | 64-67 | 4 | 19 |
| α-helix | 71-78 | 8 | |
| α-helix | 88-90 | 3 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-140 | 7 | 19 |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-172 | 8 | 19 |
| α-helix | 173-174 | 2 | |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 19 |
| α-helix | 207-216 | 10 | |
| α-helix | 225-244 | 20 | |
| α-helix | 253-260 | 8 | |
| α-helix | 268-269 | 2 | |
| β-strand | 270-274 | 5 | 22 |
| α-helix | 290-297 | 8 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 22 |
| β-strand | 317-326 | 10 | 22 |
| α-helix | 330-343 | 14 | |
| β-strand | 348 | 1 | 22 |
| β-strand | 356-361 | 6 | 22 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 22 |
| α-helix | 383-399 | 17 | |
| α-helix | 406-410 | 5 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-438 | 20 | |
| α-helix | 441-443 | 3 | |
Chain A: 39 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 150-168 | 19 | |
| α-helix | 179-181 | 3 | |
| α-helix | 185-187 | 3 | |
| α-helix | 205-207 | 3 | |
| α-helix | 210-225 | 16 | |
| β-strand | 233-236 | 4 | 57 |
| α-helix | 243-244 | 2 | |
| β-strand | 245-248 | 4 | 57 |
| α-helix | 254-280 | 27 | |
| α-helix | 283-285 | 3 | |
| α-helix | 287-315 | 29 | |
| α-helix | 321-347 | 27 | |
| α-helix | 353-365 | 13 | |
| α-helix | 366-368 | 3 | |
| α-helix | 370-392 | 23 | |
| α-helix | 393-397 | 5 | |
| β-strand | 409-410 | 2 | 58 |
| α-helix | 418-421 | 4 | |
| α-helix | 426-431 | 6 | |
| β-strand | 433-434 | 2 | 58 |
| α-helix | 441-444 | 4 | |
| α-helix | 447-462 | 16 | |
| α-helix | 482-505 | 24 | |
| α-helix | 509-519 | 11 | |
| α-helix | 525-539 | 15 | |
| β-strand | 542 | 1 | 59 |
| α-helix | 543-545 | 3 | |
| α-helix | 548-560 | 13 | |
| α-helix | 563-566 | 4 | |
| α-helix | 568-572 | 5 | |
| β-strand | 573-577 | 5 | 60 |
| α-helix | 582-591 | 10 | |
| β-strand | 611 | 1 | 59 |
| α-helix | 612-615 | 4 | |
| β-strand | 616-620 | 5 | 60 |
| α-helix | 626-628 | 3 | |
| α-helix | 632-661 | 30 | |
| α-helix | 662-667 | 6 | |
| α-helix | 676-697 | 22 | |
| α-helix | 698-702 | 5 | |
| α-helix | 703-714 | 12 | |
| α-helix | 719-736 | 18 | |
| α-helix | 742-772 | 31 | |
| α-helix | 816-819 | 4 | |
| α-helix | 823-849 | 27 | |
| α-helix | 853-862 | 10 | |
| α-helix | 869-876 | 8 | |
Chain b: 26 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-10 | 6 | 93 |
| α-helix | 11-29 | 19 | |
| β-strand | 31 | 1 | 94 |
| β-strand | 36 | 1 | 95 |
| β-strand | 37 | 1 | 94 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-50 | 3 | |
| β-strand | 52-54 | 3 | 96 |
| α-helix | 55 | 1 | |
| β-strand | 59 | 1 | 95 |
| β-strand | 60-62 | 3 | 96 |
| β-strand | 64-67 | 4 | 93 |
| β-strand | 68 | 1 | 97 |
| α-helix | 71-78 | 8 | |
| α-helix | 88-90 | 3 | |
| β-strand | 93 | 1 | 97 |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-140 | 7 | 93 |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-172 | 8 | 93 |
| α-helix | 173 | 1 | |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 93 |
| α-helix | 207-218 | 12 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-274 | 7 | 93 |
| α-helix | 290-297 | 8 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 93 |
| β-strand | 317-326 | 10 | 93 |
| α-helix | 330-343 | 14 | |
| β-strand | 348 | 1 | 93 |
| β-strand | 355-361 | 7 | 93 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 93 |
| α-helix | 384-399 | 16 | |
| α-helix | 405-408 | 4 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-438 | 20 | |
| α-helix | 443-446 | 4 | |
Chain B: 34 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 250-261 | 12 | |
| β-strand | 269-272 | 4 | 61 |
| β-strand | 277-280 | 4 | 61 |
| α-helix | 288-316 | 29 | |
| α-helix | 318-320 | 3 | |
| α-helix | 321-352 | 32 | |
| α-helix | 367-390 | 24 | |
| α-helix | 396-406 | 11 | |
| α-helix | 412-434 | 23 | |
| α-helix | 435-439 | 5 | |
| β-strand | 451-453 | 3 | 62 |
| α-helix | 459-461 | 3 | |
| α-helix | 462-466 | 5 | |
| β-strand | 467-469 | 3 | 62 |
| α-helix | 471-473 | 3 | |
| α-helix | 480-498 | 19 | |
| α-helix | 504-506 | 3 | |
| α-helix | 507-510 | 4 | |
| α-helix | 524-528 | 5 | |
| α-helix | 532-554 | 23 | |
| α-helix | 558-564 | 7 | |
| α-helix | 565-569 | 5 | |
| α-helix | 574-588 | 15 | |
| β-strand | 591 | 1 | 63 |
| α-helix | 592-594 | 3 | |
| α-helix | 597-610 | 14 | |
| α-helix | 612-615 | 4 | |
| α-helix | 618-623 | 6 | |
| β-strand | 624-628 | 5 | 64 |
| β-strand | 636 | 1 | 63 |
| α-helix | 637-640 | 4 | |
| β-strand | 641-645 | 5 | 64 |
| α-helix | 650-654 | 5 | |
| α-helix | 657-693 | 37 | |
| α-helix | 698-700 | 3 | |
| α-helix | 701-723 | 23 | |
| α-helix | 724-731 | 8 | |
| α-helix | 732-742 | 11 | |
| α-helix | 747-764 | 18 | |
| α-helix | 772-815 | 44 | |
| α-helix | 827-869 | 43 | |
| α-helix | 874-883 | 10 | |
Chain c: 26 helices, 19 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-10 | 6 | 98 |
| α-helix | 11-29 | 19 | |
| β-strand | 31 | 1 | 99 |
| β-strand | 36 | 1 | 100 |
| β-strand | 37 | 1 | 99 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| α-helix | 48-50 | 3 | |
| β-strand | 52-54 | 3 | 101 |
| α-helix | 55 | 1 | |
| β-strand | 59 | 1 | 100 |
| β-strand | 60-62 | 3 | 101 |
| β-strand | 64-68 | 5 | 98 |
| α-helix | 71-78 | 8 | |
| α-helix | 88-90 | 3 | |
| β-strand | 91-93 | 3 | 98 |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-140 | 7 | 98 |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 165-172 | 8 | 98 |
| α-helix | 173-174 | 2 | |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 98 |
| α-helix | 207-216 | 10 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 268-269 | 2 | 98 |
| β-strand | 270-274 | 5 | 102 |
| α-helix | 290-297 | 8 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 102 |
| β-strand | 317-326 | 10 | 102 |
| α-helix | 330-343 | 14 | |
| β-strand | 348 | 1 | 102 |
| β-strand | 355-361 | 7 | 102 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 102 |
| α-helix | 384-399 | 16 | |
| α-helix | 406-410 | 5 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-438 | 20 | |
| α-helix | 443-446 | 4 | |
Chain C: 39 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 150-169 | 20 | |
| α-helix | 179-182 | 4 | |
| α-helix | 185-187 | 3 | |
| α-helix | 205-207 | 3 | |
| α-helix | 210-225 | 16 | |
| β-strand | 233-236 | 4 | 65 |
| α-helix | 243-244 | 2 | |
| β-strand | 245-248 | 4 | 65 |
| α-helix | 254-279 | 26 | |
| α-helix | 283-285 | 3 | |
| α-helix | 287-315 | 29 | |
| α-helix | 321-347 | 27 | |
| α-helix | 353-365 | 13 | |
| α-helix | 370-392 | 23 | |
| α-helix | 393-397 | 5 | |
| β-strand | 409-411 | 3 | 66 |
| α-helix | 417-421 | 5 | |
| α-helix | 426 | 1 | |
| α-helix | 427-431 | 5 | |
| β-strand | 432-434 | 3 | 66 |
| α-helix | 441-443 | 3 | |
| α-helix | 447-462 | 16 | |
| α-helix | 482-506 | 25 | |
| α-helix | 509-519 | 11 | |
| α-helix | 525-539 | 15 | |
| β-strand | 542 | 1 | 67 |
| α-helix | 543-545 | 3 | |
| α-helix | 548-560 | 13 | |
| α-helix | 563-566 | 4 | |
| α-helix | 568-572 | 5 | |
| β-strand | 573-577 | 5 | 68 |
| α-helix | 582-591 | 10 | |
| β-strand | 611 | 1 | 67 |
| α-helix | 612-615 | 4 | |
| β-strand | 616-620 | 5 | 68 |
| α-helix | 626-628 | 3 | |
| α-helix | 632-661 | 30 | |
| α-helix | 664-667 | 4 | |
| α-helix | 674-697 | 24 | |
| α-helix | 698-702 | 5 | |
| α-helix | 703-714 | 12 | |
| α-helix | 719-736 | 18 | |
| α-helix | 742-772 | 31 | |
| α-helix | 816-819 | 4 | |
| α-helix | 823-849 | 27 | |
| α-helix | 853-862 | 10 | |
| α-helix | 869-876 | 8 | |
Chain d: 24 helices, 18 β-strands
| Element | Residues | Length | Sheet |
|---|
| β-strand | 5-10 | 6 | 103 |
| α-helix | 11-29 | 19 | |
| β-strand | 31 | 1 | 104 |
| β-strand | 36 | 1 | 105 |
| β-strand | 37 | 1 | 104 |
| α-helix | 38 | 1 | |
| α-helix | 39-41 | 3 | |
| β-strand | 52-54 | 3 | 106 |
| α-helix | 55 | 1 | |
| β-strand | 59 | 1 | 105 |
| β-strand | 60-62 | 3 | 106 |
| β-strand | 64-67 | 4 | 103 |
| α-helix | 71-78 | 8 | |
| α-helix | 88-90 | 3 | |
| α-helix | 104-113 | 10 | |
| α-helix | 115-127 | 13 | |
| β-strand | 134-140 | 7 | 103 |
| α-helix | 145-149 | 5 | |
| α-helix | 150-160 | 11 | |
| β-strand | 166-172 | 7 | 103 |
| α-helix | 173-174 | 2 | |
| α-helix | 184-198 | 15 | |
| β-strand | 201-206 | 6 | 103 |
| α-helix | 207-218 | 12 | |
| α-helix | 225-239 | 15 | |
| α-helix | 241-244 | 4 | |
| α-helix | 253-260 | 8 | |
| β-strand | 263 | 1 | 107 |
| β-strand | 266 | 1 | 107 |
| β-strand | 268-274 | 7 | 103 |
| α-helix | 290-297 | 8 | |
| α-helix | 300-302 | 3 | |
| β-strand | 303 | 1 | 103 |
| β-strand | 317-326 | 10 | 103 |
| α-helix | 330-343 | 14 | |
| β-strand | 355-361 | 7 | 103 |
| α-helix | 362-364 | 3 | |
| β-strand | 373-381 | 9 | 103 |
| α-helix | 384-399 | 16 | |
| α-helix | 405-408 | 4 | |
| α-helix | 412-415 | 4 | |
| α-helix | 419-439 | 21 | |
Chain D: 34 helices, 8 β-strands
| Element | Residues | Length | Sheet |
|---|
| α-helix | 250-261 | 12 | |
| β-strand | 269-272 | 4 | 75 |
| β-strand | 277-280 | 4 | 75 |
| α-helix | 288-315 | 28 | |
| α-helix | 318-320 | 3 | |
| α-helix | 321-352 | 32 | |
| α-helix | 367-390 | 24 | |
| α-helix | 397-406 | 10 | |
| α-helix | 412-438 | 27 | |
| β-strand | 451-453 | 3 | 76 |
| α-helix | 459-461 | 3 | |
| α-helix | 462-466 | 5 | |
| β-strand | 467-469 | 3 | 76 |
| α-helix | 471-473 | 3 | |
| α-helix | 480-498 | 19 | |
| α-helix | 505-506 | 2 | |
| α-helix | 507-510 | 4 | |
| α-helix | 524-528 | 5 | |
| α-helix | 532-554 | 23 | |
| α-helix | 558-564 | 7 | |
| α-helix | 565-569 | 5 | |
| α-helix | 574-588 | 15 | |
| β-strand | 591 | 1 | 77 |
| α-helix | 592-594 | 3 | |
| α-helix | 597-610 | 14 | |
| α-helix | 612-615 | 4 | |
| α-helix | 618-623 | 6 | |
| β-strand | 624-628 | 5 | 78 |
| β-strand | 636 | 1 | 77 |
| α-helix | 637-640 | 4 | |
| β-strand | 641-645 | 5 | 78 |
| α-helix | 649-654 | 6 | |
| α-helix | 657-693 | 37 | |
| α-helix | 694-696 | 3 | |
| α-helix | 698-700 | 3 | |
| α-helix | 701-724 | 24 | |
| α-helix | 725-731 | 7 | |
| α-helix | 732-742 | 11 | |
| α-helix | 747-764 | 18 | |
| α-helix | 772-815 | 44 | |
| α-helix | 827-869 | 43 | |
| α-helix | 874-883 | 10 | |
26 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.
Molecules and chains
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|
| Mitotic spindle organizing protein 1 | O, P, Q | protein | 79 | Sus scrofa | A0A287AS02 (AlphaFold model) |
| Mitotic-spindle organizing protein 2A isoform X4 | Y | protein | 155 | Sus scrofa | F1RK97 (AlphaFold model) |
| Tubulin gamma chain | a, b, c, d, e, f, g, h, i, j, k, l, m, n | protein | 451 | Sus scrofa | A0A287BRH5 (AlphaFold model) |
| CDK5 regulatory subunit-associated protein 2 | w, x | protein | 1663 | Homo sapiens | A0A0A0MRG9 |
| Gamma-tubulin complex component 3 | B, D, F, H, N | protein | 910 | Sus scrofa | F1RN46 |
| Gamma-tubulin complex component | A, C, E, G, M | protein | 905 | Sus scrofa | A0A480VJI0 |
| Tubulin gamma complex associated protein 6 | L | protein | 1715 | Sus scrofa | A0A8W4FDV6 |
| Gamma-tubulin complex component | I, K | protein | 667 | Sus scrofa | A0A8D1V2H0 |
| Gamma-tubulin complex component | J | protein | 1042 | Sus scrofa | A0A8D1PWV9 |
Sequence of entity 1 (O, P, Q), FASTA
>9G3Z_1 Mitotic spindle organizing protein 1 (chains O, P, Q)
MAGNSGSGAAAAANLNAVRETMDVLLEISRILNTGLDMETLSICVRLCEQGINPEALSSV
IKELRKATEALKAAENMTS
Sequence of entity 2 (Y), FASTA
>9G3Z_2 Mitotic-spindle organizing protein 2A isoform X4 (chains Y)
MAAPGAGPGPGAPPGLEAALQKLALRRKKVLSAEETELFELAQAAGGAMDPEVFKILVDL
LKLNVAPLAVFQMLKSMCAGQRLASEPQDPVAVPLPTTSVPETRGRNRGSSALGGGPALA
ERSGREGSSQRMPRQPSATRLPKGGGPGKSPTRST
Sequence of entity 3 (a, b, c, d, e, f, g, h, i, j, k, l, m, n), FASTA
>9G3Z_3 Tubulin gamma chain (chains a, b, c, d, e, f, g, h, i, j, k, l, m, n)
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHY
IPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFD
IIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSD
VVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQP
KNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVAL
SRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQYDKLRKREAFLEQFRKEDIFKENFDE
LDRSREVVQELIDEYHAATRPDYISWGTQEQ
Sequence of entity 4 (w, x), FASTA
>9G3Z_4 CDK5 regulatory subunit-associated protein 2 (chains w, x)
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM
KDFENQITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQER
EQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCL
KEEKSQMACPDENVSSGELRGLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLR
EKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEK
DLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREKAMENRYKSLLSESNKKLHNQEQVIK
HLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRSEGLITEKCSSQQPPGSKTIF
SKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELNKIFALRKQLEQDVLS
YQNLRKTLEEQISEIRRREESFSLYSDQTSYLSICLEENNRFQVEHFSQEELKKKVSDLI
QLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTEEAKKSRLPILIKPSRSLGN
MYRLPATQEVVTQLQSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLNAQ
PPVGAAYQDSPGEQKGIKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPE
DVLSPTSVATYLSSKSQPSAKVSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFI
FQLQKHSQCSEAIITVLCGTEGAQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLA
PEMIDSRVLENLKQQLEEQEYKLQKEQNLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQA
RELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQASDVDYCVAEGFQEQLNQCAELLE
KLEKLFLNGKSVGVEMNTQNELMERIEEDNLTYQHLLPESPEPSASHALSDYETSEKSFF
SRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQGSEF
VQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVS
LEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQN
DKLLQSLRVELKAYEKLDEEHRRLREASGEGWKGQDPFRDLHSLLMEIQALRLQLERSIE
TSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDLF
DSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGL
IEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTL
EEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSK
RQEKVIFDQLVVTHKILRKARGNLELRPGGAHPGTCSPSRPGS
Sequence of entity 5 (B, D, F, H, N), FASTA
>9G3Z_5 Gamma-tubulin complex component 3 (chains B, D, F, H, N)
MATPDQKSPNVLLQNLCCRILGKSEADVAQQFQYAVRVIGSNFAPTVERDEFLVAEKIKK
ELTRQRREADAALFSELHRKLHSQGVLKNKWSILYLLLSLSEDPRKQPSKVSGYAALFAQ
ALPRDAHSTPYYYARPQSLPLNYQERGAPSAQSAGSAGSSGVSSLGTYALNGPTPPPPPP
ALLPGQPLPAPGVGDGLRQQLGSRLAWTLTASQPSLPSTTSKAVPSSGSRGAARPRREGD
AAAGAVEVTEAALVRDILYVFQGIDGKHVKMSNADNCYTVEGKANLSKSLRDTAVRLAEL
GWLHNKIRKYTDQRSLDRSFGLVGQSFCAALHQELREYYRLLSVLHSQLQLEDDQGVNLG
LESSLTLRRLLVWTYDPKMRLKTLAALVDHCQGRKGGELASAVHAYTKTGDPYARSLVQH
ILSLVSHPVLSFLYRWIYDGELEDTYHEFFVASDPAVKADRLWHDKYALRKPMIPSFMTM
DQCRKVLLIGKSINFLHQVCHDQTPTTKMIAVTKSAESPQDAADLFTDLENAFQGKIDAA
YFETSKYLLDVLNKKYSLLDHMQAMRRYLLLGQGDFIRHLMDLLKPELVRPATTLYQHNL
TGILETAVRATNAQFDSPEILKRLDVRLLEVSPGDTGWDVFSLDYHVDGPIATVFTRECM
SHYLRAFNFLWRAKRVEYILTDIRKGHMCNARLLRSMPEFSGVLHHCHILASEMVHFIHQ
MQYYVTFEVLECSWDELWNRVQRAQDLDHIIAAHEAFLGTVISRCLLDSDSRALLNQLRA
VFDQIIELQNTQDAIYRAALEELQRRLQFEEKKKQREAEGQWGVSAAEEEQEKRRVQEFQ
ESIPKMCSQLRILTHFYQGVVQQFLVSLTTSSDESLRFLSFRLDFNEHYRAREPRLRVSL
GTRGRRSSHT
Sequence of entity 6 (A, C, E, G, M), FASTA
>9G3Z_6 Gamma-tubulin complex component (chains A, C, E, G, M)
MSEFRIHHDVNELLSLLRVHGGDGAEVYIDLLQKNRTPYVTTTVSAHSAKVKIAEFSRTP
EDFLKKYDELKSKNTRNLDPLVYLLSKLMEDRETLQYLQQNAKERAELAASAAASSTASF
GASATASKISMQELEELRKQLGSVATGPTWQQSLELTRKMLRDKQSKKNSGQRLPVLPAW
VYERPALLGDFLPGTGGSADTAVPIGSLPLASQEAAVVEDLLYVLVGVDGRYISAQPLTG
RQGRTFLVDPNLDLSIRELVSRILPVAASYSTVTRFIEEKSSFEYGQVNHALAAAMRTLV
KEYLVLVTQLEQLQRQGLLSLQKLWFYIQPAMRSLDILASLATSVDKGECIGGATLSLLH
DRSFSYTGDSQAQELCLHLTKAASTPYFEILEKWIYRGIIDDPYSEFMVEEHELRKEKIQ
EDYNDKYWDQRYTVVQRQIPSFLQKMAGKVLSTGKYLNVVRECGHDVTCPVAKEVVYTLK
ERAYVEQIEKAFSYASKVLLDFLMGEKELLAHLRSIKRYFLMDQGDFFVHFMDLTEEELK
KPVDDITPTRLEALLELALRMSTANTDPFKDDLKIDLMPHDLITQLLRVLAIETQQEKAM
VHADPTELTLSGLEAFSFDYVVTWPLSLIINRKALTRYQMLFRHMFYCKHVERQLCSVWI
SNKAAKRFSLHSAKWFAGAFTLRQRMLNFVQNIQSYMMFEVMEPTWHVLEQNLRSASNID
DVLGHHASFLDNCLKDCMLTNPELLRVFSKLMSVCVMFTNCLQRFTQSMKLDSELGHPAL
EPGAMLGPPTEAERAEERARKELARKCLAEHVDAPQLASSFEATITKFDKNFSAHLLDLL
ARLSIYSTSDCEHGMASVISRLDFNGFYTERLERLSAERSQKAAPPVPGPRGPPALVPRV
AVTAQ
Sequence of entity 7 (L), FASTA
>9G3Z_7 Tubulin gamma complex associated protein 6 (chains L)
MASVPQLLDDLCEALLPAAKAHLGQRRGSRKRAKQSLKKVAYNALFTNLFQDEARKLQPD
LPRLPVKNRILMLSFDLRVGGLAAEADRLEELVEGLETAPRGPLAELGSVLDLLVQLAGS
GPPRVLQRRRDYFLPKEHVGRNVRYGGYDCCHLSGIEADVRSIISGEEELCRDLIRKTLQ
VMEAAPGTGLPAFGLSSYGDPYGDRFERDTRVSLFGALVHSRTADLDVRLDLPPVPDSAD
VSGLAIKVPLSVDQSEDEGFQSAPNLTPDSQSEPGVTPDIDLWEAVLTYEASRRRCWEQI
GCPPGHREEPYLTEAGRDAFDRFCRLRQGELQVLGGALLQAPQPVLVKESELVKDTLNVL
LGVVSATFSLCQPAQAFTVKRGVHVSGASPESVSSLLSEVAECGTHYARLSDFSLQPVLD
SSCSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG
TALPGTGGGEPRAAFPTGVRLLSYLYQEALDNCSNEHYPVLLSLLKTSCEPYTRFIHDWV
YSGVFRDVYGEFMIQVNHEYLGCRDKSYWTHGYVLVSKEVEACVPVFLKHVAHDVYVCGK
TINLLKLCCPRHYLCCSDVPVPRISVIFSLEELKDIEKDCAIYVGRMERVARHSSLSKEE
KELRMEIAKQELIVHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFMRDQERR
RAARQEELDDDFSYARELRDRERRLKALEEQLERKARQALVDHYSKLSAEAARRERKALW
RVQRHRLADARRRFLLEEEKRVQVMPSCSWERNQGALVFQASLPCPEHPDGGGGCGSGPS
EQPKAARDGPRGPSRLMPQLPESPAEAACGLLSVGLSIRDFLPTAQGAEQPLHTGSALVL
EEALQTIGSDLPPPAPSAAVGTGPSGPQEYDFRTILRPAVATSAFPGPLQSTGGGLGSEG
QPQWEDTHVQLDMCVLDGQVALPHACSPQKTSPQEGSQAMGQLLRQVSEGDVPTGGYASG
TAPSRPRWNVHGHVSDASIKVGENVCDVVPSRPRWNVHGHVSDASIKVGENVCDVVPSRP
RWNVHGHVSDASIKVGENVCDVVPSRPRWNIHGHVSDASIKVGENVCDVVPSRPRWNVHG
HVSQSQVTLGVLSGEAEPIVPWPHQTPPDHGSQSGLSLGAQSPAQEGEPQPAAETAVEGA
ESGPQASPTAGAGSSLLSGSRLGPEARPPPPPPHLFCPGRSEDTVDLPASCRPSSQVRGQ
GLGVGGESSAGCPSHPACPFMGNEGSVPGPGVDTQSSPGLGEEAAQRWGMEQAYLAGLAG
QYRLEQYPDSYEAMSEPPVARLLHHGLPRAFALPEDSGVQPDTDETAVQLSELLPLPVLM
KHSVTAPLAAHVSLVNKAAVDYFFVELHLGAHFEALRHFLLMEDGEFAQSLSDLLFEKLG
AGQTPGELLSPLVLNSVLSKALQYSLHGDTPHAANLSFALKFLPEAFAPNAPDVLSCLEL
RYKVDWPLNIVVTEGCLSRYSGIFSFLLQLKLMMWTLKDVCFHLKRTARMSHVASSVQFR
QLQLFKHEMQHFVKVIQGYIANQILHVTWCEFRARLASVGDLEEIQRAHAEYLHKAVFRG
LLTEKAAPAMNIIHSLFSLVLKFRSQLISQPWGLAGGPHGAEHPNFALMQQSYSTFKYYS
HFLFKVVSKLVNRGYQPHLEDFLLRINFNNYYQDA
Sequence of entity 8 (I, K), FASTA
>9G3Z_8 Gamma-tubulin complex component (chains I, K)
MIHELLLALSGYPGSIFTWNKRGGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLADPHLSIS
HINYSLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KDQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAVKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Sequence of entity 9 (J), FASTA
>9G3Z_9 Gamma-tubulin complex component (chains J)
MASPAPSWTRLDPQQERDVRELIRLVSGVQDEADPNFQLALHFAWSNFRFHRFLDVNSHK
VEKTIEGIYEKFIIHSDLSKAASWKRLTDEFLNASLPSIKEIKTDAHYSILSLLLCLSDS
PSNSNYVETPRNKEVEKKDDFDWGKYLMEGEEIDLGPNVDTPNWSEESEDEDDPQPLSRE
DSGIQVDRTPLEEQDQSRKPASRVSWKVDEPDARSWLEQHVVRQYWTTRSSKFPHSLHLH
SNLAAVWDQHLYSSDPLYVPDDRVSVTETQVIRETLWLLSGVKKLFIFQLIDGKVAVRNN
IMVTHLTHSCLRSVLEQIAAYGQVVFRLQEFIDEVMGHSSESTLPGNGSVPKKSTDAPFR
TYQAFMWALYKYFISFKEELSEIEKCIINNDTTVTLAIVVDKLSPRLAQLKVLHKVFSTG
VAEVPPDTRNVVRASHLLNTLYKAILEYDNVGEASEQTVSLLFSLWVETVRPYLQIVDEW
IVHGHLCDGAREFIIQRNKNVPVNHRDFWYATYTLYSVSEKTENEEKMSDNASASSGSDQ
GPSSRQHTMVSFLKPVLKQIIMAGKSMQLLKNLQCAESTTCQAMARDAERKSLYTLFLES
VQSRLRHGEDATAQALTEQQATRETLIKMQSIAERHLELDDVHDPLLAINFARLYLEQSD
FHEKFAGGDICVDRSSESVTCQTFELTLRSCLYPHIDKQYLDCCGNLMRTLKKDYRLVEY
LQAMRNFFLMEGGDTMYDFYTSIFDKIREKETWQNVSFLNVQLQEAVGQRYPEDSSRLSI
SFENTDTAKKKLPVHTLDGLTLSYKVPWPVDIVISLECQKIYNQVFLLLLQIKWAKYSLD
VLLFGELASSAEKPQSKEGLLSGQDTAAQFGPQKEPVRQQIHRMFLLRVKLMHFVNSLHN
YIMTRILHSTGLEFQHQVEEAKDLDQLIKIHYRYLSTIHDRCLLREKVSFVKEAIMKVLN
LALMFADGWQAGLGAWHGISSAVTHGWHGTKLNIFSAVNTSDLIVIHFHHMQLRNRNLFW
TVLKPLVYYLDKWILFPLGIIG
Primary citation
Partial closure of the gamma-tubulin ring complex by CDK5RAP2 activates microtubule nucleation. Xu, Y., Munoz-Hernandez, H., Krutyholowa, R. et al. Dev Cell (2024) 59:3161. DOI 10.1016/j.devcel.2024.09.002 · PubMed
Other PDB entries of the same protein (UniProt A0A287AS02 (AlphaFold model), which also has an AlphaFold model), best resolution first:
- 9G3X 4.5 Å, Structure of the Partially-assembled gamma-Tubulin Ring Complex from Pig Brain
- 9G3Y 6.8 Å, Structure of the Native CMG-decorated gamma-Tubulin Ring Complex from Pig Brain
Browse structure collections
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