9GHK: Fyn SH3 domain/tau 214-220 peptide complex

Crystal structure of Fyn SH3 domain/tau 214-220 peptide complex. Determined by X-ray diffraction at 1.42 Å resolution. Released 27 Aug 2025.

Method: X-ray diffraction
Resolution: 1.42 Å
Organism: Homo sapiens
Chains: 3
Atoms: 1,170
Mol. weight: 15.29 kDa
Released: 27 Aug 2025

Explore 9GHK in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9GHK contains 5 α-helices and 16 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	86-89	4	1
β-strand	93	1	2
β-strand	100	1	1
α-helix	101-102	2
β-strand	103	1	2
β-strand	108-113	6	1
β-strand	119-124	6	1
β-strand	130-134	5	1
α-helix	135-137	3
β-strand	138-140	3	1

Chain B: 2 helices, 8 β-strands

Element	Residues	Length	Sheet
β-strand	87-89	3	3
β-strand	93	1	4
β-strand	100	1	3
α-helix	101-102	2
β-strand	103	1	4
β-strand	108-113	6	3
β-strand	119-124	6	3
β-strand	130-134	5	3
α-helix	135-137	3
β-strand	138-140	3	3

Chain Q: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	5-8	4

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Isoform 2 of Tyrosine-protein kinase Fyn	A, B	protein	64	Homo sapiens	P06241 (AlphaFold model)
Tau peptide ARG-THR-PRO-SER-LEU-PRO-THR-PRO-PRO-THR	Q	protein	10	Homo sapiens	P10636 (AlphaFold model)

Sequence of entity 1 (A, B), FASTA

>9GHK_1 Isoform 2 of Tyrosine-protein kinase Fyn (chains A, B)
GGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVA
PVDS

Sequence of entity 2 (Q), FASTA

>9GHK_2 Tau peptide ARG-THR-PRO-SER-LEU-PRO-THR-PRO-PRO-THR (chains Q)
RTPSLPTPPT

Primary citation

Crystal structure of Fyn SH3 domain/tau 214-220 peptide complex. Becker, S. To be published.

Other PDB entries of the same protein (UniProt P06241 (AlphaFold model), which also has an AlphaFold model), best resolution first:

7A2P 0.9 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0…
7A2X 0.92 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex…
7A2O 0.94 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.5
7A2Q 0.94 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 3.0…
7A2Y 0.97 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex…
7A2W 0.99 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex…
8KDX 1.01 Å, Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of…
7A2S 1.02 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0
7A2R 1.05 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 6.0
7A2Z 1.14 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex…
7A2T 1.22 Å, Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.0
6IPY 1.34 Å, His-tagged Fyn SH3 domain R96I mutant

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