9HI7: MC.7.G5 T cell receptor

Structure of MC.7.G5 T cell receptor in complex with MR1 R9H. Determined by X-ray diffraction at 2.81 Å resolution. Released 23 Apr 2025.

Method: X-ray diffraction
Resolution: 2.81 Å
Organism: Homo sapiens
Chains: 8
Atoms: 13,002
Mol. weight: 193.02 kDa
Released: 23 Apr 2025

Explore 9HI7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9HI7 contains 43 α-helices and 147 β-strands across 8 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 7 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	1
β-strand	22-28	7	1
β-strand	31-37	7	1
β-strand	44-45	2	1
α-helix	48-53	6
α-helix	56-84	29
β-strand	91-100	10	1
β-strand	106-114	9	1
β-strand	117-123	7	1
β-strand	128-131	4	1
α-helix	134-145	12
α-helix	147-158	12
α-helix	160-171	12
α-helix	173-176	4
β-strand	180	1	2
β-strand	183-188	6	3
β-strand	198-205	8	3
β-strand	206	1	2
β-strand	211-216	6	4
β-strand	220-221	2	4
β-strand	226-227	2	3
α-helix	228-230	3
β-strand	231-232	2	3
β-strand	238-244	7	3
β-strand	255-260	6	4
β-strand	263-268	6	4

Chain B: 3 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
α-helix	14-15	2
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
α-helix	52-54	3
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 5 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	8-10	3	8
β-strand	15-19	5	9
β-strand	24-26	3	8
β-strand	29-31	3	8
β-strand	37-44	8	9
β-strand	51-57	7	9
α-helix	63-64	2
β-strand	65-66	2	8
β-strand	69-74	6	8
β-strand	79-84	6	8
α-helix	89-91	3
β-strand	93-101	9	9
α-helix	106-107	2
β-strand	108-109	2	9
β-strand	113-118	6	9
β-strand	127-132	6	10
β-strand	133	1	11
β-strand	140-145	6	10
α-helix	154-156	3
β-strand	162-163	2	10
α-helix	164-166	3
β-strand	167-171	5	10
β-strand	176-184	9	10

Chain E: 7 helices, 27 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	12
β-strand	10-14	5	13
β-strand	19-21	3	14
β-strand	22-25	4	12
β-strand	31-37	7	13
β-strand	44-49	6	13
β-strand	56-57	2	13
β-strand	65-66	2	14
β-strand	70	1	12
β-strand	73	1	12
β-strand	76-78	3	14
α-helix	83-85	3
β-strand	87-94	8	13
α-helix	106	1
β-strand	107-108	2	13
β-strand	112-117	6	13
α-helix	120-122	3
β-strand	124	1	15
α-helix	125-126	2
β-strand	127-131	5	11
α-helix	132	1
α-helix	135-141	7
β-strand	143-153	11	11
β-strand	154	1	15
β-strand	158-164	7	16
β-strand	167-169	3	16
β-strand	173-175	3	11
β-strand	180-181	2	11
β-strand	191-200	10	11
α-helix	201-205	5
β-strand	210-217	8	16
β-strand	220	1	17
β-strand	234	1	17
β-strand	236-243	8	16

Chain F: 8 helices, 18 β-strands

Element	Residues	Length	Sheet
β-strand	3-12	10	18
β-strand	22-28	7	18
β-strand	31-37	7	18
β-strand	44-45	2	18
α-helix	48-51	4
α-helix	56-84	29
β-strand	91-100	10	18
β-strand	106-114	9	18
β-strand	117-123	7	18
β-strand	128-131	4	18
α-helix	134-145	12
α-helix	147-156	10
α-helix	157-161	5
α-helix	162-171	10
α-helix	173-176	4
β-strand	180	1	19
β-strand	183-187	5	20
β-strand	198-205	8	20
β-strand	206	1	19
β-strand	210-215	6	21
β-strand	226-227	2	20
α-helix	228-230	3
β-strand	231-232	2	20
β-strand	238-244	7	20
β-strand	255-260	6	21
β-strand	263-268	6	21

Chain G: 2 helices, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	22
α-helix	4-5	2
β-strand	6-11	6	23
β-strand	21-30	10	23
β-strand	31	1	22
β-strand	35-41	7	24
β-strand	44-45	2	24
β-strand	50-51	2	23
α-helix	52-54	3
β-strand	55-56	2	23
β-strand	62-70	9	23
β-strand	78-84	7	24
β-strand	91-94	4	24

Chain H: 4 helices, 17 β-strands

Element	Residues	Length	Sheet
β-strand	9-10	2	25
β-strand	15-19	5	26
β-strand	24-26	3	25
β-strand	29-30	2	25
β-strand	37-44	8	26
β-strand	51-57	7	26
β-strand	65-66	2	25
β-strand	69-74	6	25
β-strand	79-84	6	25
α-helix	89-91	3
β-strand	93-101	9	26
α-helix	106	1
β-strand	107-109	3	26
β-strand	113-118	6	26
β-strand	127-132	6	27
β-strand	140-145	6	27
α-helix	154-156	3
β-strand	161-163	3	27
α-helix	164-166	3
β-strand	167-171	5	27
β-strand	176-185	10	27

Chain I: 7 helices, 26 β-strands

Element	Residues	Length	Sheet
β-strand	4-7	4	28
β-strand	10-14	5	29
β-strand	19-21	3	30
β-strand	22-25	4	28
β-strand	31-37	7	29
α-helix	42-43	2
β-strand	44-49	6	29
β-strand	56-57	2	29
β-strand	65-66	2	30
β-strand	73	1	28
β-strand	76-78	3	30
α-helix	83-85	3
β-strand	87-94	8	29
β-strand	107-108	2	29
β-strand	112-117	6	29
α-helix	120-122	3
β-strand	124	1	31
α-helix	125-126	2
β-strand	127-131	5	32
α-helix	135-141	7
β-strand	143-153	11	32
β-strand	154	1	31
β-strand	158-164	7	33
β-strand	167-169	3	33
β-strand	173-175	3	32
β-strand	180-181	2	32
β-strand	191-200	10	32
α-helix	201-205	5
β-strand	210-217	8	33
β-strand	220	1	34
α-helix	231-232	2
β-strand	234	1	34
β-strand	236-243	8	33

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Major histocompatibility complex class I-related gene protein	A, F	protein	290	Homo sapiens	Q95460 (AlphaFold model)
Beta-2-microglobulin	B, G	protein	100	Homo sapiens	P61769 (AlphaFold model)
T cell receptor alpha chain MC.7.G5	D, H	protein	201	Homo sapiens	P0DTU3 (AlphaFold model)
T cell receptor beta chain MC.7.G5	E, I	protein	248	Homo sapiens	P0DTU4 (AlphaFold model)

Sequence of entity 1 (A, F), FASTA

>9HI7_1 Major histocompatibility complex class I-related gene protein (chains A, F)
MRTHSLRYFHLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHW
ERYTQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDF
LIFNKDTLSWLAVDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQRT
EPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEIDYGDILPSGDGTYQ
AWASIELDPQSSNLYSCHVEHSGVHMVLQVPGSGGGLNDIFEAQKIEWHE

Sequence of entity 2 (B, G), FASTA

>9HI7_2 Beta-2-microglobulin (chains B, G)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (D, H), FASTA

>9HI7_3 T cell receptor alpha chain MC.7.G5 (chains D, H)
MAQTVTQSQPEMSVQEAETVTLSCTYDTSESDYYLFWYKQPPSRQMILVIRQEAYKQQNA
TENRFSVNFQKAAKSFSLKISDSQLGDAAMYFCAYRSAVNARLMFGDGTQLVVKPNIQNP
DPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVLDMRSMDFKSNSAVAW
SNKSDFACANAFNNSIIPEDT

Sequence of entity 4 (E, I), FASTA

>9HI7_4 T cell receptor beta chain MC.7.G5 (chains E, I)
MEADIYQTPRYLVIGTGKKITLECSQTMGHDKMYWYQQDPGMELHLIHYSYGVNSTEKGD
LSSESTVSRIRTEHFPLTLESARPSHTSQYLCASSEARGLAEFTDTQYFGPGTRLTVLED
LKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVCTDPQP
LKEQPALNDSRYALSSRLRVSATFWQDPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVS
AEAWGRAD

Primary citation

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor. Suckling, R.J., Pamukcu, C., Simmons, R.A. et al. Front Immunol (2025) 16:1547664-1547664. DOI 10.3389/fimmu.2025.1547664 · PubMed

Other PDB entries of the same protein (UniProt Q95460 (AlphaFold model), which also has an AlphaFold model), best resolution first:

6PUD 1.8 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-5'OH-Pentyl-5-OP-U
6PUG 1.8 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-2`OH-Ethyl-5-OP-U
6PUL 1.84 Å, Structure of human MAIT A-F7 TCR in complex with human MR1 3'D-5-OP-RU
7ZT7 1.84 Å, Structure of E8 TCR in complex in human MR1 bound to 5FSA
6PUC 1.85 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-5-OP-RU
6PUH 1.88 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-Ribityl-less
6W9U 1.89 Å, Structure of human MAIT A-F7 TCR in complex with patient MR1-R9H-Ac-6-FP
4L4V 1.9 Å, Structure of human MAIT TCR in complex with human MR1-RL-6-Me-7-OH
5U6Q 1.9 Å, Structure of human MR1-3-F-SA in complex with human MAIT A-F7 TCR
6PUE 1.9 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-4'D-5-OP-RU
6PUF 1.92 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-5'D-5-OP-RU
6PUJ 1.92 Å, Structure of human MAIT A-F7 TCR in complex with human MR1-3`OH-Propyl-5-OP-U

Browse structure collections

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