KIR2DL1 bound to RIFIN PfKE01_040007400. Determined by X-ray diffraction at 2.17 Å resolution. Released 9 Apr 2025.
Explore 9HML in 3D Show helices and sheets RCSB PDB PDBe
9HML contains 12 α-helices and 33 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 11-27 | 17 | |
| α-helix | 31-35 | 5 | |
| α-helix | 49-60 | 12 | |
| α-helix | 62-65 | 4 | |
| α-helix | 77-80 | 4 | |
| α-helix | 81-85 | 5 | |
| β-strand | 98-100 | 3 | 1 |
| α-helix | 101-121 | 21 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 30-34 | 5 | 2 |
| β-strand | 38-40 | 3 | 3 |
| β-strand | 45-51 | 7 | 2 |
| β-strand | 57-64 | 8 | 1 |
| β-strand | 68-73 | 6 | 1 |
| β-strand | 75-77 | 3 | 2 |
| β-strand | 80-87 | 8 | 2 |
| α-helix | 92-94 | 3 | |
| β-strand | 96-105 | 10 | 1 |
| β-strand | 110-111 | 2 | 1 |
| α-helix | 113-117 | 5 | |
| β-strand | 118-120 | 3 | 1 |
| β-strand | 121-123 | 3 | 3 |
| β-strand | 130-132 | 3 | 4 |
| β-strand | 146-151 | 6 | 4 |
| β-strand | 157-162 | 6 | 5 |
| β-strand | 169-172 | 4 | 5 |
| β-strand | 174-175 | 2 | 4 |
| β-strand | 181-186 | 6 | 4 |
| β-strand | 195-202 | 8 | 5 |
| β-strand | 205-209 | 5 | 5 |
| α-helix | 211-215 | 5 | |
| β-strand | 216-217 | 2 | 5 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 4-7 | 4 | 6 |
| β-strand | 10-12 | 3 | 7 |
| β-strand | 18-24 | 7 | 6 |
| α-helix | 29-31 | 3 | |
| β-strand | 33-39 | 7 | 7 |
| β-strand | 46-51 | 6 | 7 |
| β-strand | 57-59 | 3 | 7 |
| β-strand | 67-72 | 6 | 6 |
| β-strand | 77-82 | 6 | 6 |
| α-helix | 87-89 | 3 | |
| β-strand | 91-98 | 8 | 7 |
| β-strand | 101 | 1 | 3 |
| β-strand | 106-109 | 4 | 7 |
| β-strand | 113-117 | 5 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Rifin PfKE01_040007400 | A | protein | 140 | Plasmodium falciparum | A0A024WGN3 (AlphaFold model) |
| KIR2DL protein | B | protein | 204 | Homo sapiens | P43626 (AlphaFold model) |
| nanobody Nb1 | C | protein | 126 | Escherichia coli |
>9HML_1 RIFIN PfKE01_040007400 (chains A) GSAKGAAACEAARIPAAIDAVIKGIVTKFGVSTESVQGLKSLFTANTYNDVTKIARAINE QYNPSSCLTGGSGADNSICPWAMENFFAARKIPGFIQREAVSMNDVIEKTVKTIVSDAPK TAETACKKATEGTGGSEPEA
>9HML_2 KIR2DL protein (chains B) TGRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKAN FSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGEN VTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHD SPYEWSKSSDPLLVSGTKHHHHHH
>9HML_3 nanobody Nb1 (chains C) QRQLVESGGGLVQPGGSLRLSCAASGRSFSDYTMGWFRQAPGKEREFVAAISWSGGSTYA DSVKGRFIISRDNVKNTVYLQMNSLEPEDTAVYYCAAERTGWSSEYDYWGKGTPVTVSSG HHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1. Sakoguchi, A., Chamberlain, S.G., Morch, A.M. et al. Nature (2025) 643:1363-1371. DOI 10.1038/s41586-025-09091-y · PubMed
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