Crystal Structures of Keap1-compound complexes. Determined by X-ray diffraction at 1.44 Å resolution. Released 10 Dec 2025.
Explore 9KVW in 3D Show helices and sheets RCSB PDB PDBe
9KVW contains 7 α-helices and 42 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 328-331 | 4 | 1 |
| β-strand | 334 | 1 | 2 |
| β-strand | 338 | 1 | 2 |
| β-strand | 342-346 | 5 | 1 |
| β-strand | 351-354 | 4 | 1 |
| α-helix | 356-358 | 3 | |
| β-strand | 363 | 1 | 3 |
| β-strand | 366-370 | 5 | 4 |
| β-strand | 373-377 | 5 | 4 |
| β-strand | 380 | 1 | 3 |
| β-strand | 389 | 1 | 3 |
| β-strand | 393-397 | 5 | 4 |
| β-strand | 402-405 | 4 | 4 |
| α-helix | 407-409 | 3 | |
| β-strand | 414 | 1 | 5 |
| β-strand | 417-421 | 5 | 6 |
| β-strand | 424-428 | 5 | 6 |
| β-strand | 431-432 | 2 | 5 |
| β-strand | 435-436 | 2 | 5 |
| β-strand | 440-444 | 5 | 6 |
| α-helix | 445-447 | 3 | |
| β-strand | 449-452 | 4 | 6 |
| α-helix | 454-456 | 3 | |
| β-strand | 461 | 1 | 7 |
| β-strand | 464-468 | 5 | 8 |
| β-strand | 471-475 | 5 | 8 |
| β-strand | 478 | 1 | 7 |
| β-strand | 483 | 1 | 7 |
| β-strand | 487-491 | 5 | 8 |
| α-helix | 492-494 | 3 | |
| β-strand | 496-500 | 5 | 8 |
| α-helix | 501-503 | 3 | |
| β-strand | 508 | 1 | 9 |
| β-strand | 511-515 | 5 | 10 |
| β-strand | 518-522 | 5 | 10 |
| β-strand | 525 | 1 | 9 |
| β-strand | 530 | 1 | 9 |
| β-strand | 534-538 | 5 | 10 |
| β-strand | 543-546 | 4 | 10 |
| α-helix | 548-550 | 3 | |
| β-strand | 555 | 1 | 11 |
| β-strand | 558-562 | 5 | 12 |
| β-strand | 565-569 | 5 | 12 |
| β-strand | 572 | 1 | 11 |
| β-strand | 577 | 1 | 11 |
| β-strand | 580-585 | 6 | 12 |
| β-strand | 590-596 | 7 | 12 |
| β-strand | 602 | 1 | 2 |
| β-strand | 605-608 | 4 | 1 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 | A | protein | 288 | Homo sapiens | Q14145 (AlphaFold model) |
>9KVW_1 Kelch-like ECH-associated protein 1 (chains A) PKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN NSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVE RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMIT AMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITV HQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
| ID | Name | Formula | Copies |
|---|---|---|---|
| A1EHH | ~{N}-[4-[(2-azanyl-2-oxidanylidene-ethyl)-[4-[(2-azanyl-2-oxidanylidene-ethyl)-… | C38 H44 N6 O9 S2 | 1 |
Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents. Chen, Y., Qin, Q., Ding, W. et al. Eur J Med Chem (2025) 296:117848-117848. DOI 10.1016/j.ejmech.2025.117848 · PubMed
Other PDB entries of the same protein (UniProt Q14145 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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