9L4H: HLA-C*14:03

Crystal structure of HLA-C*14:03 complexed with KIR2DL2. Determined by X-ray diffraction at 3.1 Å resolution. Released 24 Dec 2025.

Method: X-ray diffraction
Resolution: 3.1 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,519
Mol. weight: 65.95 kDa
Released: 24 Dec 2025

Explore 9L4H in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9L4H contains 13 α-helices and 54 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 8 helices, 21 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-102	9	1
β-strand	103	1	2
β-strand	109	1	2
β-strand	113-118	6	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	3
β-strand	186-193	8	4
β-strand	199-208	10	4
β-strand	209	1	3
β-strand	213-219	7	5
β-strand	222	1	5
β-strand	228-230	3	4
β-strand	234-235	2	4
β-strand	241-249	9	4
α-helix	254-256	3
β-strand	257-263	7	5
β-strand	270-272	3	5

Chain B: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	6
α-helix	4-5	2
β-strand	6-11	6	7
β-strand	21-30	10	7
β-strand	31	1	6
β-strand	35-41	7	8
β-strand	44-45	2	8
β-strand	50-51	2	7
β-strand	55-56	2	7
β-strand	62-70	9	7
β-strand	78-84	7	8
β-strand	91-94	4	8

Chain D: 4 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	9-13	5	9
β-strand	17-19	3	10
β-strand	24-30	7	9
β-strand	36-42	7	11
β-strand	47-52	6	11
α-helix	53	1
β-strand	54-55	2	9
β-strand	60-66	7	9
α-helix	71-73	3
β-strand	75-81	7	11
α-helix	92-96	5
β-strand	97-99	3	11
β-strand	100-102	3	10
β-strand	109-112	4	12
β-strand	117-118	2	13
β-strand	123-130	8	12
β-strand	136-140	5	14
β-strand	148-150	3	14
β-strand	160-168	9	12
β-strand	174-175	2	15
β-strand	176-180	5	14
β-strand	187	1	10
β-strand	188	1	14
α-helix	190-194	5
β-strand	195-196	2	15
β-strand	198-199	2	13

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	273	Homo sapiens	A0A6F8VJ76 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
LL8	C	protein	8	Homo sapiens
Killer cell immunoglobulin-like receptor 2DL2	D	protein	196	Homo sapiens	P43627 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9L4H_1 MHC class I antigen (chains A)
SHSMRYFSTSVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWD
RETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMFGCDLGPDGRLLRGYDQSAYDGK
DYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQR
AEHPKTHVTHHPVSEHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTF
QKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRW

Sequence of entity 2 (B), FASTA

>9L4H_2 Beta-2-microglobulin (chains B)
AIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>9L4H_3 LL8 (chains C)
LYNTVATL

Sequence of entity 4 (D), FASTA

>9L4H_4 Killer cell immunoglobulin-like receptor 2DL2 (chains D)
HRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVSKANF
SIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESV
TLSCSSRSSYDMYHLSLEGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDS
PYEWSNSSDPLLVSVI

Primary citation

Micropolymorphism outside the peptide-binding groove of human leukocyte antigen (HLA)-C*14 modulates structural stability and shapes immune responses. Liu, Q., Yang, M., Zhong, P. et al. Int J Biol Macromol (2025) 309:142772-142772. DOI 10.1016/j.ijbiomac.2025.142772 · PubMed

Other PDB entries of the same protein (UniProt A0A6F8VJ76 (AlphaFold model), which also has an AlphaFold model), best resolution first:

9L4G 2.7 Å, Crystal structure of HLA-C*14:03 complexed with 8-mer HIV gag peptide

Browse structure collections

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