9L4I: HLA-C*14:02

Crystal structure of HLA-C*14:02 complexed with KIR2DL2. Determined by X-ray diffraction at 2.5 Å resolution. Released 24 Dec 2025.

Method: X-ray diffraction
Resolution: 2.5 Å
Organism: Homo sapiens
Chains: 4
Atoms: 4,680
Mol. weight: 66.01 kDa
Released: 24 Dec 2025

Explore 9L4I in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9L4I contains 16 α-helices and 52 β-strands across 3 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 12 helices, 19 β-strands

Element	Residues	Length	Sheet
β-strand	4-12	9	1
α-helix	20	1
β-strand	21-28	8	1
β-strand	31-37	7	1
β-strand	46-47	2	1
α-helix	50-52	3
α-helix	57-84	28
β-strand	94-103	10	1
β-strand	109-118	10	1
β-strand	121-126	6	1
β-strand	133-135	3	1
α-helix	138-149	12
α-helix	152-158	7
α-helix	159-163	5
α-helix	164-174	11
α-helix	176-179	4
β-strand	183	1	2
α-helix	184-185	2
β-strand	186-192	7	3
β-strand	199-208	10	3
β-strand	209	1	2
β-strand	214-219	6	4
β-strand	222-223	2	4
α-helix	225-227	3
β-strand	228-230	3	3
α-helix	231-233	3
β-strand	234-235	2	3
β-strand	241-249	9	3
α-helix	254-256	3
β-strand	257-262	6	4
β-strand	270-272	3	4

Chain B: 1 helix, 11 β-strands

Element	Residues	Length	Sheet
β-strand	3	1	5
α-helix	4-5	2
β-strand	6-11	6	6
β-strand	21-30	10	6
β-strand	31	1	5
β-strand	36-41	6	7
β-strand	44-45	2	7
β-strand	50-51	2	6
β-strand	55-56	2	6
β-strand	62-70	9	6
β-strand	78-83	6	7
β-strand	91-94	4	7

Chain D: 3 helices, 22 β-strands

Element	Residues	Length	Sheet
β-strand	9-13	5	8
β-strand	17-19	3	9
β-strand	24-30	7	8
β-strand	36-42	7	10
β-strand	47-52	6	10
β-strand	54	1	8
β-strand	60-66	7	8
α-helix	71-73	3
β-strand	75-82	8	10
β-strand	90	1	10
α-helix	92-96	5
β-strand	97-99	3	10
β-strand	100-102	3	9
β-strand	109-112	4	11
β-strand	117-118	2	12
β-strand	123-130	8	11
β-strand	136-140	5	13
β-strand	148-151	4	13
β-strand	160-168	9	11
β-strand	174-175	2	14
β-strand	176-181	6	13
β-strand	184-188	5	13
α-helix	190-194	5
β-strand	195-196	2	14
β-strand	198-199	2	12

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
MHC class I antigen	A	protein	273	Homo sapiens	G9MDC7 (AlphaFold model)
Beta-2-microglobulin	B	protein	100	Homo sapiens	P61769 (AlphaFold model)
LL8	C	protein	8	Homo sapiens
Killer cell immunoglobulin-like receptor 2DL2	D	protein	196	Homo sapiens	P43627 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>9L4I_1 MHC class I antigen (chains A)
SHSMRYFSTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWD
RETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQWMFGCDLGPDGRLLRGYDQSAYDGK
DYIALNEDLRSWTAADTAAQITQRKWEAAREAEQRRAYLEGTCVEWLRRYLENGKETLQR
AEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTF
QKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRW

Sequence of entity 2 (B), FASTA

>9L4I_2 Beta-2-microglobulin (chains B)
MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKD
WSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Sequence of entity 3 (C), FASTA

>9L4I_3 LL8 (chains C)
LYNTVATL

Sequence of entity 4 (D), FASTA

>9L4I_4 Killer cell immunoglobulin-like receptor 2DL2 (chains D)
HRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVSKANF
SIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESV
TLSCSSRSSYDMYHLSLEGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDS
PYEWSNSSDPLLVSVI

Primary citation

Micropolymorphism outside the peptide-binding groove of human leukocyte antigen (HLA)-C*14 modulates structural stability and shapes immune responses. Liu, Q., Yang, M., Zhong, P. et al. Int J Biol Macromol (2025) 309:142772-142772. DOI 10.1016/j.ijbiomac.2025.142772 · PubMed

Browse structure collections

About this viewer

MolViewer shows 9L4I directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.